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pyogenic arthritis

Naba Pallab Chetia, Aritra Bidyananda, Manabjyoti Talukdar, Munin Borgohain
Introduction: Tuberculosis (TB) of isolated radial head is scantily reported in the literature. Nonspecific symptoms and difficulty in interpreting initial screening radiographs often lead to misdiagnosis. Case Report: We present a case of 42-year-old male elsewhere diagnosed as pyogenic arthritis of left elbow and treated by incisional drainage and broad-spectrum antibiotics, who presented to us 6 months later with multiple non-healing actively discharging sinuses...
May 2018: Journal of Orthopaedic Case Reports
Selcan Demir, Erdal Sag, Fatma Dedeoglu, Seza Ozen
Autoinflammatory diseases (AID) are diseases of the innate immune system, characterized by recurrent episodes of localized or systemic inflammation. Vasculitis may accompany AID. The causes of the association of vasculitis with monogenic AID are still debated. Among the monogenic AID, Familial Mediterranean Fever (FMF) is the most common. IgA-related vasculitis (IgAV) and Polyarteritis Nodosa (PAN) involving small and/or medium-sized vessels have an increased frequency among FMF patients. There are also case reports revealing vasculitic features in Cryopyrin-Associated Periodic Fever Syndrome (CAPS), Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS), Mevalonate Kinase Deficiency (MKD), also known as Hyper IgD syndrome (HIDS), Deficiency of IL-1 Receptor Antagonist (DIRA) and Pyogenic Arthritis, Pyoderma gangrenosum, and Acne (PAPA) patients...
2018: Frontiers in Pediatrics
Ryuji Tanaka, Yuji Yasunaga, Jiro Fujii, Takuma Yamasaki, Takeshi Shoji, Nobuo Adachi
BACKGROUND: Joint-preserving procedures should be considered as much as possible for hip disorders in pediatric and young patients. However, in patients with extensive osteonecrosis (ON) of the femoral head combined with severe collapse and advanced secondary osteoarthritis (OA), the optimal procedure has not been elucidated. This retrospective study aimed to investigate the postoperative outcomes of 11 patients who underwent transtrochanteric rotational osteotomy (TRO) alone or with a combination treatment for various hip disorders in young patients and to evaluate the usefulness of TRO...
December 13, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Holger Schäffler, Theresia Blattmann, Annette Findeisen, Felix G Meinel, Almut Meyer-Bahlburg, Georg Lamprecht, Lars Steinmüller-Magin, Ralf Trauzeddel, Steffen Emmert
BACKGROUND: The PAPA syndrome, an acronym for pyogenic sterile arthritis, pyoderma gangraenosum and acne, is an autosomal dominant hereditary disease which is caused by a mutation in the PSTPIP1 ("proline-serine-threonine phosphatase interacting protein 1") gene located on chromosome 15 and encodes the proline-serine-threonine phosphatase-interacting protein 1. An association with Crohn's disease (CD), autoimmune diseases of the liver and PAPA syndrome has not yet been reported in the literature...
November 22, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
John I Hogan, Rocío M Hurtado, Sandra B Nelson
Although less common as causes of musculoskeletal infection than pyogenic bacteria, both Mycobacterium tuberculosis and nontuberculous mycobacteria can infect bones and joints. Although tuberculous arthritis and osteomyelitis have been recognized for millennia, infections caused by nontuberculous mycobacteria are being identified more often, likely because of a more susceptible host population and improvements in diagnostic capabilities. Despite advances in modern medicine, mycobacterial infections of the musculoskeletal system remain particularly challenging to diagnose and manage...
February 2019: Thoracic Surgery Clinics
Elsayed Omer, Abdelsamed I Elshamy, Mahmoud Nassar, Joseph Shalom, Alan White, Ian E Cock
Ankylosing spondylitis, multiple sclerosis, rheumatoid arthritis and rheumatic fever are autoimmune inflammatory diseases that may be triggered in genetically susceptible individuals by specific bacterial pathogens. Inhibiting the growth of these bacteria with high antioxidant plant extracts may inhibit the aetiology of these diseases, as well as inhibiting the later phase symptoms. P. squarrosa extracts were analysed for antioxidant activity using a DPPH free radical scavenging assay. Bacterial growth inhibitory activity was evaluated using disc diffusion assays and the activity was quantified by MIC determination...
November 16, 2018: Inflammopharmacology
Jin Yi, Ruohui Tang, Jing Yang, Yueqi Chen, Jun Fei
Streptococcus pyogenes (GAS) is a clinically significant bacterial strain that causes bacterial arthritis, osteomyelitis and implant infections. Infection complications can lead to serious bone destruction. Osteoclasts, the only type of cell with bone resorption function, participate in this process. Streptolysin O (SLO) is produced by almost all clinical Streptococcus pyogenes isolates. However, the role of SLO in bone infection caused by GAS had not been previously examined. The current study was performed to define the effects of SLO on receptor activator of NF‑κB ligand‑stimulated osteoclast differentiation in vitro...
November 15, 2018: Molecular Medicine Reports
Yong Chuan Chee, Chong Hong Lim
Infective sacroiliitis is a rare disease with misleading clinical signs that often delay diagnosis. We report a case of pyogenic sacroiliac joint septic arthritis caused by Klebsiella pneumoniae that has not been reported in the literature highlighting it as one of the important etiologies of infective sacroiliitis especially among diabetics.
2018: IDCases
Fumihiro Ochi, Hisamichi Tauchi, Toshihiro Jogamoto, Hiromitsu Miura, Tomozo Moritani, Kozo Nagai, Eiichi Ishii
Streptococcus pyogenes (also referred to as group A streptococci, GAS) causes severe invasive diseases such as bacteremia, necrotizing fasciitis, pneumonia, osteomyelitis, septic arthritis, and toxic shock syndrome in children. However, there are only a few reports on pleural empyema caused by GAS in children. Here, we report the case of a 4-year-old boy who presented with pleural empyema due to GAS after influenza A virus infection. With intravenous antibiotic administration and continuous chest-tube drainage, followed by video-assisted thoracoscopic surgery, his condition improved...
2018: Case Reports in Pediatrics
Helder Nogueira, Joana Pereira, André Couto, Jorge Alves, Daniel Lopes, Joana Freitas, Nuno Alegrete, Gilberto Costa
This is a case report of pyogenic sacroiliitis in a pediatric patient caused by Streptococcus intermedius . The patient is a 16-year-old boy who presented to an emergency department with sudden onset of back pain radiating to the left lower extremity. The diagnosis was confounded by the presence of isthmic spondylolisthesis. Plain radiography demonstrated mild isthmic spondylolisthesis but no radiographic signs of tumor, trauma, infection, arthritis, or other developmental problems. The C-reactive protein level was 23 mg/L...
July 2018: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
Claudia Martinez-Rios, Mehul P Jariwala, Kerri Highmore, Karen Watanabe Duffy, Lynn Spiegel, Ronald M Laxer, Jennifer Stimec
Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is a rare autosomal-dominant autoinflammatory disease of incomplete penetrance and variable expression. PAPA syndrome is the result of a mutation in the proline serine threonine phosphatase-interacting protein 1 (PSTPIP1/CD2BP1) gene located on chromosome 15, which results in an abnormal overproduction of the pro-inflammatory cytokine interleukin-1β (IL-1). This syndrome clinically manifests as early onset of recurrent episodes of acute aseptic inflammation of the joints, generally occurring in the first two decades of life, followed by manifestation of characteristic skin lesions in the third decade, after an obvious decline in the joint symptoms...
January 2019: Pediatric Radiology
Wen-Ya Lin, Jiaan-Der Wang, Yu-Tse Tsan, Wei-Cheng Chan, Kwok-Man Tong, Shin-Tsu Chang, Yuan-Yang Cheng
Recurrent hemarthrosis in patients with hemophilia (PWH) results in chronic arthropathy requiring total joint replacement (TJR). This study aimed to compare the difference in TJR rate between patients with hemophilia A (HA) and hemophilia B (HB). A final total of 935 PWH (782 HA and 153 HB) without inhibitors were collected from the Taiwan's National Health Insurance Research Database between 1997 and 2013. Demographics, clinical characteristics, and TJR rate were compared between the 2 groups. The annual use of clotting factor concentrate was not different between HA and HB groups ( P = ...
September 13, 2018: Clinical and Applied Thrombosis/hemostasis
Dieter Vanderschaeghe, Leander Meuris, Tom Raes, Hendrik Grootaert, Annelies Van Hecke, Xavier Verhelst, Frederique Van de Velde, Bruno Lapauw, Hans Van Vlierberghe, Nico Callewaert
Over the past 30 years, it has been firmly established that a wide spectrum of (autoimmune) diseases such as rheumatoid arthritis, Crohn's and lupus, but also other pathologies like alcoholic and non-alcoholic steatohepatitis (ASH and NASH) are driven by chronic inflammation and are hallmarked by a reduced level of serum IgG galactosylation. IgG (under)galactosylation is a promising biomarker to assess disease severity, and monitor and adjust therapy. However, this biomarker has not been implemented in routine clinical chemistry due to a complex analytical procedure that necessitates IgG purification, which is difficult to perform and validate at high throughput...
September 6, 2018: Molecular & Cellular Proteomics: MCP
Laurence De Davide, Annie Beaudoin
Phlegmonous gastritis is a pyogenic infection affecting the submucosa of the gastric wall. Although rarely diagnosed, it remains a disease with high mortality. We thereby describe the case of a 42-year-old male patient known for psoriatic arthritis on Infliximab who was diagnosed with phlegmonous gastritis secondary to immunosuppressive therapy. The patient had a favourable outcome with a conservative treatment consisting of a 14-day course of broad antibiotherapy.
2018: Case Reports in Gastrointestinal Medicine
Zhiqiang Zhang, Hao Li, Hai Li, Qing Fan, Xuan Yang, Pinquan Shen, Ting Chen, Qixun Cai, Jing Zhang, Ziming Zhang
BACKGROUND: Osteomyelitis (OM) is an uncommon disease that originates from many different mechanisms in children. Treatment often involves a combination of surgical debridement combined and antibiotic therapy. The purpose of this article is to evaluate the effect of debridement combined with a new resorbable bone graft substitute (RBGS) mixed with antibiotics in the treatment of infants with OM. METHODS: Twenty-two patients diagnosed with OM at our institution underwent debridement combined with implantation of RBGS mixed with vancomycin within 48 h after admission...
August 30, 2018: Journal of Orthopaedic Surgery and Research
Pragnesh Mistry, Carmelo Carmona-Rivera, Amanda K Ombrello, Patrycja Hoffmann, Nickie L Seto, Anne Jones, Deborah L Stone, Faiza Naz, Philip Carlucci, Stefania Dell'Orso, Gustavo Gutierrez-Cruz, Hong-Wei Sun, Daniel L Kastner, Ivona Aksentijevich, Mariana J Kaplan
OBJECTIVES: Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is characterised by flares of sterile arthritis with neutrophil infiltrate and the overproduction of interleukin (IL)-1β. The purpose of this study was to elucidate the potential role of neutrophil subsets and neutrophil extracellular traps (NET) in the pathogenesis of PAPA. METHODS: Neutrophils and low-density granulocytes (LDG) were quantified by flow cytometry. Circulating NETs were measured by ELISA and PAPA serum was tested for the ability to degrade NETs...
December 2018: Annals of the Rheumatic Diseases
Mary-Louise C Greer
Whole-body MRI is increasingly utilized for assessing oncologic and non-oncologic diseases in infants, children and adolescents. Focusing on the non-oncologic indications, this review covers technical elements required to perform whole-body MRI, the advantages and limitations of the technique, and protocol modifications tailored to specific indications. Rheumatologic diseases account for the majority of non-oncologic whole-body MRI performed in pediatric patients at the author's institution. Whole-body MRI helps in establishing the diagnosis, documenting disease extent and severity, and monitoring treatment response in enthesitis-related arthritis (ERA) and chronic recurrent multifocal osteomyelitis (CRMO)...
August 2018: Pediatric Radiology
Kutty Selva Nandakumar, Mattias Collin, Kaisa E Happonen, Susanna L Lundström, Allyson M Croxford, Bingze Xu, Roman A Zubarev, Merrill J Rowley, Anna M Blom, Christian Kjellman, Rikard Holmdahl
Endo-β- N -acetylglucosaminidase (EndoS) is a family 18 glycosyl hydrolase secreted by Streptococcus pyogenes . Recombinant EndoS hydrolyzes the β-1,4-di- N -acetylchitobiose core of the N-linked complex type glycan on the asparagine 297 of the γ-chains of IgG. Here, we report that EndoS and IgG hydrolyzed by EndoS induced suppression of local immune complex (IC)-mediated arthritis. A small amount (1 µg given i.v. to a mouse) of EndoS was sufficient to inhibit IgG-mediated arthritis in mice. The presence of EndoS disturbed larger IC lattice formation both in vitro and in vivo , as visualized with anti-C3b staining...
2018: Frontiers in Immunology
Cristina Popescu, Anca Leuştean, Alina Elena Orfanu, Codruţa Georgiana Carp, Victoria Aramă
Introduction: Streptococcal infection can be responsible for multiple complications, such as toxic, septic or allergic disorders. Toxin-mediated complications (TMC) can appear during the acute phase of disease and can involve any organ, causing carditis, arthritis, nephritis, hepatitis etc. Case presentation: The case of a young woman without a history of recurrent streptococcal tonsillitis, admitted to "Matei Balş" National Institute for Infectious Diseases, Bucharest, Romania, presenting with fever, sore throat and exudative tonsillitis, is detailed...
October 2017: Journal of Critical Care Medicine
Guillaume Coiffier, Marine Ferreyra, Jean-David Albert, Nathalie Stock, Anne Jolivet-Gougeon, Aleth Perdriger, Pascal Guggenbuhl
To assess the diagnostic value of ultrasound-guided (US-guided) synovial biopsy in routine clinical practice in cases of acute and chronic arthritis. A retrospective, single-center study of US-guided synovial biopsies between 2003 and 2013. The clinical, laboratory, radiographic, synovial fluid, and histological and bacteriological results of synovial biopsies were analyzed. Arthritis was classified according to disease duration < 6 weeks (AA) or ≥ 6 weeks (CA). Synovial biopsy success rate was defined by the rate of capsular and/or synovial tissue analyzed...
August 2018: Clinical Rheumatology
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