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https://read.qxmd.com/read/30877431/alpha-synuclein-suppresses-mitochondrial-protease-clpp-to-trigger-mitochondrial-oxidative-damage-and-neurotoxicity
#1
Di Hu, Xiaoyan Sun, Xudong Liao, Xinwen Zhang, Sara Zarabi, Aaron Schimmer, Yuning Hong, Christopher Ford, Yu Luo, Xin Qi
Both α-Synuclein (αSyn) accumulation and mitochondrial dysfunction have been implicated in the pathology of Parkinson's disease (PD). Although studies suggest that αSyn and its missense mutant, A53T, preferentially accumulate in the mitochondria, the mechanisms by which αSyn and mitochondrial proteins regulate each other to trigger mitochondrial and neuronal toxicity are poorly understood. ATP-dependent Clp protease (ClpP), a mitochondrial matrix protease, plays an important role in regulating mitochondrial protein turnover and bioenergetics activity...
March 15, 2019: Acta Neuropathologica
https://read.qxmd.com/read/30877170/disruption-of-fbxl5-mediated-cellular-iron-homeostasis-promotes-liver-carcinogenesis
#2
Yoshiharu Muto, Toshiro Moroishi, Kazuya Ichihara, Masaaki Nishiyama, Hideyuki Shimizu, Hidetoshi Eguchi, Kyoji Moriya, Kazuhiko Koike, Koshi Mimori, Masaki Mori, Yuta Katayama, Keiichi I Nakayama
Hepatic iron overload is a risk factor for progression of hepatocellular carcinoma (HCC), although the molecular mechanisms underlying this association have remained unclear. We now show that the iron-sensing ubiquitin ligase FBXL5 is a previously unrecognized oncosuppressor in liver carcinogenesis in mice. Hepatocellular iron overload elicited by FBXL5 ablation gave rise to oxidative stress, tissue damage, inflammation, and compensatory proliferation of hepatocytes and to consequent promotion of liver carcinogenesis induced by exposure to a chemical carcinogen...
March 15, 2019: Journal of Experimental Medicine
https://read.qxmd.com/read/30875918/design-and-evaluation-of-a-surface-electromyography-controlled-steering-assistance-interface
#3
Edric John Cruz Nacpil, Zheng Wang, Rencheng Zheng, Tsutomu Kaizuka, Kimihiko Nakano
Millions of drivers could experience shoulder muscle overload when rapidly rotating steering wheels and reduced steering ability at increased steering wheel angles. In order to address these issues for drivers with disability, surface electromyography (sEMG) sensors measuring biceps brachii muscle activity were incorporated into a steering assistance system for remote steering wheel rotation. The path-following accuracy of the sEMG interface with respect to a game steering wheel was evaluated through driving simulator trials...
March 15, 2019: Sensors
https://read.qxmd.com/read/30875624/gastric-sleeve-surgery-in-hemodialysis-a-case-report
#4
Kateir Mariel Contreras Villamizar, Diana Carolina Afanador Rubio, Camilo Alberto González González, Paola Karina García Padilla, Martha Patricia Rodríguez Sánchez
INTRODUCTION: Morbid obesity in chronic kidney disease patients on hemodialysis limits access to renal transplantation. We report here a case of a surgical procedure for weight reduction in a hemodialysis patient and adjustment of dry weight through bioelectrical impedance. CASE PRESENTATION: A 44-year-old male with CKD on hemodialysis for 26 years. After 3 years on dialysis, he underwent a cadaveric kidney transplant. However, after 8 years of transplant, he loses the kidney graft and returns to dialysis treatment...
March 5, 2019: International Journal of Surgery Case Reports
https://read.qxmd.com/read/30874991/assessment-of-cell-free-levels-of-iron-and-copper-in-patients-with-friedreich-s-ataxia
#5
Deepti Pathak, Achal Kumar Srivastava, Sheffali Gulati, Moganty R Rajeswari
Friedreich's ataxia (FRDA), a progressive neurodegenerative disorder caused by trinucleotide (GAA) repeat expansion in frataxin (fxn) gene which results in decreased levels of frataxin protein. Insufficient frataxin levels leads to iron and copper deposits in the brain and cardiac cells. A total of hundred and twenty patients, suspected of FRDA were screened for the (GAA) repeats in the fxn gene and only confirmed patients (n = 25) were recruited in the study. The total Iron and total copper concentrations were measured in blood plasma using Nitro PAPS and Dibrom PAESA method, respectively both in patients and age, sex matched healthy controls...
March 14, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30874600/iron-induces-insulin-resistance-in-cardiomyocytes-via-regulation-of-oxidative-stress
#6
Hye Kyoung Sung, Erfei Song, James Won Suk Jahng, Kostas Pantopoulos, Gary Sweeney
Iron overload is associated with various pathological changes which contribute to heart failure. Here, we examined mechanisms via which iron alters cardiomyocyte insulin sensitivity. Treatment of primary adult and neonatal cardiomyocytes as well as H9c2 cells with iron decreased insulin sensitivity determined via Western blotting or immunofluorescent detection of Akt and p70S6K phosphorylation and glucose uptake. Using CellROX deep red or DCF-DA probes we also observed that iron increased generation of reactive oxygen species (ROS), and that pretreatment with the superoxide dismutase mimetic MnTBAP reduced ROS production and attenuated iron-induced insulin resistance...
March 15, 2019: Scientific Reports
https://read.qxmd.com/read/30873809/the-use-and-perceived-barriers-of-the-partograph-at-public-health-institutions-in-east-gojjam-zone-northwest-ethiopia
#7
Desalegne Zelellw, Teketo Tegegne
INTRODUCTION: The partograph is a vital tool used to reduce maternal and fetal mortality and morbidity and to prevent prolonged and obstructed labor, as well as postpartum hemorrhage and fistula formation. This study explored the use and barriers of the partograph among obstetric caregivers in East Gojam Zone, Northwest Ethiopia. METHODS AND MATERIALS: A cross-sectional study design consisting of both quantitative and qualitative methods was utilized. Data was collected through a structured clinical observation checklist and semistructured questions...
April 30, 2018: Annals of Global Health
https://read.qxmd.com/read/30873034/icariin-protects-bone-marrow-mesenchymal-stem-cells-against-iron-overload-induced-dysfunction-through-mitochondrial-fusion-and-fission-pi3k-akt-mtor-and-mapk-pathways
#8
Xudong Yao, Xingzhi Jing, Jiachao Guo, Kai Sun, Yi Deng, Yong Zhang, Fengjing Guo, Yaping Ye
Iron overload has been reported to contribute to bone marrow mesenchymal stem cells (BMSCs) damage, but the precise mechanism still remains elusive. Icariin, a major bioactive monomer belonging to flavonoid glucosides isolated from Herba Epimedii, has been shown to protect cells from oxidative stress induced apoptosis. The aim of this study was to investigate whether icariin protected against iron overload induced dysfunction of BMSCs and its underlying mechanism. In this study, we found that iron overload induced by 100 μM ferric ammonium citrate (FAC) caused apoptosis of BMSCs, promoted cleaved caspase-3 and BAX protein expressions while inhibited Bcl-2 protein expression, which effects were significantly attenuated by icariin treatment...
2019: Frontiers in Pharmacology
https://read.qxmd.com/read/30872605/dynamic-mitochondrial-responses-to-a-high-fat-diet-in-drosophila-melanogaster
#9
Robert P J Cormier, Camille M Champigny, Chloé J Simard, Patrick-Denis St-Coeur, Nicolas Pichaud
Mitochondria can utilize different fuels according to physiological and nutritional conditions to promote cellular homeostasis. However, during nutrient overload metabolic inflexibility can occur, resulting in mitochondrial dysfunctions. High-fat diets (HFDs) are usually used to mimic this metabolic inflexibility in different animal models. However, how mitochondria respond to the duration of a HFD exposure is still under debate. In this study, we investigated the dynamic of the mitochondrial and physiological functions in Drosophila melanogaster at several time points following an exposure to a HFD...
March 14, 2019: Scientific Reports
https://read.qxmd.com/read/30872209/using-artificial-intelligence-to-combat-information-overload-in-research
#10
Douglas Raymond
Scientists striving for impact in their fields and to develop their own careers must publish papers that represent new and important science, typically in a peer-reviewed journal. The number of scientific articles published has doubled every nine years since WWII, and now stands at more than 3 million peer-reviewed articles annually from more than 34,000 scholarly journals.
January 2019: IEEE Pulse
https://read.qxmd.com/read/30872129/molecular-mechanisms-of-protein-bound-uremic-toxin-mediated-cardiac-renal-and-vascular-effects-underpinning-intracellular-targets-for-cardiorenal-syndrome-therapy
#11
REVIEW
Feby Savira, Ruth Magaye, Yue Hua, Danny Liew, David Kaye, Tom Marwick, Bing Hui Wang
Cardiorenal syndrome (CRS) remains a global health burden with a lack of definitive and effective treatment. Protein-bound uremic toxin (PBUT) overload has been identified as a non-traditional risk factor for cardiac, renal and vascular dysfunction due to significant albumin-binding properties, rendering these solutes non-dialyzable upon the state of irreversible kidney dysfunction. Although limited, experimental studies have investigated possible mechanisms in PBUT-mediated cardiac, renal and vascular effects...
March 11, 2019: Toxicology Letters
https://read.qxmd.com/read/30871038/acetazolamide-therapy-in-patients-with-heart-failure-a-meta-analysis
#12
Janewit Wongboonsin, Charat Thongprayoon, Tarun Bathini, Patompong Ungprasert, Narothama Reddy Aeddula, Michael A Mao, Wisit Cheungpasitporn
BACKGROUND AND OBJECTIVES: Fluid overload and central sleep apnea are highly prevalent in patients with heart failure (HF). We performed this meta-analysis to assess the effects of acetazolamide therapy on acid/base balance and apnea indexes. METHODS: A literature search was conducted using EMBASE, MEDLINE, and Cochrane Database from inception through 18 November 2017 to identify studies evaluating the use of acetazolamide in HF. Study results were analyzed using a random effects model...
March 12, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/30870430/increased-salt-intake-does-not-worsen-the-progression-of-renal-cystic-disease-in-high-water-loaded-pck-rats
#13
Shizuko Nagao, Masanori Kugita, Kanako Kumamoto, Aya Yoshimura, Kazuhiro Nishii, Tamio Yamaguchi
The anti-diuretic hormone arginine vasopressin is thought to be a detrimental factor in polycystic kidney disease (PKD). We previously reported that high water intake (HWI) reduced urine osmolality and urinary arginine vasopressin, improved renal function, and reduced the kidney/body weight ratio in PCK rats, an orthologous model of human PKD. In PKD patients, however, it is reported that HWI increases total kidney volume, urine volume, and urine sodium excretion, which could be a consequence of high salt intake...
2019: PloS One
https://read.qxmd.com/read/30869493/-severe-neonatal-anemia-due-to-fetomaternal-hemorrhage-an-ilustrative-case
#14
Cristina Menéndez Hernando, Rocío Chacón Aguilar, Mercedes Fariñas Salto, Rocío Pérez Crespo, Raquel Martin Molina, Rocío Moreno Novillo, María Cabrerizo Ortiz
Fetomaternal transfusion (FMT) is defined by the transfer of fetal blood into the maternal circulation. The incidence of massive FMT is estimated to be approximately 0.2-0.9 % of births. Although a number of etiologies have been associated with FMT, most causes remain unidentified and the pregnancy is usually asymptomatic. The most frequent symptom is the decrease in fetal movements (26 %) in relation to severe anemia. Several diagnostic modalities for FMT are described (Kleihauer stain, flow cytometry). We describe a case of a newborn with chronic anemia secondary to FMT who, after treatment with transfusions of red blood cells, presented volume overload and clinical worsening as a complication...
April 1, 2019: Archivos Argentinos de Pediatría
https://read.qxmd.com/read/30869483/relation-between-fluid-overload-and-mortality-in-children-with-septic-shock
#15
Horacio Márquez-González, Luis Casanova-Bracamontes, C Mireya Muñoz-Ramírez, Leoncio Peregrino-Bejarano, Bárbara Bolaños-Téllez, Lucelli Yáñez-Gutiérrez
INTRODUCTION: Septic shock is one of the main causes of mortality. Fluid replacement stands out as the treatment of choice to reduce mortality. OBJECTIVE: To determine the relation between the percentage of fluid overload (%FO) and mortality in children with septic shock. METHODS: Cohort study in patients aged 1-17 years with septic shock, after fluid replacement with central venous pressure ≥ 5 mmHg, invasive monitoring, and complete recording of %FO up to 96 h...
April 1, 2019: Archivos Argentinos de Pediatría
https://read.qxmd.com/read/30869366/-r%C3%A3-actions-transfusionnelles
#16
Jacques Chiaroni
Transfusion reactions. As with any therapy, blood transfusion may be responsible for side effects that are referred to as «adverse recipient events». They can occur during or within hours of a transfusion or later in the days or weeks after . Their declaration to the haemovigilance device is mandatory. Whether immediate or delayed, there are three main mechanisms are defined: immunological, infectious and overload. The haemovigilance device in proportion to severity and accountability. Their prevention is based on the safety of the prepared products as well as on the compliance with the rules on prescription, selection and transfusion concerning in particular recipient identification...
November 2018: La Revue du Praticien
https://read.qxmd.com/read/30868263/effective-inhibition-of-copper-catalyzed-production-of-hydroxyl-radicals-by-deferiprone
#17
V A Timoshnikov, T Kobzeva, O Y Selyutina, N E Polyakov, G J Kontoghiorghes
Copper ions can catalyze the production of free oxygen radicals (•OH and •OOH) similar to iron ions. The capacity to initiate oxidative damage is most commonly attributed to Cu-induced toxicity in copper-related diseases where there is an increase in copper levels and also when Cu homeostasis and regulation are disrupted. An antioxidant/chelator inhibiting Cu-induced oxidative damage could play a significant role in the treatment of such Cu-related diseases. Deferiprone has high affinity for copper binding and can be considered for the potential treatment of copper toxicity and overloading conditions, such as Wilson's disease...
March 13, 2019: Journal of Biological Inorganic Chemistry: JBIC
https://read.qxmd.com/read/30867432/widespread-perk-dependent-repression-of-er-targets-in-response-to-er-stress
#18
Nir Gonen, Niv Sabath, Christopher B Burge, Reut Shalgi
The UPR (Unfolded Protein Response) is a well-orchestrated response to ER protein folding and processing overload, integrating both transcriptional and translational outputs. Its three arms in mammalian cells, the PERK translational response arm, together with the ATF6 and IRE1-XBP1-mediated transcriptional arms, have been thoroughly investigated. Using ribosome footprint profiling, we performed a deep characterization of gene expression programs involved in the early and late ER stress responses, within WT or PERK -/- Mouse Embryonic Fibroblasts (MEFs)...
March 13, 2019: Scientific Reports
https://read.qxmd.com/read/30865769/novel-displays-of-patient-information-in-critical-care-settings-a-systematic-review
#19
Rosalie G Waller, Melanie C Wright, Noa Segall, Paige Nesbitt, Thomas Reese, Damian Borbolla, Guilherme Del Fiol
OBJECTIVE: Clinician information overload is prevalent in critical care settings. Improved visualization of patient information may help clinicians cope with information overload, increase efficiency, and improve quality. We compared the effect of information display interventions with usual care on patient care outcomes. MATERIALS AND METHODS: We conducted a systematic review including experimental and quasi-experimental studies of information display interventions conducted in critical care and anesthesiology settings...
March 13, 2019: Journal of the American Medical Informatics Association: JAMIA
https://read.qxmd.com/read/30863968/sex-differences-in-ischemia-reperfusion-injury-the-role-of-mitochondrial-permeability-transition
#20
Jasmine A Fels, Giovanni Manfredi
Brain and heart ischemia are among the leading causes of death and disability in both men and women, but there are significant sex differences in the incidence and severity of these diseases. Ca2+ dysregulation in response to ischemia/reperfusion injury (I/RI) is a well-recognized pathogenic mechanism leading to the death of affected cells. Excess intracellular Ca2+ causes mitochondrial matrix Ca2+ overload that can result in mitochondrial permeability transition (MPT), which can have severe consequences for mitochondrial function and trigger cell death...
March 12, 2019: Neurochemical Research
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