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Erika Arai Furusawa, Camila Sanches Lanetzki Esposito, Rachel Sayuri Honjo, Lisa Suzuki, Gabriela Nunes Leal, Chong Ae Kim, Benita Galassi Soares Schvartsman
AIM: To describe the incidence, diagnosis, and management of systemic arterial hypertension related to renal artery stenosis in patients with Williams-Beuren syndrome. METHODS: Sixty-five patients with Williams-Beuren syndrome were evaluated for hypertension. Enrolled patients underwent Doppler sonography of the renal arteries and Doppler echocardiography. Those with Doppler sonography-detected lesions or with normal Doppler sonography but severe hypertension underwent computed tomography or gadolinium-enhanced magnetic resonance angiography of the aorta and renal vessels...
August 2018: Revista da Associação Médica Brasileira
Sree Krishna Venuthurupalli, Helen Healy, Robert Fassett, Anne Cameron, Zaimin Wang, Wendy Elizabeth Hoy
BACKGROUND: Chronic Kidney Disease, Queensland (CKD.QLD) is a multidisciplinary, collaborative research platform for CKD in Queensland. All public renal services contribute towards the CKD Registry, including Toowoomba Hospital which is a referral hospital for Darling Downs Health (DDH) serving largely regional population in Queensland. We aim to present the profile of the CKD cohort recruited to CKD.QLD Registry from Toowoomba Hospital, the first comprehensive report on pre-dialysis population from regional Australia METHODS: Study subjects were patients in the DDH service who consented to be included in the CKD...
January 20, 2019: Nephrology
Jing Liu, Jing Wu
No abstract text is available yet for this article.
January 18, 2019: Cardiovascular Research
Carli Wittgrove, Harleen Kaur, Junaid H Siddiqui
Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiologic syndrome resulting in subcortical vasogenic edema appreciated on T2/fluid-attenuated inversion recovery (FLAIR) sequence of magnetic resonance imaging (MRI). PRES classically involves bilateral parieto-occipital lobes and is usually reversible. Atypical variant of PRES includes the involvement of brainstem, basal ganglia, thalami, or periventricular white matter. We report an unusual case of PRES with isolated brainstem involvement with periventricular white matter changes in a patient with renovascular hypertension from unilateral renal artery stenosis...
November 12, 2018: Curēus
Zachary Wolfmueller, Kunal Goyal, Bhanu Prasad
BACKGROUND: We report a 61-year-old female with end-stage renal disease (ESRD) secondary to polycystic kidney disease (PKD) complicated by intradialytic hypertension (IDH). Increased sympathetic drive leading to increased stroke volume and/or vasoconstriction with an inappropriate increase in peripheral vascular resistance (PVR) has been postulated to be the cause of IDH. CASE PRESENTATION: Attempts to control her blood pressure by reducing her goal weight; increasing dialysis times/ frequency and decreasing her sodium concentrate in the dialysis fluid were unsuccessful...
January 14, 2019: BMC Nephrology
Jun-Hong Ren, Na Ma, Si-Yu Wang, You-Jing Sun, Yue-Wei Zhang, Fa-Jin Guo, Yong-Jun Li, Tian-Hui Li, Hu Ai, Wen-Duo Zhang, Peng Li, Wei-Hua Ma
BACKGROUND: Renal artery stenosis (RAS) is always associated with abnormalities in renal microvascular perfusion (RMP). However, few imaging methods can simultaneously evaluate the degree of luminal stenosis and RMP. Thus, this study will aim to evaluate the feasibility of using contrast-enhanced ultrasound (CEUS) for assessing both RAS and RMP to achieve a one-stop assessment of patients with suspected renovascular hypertension. METHODS: This will be a single-center diagnostic study with a sample size of 440...
January 5, 2019: Chinese Medical Journal
Mariana Rosso Melo, Silvia Gasparini, Guilherme F Speretta, Elaine Fernanda Silva, Gustavo Rodrigues Pedrino, Jose V Menani, Daniel B Zoccal, Débora Simões Almeida Colombari, Eduardo Colombari
The rodent renovascular hypertension model has been used to investigate the mechanisms promoting hypertension. The importance of the carotid body for renovascular hypertension has been demonstrated. As the commissural NTS (cNTS) is the first synaptic site in the central nervous system that receives information from carotid body chemoreceptors, we evaluated the contribution of cNTS to renovascular hypertension in the present study. Normotensive male Holtzman rats were implanted with a silver clip around the left renal artery to induce two-kidney, one-clip (2K1C) hypertension...
January 8, 2019: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Hua Tian, Yu-Ming Kang, Hong-Li Gao, Xiao-Lian Shi, Li-Yan Fu, Ying Li, Xiu-Yue Jia, Kai-Li Liu, Jie Qi, Hong-Bao Li, Yan-Mei Chen, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Xiao-Jing Yu
BACKGROUND: Berberine (BBR), a Chinese traditional herbal medicine, has many pharmacologic benefits such as anti-inflammation and anti-oxidation. It is widely used in clinical treatment of cardiovascular diseases such as hypertension. However, the mechanism of how BBR attenuates hypertension through affecting central neural system is not clear. PURPOSE: This study was designed to determine whether chronic infusion of BBR into the hypothalamic paraventricular nucleus (PVN) attenuates hypertension and sympathoexcitation via the ROS/Erk1/2/iNOS pathway...
January 2019: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Erika E Nishi, Nathalia R Lopes, Guiomar N Gomes, Juliana C Perry, Alex Y S Sato, Maria G Naffah-Mazzacoratti, Cássia T Bergamaschi, Ruy R Campos
The underlying mechanisms by which renal denervation (RD) decreases blood pressure (BP) remain incompletely understood. In this study, we investigated the effects of ischemic kidney denervation on different sympathetic outflows, brain and renal expression of angiotensin-II receptors, oxidative stress and renal function markers in the 2-kidney, 1-clip (2K-1C) rat model. Surgical RD was performed in Wistar male rats 4-5 weeks after clip implantation. After 10 days of RD, BP, and the activity of sympathetic nerves projecting to the contralateral kidney (rSNA) and splanchnic region were partially reduced in 2K-1C rats, with no change in systemic renin-angiotensin system (RAS)...
December 20, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Taro Horino, Osamu Ichii, Tatsuki Matsumoto, Yoshio Terada
No abstract text is available yet for this article.
December 18, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Haojian Dong, Yanqiu Ou, Zhiqiang Nie, Wenhui Huang, Yuan Liu, Yingling Zhou, Jianfang Luo, Guang Li
OBJECTIVE: Data about renal artery stenosis association with left ventricular remodeling in patients coexisting with coronary artery disease are scanty. METHODS: Patients with suspected both coronary artery disease and renal artery stenosis undergoing coronary and renal arteriography between October 2013 and December 2015 were prospectively enrolled. Left ventricular remodeling patterns were compared among different severity of renal artery stenosis group. Logistic regression was done to investigate the determinants of the left ventricular morphology...
December 14, 2018: Vascular
Zaiqiang Yu, Masahito Minakawa, Norihiro Kondo, Kazuyuki Daitoku, Ikuo Fukuda
INTRODUCTION: Middle aortic syndrome (MAS) combined with thoracic aortic aneurysm (TAA) is a rare vascular disease. One stage open surgery to treat this condition, becomes a challenge for our cardiovascular surgery. PRESENTATION OF CASE: A 69-year-old man presented with a saccular type aortic arch aneurysm, shaggy aorta and severe atherosclerotic stenosis of the thoracoabdominal aorta with middle aortic syndrome and aberrant right subclavian artery, renovascular hypertension, renal dysfunction, and intermittent claudication of both legs...
November 24, 2018: International Journal of Surgery Case Reports
Stella Stabouli, Euthymia Vargiami, Olga Maliachova, Nikoleta Printza, John Dotis, Maria Kyriazi, Konstantinos O Papazoglou, Dimitrios Zafeiriou
Arterial hypertension is a common finding in patients with neurofibromatosis (NF) type 1. Renovascular hypertension due to renal artery stenosis or midaortic syndrome could be the underlying cause. We report the case of a 4-year-old girl with NF type 1 and midaortic syndrome whose changes in blood pressure and pulse wave velocity suggested the evolution of vasculopathy, diagnosis of renovascular hypertension, and provided insights of response to treatment. Hypertension persisted after percutaneous transluminal angioplasty in the abdominal aorta, requiring escalation of antihypertensive treatment, while arterial stiffness demonstrated a mild decrease...
2018: Case Reports in Pediatrics
Sercin Ozkok, Ahmet Aslan, Yildiz Gulseren, Gonul Kutlu Aciksari, Mehmet Ali Agirbasli
A 23-year-old female patient with factor VII (FVII) deficiency was admitted with severe hypertension and renal failure. Brachial arterial pressures were 230/120 and 220/115 mm/Hg on the right and left arms, respectively. There was no blood pressure difference between the arms. Renal artery Doppler ultrasonography revealed bilateral severe renal artery stenosis (RAS). Contrast-enhanced magnetic resonance imaging angiography (CE-MRA) revealed severe mural irregularities, contrast enhancement in the aorta and its branches, and long-segment stenosis starting in the abdominal aorta and extending into the proximal renal arteries...
October 2018: Eurasian Journal of Medicine
Jianming Guo, Lianrui Guo, Gao Zeng, Zhu Tong, Xixiang Gao, Yongquan Gu
Guo J, Guo L, Zeng G, Tong Z, Gao X, Gu Y. An infant case of renovascular hypertension in moyamoya disease treated by angioplasty. Turk J Pediatr 2018; 60: 331-334. Here we report the treatment experience of an 18-month-old female infant case of renovascular hypertension due to moyamoya disease by angioplasty. Although renal blood flow was recovered immediately after operation, 12 months follow-up found severe restenosis which required us to perform a right renal autotransplantation.
2018: Turkish Journal of Pediatrics
Maysa Isernhagen Schaedler, Rhanany Alan Calloi Palozi, Cleide Adriane Signor Tirloni, Aniely Oliveira Silva, Valdinei de Oliveira Araújo, Emerson Luiz Botelho Lourenço, Lauro Mera de Souza, Francislaine Aparecida Dos Reis Lívero, Arquimedes Gasparotto Junior
BACKGROUND: One of the medicinal plants widely used by the population in the treatment of hypertension, atherosclerosis and circulatory disorders is Cuphea carthagenensis (Jacq.) J.F. Macbr. (Lythraceae), popularly known as 'sete sangrias', being found in Brazil, Hawaii and in South Pacific Islands. Despite the widespread use of this species by the population, its long-term antihypertensive and cardioprotective activities have not yet been scientifically evaluated. PURPOSE: To evaluate the possible cardioprotective effects of an ethanol-soluble fraction obtained from C...
December 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Misako Nagatsuma, Kei Takasawa, Takeru Yamauchi, Ryuichi Nakagawa, Tomoko Mizuno, Eriko Tanaka, Kouhei Yamamoto, Noriko Uemura, Kenichi Kashimada, Tomohiro Morio
Schimmelpenning syndrome is a rare neurocutaneous disorder categorized as a mosaic RASopathy due to postzygotic HRAS or KRAS mutations. We report a 6-year-old girl diagnosed with Schimmelpenning syndrome due to a postzygotic KRAS G12D mutation. The patient had three atypical symptoms of Schimmelpenning syndrome: renovascular hypertension, congenital lipomatosis, and diabetes mellitus. The first two symptoms may overlap with phenotypes of other neurocutaneous syndromes or congenital lipomatous overgrowth syndrome due to mosaic RASopathies or other somatic mosaic mutations...
February 2019: Journal of Human Genetics
Brian R Lane, Stephen K Babitz, Katerina Vlasakova, Allen Wong, Sabrina L Noyes, William Boshoven, Pam Grady, Cindy Zimmerman, Susan Engerman, Maureen Gebben, Michael Tanen, Warren E Glaab, Frank D Sistare
BACKGROUND: Partial nephrectomy (PN) is the gold standard for the treatment of small renal masses. Urinary biomarkers (UBMs) may serve as early indicators of acute kidney injury (AKI) following PN. OBJECTIVE: To evaluate the timing, specificity, and sensitivity of several candidate UBMs after PN to determine the most promising UBMs in this setting. We hypothesize that some UBMs will have utility as early markers of AKI. DESIGN, SETTING, AND PARTICIPANTS: Twenty-two patients undergoing on-clamp robotic or open PN underwent paired urine collection via ureteral catheterization of the affected kidney and Foley catheterization for the unaffected kidney obtained preoperatively, after anesthesia, and at several points in time after renovascular occlusion...
November 10, 2018: European Urology Focus
Pei Lin Chan, Florence Hui Sieng Tan
Background: Hypokalemia in the presence of hypertension is often attributed to primary hyperaldosteronism as a cause of secondary hypertension, however secondary hyperaldosteronism may present similarly. Accessory renal arteries are variants in the vascular anatomy which are often thought to be innocuous but in some circumstances can cause renovascular hypertension leading to secondary hyperaldosteronism. Case presentation: We report 2 cases of hypertension with secondary hyperaldosteronism associated with accessory renal arteries...
2018: Clinical Hypertension
Ryuji Okamoto, Masaya Taniguchi, Yuki Onishi, Naoto Kumagai, Junji Uraki, Naoki Fujimoto, Eitaro Fujii, Yutaka Yano, Toru Ogura, Masaaki Ito
It remains unknown which surrogate markers can predict diagnostic test results for primary hyperaldosteronism (PA). The Secondary Hypertension Registry Investigation in Mie Prefecture (SHRIMP) study has sequentially and prospectively recruited 128 patients with hypertension with an aldosterone-to-renin ratio (ARR) greater than 20, evaluated the differences among essential hypertension (EHT), idiopathic hyperaldosteronism (IHA), and aldosterone-producing adenoma (APA), and analyzed the predictors for the confirmatory tests...
January 2019: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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