Hye-Yeong Jo, Youngsun Lee, Hongryul Ahn, Hyeong-Jun Han, Ara Kwon, Bo-Young Kim, Hye-Yeong Ha, Sang Cheol Kim, Jung-Hyun Kim, Yong-Ou Kim, Sun Kim, Soo Kyung Koo, Mi-Hyun Park
Human pluripotent stem cells (hPSCs) have promising therapeutic applications due to their infinite capacity for self-renewal and pluripotency. Genomic stability is imperative for the clinical use of hPSCs; however, copy number variation (CNV), especially recurrent CNV at 20q11.21, may contribute genomic instability of hPSCs. Furthermore, the effects of CNVs in hPSCs at the whole-transcriptome scale are poorly understood. This study aimed to examine the functional in vivo and in vitro effects of frequently detected CNVs at 20q11...
October 29, 2020: Scientific Reports