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Gynoid lipodystrophy

Kamila Tokarska, Sławomir Tokarski, Anna Woźniacka, Anna Sysa-Jędrzejowska, Jarosław Bogaczewicz
Cellulite (also known as gynoid lipodystrophy or orange peel syndrome) is one of the most common lipodystrophy syndromes, which affects millions of post-adolescent women. Cellulite is manifested by topographic disorders of subcutaneous tissue such as nodules, edema, and abnormal fibrosis. It is located mainly on the pelvic area, especially on the buttocks. Its pathogenesis is complexed and unclear. There are several theories about its pathophysiology. Hormonal disorders, endothelial dysfunction and genetic predispositions are taken under consideration...
October 2018: Postȩpy Dermatologii i Alergologii
Jadwiga Konieczna, Itziar Abete, Aina M Galmés, Nancy Babio, Antoni Colom, Maria Angeles Zulet, Ramón Estruch, Josep Vidal, Estefanía Toledo, Andrés Díaz-López, Miguel Fiol, Rosa Casas, Josep Vera, Pilar Buil-Cosiales, Vicente Martín, Albert Goday, Jordi Salas-Salvadó, J Alfredo Martínez, Dora Romaguera
BACKGROUND & AIMS: Excess adiposity is associated with poor cardiometabolic (CM) health. To date, several techniques and indicators have been developed to determine adiposity. We aimed to compare the ability of traditional anthropometric, as well as standard and novel DXA-derived parameters related to overall and regional adiposity, to evaluate CM risk. METHODS: Using the cross-sectional design in the context of the PREDIMED-Plus trial, 1207 Caucasian senior men and women with overweight/obesity and metabolic syndrome (MetS) were assessed...
July 11, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Francisco M Pérez Atamoros, Daniel Alcalá Pérez, Daniel Asz Sigall, Alfonsina A Ávila Romay, José A Barba Gastelum, José A de la Peña Salcedo, Pablo E Escalante Salgado, Guillermo J Gallardo Palacios, Guillermo A Guerrero-Gonzalez, Rodrigo Morales De la Cerda, Rosa María Ponce Olivera, Fabiola Rossano Soriano, Eduardo Solís Tinoco, Esperanza C Welsh Hernández
Gynoid lipodystrophy (GLD) is a structural, inflammatory, and biochemical disorder of the subcutaneous tissue causing alterations in the topography of the skin. Commonly known as "cellulite," GLD affects up to 90% of women, practically in all stages of the life cycle, beginning in puberty. It is a clinical condition that considerably affects the patients' quality of life. It is a frequent reason for consultation, although the patients resort to empirical, improvised, nonevidence-based treatments which discourage and can be a source of frustration not only because of the lack of results but also due to the complications derived from those treatments...
April 30, 2018: Journal of Cosmetic Dermatology
Mario Puviani, Federica Tovecci, Massimo Milani
INTRODUCTION: Gynoid lipodystrophy, also known as cellulite, is a very common skin alteration representing mainly a cosmetic problem rather than a real disease. An effective treatment of cellulite has not been well established. The initial phase of cellulite is characterized by subdermal tissue edema with interstitial fluids retention. A new hypertonic topical product with draining action (HTC) containing NaCl 13%, escine, caffeine, and beta-sitosterol has been recently developed. A 28-day double-blind placebo-controlled study has shown that this cream is able to reduce thigh circumference and the thickness of adipose tissue...
June 2018: Journal of Cosmetic Dermatology
Priscila Bianca Rodrigues da Rocha, Bruno Dos Santos Souza, Lígia Marquez Andrade, Ricardo Neves Marreto, Eliana Martins Lima, Stephânia Fleury Taveira
The topical application of Centella asiatica extract has been commonly used for many different purposes but especially for cosmetic use in the treatment of gynoid lipodystrophy. Asiaticoside, the most active component in this extract, is responsible for its therapeutic activities. However, little is known to date about asiaticoside skin penetration. Thus, an analytical method for asiaticoside quantification in different skin layers after the topical application of C. asiatica extract was developed and skin permeation studies were performed with the plant extract to apply the analytical method developed...
December 2017: Planta Medica
Francisca Rodrigues, Ana Catarina Alves, Claudia Nunes, Bruno Sarmento, M Helena Amaral, Salette Reis, M Beatriz P P Oliveira
The aim of the present work was to develop and evaluate the potential of nanostructured lipid carriers associated with caffeine extracted from Coffee Silverskin (NLC-CS), a food by-product, as a new possible topical therapy of cellulitis. Caffeine gain increasing research interest due to their cosmetic potential, particularly in gynoid lipodystrophy, commonly known as cellulite. NLC-CS were prepared via double emulsion technique using polysorbate 60 as surfactant and characterized for their morphology, particle size, zeta potential, association encapsulation and stability...
November 20, 2016: International Journal of Pharmaceutics
Luana Ramalho Pianez, Fernanda Silva Custódio, Renata Michelini Guidi, Jauru Nunes de Freitas, Estela Sant'Ana
BACKGROUND: Carbon dioxide therapy, better known as carboxytherapy, relates to percutaneous infusion of medical carbon dioxide with therapeutic approaches, and its use in the treatment of localized fat has demonstrated good results. Gynoid lipodystrophy, also known as cellulite, affects 80%-90% of women after puberty, especially in the buttocks and thighs. Its etiology is complex and involves multifactorial aspects. Its treatment and evaluation require the use of new technologies (more effective and low-cost approaches)...
2016: Clinical, Cosmetic and Investigational Dermatology
Christina Wei, Manigandan S Thyagiarajan, Linda P Hunt, Julian P H Shield, Michael C G Stevens, Elizabeth C Crowne
BACKGROUND: Survivors of childhood acute lymphoblastic leukaemia (ALL) treated with haematopoietic stem cell transplantation and total body irradiation (HSCT/TBI) have a high cardiometabolic risk despite lacking overt clinical obesity. This study characterised body composition using different methodologies and explored associations with reduced insulin sensitivities in a group of ALL survivors treated with/without HSCT/TBI. PROCEDURE: Survivors of childhood ALL treated with HSCT/TBI (n = 20,10 M) were compared with Chemotherapy-only (n = 31), and an obese non-leukaemic controls (n = 30)...
November 2015: Pediatric Blood & Cancer
Bianca Schonvvetter, Juliana Laudicéia Marques Soares, Ediléia Bagatin
BACKGROUND: The gynoidlypodystrophy, known as cellulitis or cellulite, refers to a condition that gives the skin an undulating and uneven appearance, affecting 80-90% of women after puberty. OBJECTIVES: to investigate the efficacy and safety of manual lymphatic drainage for cellulite management. METHODS: this was an open, prospective, intervention study including 20 women aged from 20 to 40 years. Fourteen sessions of manual lymphatic drainage were performed once a week on lower limbs and buttocks...
September 2014: Anais Brasileiros de Dermatologia
Steven Petak, Carmen G Barbu, Elaine W Yu, Roger Fielding, Kathleen Mulligan, Brian Sabowitz, Chih-Hsing Wu, John A Shepherd
Dual-energy x-ray absorptiometry (DXA) measurements of body composition increasingly are used in the evaluation of clinical disorders, but there has been little guidance on how to effectively report these measures. Uniformity in reporting of body composition measures will aid in the diagnosis of clinical disorders such as obesity, sarcopenia, and lipodystrophy. At the 2013 International Society for Clinical Densitometry Position Development Conference on body composition, the reporting section recommended that all DXA body composition reports should contain parameters of body mass index, bone mineral density, BMC, total mass, total lean mass, total fat mass, and percent fat mass...
October 2013: Journal of Clinical Densitometry
Cristiane Martins da Silva, Marcus Vinicius de Mello Pinto, Luis Guilherme Barbosa, Sebastião David Dos Santos Filho, Lamara Laguardia Valente Rocha, Reggiani Vilela Gonçalves
INTRODUCTION: The objective of this study was to evaluate the effect of ultrasound and the technique of phonophoresis with hyaluronidase in patients with cellulite edematous type II in the gluteal region. METHODS: Forty-two individuals, all females, were selected and randomly divided into two groups with 21 patients in each. Group I was treated with ultrasound without hyaluronidase and Group II was treated with ultrasound with hyaluronidase. To evaluate individuals, inspection, palpation, photography data and diagnostic ultrasound were performed before and after the treatment...
August 2013: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
M Rondanelli, A Opizzi, S Perna, M A Faliva, D Buonocore, G Pezzoni, A Michelotti, R Marchetti, F Marzatico
BACKGROUND: Peloid has been popularly used as an effective base in cosmetic preparations, although its biologically-active materials and mechanisms on skin have not yet been fully determined. An association between Massaciuccoli peat and sodium chloride water of Undulna Thermae was evaluated as a 2-weeks therapy for gynoid lipodystrophy in a group of 30 overweight females (age: 20-50y, BMI: 25-35 kg/m2) by means of evidence based-medicine criteria. METHODS: The modification of the body diameters was the primary end-point, and the variation of skinfold thicknesses, bioimpendance parameters, evaluation of skin elasticity, rated thermal contact to liquid crystals and measurement of subcutaneous fat tissue were the secondary end-points...
September 2012: Annali di Igiene: Medicina Preventiva e di Comunità
José Maria Pereira de Godoy, Mayra Yara Groggia, Lucilene Ferro Laks, Maria de Fátima Guerreiro de Godoy
Aim. The aim of this paper is to report a novel intensive therapy of gynoid lipodystrophy (cellulite) based on a new hypothesis. Methods. Were evaluated in 10 patients with ages ranging between 25 and 59 years (mean 35.6 years) grade IV cellulite identified by clinical evaluation. Before initiating treatment, perimetry was performed at 5 cm intervals along both thighs, at the gluteal fold, 5, 10, and 15 cm above the gluteal fold, at the navel, and 5 cm above the navel. The patients were submitted to a 4-hour daily treatment session that consisted of manual and mechanical lymph drainage and cervical stimulation by the Godoy & Godoy technique adapted for the treatment of cellulite...
2012: Dermatology Research and Practice
Giovana Barbosa Milani, A'Dayr Natal Filho, Sílvia Maria Amado João
INTRODUCTION: Gynoid lipodystrophy (cellulite) has been cited as a common dermatological alteration. It occurs mainly in adult women and tends to gather around the thighs and buttocks. Its presence and severity have been related to many factors, including biotype, age, sex, circulatory changes, and, as some authors have suggested, mechanical alterations such as lumbar hyperlordosis. OBJECTIVE: To correlate the degree of cellulite with the angle of lumbar lordosis in asymptomatic women...
August 2008: Clinics
P Quatresooz, E Xhauflaire-Uhoda, C Piérard-Franchimont, G E Piérard
Cellulite, sometimes called gynoid lipodystrophy, is much more prevalent in women than in men. There are glaring discrepancies regarding the microanatomical descriptions of this condition in the literature. A lumpy aspect of the dermo-hypodermal interface is often cited, but it appears to represent a gender-linked characteristic of the thighs and buttocks without being a specific sign of cellulite. Incipient cellulite recognized by a discrete padded look or 'orange peel' aspect appears correlated with the presence of a network of focally enlarged fibrosclerotic strands partitioning the hypodermis and serving as a physiological buttress limiting the outpouching of fat lobules on pinching the skin...
June 2006: International Journal of Cosmetic Science
Giovanni Salti, Ilaria Ghersetich, Franca Tantussi, Bruno Bovani, Torello Lotti
BACKGROUND: Recent articles have introduced the novel concept of chemical lipolysis through local injections. Phosphatidylcholine is the active drug in the commercial preparation used for this purpose, but some studies have suggested that sodium deoxycholate, an excipient of the preparation, could be the real active substance. AIM: We decided to investigate whether phosphatidylcholine and sodium deoxycholate have any clinical efficacy in chemical lipolysis and their respective roles...
January 2008: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Omar Lupi, Ivan Jorge Semenovitch, Curt Treu, Daniel Bottino, Eliete Bouskela
Gynoid lipodystrophy, also known as cellulite, is a common multifactorial entity that affects millions of women around the world. There have been few scientific articles dealing with its physiology and treatment in the past few years, and vascular changes seem to play an important role in its pathophysiology. Skin microvascular alterations can be observed noninvasively with a new method called orthogonal polarization spectral imaging, which was used to evaluate the effectiveness of an anticellulite drug composed mainly of a 7% caffeine solution...
June 2007: Journal of Cosmetic Dermatology
Lola K Smalls, Matthew Hicks, David Passeretti, Keith Gersin, W John Kitzmiller, Adel Bakhsh, R Randall Wickett, Jennifer Whitestone, Marty O Visscher
BACKGROUND: Gynoid lipodystrophy (cellulite) affects most women, and many seek plastic surgery consultation to improve appearance. Various products are offered, but the literature on the cause and treatment is limited. Understanding the biological and biophysical factors that affect severity may facilitate the development of effective therapies. There has been a dramatic increase in the number of people who have lost significant weight as a result of bariatric surgery or medically supervised weight programs...
August 2006: Plastic and Reconstructive Surgery
Lola K Smalls, Caroline Y Lee, Jennifer Whitestone, W John Kitzmiller, R Randall Wickett, Marty O Visscher
Gynoid lipodystrophy (cellulite) is the irregular, dimpled skin surface of the thighs, abdomen, and buttocks in 85% of post-adolescent women. The distinctive surface morphology is believed to result when subcutaneous adipose tissue protrudes into the lower reticular dermis, thereby creating irregularities at the surface. The biomechanical properties of epidermal and dermal tissue may also influence severity. Cellulite-affected thigh sites were measured in 51 females with varying degrees of cellulite, in 11 non-cellulite controls, and in 10 male controls...
March 2005: Journal of Cosmetic Science
A B Rossi, A L Vergnanini
Gynoid lipodystrophy (cellulite) is an extremely controversial topic. A lack of knowledge regarding specific aetiopathogenic factors, as well as the opportunism of some professionals and the media, has fuelled debate regarding the scientific basis of this condition. This article reviews the clinical, epidemiological, histopathological and therapeutic aspects of cellulite.
July 2000: Journal of the European Academy of Dermatology and Venereology: JEADV
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