Carmen Rubio, Marta Puerto, Juan J García-Rodríquez, Van B Lu, Irma García-Martínez, Rosa Alén, Patricia Sanmartín-Salinas, M Val Toledo-Lobo, Jorge Saiz, Javier Ruperez, Coral Barbas, Luis Menchén, Fiona M Gribble, Frank Reimann, Luis G Guijarro, Jose M Carrascosa, Ángela M Valverde
OBJECTIVE: Non-alcoholic steatohepatitis (NASH) is characterized by a robust pro-inflammatory component at both hepatic and systemic levels together with a disease-specific gut microbiome signature. Protein tyrosine phosphatase 1 B (PTP1B) plays distinct roles in non-immune and immune cells, in the latter inhibiting pro-inflammatory signaling cascades. In this study, we have explored the role of PTP1B in the composition of gut microbiota and gut barrier dynamics in methionine and choline-deficient (MCD) diet-induced NASH in mice...
May 2020: Molecular Metabolism