keyword
https://read.qxmd.com/read/37673735/mouse-hygiene-status-a-tale-of-two-environments-for-mast-cells-and-allergy
#21
REVIEW
Yu-Wen Yeh, Zou Xiang
Animal models, including those employing the use of house mice (Mus musculus), are crucial in elucidating mechanisms in human pathophysiology. However, it is evident that the impreciseness of using laboratory mice maintained in super-hygienic barrier facilities to mirror relevant aspects of human physiology and pathology exists, which is a major limitation in translating mouse findings to inferring human medicine. Interestingly, free-living wild mice are found to be substantially different from laboratory-bred, specific pathogen-free mice with respect to various immune system compartments...
September 4, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/37291572/identification-of-colorectal-cancer-progression-associated-intestinal-microbiome-and-predictive-signature-construction
#22
JOURNAL ARTICLE
Jungang Liu, Xiaoliang Huang, Chuanbin Chen, Zhen Wang, Zigui Huang, Mingjian Qin, Fuhai He, Binzhe Tang, Chenyan Long, Hong Hu, Shuibo Pan, Junduan Wu, Weizhong Tang
OBJECTIVE: The relationship between intestinal microbiome and colorectal cancer (CRC) progression is unclear. This study aims to identify the intestinal microbiome associated with CRC progression and construct predictive labels to support the accurate assessment and treatment of CRC. METHOD: The 192 patients included in the study were divided into stage I-II and stage III-IV CRC patients according to the pathological stages, and preoperative stools were collected from both groups for 16S rDNA sequencing of the intestinal microbiota...
June 8, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/37228621/intermittent-fasting-protects-against-food-allergy-in-a-murine-model-via-regulating-gut-microbiota
#23
JOURNAL ARTICLE
Ru-Xue Ma, Jia-Qian Hu, Wei Fu, Jian Zhong, Can Cao, Chang-Chang Wang, Shi-Quan Qi, Xiao-Lian Zhang, Guang-Hui Liu, Ya-Dong Gao
BACKGROUND: The prevalence of food allergy (FA) is increasing. Decreases in the diversity of gut microbiota may contribute to the pathogenesis of FA by regulating IgE production of B cells. Intermittent fasting (IF) is a popular diet with the potential to regulate glucose metabolism, boosting immune memory and optimizing gut microbiota. The potential effect of long-term IF on the prevention and treatment of FA is still unknown. METHODS: Two IF protocols (16 h fasting/8 h feeding and 24 h fasting/24 h feeding) were conducted on mice for 56 days, while the control mice were free to intake food (free diet group, FrD)...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37051264/obesity-and-the-microbiome-in-atopic-dermatitis-therapeutic-implications-for-ppar-%C3%AE-agonists
#24
REVIEW
Jeremy P McAleer
Atopic dermatitis (AD) is an inflammatory skin disease characterized by epidermal barrier disruption, Th2 immune responses to skin allergens and microbial dysbiosis within affected lesions. Studies within the past decade have revealed genetic and environmental factors contributing to AD in children. Obesity is a metabolic disorder that often manifests early in life and is associated with reduced bacterial diversity, leading to skin colonization with lipophilic bacteria and intestinal colonization with pro-inflammatory species...
2023: Front Allergy
https://read.qxmd.com/read/36987580/fos-ameliorates-dnfb-induced-atopic-dermatitis-like-skin-lesions-and-the-comorbid-anxiety-and-depressive-like-behaviors-in-mice-by-modulating-the-gut-microbiota-neurotransmitter-releases-and-immune-responses
#25
JOURNAL ARTICLE
Shaoze Chen, Liu Tang, Tingting Nie, Mingyu Fang, Xiaoqin Cao
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritus and eczema lesions and psychiatric comorbidities. The Gut-brain-skin axis plays a pivotal role during AD development, which could might be a novel therapeutic strategy for AD. Herein, the present study aims to uncover the protective effects and underlying mechanisms of fructo-oligofructose (FOS), a type of prebiotic, on AD-like skin manifestations and the comorbid anxiety and depression in AD mice...
March 28, 2023: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/36968499/research-trends-in-the-field-of-the-gut-brain-interaction-functional-dyspepsia-in-the-spotlight-an-integrated-bibliometric-and-science-mapping-approach
#26
REVIEW
Tai Zhang, Beihua Zhang, Xiangxue Ma, Jiaqi Zhang, Yuchen Wei, Fengyun Wang, Xudong Tang
OBJECTIVES: This study aims to perform a bibliometric analysis of functional dyspepsia (FD), which includes visualizing bibliographic information, in order to identify prevailing study themes, topics of interest, contributing journals, countries, institutions, and authors as well as co-citation patterns. METHODS: The Web of Science™ Core Collection Database was used to retrieve all peer-reviewed scientific publications related to FD research. The validated search terms were entered into the "title" and "author keywords" fields, and the results were sorted by publication year from 2006 to 2022...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/36905215/the-animal-s-microbiome-and-cancer-a-translational-perspective
#27
REVIEW
Catarina Sofia Aluai-Cunha, Catarina Alves Pinto, Isabel Alexandra Duarte Ferreira Lopes Correia, Cláudia Alexandra Dos Reis Serra, Andreia Alexandra Ferreira Santos
Cancer is a substantial global health problem both in humans and animals with a consistent increase in mortality and incidence rate. The commensal microbiota has been involved in the regulation of several physiological and pathological processes, both within the gastrointestinal system and at distant tissue locations. Cancer isn't an exception, and different aspects of the microbiome have been described to have anti- or pro-tumour effects. Using new techniques, for example high-throughput DNA sequencing, microbial populations of the human body have been largely described and, in the last years, studies more focused on companions' animals have emerged...
March 11, 2023: Veterinary and Comparative Oncology
https://read.qxmd.com/read/36835568/the-crosstalk-between-intestinal-epithelial-cells-and-mast-cells-is-modulated-by-the-probiotic-supplementation-in-co-culture-models
#28
JOURNAL ARTICLE
Raffaella di Vito, Alessia Di Mezza, Carmela Conte, Giovanna Traina
The intestinal epithelium constitutes a selectively permeable barrier between the internal and external environment that allows the absorption of nutrients, electrolytes, and water, as well as an effective defense against intraluminal bacteria, toxins, and potentially antigenic material. Experimental evidence suggest that intestinal inflammation is critically dependent on an imbalance of homeostasis between the gut microbiota and the mucosal immune system. In this context, mast cells play a crucial role. The intake of specific probiotic strains can prevent the development of gut inflammatory markers and activation of the immune system...
February 19, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36830373/tannic-acid-induces-intestinal-dysfunction-and-intestinal-microbial-dysregulation-in-brandt-s-voles-lasiopodomys-brandtii
#29
JOURNAL ARTICLE
Minghui Gu, Ruiyang Fan, Xin Dai, Chen Gu, Aiqin Wang, Wanhong Wei, Shengmei Yang
Brandt's vole ( Lasiopodomys brandtii ) is a small herbivorous mammal that feeds on plants rich in secondary metabolites (PSMs), including tannins. However, plant defense mechanisms against herbivory by Brandt's voles are not clearly established. This study aimed to investigate the effects of dietary tannic acid (TA) on the growth performance, intestinal morphology, digestive enzyme activities, cecal fermentation, intestinal barrier function, and gut microbiota in Brandt's voles. The results showed that TA significantly hindered body weight gain, reduced daily food intake, changed the intestinal morphology, reduced digestive enzyme activity, and increased the serum zonulin levels ( p < 0...
February 7, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/36806451/understanding-the-connection-between-gut-homeostasis-and-psychological-stress
#30
REVIEW
Hongyun Zhang, Ziying Wang, Guangqiang Wang, Xin Song, Yangyang Qian, Zhuan Liao, Li Sui, Lianzhong Ai, Yongjun Xia
Long-term exposure to adverse life events that provoke acute or chronic psychological stress (hereinafter "stress") can negatively affect physical health and even increase susceptibility to psychological illnesses, such as anxiety and depression. As a part of the hypothalamic-pituitary-adrenal axis, corticotropin-releasing factor (CRF) released from the hypothalamus is primarily responsible for the stress response. Typically, CRF disrupts the gastrointestinal system and leads to gut microbiota dysbiosis, thereby increasing risk of functional gastrointestinal diseases, such as irritable bowel syndrome...
April 2023: Journal of Nutrition
https://read.qxmd.com/read/36741118/bibliometric-study-of-neuroinflammation-in-autism-spectrum-disorder
#31
Yingying Shen, Jiu-Gen Zhong, Wan-Ting Lan, Yin-Hua Li, Jia-Heng Gong, Ben-Xuan Zhao, Xiao-Hui Hou
BACKGROUND: Neuroinflammation is closely associated with the occurrence and development of autism spectrum disorder (ASD). This study aims to describe the global development history and current status of neuroinflammation in ASD from 2004 to 2021 and reveal the research hotspots and frontiers to provide a reference for scholars in related fields to carry out further research. METHODS: Journal articles on ASD and neuroinflammation-related research were obtained from the Web of Science Core Collection (WOSCC) database from its inception to 2021...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/36723172/fungal-feelings-in-the-irritable-bowel-syndrome-the-intestinal-mycobiome-and-abdominal-pain
#32
JOURNAL ARTICLE
Iam van Thiel, Wj de Jonge, Rm van den Wijngaard
Although the gut microbiota consists of bacteria, viruses, and fungi, most publications addressing the microbiota-gut-brain axis in irritable bowel syndrome (IBS) have a sole focus on bacteria. This may relate to the relatively low presence of fungi and viruses as compared to bacteria. Yet, in the field of inflammatory bowel disease research, the publication of several papers addressing the role of the intestinal mycobiome now suggested that these low numbers do not necessarily translate to irrelevance. In this review, we discuss the available clinical and preclinical IBS mycobiome data, and speculate how these recent findings may relate to earlier observations in IBS...
2023: Gut Microbes
https://read.qxmd.com/read/36657961/understanding-neuroimmune-interactions-in-disorders-of-gut-brain-interaction-from-functional-to-immune-mediated-disorders
#33
REVIEW
Tim Vanuytsel, Premysl Bercik, Guy Boeckxstaens
Functional gastrointestinal disorders-recently renamed into disorders of gut-brain interaction-such as irritable bowel syndrome and functional dyspepsia are highly prevalent conditions with bothersome abdominal symptoms in the absence of structural abnormalities. While traditionally considered as motility disorders or even psychosomatic conditions, our understanding of the pathophysiology has evolved significantly over the last two decades. Initial observations of subtle mucosal infiltration with immune cells, especially mast cells and eosinophils, are since recently being backed up by mechanistic evidence demonstrating increased release of nociceptive mediators by immune cells and the intestinal epithelium...
April 2023: Gut
https://read.qxmd.com/read/36615683/beneficial-effects-of-limosilactobacillus-fermentum-in-the-dca-experimental-model-of-irritable-bowel-syndrome-in-rats
#34
JOURNAL ARTICLE
María Jesús Rodríguez-Sojo, Jorge Garcia-Garcia, Antonio Jesús Ruiz-Malagón, Patricia Diez-Echave, Laura Hidalgo-García, José Alberto Molina-Tijeras, Elena González-Lozano, Laura López-Escanez, María Elena Rodríguez-Cabezas, Maria José Rodríguez-Sánchez, Alba Rodríguez-Nogales, Cristina Mediavilla, Julio Galvez
Limosilactobacillus fermentum&amp;nbsp;CECT5716 , a probiotic strain isolated from human milk, has reported beneficial effects on different gastrointestinal disorders. Moreover, it has shown its ability to restore altered immune responses, in association with microbiome modulation in different pathological conditions. Therefore, our aim was to assess the effects of a Limosilacbacillus fermentum CECT5716 in a rat experimental model of irritable bowel syndrome (IBS) that resembles human IBS. The experimental IBS was induced by deoxycholic acid (DCA) in rats and then, Limosilactobacillus fermentum CECT5716 (109 CFU/day/rat) was administered...
December 21, 2022: Nutrients
https://read.qxmd.com/read/36499222/the-connection-between-gut-and-lung-microbiota-mast-cells-platelets-and-sars-cov-2-in-the-elderly-patient
#35
REVIEW
Giovanna Traina
The human coronavirus SARS-CoV-2 or COVID-19 that emerged in late 2019 causes a respiratory tract infection and has currently resulted in more than 627 million confirmed cases and over 6.58 million deaths worldwide up to October 2022. The highest death rate caused by COVID-19 is in older people, especially those with comorbidities. This evidence presents a challenge for biomedical research on aging and also identifies some key players in inflammation, including mast cells and platelets, which could represent important markers and, at the same time, unconventional therapeutic targets...
November 28, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36480309/breast-milk-derived-limosilactobacillus-reuteri-prevents-atopic-dermatitis-in-mice-via-activating-retinol-absorption-and-metabolism-in-peyer-s-patches
#36
JOURNAL ARTICLE
Ce Qi, Huayu Tu, Yuning Zhao, Jingbo Zhou, Jie Chen, Haiting Hu, Renqiang Yu, Jin Sun
SCOPE: Supplementing Limosilactobacillus reuteri Fn041, a breast milk-derived probiotic from agricultural and pastoral areas, to maternal mice during late pregnancy and lactation prevents atopic dermatitis (AD) in offspring. This study aims to elucidate the molecular mechanism of Fn041-mediated immune regulation. METHODS AND RESULTS: Fn041 is administered prenatal and postnatal to maternal mice, and to offspring after weaning. The ears are administered with calcipotriol to induce AD...
December 8, 2022: Molecular Nutrition & Food Research
https://read.qxmd.com/read/36440681/colitis-aggravated-by-mrgprb2-knockout-is-associated-with-altered-immune-response-intestinal-barrier-function-and-gut-microbiota
#37
JOURNAL ARTICLE
Ming Shao, Jingwen Liu, Hesheng Luo
NEW FINDINGS: What is the central question of this study? What is the role of mas-related G protein-coupled receptor X2 (MRGPRX2/Mrgprb2) in ulcerative colitis in relation to the intestinal flora, intestinal barrier and immune response? What is the main finding and its importance? Knockout of mouse Mrgprb2 aggravates dextran sulfate sodium (DSS)-induced colitis, which is associated with altered gut microbiota and immune response and disruption of the intestinal barrier. MRGPRB2 may have a protective effect on DSS-induced colitis...
January 2023: Experimental Physiology
https://read.qxmd.com/read/36386594/mast-cell-specific-receptor-mrgprb2-regulating-experimental-colitis-is-associated-with-the-microbiota-gut-brain-axis
#38
JOURNAL ARTICLE
Ming Shao, Fangting Yuan, Jingwen Liu, Hesheng Luo
Purpose: Ulcerative colitis (UC) patients have disturbances in the microbiota-gut-brain axis, and mast cells are important components of this axis. The mast cell-specific receptor Mrgprb2 has effects on host defense against bacterial infection and neurogenic inflammation, which may help mast cells act on the axis. This study analyzed how Mrgprb2 participates in the pathogenesis of UC by affecting the microbiota-gut-brain axis. Materials and Methods: Mrgprb2 knockout (b2KO) mice and wild-type (WT) mice were fed 2% (w/v) dextran sulfate sodium (DSS) in drinking water for 7 days, which was then replaced with normal water for 14 days...
2022: Journal of Inflammation Research
https://read.qxmd.com/read/36381861/a-correlation-between-the-pathogenic-processes-of-fibromyalgia-and-irritable-bowel-syndrome-in-the-middle-aged-population-a-systematic-review
#39
REVIEW
Carla Valencia, Hameeda Fatima, Ijeoma Nwankwo, Mahvish Anam, Shrinkhala Maharjan, Zainab Amjad, Abdelrahman Abaza, Advait M Vasavada, Akhil Sadhu, Safeera Khan
Irritable bowel syndrome (IBS) is a common pathology in middle-aged patients and a regular consultation in the gastroenterology office. The prevalence is high in females with a ratio of 2:1, and due to its multifactorial etiology, it is difficult to address the symptomatology. On the other hand, fibromyalgia syndrome (FMS) is a chronic widespread pain syndrome also prevalent in the female population, characterized by systemic symptoms. It is proven that 28-59 % of patients with FMS develop IBS at some point in their illness; on the other hand, 32-77% of those with IBS will develop FMS...
October 2022: Curēus
https://read.qxmd.com/read/36362030/mast-cell-cytokines-in-acute-and-chronic-gingival-tissue-inflammation-role-of-il-33-and-il-37
#40
REVIEW
Matteo Trimarchi, Dorina Lauritano, Gianpaolo Ronconi, Alessandro Caraffa, Carla E Gallenga, Ilias Frydas, Spyros K Kritas, Ernesto Calvisi, Pio Conti
Much evidence suggests autoimmunity in the etiopathogenesis of periodontal disease. In fact, in periodontitis, there is antibody production against collagen, DNA, and IgG, as well as increased IgA expression, T cell dysfunction, high expression of class II MHC molecules on the surface of gingival epithelial cells in inflamed tissues, activation of NK cells, and the generation of antibodies against the azurophil granules of polymorphonuclear leukocytes. In general, direct activation of autoreactive immune cells and production of TNF can activate neutrophils to release pro-inflammatory enzymes with tissue damage in the gingiva...
October 31, 2022: International Journal of Molecular Sciences
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