keyword
https://read.qxmd.com/read/38506860/-classification-of-food-allergy-generalities
#1
JOURNAL ARTICLE
Jorge Cesar Martínez, Jorge Lavrut, Pablo Slullitel
The prevalence of food allergy has increased in some regions of the world, and with it the incidence, according to geographical variability, in the phenotype and clinical manifestations. Food allergy arises from the specific immune response induced by exposure to the proteins of a certain food. Food intolerance refers to non-immune reactions, caused by unique physiological characteristics of the individual, including metabolic, toxic, pharmacological and undefined mechanisms. Adverse reactions to foods are classified as: IgE-mediated: Type I Hypersensitivity, non-IgE-mediated: Type IV Hypersensitivity, mixed: Types I and IV Hypersensitivity Non-Allergic; toxic, pharmacological, metabolic, intolerances...
December 31, 2023: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://read.qxmd.com/read/38500917/anesthesia-management-using-remimazolam-for-lower-limb-amputation-in-a-patient-with-septic-shock-due-to-necrotizing-fasciitis
#2
Haruko Okazaki, Yusuke Ishida, Miki Wada, Reon Kobayashi, Katsunori Oe
We report a case of a patient with necrotizing fasciitis and septic shock caused by streptococcal toxic shock syndrome, who was anesthetized and managed with remimazolam. The patient, a woman in her 40s, was admitted to the ICU with a diagnosis of necrotizing fasciitis of the right lower extremity and septic shock and was scheduled for above-the-knee amputation under general anesthesia. She was anesthetized with remimazolam for sedation and fentanyl and remifentanil for analgesia. Intraoperatively, we were able to maintain hemodynamic stability with similar or only slightly higher doses of circulatory agonists during admission...
February 2024: Curēus
https://read.qxmd.com/read/38487883/antimicrobial-resistance-and-virulence-profiling-of-staphylococcus-pseudintermedius-isolated-from-cats-bangladesh
#3
JOURNAL ARTICLE
Eaftekhar Ahmed Rana, Tanvir Ahmad Nizami, Md Sayedul Islam, Subrata Sarker, Hafizar Rahman, Azizul Hoque, Mizanur Rahman
Staphylococcus pseudintermedius is a significant bacterial pathogen that frequently colonizes different body sites and mucous membranes of pets. The objectives of the cross-sectional study were to estimate the prevalence, antimicrobial resistance pattern, and detection of diverse resistance as well as virulence genes of S. pseudintermedius in cats. A standard bacteriological method, species-specific gene and different antimicrobial resistance as well as virulence genes were confirmed by PCR assay. A total of 233 swab samples were collected from different body sites of 102 cats, among them 146 swabs from 73 healthy cats, and 87 from 29 diseased cats...
December 2024: Veterinary Quarterly
https://read.qxmd.com/read/38464518/streptococcal-infection-and-autoimmune-diseases
#4
REVIEW
Ayaka Ohashi, Masanori A Murayama, Yoshishige Miyabe, Kazuo Yudoh, Chie Miyabe
Excessive activation of immune cells by environmental factors, such as infection or individual genetic risk, causes various autoimmune diseases. Streptococcus species are gram-positive bacteria that colonize the nasopharynx, respiratory tract, gastrointestinal tract, genitourinary tract, and skin. Group A Streptococcus (GAS) species cause various symptoms, ranging from mild infections, such as tonsillitis and pharyngitis, to serious infections, such as necrotizing fasciitis and streptococcal toxic shock syndrome...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38452154/streptolysin-s-is-required-for-streptococcus-pyogenes-nasopharyngeal-and-skin-infection-in-hla-transgenic-mice
#5
JOURNAL ARTICLE
Blake A Shannon, Jacklyn R Hurst, Ronald S Flannagan, Heather C Craig, Aanchal Rishi, Katherine J Kasper, Stephen W Tuffs, David E Heinrichs, John K McCormick
Streptococcus pyogenes is a human-specific pathogen that commonly colonizes the upper respiratory tract and skin, causing a wide variety of diseases ranging from pharyngitis to necrotizing fasciitis and toxic shock syndrome. S. pyogenes has a repertoire of secreted virulence factors that promote infection and evasion of the host immune system including the cytolysins streptolysin O (SLO) and streptolysin S (SLS). S. pyogenes does not naturally infect the upper respiratory tract of mice although mice transgenic for MHC class II human leukocyte antigens (HLA) become highly susceptible...
March 7, 2024: PLoS Pathogens
https://read.qxmd.com/read/38426312/health-benefits-of-combined-oral-contraceptives-a-narrative-review
#6
REVIEW
Herjan J T Coelingh Bennink, Femke A M van Gennip, Mireille G F Gerrits, Jan F M Egberts, Kristina Gemzell-Danielsson, Helena Kopp-Kallner
PURPOSE: This review presents an update of the non-contraceptive health benefits of the combined oral contraceptive pill. METHODS: We conducted a literature search for (review) articles that discussed the health benefits of combined oral contraceptives (COCs), in the period from 1980 to 2023. RESULTS: We identified 21 subjective and/or objective health benefits of COCs related to (i) the reproductive tract, (ii) non-gynaecological benign disorders and (iii) malignancies...
March 1, 2024: European Journal of Contraception & Reproductive Health Care
https://read.qxmd.com/read/38417865/stss-by-streptococcus-pyogenes-emm22-genotype-accompanied-by-csrs-mutation-a-case-report
#7
JOURNAL ARTICLE
Kaoru Ogawa, Jiro Kamiyama, Tadayoshi Ikebe, Shigemasa Taguchi, Kazuya Kiyota
The patient was a 22-year-old woman with no comorbidities who was transferred to our hospital due to cardiac arrest. Treatment enabled return to spontaneous circulation in the patient before arriving at the hospital. At the hospital, the patient's vital signs were unstable. Vasopressors and hyperhydration therapy were administered. Computed Tomography (CT) showed no remarkable change that caused the cardiac arrest. Antibiotics were prescribed after a blood culture exam. The patient was admitted to the ICU. In the ICU, the high-capacity vasopressors, hyperhydration therapy and transfusion of fresh frozen plasma were continued...
February 29, 2024: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38415021/sequential-extracorporeal-therapy-of-pathogen-removal-followed-by-cell-directed-extracorporeal-therapy-in-streptococcal-toxic-shock-syndrome-refractory-to-venoarterial-extracorporeal-membrane-oxygenation-a-case-report
#8
Stephen J Amerson, McKenna Hoffman, Fadi Abouzahr, Mohammad Ahmad, Rachel K Sterling, Hitesh Gidwani, Linda E Sousse, Jeffrey D Dellavolpe
BACKGROUND: Streptococcal toxic shock syndrome (STSS) is a fulminant complication of predominantly invasive group A streptococcal infections. STSS is often characterized by influenza-like symptoms, including fever, chills, and myalgia that can quickly progress to sepsis with hypotension, tachycardia, tachypnea, and multiple organ failure (kidney, liver, lung, or blood). Mortality can exceed 50% depending on the severity of symptoms. CASE SUMMARY: Here, we describe a novel, multi-extracorporeal intervention strategy in a case of severe septic shock secondary to STSS...
March 2024: Critical care explorations
https://read.qxmd.com/read/38408643/evolutionary-dynamics-of-the-novel-st22-pt-mrsa-clone-co-harbouring-panton-valentine-leucocidin-and-duplicated-toxic-shock-syndrome-toxin-1-genes
#9
JOURNAL ARTICLE
Tetsuo Yamaguchi, Kenji Furuno, Kohji Komori, Tomoko Abe, Takahiro Sato, Shinji Ogihara, Kotaro Aoki, Yoshikazu Ishii, Kazuhiro Tateda
OBJECTIVES: Globally, the isolation of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) harbouring both the Panton-Valentine leucocidin (PVL) and toxic shock syndrome toxin 1 (TSST-1) genes is rare. However, we encountered an outbreak of the ST22-PT clone exhibiting this phenotype in Japan. Notably, the TSST-1 gene was duplicated in most of the strains. This study aimed to elucidate the mechanisms underlying this gene duplication. METHODS: A total of 90 MRSA isolates were collected from the skin of outpatients in Fukuoka City, Japan, between 2017 and 2019...
February 24, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38406070/toxic-shock-syndrome-eighteen-years-of-experience-in-a-pediatric-intensive-care-unit
#10
JOURNAL ARTICLE
Inês Cascais, Ana Losa, Cláudia Correia, Diana H Pinto, Daniel Meireles, Alzira Sarmento
Introduction Toxic shock syndrome (TSS) is a life-threatening disease usually caused by a Staphylococcus aureus or group Aβ-hemolytic Streptococcus infection. Methods In this retrospective study, we included patients with TSS admitted to a tertiary hospital's pediatric intensive care unit (PICU) over the last 18 years. We compared the staphylococcal TSS (Staph-TSS) and streptococcal TSS (Strep-TSS) groups. Results We included 17 patients (64.7% male), with a median age of 6.1 years (3.0 years for streptococcal TSS versus 13...
January 2024: Curēus
https://read.qxmd.com/read/38397644/barriers-to-women-s-menstrual-hygiene-practices-during-recurrent-disasters-and-displacement-a-qualitative-study
#11
JOURNAL ARTICLE
Shela Akbar Ali Hirani
Disasters that involve displacement are particularly challenging for managing personal and menstrual hygiene, which can increase the risk of toxic shock syndrome, infections and other health conditions that can endanger women's lives. This study aimed to examine the menstrual hygiene challenges experienced by internally displaced women affected by recurrent natural disasters and subsequent displacement in the context of a low-middle-income country, i.e., Pakistan. A critical ethnographic study was undertaken in disaster-relief camps in the northern region of Pakistan...
January 30, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38391573/catastrophic-streptococcus-pyogenes-disease-a-personalized-approach-based-on-phenotypes-and-treatable-traits
#12
JOURNAL ARTICLE
Juan Carlos Ruiz-Rodríguez, Luis Chiscano-Camón, Carolina Maldonado, Adolf Ruiz-Sanmartin, Laura Martin, Ivan Bajaña, Juliana Bastidas, Rocio Lopez-Martinez, Clara Franco-Jarava, Juan José González-López, Vicent Ribas, Nieves Larrosa, Jordi Riera, Xavier Nuvials-Casals, Ricard Ferrer
Streptococcal toxic shock syndrome (STTS) is a critical medical emergency marked by high morbidity and mortality, necessitating swift awareness, targeted treatment, and early source control due to its rapid symptom manifestation. This report focuses on a cohort of 13 patients admitted to Vall d'Hebron University Hospital Intensive Care Unit, Barcelona, from November 2022 to March 2023, exhibiting invasive Streptococcus pyogenes infections and meeting institutional sepsis code activation criteria. The primary infections were community-acquired pneumonia (61...
February 15, 2024: Antibiotics
https://read.qxmd.com/read/38390461/investigating-and-summarizing-information-resources-related-to-the-clinical-presentation-and-diagnosis-of-cutaneous-manifestations-of-infectious-diseases-in-patients-with-skin-of-color
#13
REVIEW
Dorothea McGowan, Anosh Kermani, John Sheagren
Patients with skin of color (SOC) present diseases differently in many circumstances, yet there is a lack of information regarding the presentation and diagnosis of cutaneous manifestations in such patients experiencing infectious diseases. Therefore, we conducted a scoping review to investigate and summarize information pertaining to the clinical presentation and diagnosis of cutaneous manifestations of infectious diseases in patients with SOC focusing on the following viral, bacterial, toxin-mediated, and infestation diseases and fungal infections: human immunodeficiency virus, shingles, impetigo, scarlet fever, Lyme disease, toxic shock syndrome, scabies, rickettsioses, and cutaneous fungal infections...
February 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38388168/cardiovascular-toxicities-associated-with-bispecific-t-cell-engager-therapy
#14
JOURNAL ARTICLE
Ahmed Sayed, Malak Munir, Sanam M Ghazi, Mussammat Ferdousi, Satyam Krishan, Adnan Shaaban, Alma Habib, Onaopepo Kola-Kehinde, Patrick Ruz, Sarah Khan, Sneha Sharma, Alexa Meara, Syed Mahmood, Stephanie Feldman, Eric H Yang, Jiwon Kim, Narendranath Epperla, Daniel Addison
BACKGROUND: Bispecific T-cell engagers (BTEs) are novel agents used to treat hematological malignancies. Early trials were underpowered to define cardiovascular adverse events (CVAE) and no large-scale studies systematically examined the CVAEs associated with BTEs. METHODS: Leveraging the US Food and Drug Administration's Adverse Event Reporting System-(FAERS), we identified the relative frequency of CVAEs after initiation of five BTE products approved by the Food and Drug Administration between 2014 and 2023 for the treatment of hematological malignancies...
February 21, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38382839/-maternal-mortality-due-to-genital-tract-infection-in-france-2016-2018
#15
JOURNAL ARTICLE
Agnès Rigouzzo, Marie Jonard, Jacques Lepercq
Over the 2016-2018 period, maternal mortality due to direct infectious causes accounted for 13% of maternal deaths by direct causes. The increasing trend in genital-tract infections related-deaths noted in the 2013-2015 report continues for the 2016-2018 period, but this 2010-2018 increase remains at the limit of statistical significance given the low number of cases (p 0.08). The 13 deaths from direct infectious causes for the 2016-2018 period were due to 4 cases of puerperal toxic shock syndrome (Streptococcus A beta hemolyticus or Clostridium group bacilli), 6 sepsis caused by intrauterine infection due to E...
February 19, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
https://read.qxmd.com/read/38382822/epidemiological-shifts-in-and-impact-of-covid-19-on-streptococcal-toxic-shock-syndrome-in-japan-a-genotypic-analysis-of-group-a-streptococcus-isolates
#16
JOURNAL ARTICLE
Tadayoshi Ikebe, Rumi Okuno, Yumi Uchitani, Takahiro Yamaguchi, Junko Isobe, Emi Maenishi, Yoshimi Date, Hitoshi Otsuka, Yu Kazawa, Shohei Fujita, Ayaka Kobayashi, Mami Takano, Shinya Tsukamoto, Yoshiko Kanda, Makoto Ohnishi, Yukihiro Akeda
OBJECTIVES: Streptococcal toxic shock syndrome (STSS) is caused by group A Streptococcus (GAS; Streptococcus pyogenes) strains. In Japan, the number of STSS cases has decreased; however, the underlying reason remains unclear. Moreover, information on distribution and prevalence of specific emm types in STSS cases is scarce. Hence, we investigated the reason for the decreased number of STSS cases in Japan. METHODS: We genotyped emm of 526 GAS isolates obtained from 526 patients with STSS between 2019 and 2022...
February 19, 2024: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/38360044/high-dose-intravenous-immunoglobulin-versus-albumin-4-in-paediatric-toxic-shock-syndrome-a-randomised-controlled-feasibility-study
#17
JOURNAL ARTICLE
Aurélie Portefaix, Carole Dhelens, Morgan Recher, Fleur Cour-Andlauer, Jérôme Naudin, Guillaume Mortamet, Nicolas Joram, Pierre Tissières, Tiphanie Ginhoux, Behrouz Kassai, Florent Boutitie, Delphine Maucort-Boulch, Etienne Javouhey
PURPOSE: Toxic shock syndrome (TSS) is a rare disease responsible for significant morbidity and mortality. Intravenous immunoglobulin (IG) therapy in paediatric TSS could improve shock and organ failure, but more consistent efficacy and safety data are needed. Our objective was to determine whether a randomised clinical trial (RCT) assessing intravenous IG in TSS in children is feasible. METHODS: We performed a multicentre, feasibility, double-blind RCT assessing efficacy of high-dose intravenous IG versus albumin 4% (control group) within the first 12 hours of shock onset...
February 15, 2024: Archives of Disease in Childhood
https://read.qxmd.com/read/38334326/vaginal-community-state-types-csts-alter-environmental-cues-and-production-of-the-staphylococcus-aureus-toxic-shock-syndrome-toxin-1-tsst-1
#18
JOURNAL ARTICLE
Carla S Maduta, John K McCormick, Karine Dufresne
Menstrual toxic shock syndrome (mTSS) is a rare but life-threatening disease associated with the use of high-absorbency tampons. The production of the Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) superantigen is involved in nearly all cases of mTSS and is tightly controlled by regulators responding to the environment. In the prototypic mTSS strain S. aureus MN8, the major repressor of TSST-1 is the carbon catabolite protein A (CcpA), which responds to glucose concentrations in the vaginal tract...
February 9, 2024: Journal of Bacteriology
https://read.qxmd.com/read/38326759/development-of-a-multiple-cross-displacement-amplification-combined-with-nanoparticles-based-biosensor-assay-for-rapid-and-sensitive-detection-of-streptococcus-pyogenes
#19
JOURNAL ARTICLE
Zhiqian Dou, Ling Xie, Meiling Gao, Dexi Liu
BACKGROUND: S. pyogenes, is a primary pathogen that leads to pharyngitis and can also trigger severe conditions like necrotizing fasciitis and streptococcal toxic shock syndrome (STSS), often resulting in high mortality rates. Therefore, prompt identification and appropriate treatment of S. pyogenes infections are crucial in preventing the worsening of symptoms and alleviating the disease's impact. RESULTS: In this study, a newly developed technique called multiple cross displacement amplification (MCDA) was employed to detect S...
February 7, 2024: BMC Microbiology
https://read.qxmd.com/read/38307251/diversity-of-staphylococcus-aureus-associated-with-mastitis-from-dairy-cows-in-rwanda
#20
JOURNAL ARTICLE
Helga Keinprecht, Emmanuel Irimaso, Adriana Cabal Rosel, Beatrix Stessl, Christophe Ntakirutimana, Lydia Marek, Otto W Fischer, Michael P Szostak, Jennifer Zöchbauer, Thomas Wittek, Elke Müller, Amelie Desvars-Larrive, Andrea T Feßler, Sascha D Braun, Stefan Schwarz, Joachim Spergser, Monika Ehling-Schulz, Stefan Monecke, Ralf Ehricht, Werner Ruppitsch, Tom Grunert, Igor Loncaric
OBJECTIVES: The objective of the present study was to examine the diversity of S. aureus from mastitis milk samples of cows in Rwanda. METHODS: A total of 1080 quarter milk samples from 279 dairy cows were collected in 80 different farms from all five provinces of Rwanda. In total, 135 S. aureus isolates were obtained and subjected to genotyping (spa typing, DNA microarray, whole-genome sequencing (WGS)), antimicrobial susceptibility testing (AST) and phenotypic profiling by Fourier Transform Infrared (FTIR) spectroscopy (including capsular serotyping)...
January 31, 2024: Journal of Global Antimicrobial Resistance
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