keyword
https://read.qxmd.com/read/38524070/mycobacterium-gordonae-infection-in-a-patient-with-non-small-cell-lung-cancer
#1
Alissa I Elanjian, Jason P Law, Borys Hrinczenko
Mycobacterium gordonae (MG) is one of the least pathogenic nontuberculous mycobacteria (NTM). We report an unusual case of MG infection in a patient with newly diagnosed lung cancer. A 61-year-old woman presented with shortness of breath and weight loss. Six months prior to admission, she was diagnosed with MG infection based on positive sputum cultures and bronchioalveolar lavage. Despite anti-mycobacterial therapy, her symptoms worsened and she lost approximately 100 pounds. A transbronchial biopsy obtained one week prior to admission revealed adenocarcinoma of the lung...
February 2024: Curēus
https://read.qxmd.com/read/38505050/prevalence-of-pulmonary-artery-dilation-in-non-cystic-fibrosis-bronchiectasis-a-computed-tomography-analysis-from-a-cohort-of-the-us-bronchiectasis-and-nontuberculous-mycobacteria-research-registry
#2
JOURNAL ARTICLE
Elham Karamooz, Anupama G Brixey, Chara E Rydzak, Steven L Primack, Sheila Markwardt, Alan F Barker
Although pulmonary artery (PA) dilation is independently associated with significant morbidity and mortality in patients with pulmonary diseases irrespective of diagnosed pulmonary hypertension, its relationship with nontuberculous mycobacteria (NTM) is unknown. The Bronchiectasis and NTM Research Registry is a multicenter registry created to foster research in non-cystic fibrosis (CF) bronchiectasis and NTM lung disease. The majority of patients with non-CF bronchiectasis at Oregon Health & Science University have NTM infections...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38490432/clinical-phenotypes-of-nontuberculous-mycobacterial-disease-by-cluster-analysis-based-on-pulmonary-function
#3
JOURNAL ARTICLE
Nobuyoshi Hamao, Isao Ito, Issei Oi, Masahiro Shirata, Kensuke Nishioka, Yasuyuki Hayashi, Seiichiro Imai, Toyohiro Hirai
BACKGROUND: Nontuberculous mycobacterial pulmonary disease (NTM-PD) often exhibits pulmonary function impairment, such as obstructive or restrictive pattern, with variation among patients according to the damaged lesions in the lung. METHODS: Patients with NTM-PD were consecutively enrolled between September 2019 and December 2020 at the Respiratory Infection Clinic of our hospital. Patients' data were comprehensively collected through laboratory examinations, PFT, chest computed tomography, and questionnaires for the assessment of subjective symptoms and health-related quality of life (HRQOL)...
March 13, 2024: Respiratory Medicine
https://read.qxmd.com/read/38454294/bilateral-nontuberculous-mycobacterial-otitis-media-a-case-report
#4
JOURNAL ARTICLE
Riko Kajiwara, Kazuhisa Yamamoto, Shinya Ohira, Kota Wada
Established treatment strategies for nontuberculous mycobacterial (NTM) infections are currently lacking, and whether surgical treatment should be applied in combination with antibiotic therapy remains debatable. Here, we report a case of bilateral otitis media caused by Mycobacterium abscessusa, a highly antibiotic-resistant bacterium. Many reported cases of NTM otitis media are unilateral, in which hearing of the contralateral ear is preserved. In the present case, strategies to improve hearing outcomes were considered, as both ears were affected...
January 2024: Journal of International Advanced Otology
https://read.qxmd.com/read/38432118/computational-drug-repositioning-identifies-niclosamide-and-tribromsalan-as-inhibitors-of-mycobacterium-tuberculosis-and-mycobacterium-abscessus
#5
JOURNAL ARTICLE
Jeremy J Yang, Aaron Goff, David J Wild, Ying Ding, Ayano Annis, Randy Kerber, Brian Foote, Anurag Passi, Joel L Duerksen, Shelley London, Ana C Puhl, Thomas R Lane, Miriam Braunstein, Simon J Waddell, Sean Ekins
Tuberculosis (TB) is still a major global health challenge, killing over 1.5 million people each year, and hence, there is a need to identify and develop novel treatments for Mycobacterium tuberculosis (M. tuberculosis). The prevalence of infections caused by nontuberculous mycobacteria (NTM) is also increasing and has overtaken TB cases in the United States and much of the developed world. Mycobacterium abscessus (M. abscessus) is one of the most frequently encountered NTM and is difficult to treat. We describe the use of drug-disease association using a semantic knowledge graph approach combined with machine learning models that has enabled the identification of several molecules for testing anti-mycobacterial activity...
February 27, 2024: Tuberculosis
https://read.qxmd.com/read/38361522/ct%C3%A2-based-radiomics-analysis-of-consolidation-characteristics-in-differentiating-pulmonary-disease-of-non%C3%A2-tuberculous-mycobacterium-from-pulmonary-tuberculosis
#6
JOURNAL ARTICLE
Qinghu Yan, Wenlong Zhao, Haili Kong, Jingyu Chi, Zhengjun Dai, Dexin Yu, Jia Cui
Global incidence rate of non-tuberculous mycobacteria (NTM) pulmonary disease has been increasing rapidly. In some countries and regions, its incidence rate is higher than that of tuberculosis. It is easily confused with tuberculosis. The topic of this study is to identify two diseases using CT radioomics. The aim in the present study was to investigate the value of CT-based radiomics to analyze consolidation features in differentiation of non-tuberculous mycobacteria (NTM) from pulmonary tuberculosis (TB)...
March 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38311427/the-first-case-of-mycobacterium-interjectum-pulmonary-disease-in-japan-a-case-report
#7
JOURNAL ARTICLE
Asuka Yamaguchi, Naohisa Urabe, Nozomi Tokita, Masakazu Sasaki, Noboru Iizuka, Susumu Sakamoto, Kazuma Kishi
We herein report a case of Mycobacterium interjectum pulmonary disease (M. interjectum-PD) that improved considerably after azithromycin (AZM), rifampicin (RFP), and ethambutol (EB) therapy. A 69-year-old woman, managed locally for suspected NTM-PD based on chest computed tomography (CT) findings was referred to our hospital for worsening productive cough six years after the initial diagnosis. High-resolution chest CT showed right middle and left lower lobe bronchiectasis with middle and centrilobular nodules...
February 5, 2024: Internal Medicine
https://read.qxmd.com/read/38143841/transaxillary-capsulorrhaphy-with-reimplantation-to-correct-bottoming-out-deformity-in-breast-mycobacterial-periprosthetic-infection-a-case-report-with-literature-review
#8
JOURNAL ARTICLE
Tsung-Chun Huang, Jian-Jr Lee, Kuo-Hui Yang, Chia-Huei Chou, Yu-Chen Chang
Augmentation mammoplasty is one of the most popular cosmetic surgeries, but there is a high reoperation rate (29.7%) commonly due to capsular contracture, implant malpositioning, infection, and unsatisfactory size. Although infection only accounts for 2% of cases, its management is very challenging, especially with nontuberculous mycobacteria (NTM) infection. Breast prosthetic NTM infection is a rare but is a disastrous condition with an incidence of approximately 0.013%. Immediate salvage reimplantation is usually not suggested, and most studies recommend a gap of 3 to 6 months after combination antibiotics therapy before reimplantation...
November 2023: Archives of Plastic Surgery
https://read.qxmd.com/read/38089514/orbital-and-conjunctival-nontuberculous-mycobacteria-infection
#9
Chin-Tzu Kuo, Yen-Ta Chen, I-Lun Tsai, Ching-Yao Tsai, Zoe Tzu-Yi Chen
A 64-year-old female developed refractory red-eye with itching and watery discharge 2 weeks after being injured by a comb in the left eye. It presented as diffuse pinkish thickening of the bulbar conjunctiva. Biopsy and histological examinations revealed granulomatous inflammation with microgranuloma. Acid-fast-positive bacilli were found within the tissue, which was identified by culture 5 weeks later as Mycobacterium Abscessus . The orbital computed tomography with contrast medium showed irregular enhancement with an ill-defined margin along the inferior sclera...
2023: Taiwan Journal of Ophthalmology
https://read.qxmd.com/read/38031367/clinical-characteristics-and-prognostic-factors-of-non-tuberculous-mycobacterial-disease-in-patients-with-rheumatoid-arthritis
#10
JOURNAL ARTICLE
Hyemin Kim, Soyoung Lee, Ji-Won Kim, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim
BACKGROUND/AIMS: This study aimed to identify the clinical characteristics of patients with concurrent rheumatoid arthritis (RA) and suspected non-tuberculous mycobacterial (NTM) infections as well as determine their prognostic factors. METHODS: We retrospectively reviewed the medical records of 91 patients with RA whose computed tomography (CT) findings suggested NTM infection. Subsequently, we compared the clinical characteristics between patients with and without clinical or radiological exacerbation of NTM-pulmonary disease (PD) and investigated the risk factors for the exacerbation and associated mortality...
November 30, 2023: Korean Journal of Internal Medicine
https://read.qxmd.com/read/37952948/non-tuberculosis-mycobacterial-pulmonary-disease-caused-by-mycobacterium-kiyosense-a-new-species
#11
JOURNAL ARTICLE
Kotaro Yamada, Takafumi Koyauchi, Koshi Yokomura, Taiga Fujita, Hiroki Sugiyama, Ryo Shimota, Nobuhiro Shimura, Yuki Matsumoto, Shota Nakamura, Kinuyo Chikamatsu, Satoshi Mitarai, Takafumi Suda
Non-tuberculosis mycobacterial (NTM) pulmonary disease (NTM-PD) is quite common, and newly identified species are being reported increasingly frequently thanks to advances in identification technologies. A 56-year-old woman had mild sputum production showed bronchiectasis with multiple small nodules, consistent with NTM-PD, on chest computed tomography. Mycobacterial species were isolated from the specimens; however, conventional methods could not identify the species. We conducted whole-genome sequencing and identified the NTM isolates as Mycobacterium kiyosense, a species newly registered in 2023 from Japan...
November 13, 2023: Internal Medicine
https://read.qxmd.com/read/37920597/diagnosis-of-mycobacterium-avium-complex-infection-utilizing-metagenomics-next-generation-sequencing-a-case-report
#12
Hongli Li, Luqing Wei, Fenge Li
Mycobacterium avium-intracellulare complex (MAC) is a type of nontuberculous mycobacteria (NTM) and is associated with underlying pulmonary diseases, such as chronic obstructive pulmonary disease, bronchiectasis, chronic aspiration or recurrent pneumonia, inactive or active tuberculosis, pneumoconiosis, and bronchogenic carcinoma. The risk factors for NTM-PD include host, drug, and environmental factors. In this report, we present the case of a 61-year-old man who developed bilateral lung nodules and was experiencing severe hemoptysis...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37869158/case-report-intraabdominal-infection-of-mycobacterium-syngnathidarum-in-an-immunocompetent-patient-confirmed-by-whole-genome-sequencing
#13
Hu Ge, Xiongwei Liang, Qiuran Lu, Aixiang He, Peiwen Zhong, Jun Liu, Yan Yu, Honglian Song
BACKGROUND: The taxonomic group of non-tuberculous mycobacteria (NTM) encompasses more than 190 species and subspecies, some of which can cause pulmonary and extrapulmonary diseases across various age groups in humans. However, different subspecies exhibit differential drug sensitivities, and traditional detection techniques struggle to accurately classify NTM. Therefore, clinicians need more effective detection methods to identify NTM subtypes, thus providing personalized medication for patients...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37832933/nontuberculous-mycobacterial-infection-mimicking-gynecologic-malignancy-in-a-woman-living-with-hiv
#14
Tsung-Yu Tsai, Yi-Jou Tai, Aristine Cheng, Tai-Fen Lee, Szu-Ting Huang, Kuan-Yin Lin, Chien-Ching Hung
The weakened immune system in people living with HIV (PLWH) can lead to infectious diseases occurring more aggressively and mimicking the clinical manifestations of malignancies. Mycobacterium sherrisii, a slow-growing nontuberculous mycobacterium, may cause opportunistic infections among PLWH. We present a case of a 41-year-old woman who initially presented with fever, vaginal spotting, and a bulky pelvic mass, raising suspicion of uterine malignancy. Following a surgical resection, she was pathologically diagnosed with leiomyoma and endometriosis...
December 2023: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/37562711/disseminated-coinfection-with-mycobacterium-avium-complex-and-mycobacterium-kansasii-in-a-patient-with-idiopathic-cd4-lymphocytopenia-a-case-report
#15
Dujrath Somboonviboon, Wittaya Thongtaeparak, Papatsiri Suntavaruk, Worapong Nasomsong
Simultaneously disseminated coinfection with two species of nontuberculous mycobacteria (NTM) is extremely rare and had been reported only in immunocompromised individuals. Here, we report a 59-year-old Thai man, previously healthy. He presented with a 2-month history of prolonged fever, constitutional symptoms, and hepatosplenomegaly. His chest and abdomen computed tomography illustrated multiple enlarged mediastinal lymph nodes accompanied with multifocal crazy-paving appearance in both lungs and hepatosplenomegaly...
August 8, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37558481/pulmonary-artery-aneurysm-in-a-patient-with-nontuberculous-mycobacteria-infection
#16
JOURNAL ARTICLE
Soichi Maruyama, Haruhiko Furusawa, Satoshi Endo, Takashi Kumagai, Takahiro Mitsumura, Sho Shimada, Takashi Yamana, Rie Sakakibara, Yuki Iijima, Sho Shibata, Takayuki Honda, Tsuyoshi Shirai, Tsukasa Okamoto, Tomoya Tateishi, Meiyo Tamaoka, Yuko Kinowaki, Hironori Ishibashi, Kenichi Okubo, Yasunari Miyazaki
Nontuberculous mycobacterial (NTM) infection sometimes leads to the development of pulmonary artery aneurysm (PAA), a rare but life-threatening complication. We herein report a 64-year-old woman with a history of NTM infection who presented with severe hemoptysis. Computed tomography revealed a ruptured PAA, which was treated successfully with pulmonary artery embolization. Subsequent right total pneumonectomy was performed to control infection. This case emphasizes the need to consider PAA in patients with NTM infection who present with hemoptysis...
August 9, 2023: Internal Medicine
https://read.qxmd.com/read/37550642/disseminated-non-tuberculous-mycobacterial-infection-caused-by-mycobacterium-obuense-in-an-immunocompromised-patient-a-case-report
#17
JOURNAL ARTICLE
Maiko Naito, Kentaro Fukushima, Shinsuke Kusakabe, Takaya Endo, Takayuki Shiroyama, Kika Ohira, Koji Azuma, Satoshi Tanizaki, Yumiko Yamamoto, Yuki Hosono, Yujiro Naito, Shinji Futami, Kotaro Miyake, Haruhiko Hirata, Yoshito Takeda, Atsushi Kumanogoh
BACKGROUND: Mycobacterium obuense (M. obuense) is a rapidly growing mycobacterium (RGM) which has been considered nonpathogenic. Here, we report a case of disseminated non-tuberculous mycobacterial (NTM) infection caused by M. obuense in an immunocompromised patient. CASE PRESENTATION: A 16-year-old boy was referred to our hospital due to acute myeloid leukemia. During the treatment of leukemia, the patient exhibited continuous fever, and diffuse miliary nodules with random distribution were found on chest computed tomography...
August 8, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/37489788/nontuberculous-mycobacterial-infection-mimicking-lung-cancer-in-a-patient-with-usual-interstitial-pneumonia-pattern-interstitial-lung-disease-a-case-report
#18
Chaebin Lee, Jongsoo Park, Jae-Kwang Lim, Jongmin Park, Byunggeon Park
BACKGROUND: It has been reported that structure damage in the parenchymal lung disease such as idiopathic pulmonary fibrosis (IPF) is associated with high susceptibility to nontuberculous mycobacterial (NTM) infection. Radiologic features of NTM lung disease in destructive lung parenchyma can be atypical, which can cause confusion with other diseases including malignancy. Prompt and accurate identification of newly developed lesions in the follow-up computed tomography (CT) of IPF patients is challenging but crucial...
July 25, 2023: Current medical imaging
https://read.qxmd.com/read/37361939/nasopharyngeal-mycobacterium-abscessus-infection-a-case-report-and-literature-review
#19
Masanori Kaji, Ho Namkoong, Genta Nagao, Shuhei Azekawa, Kensuke Nakagawara, Hiromu Tanaka, Atsuho Morita, Takanori Asakura, Hirofumi Kamata, Yoshifumi Uwamino, Mitsunori Yoshida, Koichi Fukunaga, Naoki Hasegawa
BACKGROUND: Mycobacterium abscessus ( M. abscessus ) is a rapidly growing bacterium (RGM) that causes refractory pulmonary and extrapulmonary infections. However, studies investigating pharyngeal and laryngeal M. abscessus infections are limited. CASE PRESENTATION: A 41-year-old immunocompetent woman complaining of bloody sputum was referred to our hospital. Although her sputum culture tested positive for M. abscessus subsp. abscessus , radiological findings were not indicative of pulmonary infection or sinusitis...
2023: Infection and Drug Resistance
https://read.qxmd.com/read/37244350/vertebral-osteomyelitis-due-to-mycobacterium-abscessus-subsp-massiliense-with-paravertebral-abscess-a-case-report-and-review
#20
Fadlyansyah F Husain, Toshio Nakamae, Naosuke Kamei, Keitaro Omori, Toshiaki Maruyama, Kazuto Nakao, Nobuo Adachi
The incidence of vertebral osteomyelitis (VO) caused by non-tuberculosis mycobacteria (NTM) without immunocompetence is extremely rare. Herein, we reported on a case of VO caused by NTM. A 38-year-old man was admitted to our hospital with persisting low back and leg pain which had lasted for a year. Before coming to our hospital, the patient was treated with antibiotics and iliopsoas muscle drainage. The biopsy confirmed the presence of a NTM, Mycobacterium abscessus subsp. massiliense. Several tests were conducted which showed the infection had progressively increased, such as vertebral endplate destruction on plain radiography, computed tomography scan, and epidural and paraspinal muscle abscesses on magnetic resonance imaging...
May 25, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
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