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Glaucoma , cataract,

Jin-Ling Zhang, Xiang-Yuan Song, Ya-Ying Chen, Thi Hoang Anh Nguyen, Jing-Yi Zhang, Shi-San Bao, Yu-Yan Zhang
Glaucoma eventually leads to optic nerve damage and vision loss without medical intervention. More than 50% of glaucoma caused blindness are attributed to primary angle closure glaucoma, particularly in Asians. It is reported that immune inflammation is involved in the progress of glaucoma. Increased inflammation cytokines are detected in the aqueous humor of chronic primary angle closure glaucoma (CPACG). IL-36, IL-37 and IL-38, are novel cytokines and are involved in many inflammatory diseases, including inflammatory bowel diseases and acute anterior uveitis, but the possible contributing role in the pathogenesis of CPACG is unclear...
March 19, 2019: International Immunopharmacology
Mehmet Baykara, Ceren Poroy, Cansu Erseven
Purpose: To evaluate the success, safety, and complication rates of gonioscopy-assisted transluminal trabeculotomy (GATT) combined with cataract surgery. Methods: A retrospective study was conducted for 32 patients who underwent GATT combined with phacoemulsification and intraocular lens implantation. Patients with primary open-angle glaucoma were enrolled. The primary outcome measures were visual acuity, intraocular pressure (IOP), the number of antiglaucoma medications used, and complications...
April 2019: Indian Journal of Ophthalmology
Sonam Yangzes, Natasha Gautam Seth, Ramandeep Singh, Parul Chawla Gupta, Jitender Jinagal, Surinder Singh Pandav, Vishali Gupta, Amod Gupta, Jagat Ram
Purpose: To evaluate the long-term outcomes of cataract surgery in children with uveitis. Methods: Retrospective, noncomparative review of medical records of children (≤16 years) with uveitic cataract who had undergone cataract surgery between January 2001 and December 2014 at a tertiary care center was done. The main outcome measures were visual acuity and postoperative complications. Results: We recruited 37 children (58 eyes) who were diagnosed with uveitic cataract and underwent cataract surgery...
April 2019: Indian Journal of Ophthalmology
Nóra Szentmáry, Loay Daas, Lei Shi, Kornelia Lenke Laurik, Sabine Lepper, Georgia Milioti, Berthold Seitz
Purpose: To summarize actual literature data on clinical signs, differential diagnosis, and treatment of acanthamoeba keratitis. Methods: Review of literature. Results: Clinical signs of acanthamoeba keratitis are in early stages grey-dirty epithelium, pseudodendritiformic epitheliopathy, perineuritis, multifocal stromal infiltrates, ring infiltrate and in later stages scleritis, iris atrophy, anterior synechiae, secondary glaucoma, mature cataract, and chorioretinitis...
March 2019: Journal of Current Ophthalmology
Simona Bungau, Mohamed M Abdel-Daim, Delia Mirela Tit, Esraa Ghanem, Shimpei Sato, Maiko Maruyama-Inoue, Shin Yamane, Kazuaki Kadonosono
Oxidative stress and inflammation play a critical role in the initiation and progression of age-related ocular abnormalities as cataract, glaucoma, diabetic retinopathy, and macular degeneration. Therefore, phytochemicals with proven antioxidant and anti-inflammatory activities, such as carotenoids and polyphenols, could be of benefit in these diseases. We searched PubMed and Web of Science databases for original studies investigating the benefits of different carotenoids and polyphenols in age-related ophthalmic diseases...
2019: Oxidative Medicine and Cellular Longevity
Tanya S Glaser, Michael S Mulvihill, Sharon F Freedman
PURPOSE: To assess the factors associated with successful outcomes in the management of childhood glaucoma treated with endoscopic cyclophotocoagulation (ECP) as both primary and adjunctive surgery. METHODS: The medical records of consecutive children with glaucoma treated by a single surgeon at a single center over a 17-year period using ECP procedures were reviewed retrospectively. Treatment failure was defined as (1) intraocular pressure (IOP) >24 mm Hg at two consecutive examinations despite maximal medical treatment, (2) any additional glaucoma surgery, (3) sight-threatening complications, or (4) progression to no light perception visual acuity...
March 16, 2019: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Tamara V Azizova, Nobuyuki Hamada, Evgeny V Bragin, Maria V Bannikova, Evgeniya S Grigoryeva
In this study, the risk of cataract removal surgery was assessed in a cohort of workers occupationally exposed to ionizing radiation over a prolonged period. The study cohort includes 22,377 workers of the Mayak Production Association (about 25% of whom are females) first employed at one of the main facilities in 1948-1982, who were followed up to the end of 2008. Dose estimates used in the study are provided by the Mayak Worker Dosimetry System 2008. The mean cumulative dose from external γ-rays [personal dose equivalent Hp (10)] is 0...
March 16, 2019: Radiation and Environmental Biophysics
José Martinho, Hugo Ferreira, Siri Paulo, Anabela Paula, Carlos-Miguel Marto, Eunice Carrilho, Manuel Marques-Ferreira
(1) Background: Oculo-facio-cardio-dental (OFCD) syndrome is a rare pathological condition with an X-linked dominant trait that only occurs in females; no males are born with OFCD syndrome. This syndrome is characterized by congenital cataracts with secondary glaucoma ocular defects, ventricular and atrial septal defects, or mitral valve prolapses. Facial traits are a long narrow face and a high nasal bridge with a bifid nasal tip. Dental anomalies include radiculomegaly, oligodontia, root dilacerations, malocclusion, and delayed eruption...
March 14, 2019: International Journal of Environmental Research and Public Health
Andrew M Williams, Benjamin Botsford, Peter Mortensen, Daniel Park, Evan L Waxman
Objective: The objective of the study was to characterize the population served by the student-led Guerrilla Eye Service (GES), a mobile outreach program that delivers comprehensive ophthalmic care to underserved communities in the greater Pittsburgh area. Patients and methods: Patients attending GES missions at a single urban free clinic from 2012 through 2017 were included in this retrospective case series. All patients underwent a comprehensive eye examination at no cost, with referral to a university eye clinic if necessary...
2019: Clinical Ophthalmology
Declan Timothy Waugh
This study provides diverse lines of evidence demonstrating that fluoride (F) exposure contributes to degenerative eye diseases by stimulating or inhibiting biological pathways associated with the pathogenesis of cataract, age-related macular degeneration and glaucoma. As elucidated in this study, F exerts this effect by inhibiting enolase, τ-crystallin, Hsp40, Na⁺, K⁺-ATPase, Nrf2, γ -GCS, HO-1 Bcl-2, FoxO1, SOD, PON-1 and glutathione activity, and upregulating NF-κB, IL-6, AGEs, HsP27 and Hsp70 expression...
March 8, 2019: International Journal of Environmental Research and Public Health
Tobias H Neuhann, Dana M Hornbeak, Raphael T Neuhann, Jane Ellen Giamporcaro
PURPOSE: To assess 5-year outcomes after implantation of 1 trabecular microbypass stent during cataract surgery in eyes with open-angle glaucoma (OAG) or ocular hypertension. SETTING: Private ophthalmology clinic (AaM Augenklinik am Marienplatz, Munich, Germany). DESIGN: Prospective nonrandomized consecutive case series. METHODS: One trabecular microbypass stent was implanted after phacoemulsification cataract surgery by one surgeon over 4 years...
March 2019: Journal of Cataract and Refractive Surgery
A K Makuloluwa, S Tiew, M Briggs
There is variability in the management of ophthalmic patients on anti-thrombotic agents (antiplatelets and anticoagulants) during the peri-operative period. A survey carried out in a UK teaching hospital on a cohort of ophthalmologists showed majority were comfortable with antiplatelet management but there was variability in managing patients on warfarin and direct oral anticoagulants (DOACs); 40% were unaware of existing guidelines. We aim to review the recommendations in the literature with regards to managing anti-thrombotic agents during the peri-operative period of ophthalmic surgery...
March 8, 2019: Eye
Mukharram M Bikbov, Gyulli M Kazakbaeva, Rinat M Zainullin, Venera F Salavatova, Timur R Gilmanshin, Dilya F Yakupova, Yulia V Uzianbaeva, Inga I Arslangareeva, Songhomitra Panda-Jonas, Svetlana R Mukhamadieva, Renat I Khikmatullin, Said K Aminev, Ildar F Nuriev, Artur F Zaynetdinov, Jost B Jonas
PURPOSE: To assess the normal distribution of intraocular pressure (IOP) and its associations with ocular, medical, and socioeconomic factors in a Russian population. DESIGN: Population-based cross-sectional study METHODS: The Ural Eye and Medical Study conducted in a rural and urban area in Ufa/Bashkortostan included 5,899 (80.5%) participants out of 7328 eligible individuals aged 40+ years. IOP was measured by non-contact tonometry. RESULTS: After excluding individuals after glaucoma surgery or with anti-glaucomatous therapy, mean IOP was 13...
March 5, 2019: American Journal of Ophthalmology
Michael M Lin, Abdulrahman Rageh, Angela V Turalba, Hang Lee, Iryna A Falkenstein, Ambika S Hoguet, Pallavi Ojha, Veena S Rao, Kitiya Ratanawongphaibul, Douglas J Rhee, Lucy Q Shen, Brian J Song, Teresa C Chen
PRéCIS:: This retrospective study found that combined phacoemulsification and endocyclophotocoagulation reduced intraocular pressure to a greater degree in angle closure glaucoma versus open-angle glaucoma and was effective for all stages of glaucoma. PURPOSE: Endocyclophotocoagulation (ECP, Endo Optiks, Little Silver, NJ, USA) laser treatment of the ciliary processes is believed to decrease intraocular pressure (IOP) by reducing aqueous production. Anecdotal experience in angle closure glaucoma suggests that it may also lower IOP by opening the drainage angle to promote aqueous outflow...
March 4, 2019: Journal of Glaucoma
Ian Murdoch, Helen Baker, Capucine Odouard, Imani Kapessa, Jonathan Clarke, Kazim Dhalla
INTRODUCTION: The glaucomas often co-exist with cataract. We previously reported a large trial of anti-scarring treatment in combined phacotrabeculectomy surgery. Long-term outcomes in an African population are extremely rarely reported. We present here the outcomes in IOP, acuity, bleb morphology and patient perceptions at 3-5-years post surgery. METHODS: Tanzanian patients with glaucoma and visually significant cataract underwent combined phacotrabeculectomy surgery...
March 1, 2019: Eye
David Justin Hernstadt, Jason Cheng, Hla Myint Htoon, Tiakumzuk Sangtam, Anoop Thomas, Chelvin Cheryl Agnes Sng
PURPOSE: To evaluate the safety and efficacy of combined iStent® trabecular micro-bypass device (Glaukos, Laguna Hills, CA) and phacoemulsification in eyes with primary angle closure disease. METHODS: A two-center prospective interventional case series of consecutive patients with primary angle closure (PAC) or primary angle closure glaucoma (PACG) on at least one glaucoma medication, who underwent iStent implantation with cataract surgery. Postoperatively, patients were assessed on days 1 and 7, and months 1, 3, 6, and 12...
February 28, 2019: Advances in Therapy
Hamed Esfandiari, Shabnam Ansari, Hossein Mohammad-Rabei, Marilyn B Mets
Marfan syndrome is an autosomal dominant genetic connective tissue disorder that results from mutations in the fibrillin-1 gene located on chromosome band 15q15-21. Fibrillin, a glycoprotein, is widely expressed throughout the body and contributes to the elasticity and force-bearing capacity of connective tissue. In the eye, fibrillin is a key constituent of the ciliary zonules, which suspend the crystalline lens in place. The zonular defect leads to ectopia lentis, which is a hallmark of Marfan ocular abnormalities and occurs in 60% to 80% of cases...
January 2019: Journal of Ophthalmic & Vision Research
Thomas S Shute, Devesh K Varma, Diamond Tam, Thomas Klein, Prima Moinul, Iqbal Ike K Ahmed, Arsham Sheybani
Purpose: To investigate a potential link between the incidence of malignant glaucoma after cataract surgery and seasonal variations in daylight. Methods: In total, 18,374 uncomplicated cataract surgeries were performed between June 2008 and June 2013 at an ambulatory surgery center in Toronto. Toronto's average monthly daylight over that time period-in hours per day for each month-was determined. The number of malignant glaucoma cases that developed after cataract surgery performed in months with above average daylight was compared to the number of cases that developed after cataract surgery performed in months with below average daylight...
January 2019: Journal of Ophthalmic & Vision Research
Pradeep Paul George, Olivia Chng Shih Yun, Kalin Siow, Nakul Saxena, Bee Hoon Heng, Josip Car, Craig Lockwood
PURPOSE: In Singapore, optometrists' roles are limited compared to their counterparts elsewhere. The purpose of the survey is to investigate optometrists' current roles, views on extended roles, self-reported primary eye care knowledge, needs for continuing professional education (CPE) and views on suitable modes for CPE. METHODS: Members of the Optometrist and Optician Board (OOB) were invited via email to take part in an anonymous online survey. The survey questions covered the following areas: current scope of practice, self-rated primary eye care knowledge, confidence in screening, co-managing minor eye conditions, CPE and referral behavior...
February 25, 2019: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
Praveen S Kumar, Aparna Rao, Sirisha Senthil
PURPOSE: We report a case of premature expression of pseudoexfoliation syndrome with presenile cataract in a 28-year-old lady with primary developmental glaucoma who had undergone glaucoma filtration surgery 26 years ago. METHODS/RESULTS: We report a case of a 28-year-old Indian lady with progressive diminution of vision associated with photophobia in the left eye for 5 years and loss of vision in the right eye since childhood. She underwent glaucoma filtration surgery in the left eye at the age of 2 and was on 2 topical glaucoma medications when she presented to us...
February 21, 2019: Journal of Glaucoma
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