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Drug-resistant tuberculosis in 2017

André N H Bulabula, Jenna A Nelson, Eric M Musafiri, Rhoderick Machekano, Nadia A Sam-Agudu, Andreas H Diacon, Maunank Shah, Jacob Creswell, Grant Theron, Robin M Warren, Karen R Jacobson, Jean-Paul Chirambiza, Dieudonné Kalumuna, Bertin C Bisimwa, Patrick D M C Katoto, Michel K Kaswa, Freddy M Birembano, Liliane Kitete, Martin P Grobusch, Zacharie M Kashongwe, Jean B Nachega
Background: Multidrug-resistant tuberculosis (MDR-TB) jeopardizes global TB control. The prevalence and predictors of Rifampicin-resistant (RR) TB, a proxy for MDR-TB, and the treatment outcomes with standard and shortened regimens have not been assessed in post-conflict regions, such as the South Kivu province in the eastern Democratic Republic of the Congo (DRC). We aimed to fill this knowledge gap and to inform the DRC National TB Program. Methods: of adults and children evaluated for pulmonary TB by sputum smear microscopy and Xpert MTB/RIF (Xpert) from February 2012 to June 2017...
February 13, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Chih-Bin Lin, Hung-Chieh Sun, Chen-Yuan Chiang, Che-Wei Wu, Hsu-Wen Chou, Tao-Qian Tang, Jen-Jyh Lee
Objectives: The objective of this study is to evaluate the treatment outcomes of patients with multidrug-resistant tuberculosis (MDR-TB) under special programmatic management in Eastern Taiwan over the past 10 years. Materials and Methods: All newly diagnosed MDR-TB patients and MDR-TB patients enrolled previously with persistent positive cultures were included in this study, from May 2007 to April 2017, in Eastern Taiwan. A panel of pulmonologists designed the initial MDR-TB regimens...
January 2019: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
M Reimann, D Schaub, B Kalsdorf, C Runge, P Sanchez Carballo, E Terhalle, H J F Salzer, C Lange, J Heyckendorf
BACKGROUND: Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide. Active cigarette smoking may have a significant impact on treatment responses to anti-tuberculosis treatment. OBJECTIVE: To ascertain the effect of smoking on Mycobacterium tuberculosis sputum culture conversion rates following treatment initiation in patients with susceptible, multidrug-resistant and extensively drug-resistant TB (M/XDR-TB). METHOD: Sputum cultures of smoking and non-smoking patients with pulmonary TB (PTB) treated at a referral centre in Germany were evaluated...
January 1, 2019: International Journal of Tuberculosis and Lung Disease
Yuanbo Lan, Yuqin Li, Ling Chen, Jianyong Zhang, Hong Zhang
Objectives: Tuberculosis (TB) is the leading cause of death from infectious diseases in the world, with an estimated 1.6 million deaths from TB in 2017. The objectives of this study were to determine drug resistance profiles of Mycobacterium tuberculosis clinical isolates and to analyze the trends in drug-resistant and multidrug-resistant tuberculosis (MDR-TB) from 2008 to 2015 at a major hospital in Guizhou, a high-TB burden and resource-limited province of China. Patients and methods: A total of 462 clinical isolates were collected from patients with pulmonary TB during the period from January 2013 to December 2015 and used for determining drug resistance profiles against four first-line and six second-line anti-TB drugs, and the results were compared with those of two previous studies...
2019: Infection and Drug Resistance
Vibol Iem, Anna Dean, Matteo Zignol, Phouvang Vongvichit, Donekham Inthavong, Souvimone Siphanthong, Theppouthone Sorsavanh, Sang Jae Kim, Soyoun Shin, Jacques Sebert, Phonenaly Chittamany
OBJECTIVE: To present results of the first national anti-tuberculosis (TB) drug resistance survey conducted in Lao PDR between May 2016 and August 2017 to determine the prevalence of resistance to first-line anti-TB drugs among new and previously treated pulmonary TB cases in the country. METHODS: Patients with sputum smear-positive pulmonary TB were enrolled from 42 TB laboratories distributed in 40 clusters throughout the country. Survey sites were selected using probability-proportional-to-size sampling among all diagnostic centers in the country...
January 21, 2019: Tropical Medicine & International Health: TM & IH
Seifu Gizaw Feyisa, Ahmed Abdulahi Abdurahman, Worku Jimma, Eshetu Ejeta Chaka, Jalil Kardan-Yamchi, Hossein Kazemian
Introduction: Antitubercular drug resistance strain is a horrifying barrier to effective TB treatment and prevention. The present study aimed to determine the prevalence and geographical distribution of rifampicin-resistance M. tuberculosis (MTB) strains. Methods: We searched two electronic databases, PubMed and EMBASE, until 26 March 2017 and updated our search on 27 April 2018 and accessed all prevalence studies of MTB strain and their drug susceptibility patterns to rifampicin...
January 2019: Heliyon
Andrea Rachow, Olena Ivanova, Robert Wallis, Salome Charalambous, Ilesh Jani, Nilesh Bhatt, Beate Kampmann, Jayne Sutherland, Nyanda E Ntinginya, Denise Evans, Knut Lönnroth, Stefan Niemann, Ulrich E Schaible, Christof Geldmacher, Ian Sanne, Michael Hoelscher, Gavin Churchyard
BACKGROUND: Up to fifty percent of microbiologically cured tuberculosis (TB) patients may be left with permanent, moderate or severe pulmonary function impairment. Very few studies have systematically examined pulmonary outcomes in patients to understand the pathophysiologic basis and long-term socio-economic consequences of this injury. The planned multi-country, multi-centre observational TB cohort study, aims to advance the understanding of the clinical, microbiological, immunological and socio-economic risk factors affecting long-term outcome of pulmonary TB...
January 7, 2019: BMC Pulmonary Medicine
Mohammad Reza Jabbari Amiri, Rora Siami, Azad Khaledi
Background: Pulmonary tuberculosis is one of the most important health concerns. Pulmonary fungal infections have clinical and radiological characteristics similar to tuberculosis which may be easily misdiagnosed as tuberculosis. This study aimed to evaluate tuberculosis (TB) status and coinfection of TB with pulmonary fungal infections in patients referred to reference laboratory of health centers Ghaemshahr city during 2007-2017. Methods: This cross-sectional study was conducted during eleven years, between 2007-2017, on 3577 patients with suspected TB referred to health centers of Ghaemshahr City...
November 2018: Ethiopian Journal of Health Sciences
Manouchehr Fadaee, Jalil Rashedi, Sepideh Arabi, Behroz Mahdavi Poor, Hossein Samadi Kafil, Mahya Pourostadi, Abdolhassan Kazemi, Mohammad Asgharzadeh
Tuberculosis (TB) is a public health problem in developing countries. In recent decades, the incidence of the disease has been gradually reducing in Iran. However, the reducing incidence of the disease has stopped in the country during recent years. It could be due to increase of immigration, diabetes, HIV/AIDS, and the prevalence of drug-resistant strains. In order to prevent the spread of TB cases and control this disease, it is essential to identify the predisposing factors, which may be related to bacteria, host and environment...
December 28, 2018: Infectious Disorders Drug Targets
Daniel J Frank, David J Horne, Noton K Dutta, Moagi Tube Shaku, Rajhmun Madensein, Thomas R Hawn, Adrie J C Steyn, Petros C Karakousis, Bavesh Davandra Kana, Graeme Meintjes, Barbara Laughon, Zaid Tanvir
New therapeutics to augment current approaches and shorten treatment duration are of critical importance for combating tuberculosis (TB), especially those with novel mechanisms of action to counter the emergence of drug-resistant TB. Host-directed therapy (HDT) offers a novel strategy with mechanisms that include activating immune defense mechanisms or ameliorating tissue damage. These and related concepts will be discussed along with issues that emerged from the workshop organized by the Stop TB Working Group on New Drugs, held at the Gordon Research Conference for Tuberculosis Drug Development in Lucca, Italy in June 2017, titled "Strategic Discussion on Repurposing Drugs & Host Directed Therapies for TB...
December 21, 2018: Journal of Infectious Diseases
Janaina Gomes Nascimento Oliosi, Barbara Reis-Santos, Rodrigo Leite Locatelli, Carolina Maia Martins Sales, Walter Gomes da Silva Filho, Kerollen Cristina da Silva, Mauro Niskier Sanchez, Kaio Vinicius Freitas de Andrade, Gleide Santos de Araújo, Priya B Shete, Susan Martins Pereira, Lee W Riley, Christian Lienhardt, Ethel Leonor Noia Maciel
BACKGROUND: Social protection interventions might improve tuberculosis outcomes and could help to control the epidemic in Brazil. The aim of this study was to evaluate the independent effect of the Bolsa Familia Programme (BFP) on tuberculosis treatment outcomes in Brazil. METHODS: We prospectively recruited and followed up individuals (aged ≥18 years) who initiated tuberculosis treatment at 42 health-care centres across seven cities in Brazil, between March 1, 2014, and April 30, 2017...
December 21, 2018: Lancet Global Health
Bassirou Diarra, Mahamadou Kone, Antieme Combo Georges Togo, Yeya Dit Sadio Sarro, Aissata Boubakar Cisse, Amadou Somboro, Boureima Degoga, Mohamed Tolofoudie, Bourahima Kone, Moumine Sanogo, Bocar Baya, Ousmane Kodio, Mamoudou Maiga, Michael Belson, Susan Orsega, Meryam Krit, Sounkalo Dao, Ibrahim Izétiegouma Maiga, Robert L Murphy, Leen Rigouts, Seydou Doumbia, Souleymane Diallo, Bouke Catherine de Jong
OBJECTIVE: Ancestral M. tuberculosis complex lineages such as M. africanum are underrepresented among retreatment patients and those with drug resistance. To test the hypothesis that they respond faster to TB treatment, we determined the rate of smear conversion of new pulmonary tuberculosis patients in Bamako, Mali by the main MTBc lineages. METHODS: Between 2015 and 2017, we conducted a prospective cohort study of new smear positive pulmonary tuberculosis patients in Bamako...
2018: PloS One
C K Indumathi, Aruna Sethuraman, Saurav Jain, Savita Krishnamurthy
OBJECTIVES: To compare the incidence of anti tuberculosis drug-induced hepatotoxicity (ATDH) with those on old vs. revised WHO doses in human immunodeficiency virus (HIV) negative children. The secondary objective was to determine the overall incidence of hepatitis in children on Anti tubercular treatment (ATT) and isoniazid prophylactic therapy (IPT). METHODS: Children attending pediatric outpatient / admitted in wards, on ATT/ IPT between January 2007 and December 2017 (11 y) were included...
December 4, 2018: Indian Journal of Pediatrics
Jung-Kyu Lee, Ji Yeon Lee, Deog Kyeom Kim, Ho Il Yoon, Ina Jeong, Eun Young Heo, Young Sik Park, Yong Suk Jo, Jae Ho Lee, Sung Soo Park, Jong Sun Park, Junghyun Kim, Sang-Min Lee, Joon-Sung Joh, Chang-Hoon Lee, Jinwoo Lee, Sun Mi Choi, Ju-Hee Park, Sang Hoon Lee, Young-Jae Cho, Yeon Joo Lee, Se Joong Kim, Nakwon Kwak, Yong Ran Hwang, Hyeonjeong Kim, Jongeun Ki, Ji Na Lim, Hyoung Sook Choi, Myungsun Lee, Taeksun Song, Hyun Su Kim, Jiyeon Han, Heejung Ahn, Seokyung Hahn, Jae-Joon Yim
BACKGROUND: Linezolid improves the treatment outcomes of multidrug-resistant tuberculosis substantially. We investigated whether use of linezolid instead of ethambutol increases the proportion of sputum culture conversion at 8 weeks of treatment in patients with pulmonary tuberculosis. METHODS: We did a phase 2, multicentre, randomised, open-label trial for patients with pulmonary tuberculosis at the three affiliated hospitals to Seoul National University and National Medical Center (Seoul-Seongnam, South Korea)...
November 23, 2018: Lancet Infectious Diseases
L Xu, Y X Sun, S Y Zhan
Objective: To evaluate the diagnostic accuracy of line probe assays for drug- resistant tuberculosis (TB) in China. Methods: Chinese databases (CNKI, Wanfang, SinoMed, VIP Information) and English databases (PubMed, Embase, Cochrane Library) were used to retrieve the literatures regarding the accuracy of line probe assays in the diagnosis of drug-resistant tuberculosis in China between January 1, 2000 and September 1, 2017. Quality Assessment of Diagnostic Accuracy Studies-2 was used to evaluate the quality of the included studies...
November 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Kunchok Dorjee, Sonam Topgyal, Chungdak Dorjee, Tenzin Tsundue, Tenzin Namdol, Tenzin Tsewang, Tenzin Nangsel, Dekyi Lhadon, Tsering Choetso, Tenzin Dawa, Tenzin Phentok, Andrea N DeLuca, Lobsang Tsering, Dawa Phunkyi, Tsetan D Sadutshang, Elizabeth Bonomo, Zorba Paster, Richard E Chaisson
Background: Tuberculosis prevalence is high among Tibetan refugees in India, with almost half of cases occurring in congregate facilities, including schools. A comprehensive program of tuberculosis case-finding, and diagnosis and treatment of TB infection (TBI) was undertaken in schools for Tibetan refugee children. Methods: Under the Zero TB Kids program, schoolchildren and staff in Tibetan schools in Himachal Pradesh, India, were screened for tuberculosis with an algorithm using symptom criteria, chest radiography, molecular diagnostics, and tuberculin skin tests...
November 20, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Ye Minn Htun, Tin Mi Mi Khaing, Yin Yin, Zaw Myint, Si Thu Aung, Tin Maung Hlaing, Ngamphol Soonthornworasiri, Udomsak Silachamroon, Yuthichai Kasetjaroen, Jaranit Kaewkungwal
BACKGROUND: Delays in diagnosis and treatment initiation may allow the emergence of new cases by transmission to the community, and is one of the challenges facing programme management of drug resistance in Myanmar. This study aimed to explore delays in diagnosis and treatment initiation, and associated factors among patients with multidrug-resistant tuberculosis. METHODS: A cross-sectional study was conducted at Yangon Regional Tuberculosis Centre, Myanmar. Data were collected by face-to-face interviews and treatment-card reviews of all adult patients who had registered and started treatment with the standard regimen from May to November, 2017...
November 20, 2018: BMC Health Services Research
Micheli Luize Grenzel, Antonio José Grande, Anamaria Mello Miranda Paniago, Mauricio Antonio Pompilio, Sandra Maria do Valle Leone de Oliveira, Anete Trajman
INTRODUCTION: Prison inmates can transmit tuberculosis, including drug-resistant strains, to correctional facility workers and the community. In this systematic literature review, we investigated the magnitude of active and latent tuberculosis infection (LTBI) and associated risk factors among correctional facility workers. METHODS: We searched MEDLINE, EMBASE, LILACS, Cochrane CENTRAL, ISI Web of Science, CINAHL, and SCOPUS databases (January 1, 1989-December 31, 2017) for studies with the MeSH terms "prison" (and similar) AND "tuberculosis", without language restriction...
2018: PloS One
Abrham Belachew Muluye, Selamu Kebamo, Tesfa Teklie, Getachew Alemkere
BACKGROUND: Although it is a preventable and treatable disease, tuberculosis remains a major medical and public health problem throughout the world. The control and elimination of tuberculosis is currently challenged by the development and spread of antituberculosis drug resistance. The resistance is often correlated to the absence of properly implemented control measures that lead to poor treatment outcomes. Therefore, the aim of the current study was to assess poor treatment outcomes and its determinants among tuberculosis patients in selected health facilities in East Wollega zone, Western Ethiopia...
2018: PloS One
Kouassi N'Guessan, Timothée Ouassa, Anna S Dean, Riccardo Alagna, Guy Damien Adagra, Valeri Ibode, Daniela M Cirillo, Jacquemin Kouakou
Setting: Tuberculosis (TB) drug resistance survey was conducted in 2016-2017 to estimate the burden of drug-resistant TB in Côte d'Ivoire. Design: A cross-sectional cluster-based survey was conducted. All eligible smear positive patients were interviewed using a structured questionnaire to collect clinical and sociodemographic information and tested by the Xpert Mycobacterium tuberculosis /rifampicin (MTB/RIF) assay. If resistant to rifampicin, solid and liquid cultures were performed...
September 28, 2018: European Journal of Microbiology & Immunology
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