keyword
Keywords Drug-resistant tuberculosis in...

Drug-resistant tuberculosis in 2017

https://read.qxmd.com/read/38526186/drug-resistant-tuberculosis-georgia-kazakhstan-kyrgyzstan-moldova-and-ukraine-2017-2022
#1
JOURNAL ARTICLE
Victor Naestholt Dahl, Tetiana Butova, Alex Rosenthal, Alina Grinev, Andrei Gabrielian, Sergo Vashakidze, Natalia Shubladze, Bekzat Toxanbayeva, Lyailya Chingissova, Valeriu Crudu, Dumitru Chesov, Gulmira Kalmambetova, Gulbarchyn Saparova, Christian Morberg Wejse, Dmytro Butov
In 2021, the World Health Organization recommended new extensively drug-resistant (XDR) and pre-XDR tuberculosis (TB) definitions. In a recent cohort of TB patients in Eastern Europe, we show that XDR TB as currently defined is associated with exceptionally poor treatment outcomes, considerably worse than for the former definition (31% vs. 54% treatment success).
April 2024: Emerging Infectious Diseases
https://read.qxmd.com/read/38525642/treating-drug-resistant-tuberculosis-in-an-era-of-shorter-regimens-insights-from-rural-south-africa
#2
JOURNAL ARTICLE
J-D K Lotz, J Porter, H Conradie, T Boyles, B Gaunt, S Dimanda, D Cort
BACKGROUND: Progressive interventions have recently improved programmatic outcomes in drug-resistant tuberculosis (DR-TB) care in South Africa (SA). Amidst these, a shorter regimen was introduced in 2017 with weak evidence, and has shown mixed results. Outcomes still fall short of national targets, and the coronavirus disease 2019 pandemic has undermined progress to date. OBJECTIVES: To describe the outcomes of participants treated for DR-TB using a shorter, compared with a longer, regimen in a deeply rural SA setting, and to explore other factors affecting these outcomes...
November 6, 2023: South African Medical Journal
https://read.qxmd.com/read/38525535/treatment-of-multidrug-resistant-or-rifampicin-resistant-tuberculosis-with-an-all-oral-9-month-regimen-containing-linezolid-or-ethionamide-in-south-africa-a-retrospective-cohort-study
#3
JOURNAL ARTICLE
Hannah Morgan, Norbert Ndjeka, Tasnim Hasan, Medea Gegia, Fuad Mirzayev, Linh Nguyen, Samuel Schumacher, Timothy E Schlub, Kogieleum Naidoo, Greg J Fox
BACKGROUND: In 2019, the South African tuberculosis program replaced ethionamide with linezolid as a part of an all-oral 9-month regimen. We evaluated treatment outcomes for patients assigned to regimens including linezolid in 2019 and ethionamide in 2017. METHOD: This retrospective cohort study included patients treated for multi-drug resistant/rifampicin-resistant tuberculosis throughout South Africa between 1 Jan to 31 Dec 2017 and from 1 Jan to 31 Dec 2019. The cohort treated with a 9-month regimen containing ethionamide for four months, was compared with a cohort treated with a 9-month regimen containing linezolid for two months...
March 25, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38516788/characteristic-snps-defining-the-major-multidrug-resistant-mycobacterium-tuberculosis-clusters-identified-by-euseqmytb-to-support-routine-surveillance-eu-eea-2017-to-2019
#4
JOURNAL ARTICLE
Albert J de Neeling, Elisa Tagliani, Csaba Ködmön, Marieke J van der Werf, Dick van Soolingen, Daniela Maria Cirillo, Richard M Anthony
BackgroundThe EUSeqMyTB project, conducted in 2020, used whole genome sequencing (WGS) for surveillance of drug-resistant Mycobacterium tuberculosis in the European Union/European Economic Area (EU/EEA) and identified 56 internationally clustered multidrug-resistant (MDR) tuberculosis (TB) clones.AimWe aimed to define and establish a rapid and computationally simple screening method to identify probable members of the main cross-border MDR-TB clusters in WGS data to facilitate their identification and track their future spread...
March 2024: Euro Surveillance
https://read.qxmd.com/read/38449006/clinical-characteristics-and-drug-resistance-of-nocardia-in-henan-china-2017-2023
#5
REVIEW
Yungang Han, Meijin Cheng, Zheng Li, Huihui Chen, Shuang Xia, Yue Zhao, Yali Wang, Wenyi He, Wei Wang
BACKGROUND: The aim of this study was to investigate the clinical features of Nocardia infections, antibiotic resistance profile, choice of antibiotics and treatment outcome, among others. In addition, the study compared the clinical and microbiological characteristics of nocardiosis in bronchiectasis patients and non-bronchiectasis patients. METHODS: Detailed clinical data were collected from the medical records of 71 non-duplicate nocardiosis patients from 2017 to 2023 at a tertiary hospital in Zhengzhou, China...
March 6, 2024: Annals of Clinical Microbiology and Antimicrobials
https://read.qxmd.com/read/38389615/single-sequence-whole-spine-screening-magnetic-resonance-imaging-diagnostic-and-therapeutic-role-in-multiple-level-spinal-tuberculosis
#6
JOURNAL ARTICLE
Atul Sareen, Mayukh Guha, Kuldeep Bansal, Amit Hegde, Tankeswar Boruah
INTRODUCTION: Spinal tuberculosis (TB) is the most common form of skeletal tuberculosis. Paradiscal continuous vertebral involvement at a single level is the most prevalent pattern among all forms of spinal TB. There is a wide range of reported incidences of multiple-level non-contiguous spinal TB in the literature. We would like to discuss on the utility of single whole spine screening T2-weighted (T2W) mid-sagittal magnetic resonance imaging (MRI) film in diagnosing multiple-level spinal TB and therapeutic benefits it can provide...
January 2024: Curēus
https://read.qxmd.com/read/38310759/diagnosing-osteoarticular-tuberculosis-and-detecting-rifampicin-resistance-a-comparative-analysis-of-truenat-mtb-plus-vs-genexpert-ultra
#7
JOURNAL ARTICLE
Kusum Sharma, Megha Sharma, Aman Sharma, Mandeep Singh Dhillon
SETTING: Diagnosing osteoarticular tuberculosis (OATB) and detecting drug resistance is a challenge in an endemic country like India. OBJECTIVE: Truenat MTB Plus assay (TruPlus), a chip-based portable machine, was compared with GeneXpert Ultra (GxUltra) for diagnosing drug-resistant OATB. DESIGN: 115 synovial fluid and pus specimens [22 culture-positive confirmed, 58 culture-negative clinically-suspected, 35 non-TB controls] processed between 2017 and 2023 were subjected to TruPlus, GxUltra and multiplex-PCR for diagnosing OATB...
March 2024: Tuberculosis
https://read.qxmd.com/read/38222127/effectiveness-of-rifabutin-based-regimens-in-treating-helicobacter-pylori-infections
#8
REVIEW
Jaikirat Singh Gugnani, Fnu Abhishek, Yash Agarwal, Abhiram Rao Damera, Harkamalpreet Kaur, Bayan Taleb, Rohan Mane, Ujjwal Soni, Kapil D Nayar
Helicobacter pylori has been reported as a health problem worldwide, affecting a sizable portion of people. Peptic ulcers, gastric cancer, and various extra gastric conditions are associated with this bacterium. The rampant overprescribing of antibiotics has led to the emergence of H. pylori strains resistant to multiple antibiotics, causing a decline in the effectiveness of current treatments. Recently, there has been growing interest in researching alternative treatment options for H. pylori infections that do not respond to initial therapy...
December 2023: Curēus
https://read.qxmd.com/read/38213049/the-profile-of-multidrug-tuberculosis-regimen-and-treatment-outcomes-in-pulmonary-mdr-tb-patients-at-the-tertiary-referral-hospital-dr-soetomo-east-java-indonesia-a-seven-year-retrospective-study-on-bedaquiline
#9
JOURNAL ARTICLE
Muhamad Frendy Setyawan, Ni Made Mertaniasih, Soedarsono Soedarsono
BACKGROUND: The use of bedaquiline has been reported to minimize the number of lost to follow-up and fewer rejections from the patients. This study is the first to depict the use of bedaquiline. It aims to provide information related to the profile of the MDR-TB drug regimen in the last 7 years with the treatment outcomes of pulmonary MDR-TB patients at a tertiary referral hospital in East Java. METHODS: This study was a retrospective, descriptive, and data analysis on 1053 pulmonary MDR-TB patients in tertiary referral hospital Dr Soetomo, East Java, Indonesia, with the SPSS software version 25 and Microsoft Excel 2021...
October 2023: Acta Medica Indonesiana
https://read.qxmd.com/read/38200467/effect-of-mixed-mycobacterium-tuberculosis-infection-on-rapid-molecular-diagnostics-among-patients-starting-mdr-tb-treatment-in-uganda
#10
JOURNAL ARTICLE
Kevin Komakech, Lydia Nakiyingi, Ashab Fred, Beatrice Achan, Moses Joloba, Bruce J Kirenga, Willy Ssengooba
BACKGROUND: Mixed M. tuberculosis (MTB) infection occurs when one is infected with more than one clonally distinct MTB strain. This form of infection can assist MTB strains to acquire additional mutations, facilitate the spread of drug-resistant strains, and boost the rate of treatment failure. Hence, the presence of mixed MTB infection could affect the performance of some rapid molecular diagnostic tests such as Line Probe Assay (LPA) and GeneXpert MTB/RIF (Xpert) assays. METHODS: This was a cross-sectional study that used sputum specimens collected from participants screened for STREAM 2 clinical trial between October 2017 and October 2019...
January 10, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38182990/differential-distribution-of-linezolid-in-diseased-and-nondiseased-bones-in-patients-with-spinal-tuberculosis
#11
JOURNAL ARTICLE
Yuan Li, Guohua Lei, Weijie Dong, Tinglong Lan, Jun Fan, Shibing Qin
BACKGROUND: Linezolid exhibits antibacterial activity against sensitive and drug-resistant strains of Mycobacterium tuberculosis. Knowledge on the distribution of linezolid in different types of bones in patients with spinal tuberculosis (TB) is lacking, which limits the pharmacokinetic and pharmacodynamic studies of linezolid. This study aimed to evaluate the distribution of linezolid in diseased and nondiseased bones in patients with spinal TB. METHODS: Spinal TB patients treated with linezolid-containing regimens and whose diseased and nondiseased bones were collected during surgery were enrolled retrospectively from January 2017 to February 2022...
January 5, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38104727/the-association-between-phylogenetic-lineage-and-the-subclinical-phenotype-of-pulmonary-tuberculosis-a-retrospective-2-cohort-study
#12
JOURNAL ARTICLE
Richard Long, Matthew Croxen, Robyn Lee, Alexander Doroshenko, Angela Lau, Leyla Asadi, Courtney Heffernan, Catherine Paulsen, Mary Lou Egedahl, Colin Lloyd, Vincent Li, Gregory Tyrrell
BACKGROUND: Subclinical pulmonary tuberculosis (PTB) is an asymptomatic disease state between established TB infection and symptomatic (clinical) TB disease. It is present in 20-25% of PTB patients in high-income countries. Mycobacterium tuberculosis complex (MTBC) genetic heterogeneity, and differential host immunological responses, have been implicated in its pathogenesis. METHODS: To determine the association between MTBC lineage and PTB disease phenotype, we used two retrospective cohorts of PTB patients in Canada and two independent lineage attribution methods (DNA fingerprinting and genome sequencing)...
December 15, 2023: Journal of Infection
https://read.qxmd.com/read/38084529/impact-of-cartridge-based-nucleic-acid-amplification-test-cbnaat-introduction-on-the-detection-of-pulmonary-and-extra-pulmonary-tuberculosis-in-bhubaneswar-odisha
#13
JOURNAL ARTICLE
Himadri Bhusan Bal, Sarita Kar, Sarita Otta, Sujeet Kumar, Suryakanta Samal, Archana Pattnaik, Sunil Swick Rout, Jyotirmayee Turuk, Dasarathi Das, Sanghamitra Pati, Sidhartha Giri
BACKGROUND: Compared to conventional microscopy, the cartridge-based nucleic acid amplification test (CBNAAT, Xpert MTB/RIF, Cepheid, USA) has the dual advantage of higher sensitivity to detect Mycobacterium tuberculosis (M. tb), and the ability to detect rifampicin resistance. AIM: To evaluate the impact of the CBNAAT on the detection of pulmonary and extra-pulmonary tuberculosis from private and public healthcare facilities in Bhubaneswar, Odisha. MATERIALS AND METHODS: The study included specimens received between June 2015 to February 2017 from public and private health sectors for tuberculosis diagnosis at a national reference laboratory for tuberculosis in Bhubaneswar, where the CBNAAT was initiated in February 2016...
2023: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38029240/epidemiology-of-nontuberculous-mycobacteria-in-tuberculosis-suspects-southwest-of-china-2017-2022
#14
JOURNAL ARTICLE
Dong-Mei Wang, Hong Liu, Yong-Li Zheng, Yuan-Hong Xu, Yi Liao
OBJECTIVES: This study summarizes the epidemiological characteristics, species distribution, and drug sensitivity of clinical nontuberculous mycobacteria (NTM) isolates at the Public Health Clinical Center of Chengdu, China, from January 2017 to December 2022. METHODS: We retrospectively analyzed data from patients with clinically isolated NTM strains. Chi-square analysis assessed the rate of Mycobacterium strain isolation over 6 years. RESULTS: The number of samples tested for Mycobacterium tuberculosis (MTB) and/or NTM increased each year, while MTB detection decreased and NTM detection rose significantly each year (P=0...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38005919/the-effect-of-hiv-and-antiretroviral-therapy-on-drug-resistant-tuberculosis-treatment-outcomes-in-eastern-cape-south-africa-a-cohort-study
#15
JOURNAL ARTICLE
Brittney van de Water, Nadia Abuelezam, Jenny Hotchkiss, Mandla Botha, Limpho Ramangeola
South Africa has a dual high burden of HIV and drug-resistant TB (DR-TB). We sought to understand the association of HIV and antiretroviral therapy status with TB treatment outcomes. This was a retrospective chart review of 246 patients who began treatment at two DR-TB hospitals in Eastern Cape, South Africa between 2017 and 2020. A categorical outcome with three levels was considered: unfavorable, transferred out, and successful. Descriptive statistics and logistic regression were used to compare the individuals without HIV, with HIV and on antiretroviral therapy (ART), and with HIV but not on ART...
November 10, 2023: Viruses
https://read.qxmd.com/read/37980524/cost-of-digital-technologies-and-family-observed-dot-for-a-shorter-mdr-tb-regimen-a-modelling-study-in-ethiopia-india-and-uganda
#16
JOURNAL ARTICLE
Laura Rosu, Jason Madan, Gay Bronson, Jasper Nidoi, Mamo G Tefera, Muniyandi Malaisamy, Bertel S Squire, Eve Worrall
BACKGROUND: In 2017, the WHO recommended the use of digital technologies, such as medication monitors and video observed treatment (VOT), for directly observed treatment (DOT) of drug-susceptible TB. The WHO's 2020 guidelines extended these recommendations to multidrug-resistant tuberculosis (MDR-TB), based on low evidence. The impact of COVID on health systems and patients underscored the need to use digital technologies in the management of MDR-TB. METHODS: A decision-tree model was developed to explore the costs of several potential DOT alternatives: VOT, 99DOTS (Directly-observed Treatment, Short-course) and family-observed DOT...
November 18, 2023: BMC Health Services Research
https://read.qxmd.com/read/37972037/major-adverse-cardiovascular-events-and-hyperuricemia-during-tuberculosis-treatment
#17
JOURNAL ARTICLE
Hong-Joon Shin, Joon-Young Yoon, Young-Ok Na, Jae-Kyeong Lee, Bo Gun Kho, Tae-Ok Kim, Yu-Il Kim, Sung-Chul Lim, Sae-Hee Jeong, Yong-Soo Kwon
BACKGROUND: Hyperuricemia is common during tuberculosis (TB) treatment, especially in association with pyrazinamide (PZA). This study investigated the relationship between major adverse cardiovascular events (MACEs) and hyperuricemia during TB treatment. METHODS: We conducted a single-center retrospective cohort study. From January 2010 through June 2017, we assessed all consecutive TB patients at Chonnam National University Hospital in South Korea. Hyperuricemia was defined as serum uric acid levels exceeding 7...
2023: PloS One
https://read.qxmd.com/read/37971566/molecular-identification-of-multiple-drug-resistance-mdr-strain-of-mycobacterium-tuberculosis
#18
JOURNAL ARTICLE
Zahra Hosseinali, Jafar Mohammadshahi, Amir Teimourpour, Shahram Habibzadeh, Majid Esmaelizad, Mohsen Arzanlou, Hafez Mirzanejad-Asl, Mahin Sadeghnezhad, Shabnam Sohrabi, Roghayeh Teimourpour
BACKGROUND AND OBJECTIVES: Isoniazid and rifampin are the first -line drugs against Mycobacterium tuberculosis. Resistance to these important drugs is a serious threat to human public health. Therefore, this study aimed at molecular detection of resistance to these valuable drugs. MATERIALS AND METHODS: In this descriptive cross-sectional study, 111 non - duplicated clinical samples including sputum and Bronchoalveolar lavage (BAL) samples were collected from patients referred to the Ardabil Health Center between 2017 and 2020...
November 16, 2023: Molecular Biology Reports
https://read.qxmd.com/read/37962987/impact-of-prior-tb-treatment-with-new-companion-drugs-on-clinical-outcomes-in-patients-receiving-concomitant-bedaquiline-and-delamanid-for-mdr-rr-tb
#19
JOURNAL ARTICLE
L Mikiashvili, R R Kempker, Ts Chakhaia, N Bablishvili, Z Avaliani, N Lomtadze, M C Schechter, M Kipiani
BACKGROUND: There is scarce data on the clinical outcomes of persons retreated with new/companion anti-tuberculosis (TB) drugs for multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB). We sought to evaluate the efficacy and safety of bedaquiline and delamanid containing regimens among patients with and without prior exposure to the new/companion drugs (bedaquiline, delamanid, linezolid, clofazimine, and fluoroquinolones). METHODS: We conducted a retrospective cohort study among patients with pulmonary MDR/RR-TB in Georgia who received bedaquiline and delamanid combination as a part of a salvage regimen from November 2017 to December 2020 in a programmatic setting...
November 14, 2023: Clinical Infectious Diseases
https://read.qxmd.com/read/37961929/a-retrospective-cohort-analysis-of-treatment-outcomes-of-patients-with-tuberculosis-who-used-substances-in-tel-aviv-israel
#20
JOURNAL ARTICLE
Ehud Kaliner, Sandy Bornstein, Doaa Kabha, Moshe Lidji, Rivka Sheffer, Zohar Mor
AIMS: To outline the demographic, clinical, laboratory characteristics, and treatment outcomes of tuberculosis (TB) patients who used substances. METHODS: This retrospective cohort study compared 50 TB patients who used substances with a matched random sample of 100 TB patients who did not use substances between 2007 and 2017. Treatment failure was defined as a sputum smear or culture that tested positive after 5 months of treatment, loss to follow-up, unevaluated patients, or death...
November 13, 2023: Alcohol and Alcoholism
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