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https://read.qxmd.com/read/30778241/c-maf-dependent-t-reg-cell-control-of-intestinal-t-h-17-cells-and-iga-establishes-host-microbiota-homeostasis
#1
Christian Neumann, Jonas Blume, Urmi Roy, Peggy P Teh, Ajithkumar Vasanthakumar, Alexander Beller, Yang Liao, Frederik Heinrich, Teresita L Arenzana, Jason A Hackney, Celine Eidenschenk, Eric J C Gálvez, Christina Stehle, Gitta A Heinz, Patrick Maschmeyer, Tom Sidwell, Yifang Hu, Derk Amsen, Chiara Romagnani, Hyun-Dong Chang, Andrey Kruglov, Mir-Farzin Mashreghi, Wei Shi, Till Strowig, Sascha Rutz, Axel Kallies, Alexander Scheffold
Foxp3+ regulatory T cells (Treg cells) are crucial for the maintenance of immune homeostasis both in lymphoid tissues and in non-lymphoid tissues. Here we demonstrate that the ability of intestinal Treg cells to constrain microbiota-dependent interleukin (IL)-17-producing helper T cell (TH 17 cell) and immunoglobulin A responses critically required expression of the transcription factor c-Maf. The terminal differentiation and function of several intestinal Treg cell populations, including RORγt+ Treg cells and follicular regulatory T cells, were c-Maf dependent...
February 18, 2019: Nature Immunology
https://read.qxmd.com/read/30778226/protein-coding-variants-implicate-novel-genes-related-to-lipid-homeostasis-contributing-to-body-fat-distribution
#2
Anne E Justice, Tugce Karaderi, Heather M Highland, Kristin L Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul L Auer, Rebecca S Fine, Xiuqing Guo, Claudia Schurmann, Adelheid Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W Winkler, Adam E Locke, Carolina Medina-Gomez, Tõnu Esko, Sailaja Vedantam, Ayush Giri, Ken Sin Lo, Tamuno Alfred, Poorva Mudgal, Maggie C Y Ng, Nancy L Heard-Costa, Mary F Feitosa, Alisa K Manning, Sara M Willems, Suthesh Sivapalaratnam, Goncalo Abecasis, Dewan S Alam, Matthew Allison, Philippe Amouyel, Zorayr Arzumanyan, Beverley Balkau, Lisa Bastarache, Sven Bergmann, Lawrence F Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A Böger, Jette Bork-Jensen, Erwin P Bottinger, Donald W Bowden, Ivan Brandslund, Linda Broer, Amber A Burt, Adam S Butterworth, Mark J Caulfield, Giancarlo Cesana, John C Chambers, Daniel I Chasman, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, Francis S Collins, James P Cook, Amanda J Cox, David S Crosslin, John Danesh, Paul I W de Bakker, Simon de Denus, Renée de Mutsert, George Dedoussis, Ellen W Demerath, Joe G Dennis, Josh C Denny, Emanuele Di Angelantonio, Marcus Dörr, Fotios Drenos, Marie-Pierre Dubé, Alison M Dunning, Douglas F Easton, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C Florez, Myriam Fornage, Caroline S Fox, Paul W Franks, Nele Friedrich, Wei Gan, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Giorgia Girotto, Mathias Gorski, Harald Grallert, Niels Grarup, Megan L Grove, Stefan Gustafsson, Jeff Haessler, Torben Hansen, Andrew T Hattersley, Caroline Hayward, Iris M Heid, Oddgeir L Holmen, G Kees Hovingh, Joanna M M Howson, Yao Hu, Yi-Jen Hung, Kristian Hveem, M Arfan Ikram, Erik Ingelsson, Anne U Jackson, Gail P Jarvik, Yucheng Jia, Torben Jørgensen, Pekka Jousilahti, Johanne M Justesen, Bratati Kahali, Maria Karaleftheri, Sharon L R Kardia, Fredrik Karpe, Frank Kee, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S Kooner, Peter Kovacs, Bernhard K Krämer, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A Lakka, David Lamparter, Leslie A Lange, Claudia Langenberg, Eric B Larson, Nanette R Lee, Wen-Jane Lee, Terho Lehtimäki, Cora E Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Dajiang J Liu, Jian'an Luan, Leo-Pekka Lyytikäinen, Stuart MacGregor, Reedik Mägi, Satu Männistö, Gaëlle Marenne, Jonathan Marten, Nicholas G D Masca, Mark I McCarthy, Karina Meidtner, Evelin Mihailov, Leena Moilanen, Marie Moitry, Dennis O Mook-Kanamori, Anna Morgan, Andrew P Morris, Martina Müller-Nurasyid, Patricia B Munroe, Narisu Narisu, Christopher P Nelson, Matt Neville, Ioanna Ntalla, Jeffrey R O'Connell, Katharine R Owen, Oluf Pedersen, Gina M Peloso, Craig E Pennell, Markus Perola, James A Perry, John R B Perry, Tune H Pers, Ailith Ewing, Ozren Polasek, Olli T Raitakari, Asif Rasheed, Chelsea K Raulerson, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Paul M Ridker, Manuel A Rivas, Neil R Robertson, Antonietta Robino, Igor Rudan, Katherine S Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Pamela J Schreiner, Matthias B Schulze, Robert A Scott, Marcelo Segura-Lepe, Xueling Sim, Andrew J Slater, Kerrin S Small, Blair H Smith, Jennifer A Smith, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E Stirrups, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Karin M A Swart, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Deborah J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H Thuesen, Anke Tönjes, Mina Torres, Emmanouil Tsafantakis, Jaakko Tuomilehto, André G Uitterlinden, Matti Uusitupa, Cornelia M van Duijn, Mauno Vanhala, Rohit Varma, Sita H Vermeulen, Henrik Vestergaard, Veronique Vitart, Thomas F Vogt, Dragana Vuckovic, Lynne E Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A Wang, Shuai Wang, Nicholas J Wareham, Helen R Warren, Dawn M Waterworth, Jennifer Wessel, Harvey D White, Cristen J Willer, James G Wilson, Andrew R Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Laura M Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, He Zheng, Wei Zhou, M Carola Zillikens, Fernando Rivadeneira, Ingrid B Borecki, J Andrew Pospisilik, Panos Deloukas, Timothy M Frayling, Guillaume Lettre, Karen L Mohlke, Jerome I Rotter, Zoltán Kutalik, Joel N Hirschhorn, L Adrienne Cupples, Ruth J F Loos, Kari E North, Cecilia M Lindgren
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF <5%) coding novel variants...
February 18, 2019: Nature Genetics
https://read.qxmd.com/read/30777116/combined-ascorbic-acid-and-t-3-produce-better-healing-compared-to-bone-marrow-mesenchymal-stem-cells-in-an-achilles-tendon-injury-rat-model-a-proof-of-concept-study
#3
Francesco Oliva, Nicola Maffulli, Clarissa Gissi, Francesca Veronesi, Lucia Calciano, Milena Fini, Silvia Brogini, Marialucia Gallorini, Cristina Antonetti Lamorgese Passeri, Roberta Bernardini, Rosella Cicconi, Maurizio Mattei, Anna Concetta Berardi
BACKGROUND: This pilot study aimed to ascertain whether the local application of ascorbic acid (AA), of T3 , and of rat (r) bone marrow mesenchymal stem cells (BMSCs), alone or in all possible combinations, promoted healing after an Achilles tendon injury in a rat model. METHODS: An Achilles tendon defect was produced in 24 6-8-week-old male inbred Lewis rats. The animals were then randomly divided into eight groups of three rats each. The tendon defect was filled with 50 μL of phosphate-buffered saline (PBS) containing (1) 50 μg/mL AA (AA group), (2) 10-7  M T3 (T3 group), (3) 4 × 106 rBMSCs (rBMSC group), (4) 50 μg/mL AA + 10-7  M T3 (AA + T3 group), (5) 4 × 106 rBMSCs + 50 μg/mL AA (rBMSC + AA group), (6) 4 × 106 rBMSCs + 10-7  M T3 (rBMSC + T3 group), (7) 4 × 106 rBMSCS + 50 μg/mL AA + 10-7  M T3 (rBMSC + AA + T3 group), and (8) PBS only (control group: CTRL)...
February 18, 2019: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/30776773/developmental-validation-of-a-novel-six-dye-typing-system-with-47-a-indels-and-2-y-indels
#4
Ling Chen, Weian Du, Weibin Wu, Anlu Yu, Xiyong Pan, Peipei Feng, Chunlei Feng, Chen Li, Lingdan Xu, Changhui Liu, Chao Liu
In this study, a multiplex amplification system including 47 autosomal InDels, 2 Y-chromosome InDels, and the sex-determining marker (Amelogenin) was developed with six fluorescent dyes labeling. These InDels were selected from the previous study based on a series of criteria (0.3 < MAF < 0.5, HET > 0.4, etc). The system was designated the AGCU InDel 50 kit and was validated in a series of studies, including a degradation study; tests for sensitivity, species specificity, reproducibility, stability, applicability to case samples, balance of peak height, and PCR conditions; and a population study...
February 12, 2019: Forensic Science International. Genetics
https://read.qxmd.com/read/30773329/management-of-mandibular-angle-fractures-using-3-dimensional-or-standard-miniplates-a-systematic-review-and-meta-analysis
#5
Patiguli Wusiman, Bin Nie, Wei Dong Li, Adili Moming
PURPOSE: This study proposed to compare clinical outcomes between three-dimensional (3D) plate and standard miniplate fixation systems for the management of mandibular angle fractures (MAFs). METHODS: A systematic review search of several databases, including MEDLINE-Ovid, Embase, Springer Link, and PubMed, for relevant articles in English and without date restrictions was performed in February 2018. The quality of studies was assessed, and the relative risk (RR) with its corresponding 95% confidence interval (CI) was assessed to measure postoperative complications...
February 1, 2019: Journal of Cranio-maxillo-facial Surgery
https://read.qxmd.com/read/30770844/quantification-of-frequency-dependent-genetic-architectures-in-25-uk-biobank-traits-reveals-action-of-negative-selection
#6
Armin P Schoech, Daniel M Jordan, Po-Ru Loh, Steven Gazal, Luke J O'Connor, Daniel J Balick, Pier F Palamara, Hilary K Finucane, Shamil R Sunyaev, Alkes L Price
Understanding the role of rare variants is important in elucidating the genetic basis of human disease. Negative selection can cause rare variants to have larger per-allele effect sizes than common variants. Here, we develop a method to estimate the minor allele frequency (MAF) dependence of SNP effect sizes. We use a model in which per-allele effect sizes have variance proportional to [p(1 - p)]α , where p is the MAF and negative values of α imply larger effect sizes for rare variants. We estimate α for 25 UK Biobank diseases and complex traits...
February 15, 2019: Nature Communications
https://read.qxmd.com/read/30770703/gut-microbiota-dependent-ccr9-cd4-t-cells-are-altered-in-secondary-progressive-multiple-sclerosis
#7
Atsushi Kadowaki, Ryoko Saga, Youwei Lin, Wakiro Sato, Takashi Yamamura
The mechanism underlying the progression of relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis (SPMS), characterized by accumulating fixed disability, is yet to be fully understood. Although alterations in the gut microbiota have recently been highlighted in multiple sclerosis pathogenesis, the mechanism linking the altered gut environment with the remote CNS pathology remains unclear. Here, we analyse human CD4+ memory T cells expressing the gut-homing chemokine receptor CCR9 and found a reduced frequency of CCR9+ memory T cells in the peripheral blood of patients with SPMS relative to healthy controls...
February 15, 2019: Brain: a Journal of Neurology
https://read.qxmd.com/read/30766545/a-new-panel-based-next-generation-sequencing-method-for-adme-genes-reveals-novel-associations-of-common-and-rare-variants-with-expression-in-a-human-liver-cohort
#8
Kathrin Klein, Roman Tremmel, Stefan Winter, Sarah Fehr, Florian Battke, Tim Scheurenbrand, Elke Schaeffeler, Saskia Biskup, Matthias Schwab, Ulrich M Zanger
We developed a panel-based NGS pipeline for comprehensive analysis of 340 genes involved in absorption, distribution, metabolism and excretion (ADME) of drugs, other xenobiotics, and endogenous substances. The 340 genes comprised phase I and II enzymes, drug transporters and regulator/modifier genes within their entire coding regions, adjacent intron regions and 5' and 3'UTR regions, resulting in a total panel size of 1,382 kbp. We applied the ADME NGS panel to sequence genomic DNA from 150 Caucasian liver donors with available comprehensive gene expression data...
2019: Frontiers in Genetics
https://read.qxmd.com/read/30755118/abo-system-is-not-associated-with-proximal-femoral-fracture-pattern-in-southern-italy
#9
Giuseppe Toro, Federica Lepore, Stefano D Cicala, Pietro Concilio, Giampiero Calabrò, Antonio Toro, Nicola Maffulli
INTRODUCTION: The mechanism that leads to a given fracture pattern is not understood. Heredity could act in this field through the ABO system. We investigated the relationship between ABO blood system and hip fracture pattern in a population from Southern Italy. METHODS: Hip fractures were identified through a registry evaluation of the activity of a level I Hospital, and subsequently classified in 'intracapsular' or 'extracapsular' according to their anatomical location...
November 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://read.qxmd.com/read/30753305/hip-fractures-in-children-and-adolescents
#10
Rocco Papalia, Guglielmo Torre, Nicola Maffulli, Vincenzo Denaro
Background: Femoral neck fractures account for <1% of the fractures in children, and are produced by high energy trauma. The most commonly accepted treatment for such fractures is gentle manual anatomical reduction and internal fixation, yielding a healing rate between 80% and 90%. Sources of data: Electronic search through major web databases (Medline, Cochrane and Google Scholar). All types of article were eligible for inclusion, except for reviews, systematic reviews, meta-analyses and case reports...
February 7, 2019: British Medical Bulletin
https://read.qxmd.com/read/30739591/lesbian-gay-and-heterosexual-adoptive-parents-attitudes-towards-racial-socialization-practices
#11
Adeline Wyman Battalen, Sarah J Dow-Fleisner, David M Brodzinsky, Ruth G McRoy
We tested the validity and measurement invariance of the Transracial Adoptive Parenting scale (TAPS) across sexual orientation with a nationwide sample of adoptive parents. Our study sample consisted of 737 heterosexual, 102 lesbian, and 64 gay adoptive parents from the Modern Adoptive Families (MAF) study, a cross-sectional survey. We conducted reliability analyses, as well as exploratory and confirmatory factor analyses for the 29-item TAPs. We then tested for measurement invariance based on sexual orientation...
February 10, 2019: Journal of Evidence-informed Social Work
https://read.qxmd.com/read/30739504/mir-155-influences-cell-mediated-immunity-in-balb-c-mice-treated-with-aflatoxin-m-1
#12
Kobra Shirani, Bamdad Riahi Zanjani, Soghra Mehri, Kamal Razavi-Azarkhiavi, Ali Badiee, A Wallace Hayes, John P Giesy, Gholamreza Karimi
Aflatoxin M1 (AFM1 ) is a 4-hydroxylated metabolite of aflatoxin B1 (AFB1 ). It induces various toxicological effects including immunotoxicity. In the present study, we investigated the effects of AFM1 on immune system and its modulation by MicroRNA (miR)-155. AFM1 was administered intraperitoneally at doses of 25 and 50 µg/kg for 28 days to Balb/c mice and different immune system parameters were analyzed. The levels of miR-155 and targeted proteins were evaluated in isolated T cells from spleens of mice...
February 11, 2019: Drug and Chemical Toxicology
https://read.qxmd.com/read/30733606/publisher-correction-c-maf-controls-immune-responses-by-regulating-disease-specific-gene-networks-and-repressing-il-2-in-cd4-t-cells
#13
Leona Gabryšová, Marisol Alvarez-Martinez, Raphaëlle Luisier, Luke S Cox, Jan Sodenkamp, Caroline Hosking, Damián Pérez-Mazliah, Charlotte Whicher, Yashaswini Kannan, Krzysztof Potempa, Xuemei Wu, Leena Bhaw, Hagen Wende, Michael H Sieweke, Greg Elgar, Mark Wilson, James Briscoe, Vicki Metzis, Jean Langhorne, Nicholas M Luscombe, Anne O'Garra
In the version of this article initially published, the Supplementary Data file was an incorrect version. The correct version is now provided. The error has been corrected in the HTML and PDF version of the article.
February 8, 2019: Nature Immunology
https://read.qxmd.com/read/30723268/author-correction-c-maf-dependent-regulatory-t-cells-mediate-immunological-tolerance-to-a-gut-pathobiont
#14
Mo Xu, Maria Pokrovskii, Yi Ding, Ren Yi, Christy Au, Oliver J Harrison, Carolina Galan, Yasmine Belkaid, Richard Bonneau, Dan R Littman
In this Letter, the 'Competing interests' statement should have stated: 'D.R.L. consults for and has equity in Vedanta Biosciences.' The original Letter has not been corrected.
February 5, 2019: Nature
https://read.qxmd.com/read/30722011/high-imputation-accuracy-from-informative-low-density-to-medium-density-single-nucleotide-polymorphism-genotypes-is-achievable-in-sheep
#15
Aine C O'Brien, Michelle M Judge, Sean Fair, Donagh P Berry
The objective of the present study was to quantify the accuracy of imputing medium-density single nucleotide polymorphism (SNP) genotypes from lower-density panels (384 to 12,000 SNPs) derived using alternative selection methods to select the most informative SNPs. Four different selection methods were used to select SNPs based on genomic characteristics (i.e. minor allele frequency (MAF) and linkage disequilibrium (LD)) within five sheep breeds (642 Belclare; 645 Charollais; 715 Suffolk; 440 Texel; and 620 Vendeen) separately...
February 5, 2019: Journal of Animal Science
https://read.qxmd.com/read/30719775/in-situ-enzyme-immobilization-with-oxygen-sensitive-luminescent-metal-organic-frameworks-to-realize-all-in-one-multifunctions
#16
Yuzhi Xu, Si-Yang Liu, Junling Liu, Li Zhang, Danping Chen, Jun Chen, Yingjun Ma, Jie-Peng Zhang, Zong Dai, Xiaoyong Zou
Metal-organic frameworks (MOFs) for enzyme immobilization have already shown superior tunable and designable characteristics, however, their devisable responsive properties have rarely been exploited. Herein, we integrated a responsive MOF into MOF-enzyme composite to propose an "all-in-one" multifunctional composite with catalytic and luminescence functions implemented within a single particle. As a proof-of-concept, glucose oxidase (GOx) was in situ encapsulated within an oxygen (O₂)-sensitive, noble-metal-free luminescent Cu(I) triazolate framework (MAF-2), namely GOx@MAF-2...
February 4, 2019: Chemistry: a European Journal
https://read.qxmd.com/read/30719286/improving-genomic-predictions-by-correction-of-genotypes-from-genotyping-by-sequencing-in-livestock-populations
#17
Xiao Wang, Mogens Sandø Lund, Peipei Ma, Luc Janss, Haja N Kadarmideen, Guosheng Su
Background: Genotyping by sequencing (GBS) is a robust method to genotype markers. Many factors can influence the genotyping quality. One is that heterozygous genotypes could be wrongly genotyped as homozygotes, dependent on the genotyping depths. In this study, a method correcting this type of genotyping error was demonstrated. The efficiency of this correction method and its effect on genomic prediction were assessed using simulated data of livestock populations. Results: Chip array (Chip) and four depths of GBS data was simulated...
2019: Journal of Animal Science and Biotechnology
https://read.qxmd.com/read/30718926/identification-of-28-new-susceptibility-loci-for-type-2-diabetes-in-the-japanese-population
#18
Ken Suzuki, Masato Akiyama, Kazuyoshi Ishigaki, Masahiro Kanai, Jun Hosoe, Nobuhiro Shojima, Atsushi Hozawa, Aya Kadota, Kiyonori Kuriki, Mariko Naito, Kozo Tanno, Yasushi Ishigaki, Makoto Hirata, Koichi Matsuda, Nakao Iwata, Masashi Ikeda, Norie Sawada, Taiki Yamaji, Motoki Iwasaki, Shiro Ikegawa, Shiro Maeda, Yoshinori Murakami, Kenji Wakai, Shoichiro Tsugane, Makoto Sasaki, Masayuki Yamamoto, Yukinori Okada, Michiaki Kubo, Yoichiro Kamatani, Momoko Horikoshi, Toshimasa Yamauchi, Takashi Kadowaki
To understand the genetics of type 2 diabetes in people of Japanese ancestry, we conducted A meta-analysis of four genome-wide association studies (GWAS; 36,614 cases and 155,150 controls of Japanese ancestry). We identified 88 type 2 diabetes-associated loci (P < 5.0 × 10-8 ) with 115 independent signals (P < 5.0 × 10-6 ), of which 28 loci with 30 signals were novel. Twenty-eight missense variants were in linkage disequilibrium (r2  > 0.6) with the lead variants. Among the 28 missense variants, three previously unreported variants had distinct minor allele frequency (MAF) spectra between people of Japanese and European ancestry (MAFJPN  > 0...
February 4, 2019: Nature Genetics
https://read.qxmd.com/read/30714306/the-effect-of-the-mandibular-plane-angle-on-fracture-line-stability-an-ex-vivo-experimental-study
#19
Muhammed Ben Said, Senem Yildirimturk, Yigit Sirin
BACKGROUND/AIMS: The mandibular angle fractures fixated with plate osteosynthesis techniques have to withstand the effects of muscle attachments. The individual variations in the cranio-facial morphology may alter the biomechanical resistance of the bone-plate construct. The aim of the present study was to determine the influence of variations in the mandibular plane angle (MPa) on the biomechanical stability of sheep mandibular angle fractures (MAFs). MATERIALS AND METHODS: Sixty sheep hemi-mandibles were used in this study...
February 3, 2019: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://read.qxmd.com/read/30709954/peripheral-lymphocyte-multidrug-resistance-activity-as-a-predictive-tool-of-biological-therapeutic-response-in-rheumatoid-arthritis
#20
Gergely Toldi, Patrizia Batel, Sándor Baráth, Péter Szerémy, András Apjok, Kata Filkor, Sándor Szántó, Gabriella Szűcs, Szilvia Szamosi, Thomas Häupl, Andreas Grützkau, Zoltán Szekanecz
OBJECTIVE: Multidrug resistance (MDR) transporters may be used as biomarkers to monitor disease progression in RA and as a predictive tool to establish responsiveness to biological therapy. In this multicenter clinical trial, we aimed to assess the predictive value of MDR1, MRP1 and BCRP activity measurement for biological therapeutic response in RA before as well as 4 to 6 and 12 weeks after the initiation of biological therapy. METHODS: Peripheral blood samples were collected from 27 bDMARD Responders and 12 Non-responders at the indicated time points as well as from 35 healthy controls...
February 1, 2019: Journal of Rheumatology
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