Ji-Xuan Han, Zhi-Hang Tao, Ji-Lin Wang, Lu Zhang, Chen-Yang Yu, Zi-Ran Kang, Yuanhong Xie, Jialu Li, Shiyuan Lu, Yun Cui, Jia Xu, Enhao Zhao, Ming Wang, Jinxian Chen, Zheng Wang, Qiang Liu, Hui-Min Chen, Wenyu Su, Tian-Hui Zou, Cheng-Bei Zhou, Jie Hong, Haoyan Chen, Hua Xiong, Ying-Xuan Chen, Jing-Yuan Fang
Epidemiological studies have indicated an association between statin use and reduced incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a potential chemopreventive effect. Statins are also associated with reduced dysbiosis in the gut microbiome, yet the role of the gut microbiome in the protective effect of statins in CRC is unclear. Here we validated the chemopreventive role of statins by retrospectively analysing a cohort of patients who underwent colonoscopies. This was confirmed in preclinical models and patient cohorts, and we found that reduced tumour burden was partly due to statin modulation of the gut microbiota...
May 2023: Nature Microbiology