Min Li, Yaxin Guo, Yao Deng, Wenhui Gao, Baoying Huang, Weiyong Yao, Yingze Zhao, Qing Zhang, Mengkun Huang, Maoshun Liu, Lei Li, Peipei Guo, Jinmin Tian, Xin Wang, Ying Lin, Jinxian Gan, Yuanyuan Guo, Yuechao Hu, Jianing Zhang, Xiaonan Yang, Bingli Shang, Mengjie Yang, Yang Han, Yalan Wang, Peilei Cong, Mengzhe Li, Qiaohong Chu, Danni Zhang, Qihui Wang, Tong Zhang, Guizhen Wu, Wenjie Tan, George F Gao, Jun Liu
Investigating immune memory to vaccinia virus and pre-existing immunity to mpox virus (MPXV) among the population is crucial for the global response to this ongoing mpox epidemic. Blood was sampled from vaccinees inoculated with vaccinia virus Tiantan (VTT) strain born before 1981 and unvaccinated control subjects born since 1982. After at least 40 years of the inoculation, 60% or 5% VTT vaccinees possess neutralizing antibodies (NAbs) to VTT or MPXV, with at least 50% having T cell memory to VTT protein antigens...
December 29, 2023: Cell Reports