Yuan Cheng, Chen-Yang He, Ding-Yuan Tian, Si-Han Chen, Jun-Rong Ren, Hao-Lun Sun, Man-Yu Xu, Cheng-Rong Tan, Dong-Yu Fan, Jie-Ming Jian, Pu-Yang Sun, Gui-Hua Zeng, Ying-Ying Shen, An-Yu Shi, Wang-Sheng Jin, Xian-Le Bu, Hong-Ming Liu, Yu-Ming Xu, Jun Wang, Yan-Jiang Wang
Cerebral amyloid-β (Aβ) accumulation due to impaired Aβ clearance is a pivotal event in the pathogenesis of Alzheimer's disease (AD). Considerable brain-derived Aβ is cleared via transporting to the periphery. The liver is the largest organ responsible for the clearance of metabolites in the periphery. Whether the liver physiologically clears circulating Aβ and its therapeutic potential for AD remains unclear. Here, we found that about 13.9% of Aβ42 and 8.9% of Aβ40 were removed from the blood when flowing through the liver, and this capacity was decreased with Aβ receptor LRP-1 expression down-regulated in hepatocytes in the aged animals...
March 25, 2023: Acta Neuropathologica