Read by QxMD icon Read


Feng Qiu, Ming-Ran Zhang, Zhen Zhou, Jin-Xian Pu, Xiao-Jun Zhao
Bladder cancer is the most common malignancy with high recurrence. Currently, the long noncoding RNAs (lncRNAs) have been suggested to play vital roles in the pathogenesis of bladder cancer. The present study investigated the role of lncRNA MIR503 host gene (MIR503HG) in the pathogenesis of bladder cancer by using both in vitro and in vivo functional assays. The expression of MIR503HG was downregulated in bladder cancer tissues and cell lines. Low expression of MIR503HG was associated with advanced tumor stage, advanced histological grade, and lymph node metastasis...
January 22, 2019: Journal of Cellular Biochemistry
Li Li, Wei Liang, Jin-Xian Zhu, Chun-Jie Dong, Yuan-Mei Zou, Bi-Cui Ye, Lin Gao
Purpose: The role of chemotherapy has evolved greatly in advanced nasopharyngeal carcinoma (NPC). We undertook this network meta-analysis to establish the optimal chemotherapy strategy in advanced NPC. Materials and methods: This network meta-analysis recruited randomized clinical trials involving patients with advanced NPC randomly allocated to induction chemotherapy plus concurrent chemoradiotherapy (CRT; induction + CRT), CRT plus adjuvant chemotherapy (CRT + adjuvant), CRT or radiotherapy (RT) alone...
2019: Cancer Management and Research
Ci-Yu Wang, Jun Gao, Xian-Min Jin
We present a rotated polarization directional coupler (RPDC) on a photonic chip. We demonstrate a double-track approach to modify the distribution of the refractive index between adjacent tracks and form a single waveguide with an arbitrary birefringent optical axis. We construct a RPDC with the two axis-rotated waveguides coupled in a strong regime. The obtained extinction ratios on average are about 16 dB and 20 dB for the corresponding orthogonal polarizations. We perform reconstruction of the Stokes vector to test the projection performance of our RPDC, and observe the average fidelities up to 98...
January 1, 2019: Optics Letters
Yuan Chen, Jun Gao, Zhi-Qiang Jiao, Ke Sun, Wei-Guan Shen, Lu-Feng Qiao, Hao Tang, Xiao-Feng Lin, Xian-Min Jin
Twisted light carrying orbital angular momentum (OAM) provides an additional degree of freedom for modern optics and an emerging resource for both classical and quantum information technologies. Its inherently infinite dimensions can potentially be exploited by using mode multiplexing to enhance data capacity for sustaining the unprecedented growth in big data and internet traffic and can be encoded to build large-scale quantum computing machines in high-dimensional Hilbert space. While the emission of twisted light from the surface of integrated devices to free space has been widely investigated, the transmission and processing inside a photonic chip remain to be addressed...
December 7, 2018: Physical Review Letters
Hyun-Ju Kim, Hye-Jin Yoon, Ji-Wan Park, Xiangguo Che, Xian Jin, Je-Yong Choi
G protein-coupled receptor 119 (GPR119) is known to be a promising therapeutic target for type 2 diabetes. Recently, it has been reported that the GPR119 agonist increases bone mineral density in an animal model of diabetes, suggesting that GPR119 may play a key role in bone metabolism. In this study, we investigated the functional role of GPR119 in receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation. We found that the GPR119 expression was markedly increased in preosteoclasts and then downregulated in mature osteoclasts...
November 27, 2018: Journal of Cellular Physiology
Xiaomei Zhang, Yi Zhou, Yu-Long Li, Jin-Xian Liu
The seagrass Zostera japonica Asch. & Graebn. is among the few seagrass species that thrive both in temperate and tropical intertidal zones. The degradation of Z. japonica in its native range and continued expansion in some localities have raised concerns with regard to its conservation and management. Population genetic studies of Z. japonica across its biogeographic range and within meadows are scarce. Previously developed microsatellites via traditional methods are not sufficient in quantity and perform inconsistently between the temperate and tropical populations...
November 17, 2018: Molecular Biology Reports
Ji-Long Wang, Xiao-Jiao Du, Jin-Xian Yang, Song Shen, Hong-Jun Li, Ying-Li Luo, Shoaib Iqbal, Cong-Fei Xu, Xiao-Dong Ye, Jie Cao, Jun Wang
Engineering nanoparticles of reasonable surface poly(ethylene glycol) (PEG) length is important for designing efficient drug delivery systems. Eliminating the disturbance by other nanoproperties, such as size, PEG density, etc., is crucial for systemically investigating the impact of surface PEG length on the biological behavior of nanoparticles. In the present study, nanoparticles with different surface PEG length but similar other nanoproperties were prepared by using poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL) copolymers of different molecular weights and incorporating different contents of PCL3500 homopolymer...
November 2018: Biomaterials
Zongjie Wang, Hitendra Kumar, Zhenlin Tian, Xian Jin, Jonathan F Holzman, Frederic Menard, Keekyoung Kim
We present the first cell-attachable and visible-light-crosslinkable bioinks based on gelatin methacryloyl (GelMA) with eosin Y (EY) photoinitiation for stereolithography three-dimensional (3D) bioprinting. To develop a visible-light-crosslinkable hydrogel, we systematically studied five combinations of GelMA and EY photoinitiator with various concentrations. Their mechanical properties, microstructures, and cell viability and confluency after encapsulation were investigated rigorously to elucidate the effects of the EY and GelMA macromer concentrations on the characteristics of the hydrogel...
August 15, 2018: ACS Applied Materials & Interfaces
Yin-Hui Huang, Xian-Yi Jin, Yong-Yi Zhao, Hang Cong, Zhu Tao
A selective and sensitive fluorescent chemosensor based on an anthracene-functionalized triazole-linked multifarene[2,2] was successfully synthesized and investigated with regard to the recognition of metal ions using fluorescence spectroscopy, 1H NMR titration, and IR spectroscopy. The proposed sensor exhibited desirable properties for potential fluorescence enhanced chemosensor applications, including selective affinity and low Zn2+ and Cd2+ detection limits compared with other metal ions. Quantum chemical calculations described the synthesized chemosensor's static structure and its coordination to Zn2+ and Cd2+...
July 25, 2018: Organic & Biomolecular Chemistry
Cui Li, Ju Hui Jing, Jin Xian Liu, Bao Feng Chai
The maintaining mechanism of community diversity is the core of community ecology. The mine tailing is a good field for studying on the underlying mechanism of community diversity, as a kind of original bare land with heavy metal pollution, where the physicochemical characteristics of soil change with the restoration periods. We examined the driving forces for bacterial community diversity based on the investigation of edaphic factors, plant community, and bacterial communities in Shibahe copper mine tailing, Shanxi...
June 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Cui Li, Ju-Hui Jing, Jin-Xian Liu, Bao-Feng Chai
The relative importance of the deterministic versus stochastic processes underlying community dynamics has long been a central theme in community ecology, and is intensively debated in the field. Microbial communities play key roles in nutrient cycling and the flow of energy in ecosystems. The research on the structural dynamics of microbial community will provide data and theoretical support for understanding the assembly mechanisms of community, and for predicting the dynamics of microbial community under environmental stress...
April 8, 2018: Huan Jing Ke Xue= Huanjing Kexue
Jun Gao, Lu-Feng Qiao, Zhi-Qiang Jiao, Yue-Chi Ma, Cheng-Qiu Hu, Ruo-Jing Ren, Ai-Lin Yang, Hao Tang, Man-Hong Yung, Xian-Min Jin
Quantum information technologies provide promising applications in communication and computation, while machine learning has become a powerful technique for extracting meaningful structures in "big data." A crossover between quantum information and machine learning represents a new interdisciplinary area stimulating progress in both fields. Traditionally, a quantum state is characterized by quantum-state tomography, which is a resource-consuming process when scaled up. Here we experimentally demonstrate a machine-learning approach to construct a quantum-state classifier for identifying the separability of quantum states...
June 15, 2018: Physical Review Letters
Rui Sun, Hong-Yan Xie, Jin-Xian Qian, Yan-Ni Huang, Fan Yang, Fang-Lin Zhang, Zhi-Ming Shao, Da-Qiang Li
The molecular underpinnings behind malignant progression of breast cancer from a localized lesion to an invasive and ultimately metastatic disease are incompletely understood. Here we report that F-box only protein 22 (FBXO22) plays a dual role in mammary tumorigenesis and metastasis. FBXO22 was upregulated in primary breast tumors and promoted cell proliferation and colony formation in vitro and xenograft tumorigenicity in vivo. Surprisingly, FBXO22 suppressed epithelial-mesenchymal transition (EMT), cell motility, and invasiveness in vitro and metastatic lung colonization in vivo...
June 26, 2018: Cancer Research
Thissa N Siriwardena, Alice Capecchi, Bee-Ha Gan, Xian Jin, Runze He, Dengwen Wei, Lan Ma, Thilo Köhler, Christian van Delden, Sacha Javor, Jean-Louis Reymond
We used nearest-neighbor searches in chemical space to improve the activity of the antimicrobial peptide dendrimer (AMPD) G3KL and identified dendrimer T7, which has an expanded activity range against Gram-negative pathogenic bacteria including Klebsiellae pneumoniae, increased serum stability, and promising activity in an in vivo infection model against a multidrug-resistant strain of Acinetobacter baumannii. Imaging, spectroscopic studies, and a structural model from molecular dynamics simulations suggest that T7 acts through membrane disruption...
July 9, 2018: Angewandte Chemie
Xian Jin, Liang Liu, Yaping Zhang, Yin Xiang, Guizhi Yin, Yi Lu, Ludong Shi, Jian Dong, Chengxing Shen
Objective: Increased monocytes, particularly the inflammatory subset, are associated with accelerated atherosclerosis in diabetes through thus far incompletely defined mechanisms. The present study tested the hypothesis that advanced glycation end products (AGEs) promote bone marrow monocytes to proliferate and drive them into an inflammatory phenotype. Methods and Results: In vivo, AGEs (25 mg/kg i.p. for 7 days) increased proportions of CD115+ monocytes and the inflammatory subset, the CD115+ Ly6Chigh cells, in murine bone marrow (flow cytometry analysis (FCM)), and enhanced gene expression of proinflammatory cytokines (IL-1 β and TNF- α ) but only slightly upregulated mRNA expression of anti-inflammatory cytokine (IL-10) (real-time PCR) in monocytes...
2018: Journal of Diabetes Research
Hao Tang, Xiao-Feng Lin, Zhen Feng, Jing-Yuan Chen, Jun Gao, Ke Sun, Chao-Yue Wang, Peng-Cheng Lai, Xiao-Yun Xu, Yao Wang, Lu-Feng Qiao, Ai-Lin Yang, Xian-Min Jin
Quantum walks, in virtue of the coherent superposition and quantum interference, have exponential superiority over their classical counterpart in applications of quantum searching and quantum simulation. The quantum-enhanced power is highly related to the state space of quantum walks, which can be expanded by enlarging the photon number and/or the dimensions of the evolution network, but the former is considerably challenging due to probabilistic generation of single photons and multiplicative loss. We demonstrate a two-dimensional continuous-time quantum walk by using the external geometry of photonic waveguide arrays, rather than the inner degree of freedoms of photons...
May 2018: Science Advances
Zhuan Zhuan Ma, Sha Sha Qiao, Miao Wen Cao, Yong Na Zhou, Jin Xian Liu, Tong Jia, Cui Li, Bao Feng Chai
Environmental selection and dispersal limitation are two basic processes underlying community assembly. The relative importance of those two processes differs across scales, community identities, and community types. The processes responsible for structuring microbial communities in soil of temperate subalpine forest are poorly understood. Here, we investigated the relationship between soil bacterial community structure and environmental factors, and quantified the relative role of edaphic factors, vegetation, and spatial variables in shaping the structure of six soil bacterial communities (LpMC1, LpMC2, PwMC, PmMC, PtMC, and BMC) in five forest types including Larix principis-rupprechtii, Picea wilsonii, Picea meyeri, Pinus tabulaeformis, and Betula platyphylla in Pangquangou Nature Reserve by using PCR-DGGE technology...
April 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Ivan Di Bonaventura, Stéphane Baeriswyl, Alice Capecchi, Bee-Ha Gan, Xian Jin, Thissa N Siriwardena, Runze He, Thilo Köhler, Arianna Pompilio, Giovanni Di Bonaventura, Christian van Delden, Sacha Javor, Jean-Louis Reymond
We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa.
May 15, 2018: Chemical Communications: Chem Comm
Xin-Jing Yang, Jin-Xian Qian, Yao Wei, Qiang Guo, Jun Jin, Xue Sun, Sheng-Lan Liu, Chun-Fang Xu, Guo-Xing Zhang
Background: Tanshinone IIA sodium sulfonate (TSS) is known to possess anti-inflammatory effects and has exhibited protective effects in various inflammatory conditions; however, its role in lipopolysaccharide- (LPS-) induced intestinal injury is still unknown. Objective: The present study is designed to explore the role and possible mechanism of TSS in LPS-induced intestinal injury. Methods: Male C57BL/6J mice, challenged with intraperitoneal LPS injection, were treated with or without TSS 0...
2018: Gastroenterology Research and Practice
Jin-Xian Feng, Si-Yao Tong, Ye-Xiang Tong, Gao-Ren Li
The search for high active, stable, and cost-efficient hydrogen evolution reaction (HER) electrocatalysts for water electrolysis has attracted great interest. The coordinated water molecules in the hydronium ions will obviously reduce the positive charge density of H+ and hamper the ability of H+ to receive electrons from the cathode, leading to large overpotential of HER on nonprecious metal catalysts. Here we realize Pt-like hydrogen evolution electrocatalysis on polyaniline (PANI) nanodots (NDs)-decorated CoP hybrid nanowires (HNWs) supported on carbon fibers (CFs) (PANI/CoP HNWs-CFs) as PANI can effectively capture H+ from hydronium ions to form protonated amine groups that have higher positive charge density than those of hydronium ions and can be electro-reduced easily...
April 18, 2018: Journal of the American Chemical Society
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"