keyword
https://read.qxmd.com/read/38514258/-guidelines-for-image-guided-ablation-of-primary-liver-cancer-2023-version
#21
JOURNAL ARTICLE
(no author information available yet)
Image-guided ablation for primary liver cancer has many advantages, including high efficacy, minimal invasion, easy operation, high tolerance, short hospitalization, fast recovery, and few complications. Percutaneous radiofrequency and microwave ablation are the most mature technologies, which have been recognized by many domestic and foreign guidelines as the first-line treatment for small liver cancers. As a large country with large numbers of liver cancers, Chinese doctors have accumulated rich experience in ablation therapy for liver cancer and achieved systematic research results...
February 20, 2024: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://read.qxmd.com/read/38514081/-18-f-bms-986229-pet-to-assess-programmed-death-ligand-1-status-in-gastroesophageal-cancer
#22
JOURNAL ARTICLE
Samuel L Cytryn, Neeta Pandit-Taskar, Melissa A Lumish, Steven B Maron, Ping Gu, Geoffrey Y Ku, Joanne F Chou, Marinela Capanu, Ariel Antoine, Diane Loegel, Lara Feder, Steven Philemond, Serge K Lyashchenko, Jason S Lewis, Viktoriya Paroder, Amitabh Srivastava, Laura H Tang, Heiko Schoder, Yelena Y Janjigian
Anti-programmed death 1 (PD-1) inhibitors are the standard of care for advanced gastroesophageal cancer. Although recommendations and approval by regulatory agencies are often based on programmed death ligand 1 (PD-L1) expression, pathologic assessments of PD-L1 status have several limitations. Single-site biopsies do not adequately capture disease heterogeneity within individual tumor lesions or among several lesions within the same patient, the PD-L1 combined positive score is a dynamic biomarker subject to evolution throughout a patient's disease course, and repeated biopsies are invasive and not always feasible...
March 21, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38513187/assessing-the-global-impact-of-ambient-air-pollution-on-cancer-incidence-and-mortality-a-comprehensive-meta-analysis
#23
REVIEW
Thilagavathi Ramamoorthy, Anita Nath, Shubhra Singh, Stany Mathew, Apourv Pant, Samvedana Sheela, Gurpreet Kaur, Krishnan Sathishkumar, Prashant Mathur
PURPOSE: This study aims to examine the association between exposure to major ambient air pollutants and the incidence and mortality of lung cancer and some nonlung cancers. METHODS: This meta-analysis used PubMed and EMBASE databases to access published studies that met the eligibility criteria. Primary analysis investigated the association between exposure to air pollutants and cancer incidence and mortality. Study quality was assessed using the Newcastle Ottawa Scale...
March 2024: JCO global oncology
https://read.qxmd.com/read/38513088/mechanisms-of-resistance-to-bispecific-t-cell-engagers-in-multiple-myeloma-and-their-clinical-implications
#24
JOURNAL ARTICLE
Eric Letouzé, Philippe Moreau, Nikhil C Munshi, Mehmet K Samur, Stephane Minvielle, Cyrille Touzeau
Bispecific T cell engagers (TCE) are revolutionizing patient care in multiple myeloma (MM). These monoclonal antibodies, that redirect T cells against cancer cells, are now approved for the treatment of triple-class exposed relapsed refractory multiple myeloma (RRMM). They are currently tested in earlier lines of the disease, including in first line. Yet, primary resistance occurs in about one third of RRMM patients, and most responders eventually develop acquired resistance. Understanding the mechanisms of resistance to bispecific TCE is thus essential to improve immunotherapies in MM...
March 21, 2024: Blood Advances
https://read.qxmd.com/read/38512934/association-between-adverse-childhood-experiences-and-self-reported-health-risk-behaviors-among-cancer-survivors-a-population-based-study
#25
JOURNAL ARTICLE
Sayantani Sarkar, Brianna Jackson, Laura L Manzo, Sangchoon Jeon, Hermine Poghosyan
AIMS: Existing evidence shows that people who report Adverse Childhood Experiences (ACEs) are more likely to exhibit health-risk behaviors. However, limited research on this topic pertains to oncology population. We aim to address this knowledge gap by estimating the prevalence of ACEs and investigating their association with self-reported health-risk behaviors among adult cancer survivors living in the U.S. METHODS: We conducted a secondary analysis using cross-sectional data from the 2021 Behavioral Risk Factor Surveillance System ACE module...
2024: PloS One
https://read.qxmd.com/read/38512531/primary-vs-pre-emptive-anti-seizure-medication-prophylaxis-in-anti-cd19-car-t-cell-therapy
#26
JOURNAL ARTICLE
Umberto Pensato, Federica Pondrelli, Chiara de Philippis, Gian Maria Asioli, Alessandra Crespi, Alessandro Buizza, Daniele Mannina, Beatrice Casadei, Enrico Maffini, Laura Straffi, Simona Marcheselli, Pier Luigi Zinzani, Francesca Bonifazi, Maria Guarino, Stefania Bramanti
INTRODUCTION: Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated. METHODS: Consecutive patients affected by refractory non-Hodgkin lymphoma who received anti-CD19 CAR T-cells were included. Patients were selected and assessed using similar internal protocols. ASM was started either as a primary prophylaxis (PP-group) before CAR T-cells infusion or as a pre-emptive therapy (PET-group) only upon the onset of neurotoxicity development...
March 21, 2024: Neurological Sciences
https://read.qxmd.com/read/38510886/the-use-of-granulocyte-colony-stimulating-factor-as-primary-prophylaxis-in-patients-undergoing-chemotherapy-an-experience-of-moroccan-oncologists
#27
JOURNAL ARTICLE
Mohamed Kaakoua, Soukayna Boujmadi, Rhizlane Belbaraka, Ismail Essadi
Febrile neutropenia (FN) is a frequent and serious emergency for oncologic patients undergoing chemotherapy. Using granulocyte colony-stimulating factor (G-CSF) as primary prophylaxis of febrile neutropenia is an integral part of the management of cancer patients. Our study aims to identify the challenges that prevent Moroccan oncologists from prescribing G-CSF for primary prevention. Seventy doctors participated in our study, with a participation rate of 35.35%. Twenty-two participants had at least five years of experience in oncology...
February 2024: Curēus
https://read.qxmd.com/read/38509863/cdc2-plasticity-and-acquisition-of-a-dc3-like-phenotype-mediated-by-il-6-and-pge2-in-a-patient-derived-colorectal-cancer-organoids-model
#28
JOURNAL ARTICLE
Beatriz Subtil, Iris A E van der Hoorn, Jorge Cuenca-Escalona, Anouk M D Becker, Mar Alvarez-Begue, Kirti K Iyer, Jorien Janssen, Tom van Oorschot, Dennis Poel, Mark A J Gorris, Koen van den Dries, Alessandra Cambi, Daniele V F Tauriello, I Jolanda M de Vries
Metastatic colorectal cancer (CRC) is highly resistant to therapy and prone to recur. The tumor-induced local and systemic immunosuppression allows cancer cells to evade immunosurveillance, facilitating their proliferation and dissemination. Dendritic cells (DCs) are required for the detection, processing, and presentation of tumor antigens, and subsequently for the activation of antigen-specific T cells to orchestrate an effective antitumor response. Notably, successful tumors have evolved mechanisms to disrupt and impair DC functions, underlining the key role of tumor-induced DC dysfunction in promoting tumor growth, metastasis initiation, and treatment resistance...
March 21, 2024: European Journal of Immunology
https://read.qxmd.com/read/38509261/dyslipidemia-lipid-lowering-agents-and-neuroendocrine-neoplasms-new-horizons
#29
REVIEW
Roberta Modica, Anna La Salvia, Alessia Liccardi, Alessia Cozzolino, Antonella Di Sarno, Flaminia Russo, Annamaria Colao, Antongiulio Faggiano
PURPOSE: Neuroendocrine neoplasms (NENs) are a heterogeneous group of malignancies originating from cells with a neuroendocrine phenotype. The complex relationship between lipid metabolism and cancer is gaining interest and a potential anti-cancer effect of lipid lowering agents is being considered. This review aims to discuss the current understanding and treatment of dyslipidaemia in NENs, focusing on the role of lipid lowering agents, including new therapeutic approaches, and future perspectives as possible tool in cancer prevention and tumor-growth control...
March 20, 2024: Endocrine
https://read.qxmd.com/read/38507590/breaking-physical-barrier-of-fibrotic-breast-cancer-for-photodynamic-immunotherapy-by-remodeling-tumor-extracellular-matrix-and-reprogramming-cancer-associated-fibroblasts
#30
JOURNAL ARTICLE
Zi-Wen Qiu, Ying-Tao Zhong, Zhen-Ming Lu, Ni Yan, Ren-Jiang Kong, Jia-Qi Huang, Zhuo-Feng Li, Jun-Mei Nie, Runqing Li, Hong Cheng
Cancer-associated fibroblasts (CAFs) assist in breast cancer (BRCA) invasion and immune resistance by overproduction of extracellular matrix (ECM). Herein, we develop FPC@S, a photodynamic immunomodulator that targets the ECM, to improve the photodynamic immunotherapy for fibrotic BRCA. FPC@S combines a tumor ECM-targeting peptide, a photosensitizer (protoporphyrin IX) and an antifibrotic drug (SIS3). After anchoring to the ECM, FPC@S causes ECM remodeling and BRCA cell death by generating reactive oxygen species (ROS) in situ ...
March 20, 2024: ACS Nano
https://read.qxmd.com/read/38507548/specific-deletion-of-mettl3-in-iecs-triggers-the-development-of-spontaneous-colitis-and-dysbiosis-of-t-lymphocytes-in-mice
#31
JOURNAL ARTICLE
Miao Fang, Jie Yao, Haifeng Zhang, Jiahui Sun, Yiping Yin, Hongzhou Shi, Guangqing Jiang, Xin Shi
The enzymatic core component of m6A writer complex, Mettl3, plays a crucial role in facilitating the development and progress in gastric and colorectal cancer (CRC). However, its underlying mechanism in regulating intestinal inflammation remains unclear and poorly investigated. Firstly, the characteristics of Mettl3 expression in IBD patients were examined. Afterwards we generated the mice line with IECs-specific deletion of Mettl3 verified by various experiments. We continuously recorded and compared the physiological status including survival rate etc...
March 20, 2024: Clinical and Experimental Immunology
https://read.qxmd.com/read/38506751/projecting-the-impact-of-multi-cancer-early-detection-on-late-stage-incidence-using-multi-state-disease-modeling
#32
JOURNAL ARTICLE
Jane M Lange, Kemal Caglar Gogebakan, Roman Gulati, Ruth Etzioni
BACKGROUND: Downstaging- reduction in late-stage incidence-has been proposed as an endpoint in randomized trials of multi-cancer early detection (MCED) tests. How downstaging depends on test performance and follow-up has been studied for some cancers but is understudied for cancers without existing screening and for MCED tests that include these cancer types. METHODS: We develop a model for cancer natural history that can be fit to registry incidence patterns under minimal inputs and can be estimated for solid cancers without existing screening...
March 20, 2024: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/38506593/relationship-between-subjective-questionnaires-and-videofluoroscopy-of-dysphagia-evaluation-a-systematic-review-and-meta-analysis
#33
JOURNAL ARTICLE
Chih-Jun Lai, Jing-Rong Jhuang, Yu-Kang Tu, Chih-Min Liu, Ching-Ying Tsai, Kuo-Liong Chien
BACKGROUND: Early detection of dysphagia is important for preventing aspiration pneumonia. Although videofluoroscopy is currently the primary diagnostic tool for dysphagia, access to this tool may be limited because of radiation exposure risk, high cost, and other factors. PURPOSE: In this study, a meta-analysis was used to determine the strength of the correlation between dysphagia detection outcomes obtained using subjective questionnaires and videofluoroscopy...
March 21, 2024: Journal of Nursing Research: JNR
https://read.qxmd.com/read/38505617/immunotherapeutic-il-6r-and-targeting-the-mct-1-il-6-cxcl7-pd-l1-circuit-prevent-relapse-and-metastasis-of-triple-negative-breast-cancer
#34
JOURNAL ARTICLE
Aushia Tanzih Al Haq, Pao-Pao Yang, Christopher Jin, Jou-Ho Shih, Li-Mei Chen, Hong-Yu Tseng, Yen-An Chen, Yueh-Shan Weng, Lu-Hai Wang, Michael P Snyder, Hsin-Ling Hsu
Rationale: Multiple copies in T-cell malignancy 1 (MCT-1) is a prognostic biomarker for aggressive breast cancers. Overexpressed MCT-1 stimulates the IL-6/IL-6R/gp130/STAT3 axis, which promotes epithelial-to-mesenchymal transition and cancer stemness. Because cancer stemness largely contributes to the tumor metastasis and recurrence, we aimed to identify whether the blockade of MCT-1 and IL-6R can render these effects and to understand the underlying mechanisms that govern the process. Methods: We assessed primary tumor invasion, postsurgical local recurrence and distant metastasis in orthotopic syngeneic mice given the indicated immunotherapy and MCT-1 silencing (shMCT-1)...
2024: Theranostics
https://read.qxmd.com/read/38502173/a-social-media-delivered-melanoma-prevention-program-for-young-women-engaged-in-frequent-uv-tanning-protocol-for-a-randomized-controlled-trial
#35
JOURNAL ARTICLE
Jerod L Stapleton, Sharon L Manne, Sherry L Pagoto, Allison Leip, Kathryn Greene, Joel J Hillhouse, Allison S Merritt, Brent J Shelton
BACKGROUND: Rates of melanoma have increased dramatically in the United States over the past 25 years, and it has become among the most prevalent cancers for young adult women. Intentional skin tanning leads to a pattern of intense and intermittent UV radiation exposure that is associated with increased risk of melanoma. Frequent tanning is most common among young women and is linked to a variety of sociocultural pressures that negatively impact body image and drive appearance control behaviors...
March 19, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38502057/distinct-molecular-profiles-drive-multifaceted-characteristics-of-colorectal-cancer-metastatic-seeds
#36
JOURNAL ARTICLE
Yuanyuan Zhao, Bing Zhang, Yiming Ma, Mengmeng Guo, Fuqiang Zhao, Jianan Chen, Bingzhi Wang, Hua Jin, Fulai Zhou, Jiawei Guan, Qian Zhao, Qian Liu, Hongying Wang, Fangqing Zhao, Xia Wang
Metastasis of primary tumors remains a challenge for early diagnosis and prevention. The cellular properties and molecular drivers of metastatically competent clones within primary tumors remain unclear. Here, we generated 10-16 single cell-derived lines from each of three colorectal cancer (CRC) tumors to identify and characterize metastatic seeds. We found that intrinsic factors conferred clones with distinct metastatic potential and cellular communication capabilities, determining organ-specific metastasis...
May 6, 2024: Journal of Experimental Medicine
https://read.qxmd.com/read/38501834/-bioactive-components-of-whole-grain-and-their-effect-on-health
#37
JOURNAL ARTICLE
Luis Valladares, Fernando Vio Del Río
Non-communicable diseases represent a global health burden with increasing prevalence. To prevent or improve this type of diseases, dietary strategies based on healthy foods have been suggested. Cereals are the most consumed foods in the world and preventive effects of whole grains on health have been described. The germ and bran of cereals are abundant in bioactive compounds, including phytochemicals, vitamins, minerals and fibers, and these compounds are effective in preventing and improving non-communicable diseases...
March 14, 2024: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/38501027/the-gail-model-and-its-use-in-preventive-screening-a-comparison-of-the-corbelli-study
#38
JOURNAL ARTICLE
William R Pruitt, Beryl Samuels, Scott Cunningham
Background This study aims to determine the usage of the Gail model in screening for breast cancer during physical examinations of women by sampling primary care physicians in two regions of Texas - Hidalgo County and Johnson County. A Gail score of 1.66% or higher indicates increased breast cancer risk. Three specialties are surveyed: internal medicine (IM), family medicine (FM), and gynecology (GYN). The null hypothesis for this study is that primary care physicians do not use the Gail model in screening for breast cancer during physical examinations of women...
March 2024: Curēus
https://read.qxmd.com/read/38500838/the-s-wedish-initiative-for-the-st-u-dy-of-prim-ary-sclerosing-cholangitis-suprim
#39
JOURNAL ARTICLE
Martin Cornillet, Christina Villard, Fredrik Rorsman, Antonio Molinaro, Emma Nilsson, Stergios Kechagias, Erik von Seth, Annika Bergquist
BACKGROUND: Despite more than 50 years of research and parallel improvements in hepatology and oncology, there is still today neither a treatment to prevent disease progression in primary sclerosing cholangitis (PSC), nor reliable early diagnostic tools for the associated hepatobiliary cancers. Importantly, the limited understanding of the underlying biological mechanisms in PSC and its natural history not only affects the identification of new drug targets but implies a lack of surrogate markers that hampers the design of clinical trials and the evaluation of drug efficacy...
April 2024: EClinicalMedicine
https://read.qxmd.com/read/38500558/primary-adipocytes-as-targetable-drug-depot-to-prevent-post-surgical-cancer-recurrence
#40
JOURNAL ARTICLE
Yang Bo, Yueji Wang, Joonsu Han, Rimsha Bhatta, Yusheng Liu, Dhyanesh Baskaran, Jiadiao Zhou, Hua Wang
Surgery followed by adjuvant chemotherapy or radiation therapy remains the mainstream treatment for breast cancer in the clinic. However, cancer recurrence post surgery is still common. In view of the clinical practice that autologous fat tissue grafting is often used to facilitate breast reconstruction after lumpectomy, here we develop an in vivo targetable adipocyte-based drug depot for the prevention of post-surgical cancer recurrence. We show that primary adipocytes can be metabolically labeled with clickable chemical tags (e...
April 2024: Materials today. Bio
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