keyword
https://read.qxmd.com/read/37496373/novel-methodology-for-detection-and-prediction-of-mild-cognitive-impairment-using-resting-state-eeg
#21
JOURNAL ARTICLE
Jinxian Deng, Boxin Sun, Voyko Kavcic, Mingyan Liu, Bruno Giordani, Tongtong Li
BACKGROUND: Early discrimination and prediction of cognitive decline are crucial for the study of neurodegenerative mechanisms and interventions to promote cognitive resiliency. METHODS: Our research is based on resting-state electroencephalography (EEG) and the current dataset includes 137 consensus-diagnosed, community-dwelling Black Americans (ages 60-90 years, 84 healthy controls [HC]; 53 mild cognitive impairment [MCI]) recruited through Wayne State University and Michigan Alzheimer's Disease Research Center...
July 26, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/37491191/association-between-albumin-to-globulin-ratio-and-the-risk-of-overall-survival-in-advanced-non-small-cell-lung-cancer-patients-with-anlotinib-treatment-a-retrospective-cohort-study
#22
JOURNAL ARTICLE
Jinzhan Chen, Congyi Xie, Yimin Yang, Shuwen Yang, Jinxian Huang, Feiyang Ye, Zhenyang Lin, Lin Tong, Jiaxin Liu
OBJECTIVE: Researches about the association between serum albumin-to-globulin ratio (AGR) and the prognosis of lung cancer are limited. We aimed to investigate the relationship between AGR and overall survival (OS) in patients with advanced non-small-cell lung cancer (NSCLC) treated with anlotinib. METHODS: A retrospective cohort study was conducted on 196 advanced NSCLC patients with anlotinib treatment between June 1, 2018 and June 1, 2021. The exposure was AGR, calculated by baseline serum albumin / (serum total protein - serum albumin)...
July 25, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/37404805/identification-and-validation-of-aging-related-gene-signatures-and-their-immune-landscape-in-diabetic-nephropathy
#23
JOURNAL ARTICLE
Yingchao Liang, Zhiyi Liang, Jinxian Huang, Mingjie Jia, Deliang Liu, Pengxiang Zhang, Zebin Fang, Xinyu Hu, Huilin Li
BACKGROUND: Aging and immune infiltration have essential role in the physiopathological mechanisms of diabetic nephropathy (DN), but their relationship has not been systematically elucidated. We identified aging-related characteristic genes in DN and explored their immune landscape. METHODS: Four datasets from the Gene Expression Omnibus (GEO) database were screened for exploration and validation. Functional and pathway analysis was performed using Gene Set Enrichment Analysis (GSEA)...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37384968/a-black-goat-derived-novel-genotype-of-aichi-virus-c-blurs-the-boundary-between-caprine-and-porcine-kobuviruses
#24
JOURNAL ARTICLE
Mengkun Huang, Jinxian Gan, Ziqian Xu, Yuanyuan Guo, Zhangfu Chen, George F Gao, Hao Liang, William J Liu
Aichi virus C, a species in the genus Kobuvirus, causes diarrhea diseases in pigs and goats and pose health threat and economic loss for stock farming. A nearly complete genome sequence of caprine kobuvirus GCCDC14 was obtained from an anal swab of a black goat died from diarrhea collected in Hubei, China in 2019. Phylogenetic analyses suggested that GCCDC14 is a novel genotype of Aichi virus C, forming a sister branch to other caprine kobuviruses, with P1 and VP0 genes more closely related to porcine kobuviruses and VP3 in an independent branch...
June 24, 2023: Virology
https://read.qxmd.com/read/37302990/inhibition-of-anxa2-activity-attenuates-epileptic-susceptibility-and-glua1-phosphorylation
#25
JOURNAL ARTICLE
Limin Ma, Qingyuan Wu, Jinxian Yuan, You Wang, Peng Zhang, Qiankun Liu, Dandan Tan, Minxue Liang, Yangmei Chen
INTRODUCTION: Annexin A2 (ANXA2) participates in the pathology of a variety of diseases. Nevertheless, the impact of ANXA2 on epilepsy remains to be clarified. AIMS: Hence, the study aimed at investigating the underlying role of ANXA2 in epilepsy through behavioral, electrophysiological, and pathological analyses. RESULTS: It was found that ANXA2 was markedly upregulated in the cortical tissues of temporal lobe epilepsy patients (TLE), kainic acid (KA)-induced epilepsy mice, and in a seizure-like model in vitro...
June 11, 2023: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/37275645/body-composition-and-risk-of-liver-cancer-a-population-based-prospective-cohort-study-on-gender-difference
#26
JOURNAL ARTICLE
Sainan Pi, Anran Liu, Beibei Zhu, Yunxiao Zhu, Jinqiu Yuan, Zheming Zhang, Chang Gao, Jinxian Fu, Yao Liu, Xujing Liang, Bin Xia, Youpeng Chen
BACKGROUND: Obesity is a common and highly convincing risk factor for many cancers, including liver cancer. Sex disparities in the body composition and regulatory mechanisms involved in energy homeostasis may contribute to the difference in the incidence of cancer. However, evidence on the gender-specific association between body composition and liver cancer incidence is limited. We performed this study to investigate the linear and non-linear associations of body composition with liver cancer risk by gender...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37252265/a-review-on-the-balancing-design-of-micro-drills
#27
REVIEW
Xiangyu Huang, Feng Jiang, Zhibin Wang, Xian Wu, Shizhan Huang, Yufa Liu, Jinxian Zhang, Xixiang Shi
In recent years, micro-hole drilling with a diameter of less than 1 mm has been widely applied in electronic information, semiconductor, metal processing, and other fields. Compared with conventional drilling, the engineer problems that micro drills are more prone to suffer failure in advance have restricted further development of mechanical micro drilling. In this paper, the main substrate materials of micro drills were introduced. And two important technical means to improve properties of tool material, namely, grain refinement and tool coating, were also introduced, which are current main research directions of micro drills from the perspective of materials...
2023: International Journal, Advanced Manufacturing Technology
https://read.qxmd.com/read/37244177/facile-formation-of-zn-incorporated-nife-layered-double-hydroxide-as-highly-efficient-oxygen-evolution-catalyst
#28
JOURNAL ARTICLE
Pengfei Zhou, Songbo Chen, Haoyun Bai, Chunfa Liu, Jinxian Feng, Di Liu, Lulu Qiao, Shuangpeng Wang, Hui Pan
Electrochemical water splitting is the primary method to produce green hydrogen, which is considered an efficient alternative to fossil fuels for achieving carbon neutrality. For meeting the increasing market demand for green hydrogen, high-efficiency, low-cost, and large-scale electrocatalysts are crucial. In this study, we report a simple spontaneous corrosion and cyclic voltammetry (CV) activation method to fabricate Zn-incorporated NiFe layered double hydroxide (LDH) on commercial NiFe foam, which shows excellent oxygen evolution reaction (OER) performance...
May 22, 2023: Journal of Colloid and Interface Science
https://read.qxmd.com/read/37228407/validation-of-a-portable-monitor-compared-with-polysomnography-for-screening-of-obstructive-sleep-apnea-in-polio-survivors
#29
JOURNAL ARTICLE
Qidi Ding, Jianghua Liu, Jinxian Wu, Juan Du, Xiao Li, Meng Wang, Yunliang Sun, Yan Yu, Jingyu Wang, Ting Sun, Chi Zhang, Changjun Lv, Kingman P Strohl, Fang Han, Xiaosong Dong
SUBJECTIVE: Sleep-disordered breathing (SDB) is highly prevalent in polio survivors. Obstructive sleep apnea (OSA) is the most frequent type. Full polysomnography (PSG) is recommended for OSA diagnosis in patients with comorbidities by current practice guidelines, but it is not always accessible. The purpose of this study was to evaluate whether type 3 portable monitor (PM) or type 4 PM might be a viable alternative to PSG for the diagnosis of OSA in postpolio subjects. METHODS: A total of 48 community-living polio survivors (39 men and 9 women) with an average age of 54...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37193689/global-burden-of-hematologic-malignancies-and-evolution-patterns-over-the-past-30-years
#30
JOURNAL ARTICLE
Nan Zhang, Jinxian Wu, Qian Wang, Yuxing Liang, Xinqi Li, Guopeng Chen, Linlu Ma, Xiaoyan Liu, Fuling Zhou
Hematologic malignancies are among the most common cancers, and understanding their incidence and death is crucial for targeting prevention, clinical practice improvement, and research resources appropriately. Here, we investigated detailed information on hematological malignancies for the period 1990-2019 from the Global Burden of Disease study. The age-standardized incidence rate (ASIR), the age-standardized death rate (ASDR), and the corresponding estimated annual percentage changes (EAPC) were calculated to assess temporal trends in 204 countries and territories over the past 30 years...
May 17, 2023: Blood Cancer Journal
https://read.qxmd.com/read/37180435/changes-in-the-gut-microbiota-structure-and-function-in-rats-with-doxorubicin-induced-heart-failure
#31
JOURNAL ARTICLE
Yawen Fan, Lichang Liang, Xinzheng Tang, Jinxian Zhu, Lei Mu, Mengni Wang, Xuecheng Huang, Shenglan Gong, Jinghan Xu, Tianjiao Liu, Tianfeng Zhang
OBJECTIVES: The rat model of heart failure (HF) induced by doxorubicin (DOX), a broad spectrum and highly effective chemotherapeutic anthracycline with high-affinity to myocardial tissue that causes severe dose-dependent irreversible cardiotoxicity has been widely recognized and applied in HF pathogenesis and drug therapy studies. The gut microbiota (GM) has attracted significant attention due to its potential role in HF, and research in this area may provide beneficial therapeutic strategies for HF...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/37071330/comprehensive-analysis-of-clinical-prognostic-features-and-tumor-microenvironment-landscape-of-cd11b-cd64-patients-with-acute-myeloid-leukemia
#32
JOURNAL ARTICLE
Qian Wang, Nan Zhang, Li Liu, Linlu Ma, Yuxin Tan, Xiaoyan Liu, Jinxian Wu, Guopeng Chen, Xinqi Li, Yuxing Liang, Fuling Zhou
BACKGROUND: Immunophenotyping surface molecules detected in the clinic are mainly applied in diagnostic confirmation and subtyping. However, the immunomodulatory molecules CD11b and CD64, are highly associated with leukemogenesis. Hence, the prognostic value of them and their potential biological functions merit further investigation. METHODS: Flow cytometry was operated to detect immunophenotypic molecules from AML bone marrow samples. Multivariate cox regression, Kaplan-Meier analyses, and nomogram were conducted to predict survival...
April 18, 2023: Cellular Oncology (Dordrecht)
https://read.qxmd.com/read/37069401/microbiota-derived-tryptophan-catabolites-mediate-the-chemopreventive-effects-of-statins-on-colorectal-cancer
#33
JOURNAL ARTICLE
Ji-Xuan Han, Zhi-Hang Tao, Ji-Lin Wang, Lu Zhang, Chen-Yang Yu, Zi-Ran Kang, Yuanhong Xie, Jialu Li, Shiyuan Lu, Yun Cui, Jia Xu, Enhao Zhao, Ming Wang, Jinxian Chen, Zheng Wang, Qiang Liu, Hui-Min Chen, Wenyu Su, Tian-Hui Zou, Cheng-Bei Zhou, Jie Hong, Haoyan Chen, Hua Xiong, Ying-Xuan Chen, Jing-Yuan Fang
Epidemiological studies have indicated an association between statin use and reduced incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a potential chemopreventive effect. Statins are also associated with reduced dysbiosis in the gut microbiome, yet the role of the gut microbiome in the protective effect of statins in CRC is unclear. Here we validated the chemopreventive role of statins by retrospectively analysing a cohort of patients who underwent colonoscopies. This was confirmed in preclinical models and patient cohorts, and we found that reduced tumour burden was partly due to statin modulation of the gut microbiota...
May 2023: Nature Microbiology
https://read.qxmd.com/read/37030814/learning-by-restoring-broken-3d-geometry
#34
JOURNAL ARTICLE
Jinxian Liu, Bingbing Ni, Ye Chen, Zhenbo Yu, Hang Wang
The key point for an experienced craftsman to repair broken objects effectively is that he must know about them deeply. Similarly, we believe that a model can capture rich geometry information from a shape/scene and generate discriminative representations if it is able to find distorted parts of shapes/scenes and restore them. Inspired by this observation, we propose a novel self-supervised 3D learning paradigm named learning by restoring broken shapes/scenes (collectively called 3D geometry). We first develop a destroy-method cluster, from which we sample methods to break some local parts of an object...
April 3, 2023: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://read.qxmd.com/read/36901754/transcriptome-analysis-of-retinal-and-choroidal-pathologies-in-aged-balb-c-mice-following-systemic-neonatal-murine-cytomegalovirus-infection
#35
JOURNAL ARTICLE
Xinyan Zhang, Jinxian Xu, Brendan Marshall, Zheng Dong, Yutao Liu, Diego G Espinosa-Heidmann, Ming Zhang
Our previous studies have shown that systemic neonatal murine cytomegalovirus (MCMV) infection of BALB/c mice spread to the eye with subsequent establishment of latency in choroid/RPE. In this study, RNA sequencing (RNA-Seq) analysis was used to determine the molecular genetic changes and pathways affected by ocular MCMV latency. MCMV (50 pfu per mouse) or medium as control were injected intra-peritoneally (i.p.) into BALB/c mice at <3 days after birth. At 18 months post injection, the mice were euthanized, and the eyes were collected and prepared for RNA-Seq...
February 21, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36805071/enhanced-lithium-polysulfide-adsorption-on-an-iron-oxide-modified-separator-for-li-s-batteries
#36
JOURNAL ARTICLE
Jiao Wu, Qingguo Feng, Yuchao Wang, Jinxian Wang, Xin Zhao, Longsheng Zhan, Mengjie Liu, Zhaoqing Jin, Zhiyan Chen, Yongpeng Lei
Lithium-sulfur (Li-S) batteries are candidates for next-generation energy storage systems because of their low cost, high theoretical specific capacity and safety. However, the serious lithium polysulfide (LiPS) shuttle effect leads to a loss of reactive active substances and reduction of coulombic efficiency. In the current work, iron oxide (IO-700)-prepared by calcining a mixture of carbon spheres and ferric nitrate under an air atmosphere at 700 °C-was designed as a separator modifier to effectively adsorb LiPSs and accelerate the kinetics of the transformation of the intermediates, thereby inhibiting the shuttle effect...
February 20, 2023: Chemical Communications: Chem Comm
https://read.qxmd.com/read/36688664/ecological-processes-of-bacterial-and-fungal-communities-associated-with-typha-orientalis-roots-in-wetlands-were-distinct-during-plant-development
#37
JOURNAL ARTICLE
Lixiao Wang, Jinxian Liu, Meiting Zhang, Tiehang Wu, Baofeng Chai
Root-associated microbiomes are essential for the ecological function of the root system. However, their assembly mechanisms in wetland are poorly understood. In this study, we explored and compared the ecological processes of bacterial and fungal communities in water, bulk soil, rhizosphere soil, and root endosphere niches for 3 developmental stages of Typha orientalis at different wetland sites, and assessed the potential functions of root endosphere microbiomes with function prediction. Our findings suggest that the microbial diversity, composition, and interaction networks along the water-soil-plant continuum are shaped predominantly by compartment niche and developmental stage, rather than by wetland site...
January 23, 2023: Microbiology Spectrum
https://read.qxmd.com/read/36506806/single-cell-transcriptome-sequencing-reveals-the-immune-response-and-homeostasis-mechanism-following-administration-of-bbibp-corv-sars-cov-2-inactivated-vaccine
#38
JOURNAL ARTICLE
Jianhua Yin, Yingze Zhao, Fubaoqian Huang, Yunkai Yang, Yaling Huang, Zhenkun Zhuang, Yanxia Wang, Zhifeng Wang, Xiumei Lin, Yuhui Zheng, Wenwen Zhou, Shuo Wang, Ziqian Xu, Beiwei Ye, Yaxin Guo, Wenwen Lei, Lei Li, Jinmin Tian, Jinxian Gan, Hui Wang, Wei Wang, Peiyao Ma, Chang Liu, Xiaoyu Wei, Xuyang Shi, Zifei Wang, Yang Wang, Ying Liu, Mingming Yang, Yue Yuan, Yumo Song, Wen Ma, Zhuoli Huang, Ya Liu, Yunting Huang, Haorong Lu, Peipei Liu, Hao Liang, Yong Hou, Xun Xu, Longqi Liu, Yuntao Zhang, Guizhen Wu, George F Gao, Xin Jin, Chuanyu Liu, Xiaoming Yang, William J Liu
The BBIBP-CorV severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivated vaccine has been authorized for emergency use and widely distributed. We used single-cell transcriptome sequencing to characterize the dynamics of immune responses to the BBIBP-CorV inactivated vaccine. In addition to the expected induction of humoral immunity, we found that the inactivated vaccine induced multiple, comprehensive immune responses, including significantly increased proportions of CD16+ monocytes and activation of monocyte antigen presentation pathways; T-cell activation pathway upregulation in CD8+ T cells, along with increased activation of CD4+ T cells; significant enhancement of cell-cell communications between innate and adaptive immunity; and the induction of regulatory CD4+ T cells and co-inhibitory interactions to maintain immune homeostasis after vaccination...
December 5, 2022: The innovation
https://read.qxmd.com/read/36465622/low-dose-aspirin-protects-unexplained-recurrent-spontaneous-abortion-via-downregulation-of-hmgb1-inflammation-activation
#39
JOURNAL ARTICLE
Xiaofeng Xu, Jing Wang, Damin Zhu, Jiaqian Yin, Jinxian Liu, Xiao Wu, Wenjuan Yang, Qian Hu, Yu Ren, Zhiguo Zhang, Ping Zhou, Zhaolian Wei, Huijuan Zou, Yunxia Cao
BACKGROUND: High mobility group box protein 1 (HMGB1) is considered as a kind of sterile inflammatory mediators, which is an overexpression in patients with unexplained recurrent spontaneous abortion (URSA). Specific targeting effect of aspirin on HMGB1 has been revealed. Our previous studies have explored the application of HMGB1 as a therapeutic target of aspirin in URSA disease of mice model and human, but the dynamic process of aspirin downregulating HMGB1 concentration has not been demonstrated...
2022: Frontiers in Endocrinology
https://read.qxmd.com/read/36432840/control-of-mosses-on-water-flux-in-an-alpine-shrub-site-on-the-qilian-mountains-northwest-china
#40
JOURNAL ARTICLE
Zhangwen Liu, Rensheng Chen, Jinxian Qi, Zhiying Dang, Chuntan Han, Yong Yang
Mosses are an important component of the alpine shrub, but little is known about their contribution to ecosystem water and energy exchange, especially potential opportunities for alpine shrub expansion under a warming climate. We studied the role of mosses in alpine shrub evapotranspiration by conducting herb and moss removal experiments with different Potentilla fruticosa L. shrub coverage in the Qilian Mountains, Northwest China. The understory evapotranspiration was measured using lysimeters in different shrub coverage (dense shrub cover, medium shrub cover, and thin shrub cover) during the growing season of 2012...
November 15, 2022: Plants (Basel, Switzerland)
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