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Qingjun Wu, Huijuan Xia, Hao Jia, Hao Wang, Cheng Jiang, Liansheng Wang, Jun Zhao, Renzhong Tai, Sanshui Xiao, Dongxian Zhang, Shumin Yang, Jianzhong Jiang
To overcome the limits of traditional technologies, which cannot achieve high resolution and high throughput simultaneously, here we propose, to the best of our knowledge, a novel method, i.e., achromatic Talbot lithography, to fabricate large-area nanopatterns fast and precisely. We successfully demonstrate reflection color filters with a maximum size of about 0.72×0.72  mm2 with a time of only 20 s that have colors similar to simulations and small-area devices fabricated by electron beam lithography...
February 15, 2019: Optics Letters
Qizhong Zhu, Matisse Wei-Yuan Tu, Qingjun Tong, Wang Yao
Van der Waals heterostructures of two-dimensional (2D) materials provide a powerful approach toward engineering various quantum phases of matter. Examples include topological matter such as quantum spin Hall (QSH) insulator and correlated matter such as exciton superfluid. It can be of great interest to realize these vastly different quantum phases matter on a common platform; however, their distinct origins tend to restrict them to material systems of incompatible characters. Here, we show that heterobilayers of 2D valley semiconductors can be tuned through interlayer bias between an exciton superfluid, a quantum anomalous Hall insulator, and a QSH insulator...
January 2019: Science Advances
Chao He, Jinjin Liang, Shaonan Liu, Shaoli Wang, Qingjun Wu, Wen Xie, Youjun Zhang
Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae), a globally invasive species complex that causes serious damage to field crops, has developed resistance to imidacloprid and many other pesticides. Insect detoxify to pesticides may partially depend on ABC transporters, which contribute to the detoxification of xenobiotics. To determine whether genes in the ABCG subfamily are involved in imidacloprid detoxification in B. tabaci Q, we cloned four ABCG subfamily genes based on the published MED/Q genome and on our previous study of the transcriptional response of ABC transporters in B...
January 2019: Pesticide Biochemistry and Physiology
Aysajan Abdusalam, Qingjun Li
Plant populations at high elevation face extreme climatic conditions and resource limitations. The existence of distylous species at different elevations can help us investigate their adaptation to high altitudes, the evolution of their morphological characteristics, as well as their responses to limited resources. Here, 17 populations of Primula nivalis at different elevations were evaluated regarding variations in plant morphological characteristics, biomass allocation, and morphological plasticity in a heterogeneous environment...
December 2018: Plant Diversity
Shiqi Ji, Xiaolin Su, Haijian Zhang, Zhixing Han, Yuqian Zhao, Qingjun Liu
In recent years, renal cell carcinoma (RCC) has exhibited an increasing incidence and mortality rate worldwide. Accumulating evidence has identified that microRNAs (miRNAs) function as negative or positive regulators of many malignant tumors; however, the roles of miR-372 in RCC remain unclear. The focus of the present study was the functions of miR-372 in RCC metastasis and EMT. Data revealed that miR-372 expression levels were significantly downregulated in RCC tissue samples and cells. Moreover, the decreased expression levels were strongly associated with the poor survival rates and adverse clinical characteristics of RCC patients...
February 2019: Oncology Letters
Yating Liu, Wen Xie, Litao Guo, Xin Yang, Jinjian Yang, Shaoli Wang, Qingjun Wu, Xuguo Zhou, Youjun Zhang
Sex determination genes are important regulators of reproduction as well as of the development of both behavioural and morphological sex characteristics. The sweetpotato whitefly, Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae), is an emerging insect pest worldwide. The recent release of the genome sequence of the highly invasive B. tabaci Q/MED allows us to investigate the mechanisms and genes involved in sex determination. The combined genome- and transcriptome-wide analyses identified 26 genes putatively associated with sex determination in B...
February 4, 2019: Insect Molecular Biology
Zongyi Li, Haoyun Duan, Wenjing Li, Xiaoli Hu, Yanni Jia, Can Zhao, Songmei Zhang, Qingjun Zhou, Weiyun Shi
Eye is a complex organ with highly specialized tissue structure. The establishment of human pluripotent stem cells (hPSCs) has allowed the simulation of eye development in vitro. Most differentiation works of hPSC-derived ocular cells focus on a single, tissue-specific lineage, however, which face the difficulty in reflecting the complexity of eye development. Recently, generation of a self-formed ectodermal automomous multi-zone of ocular cells availably mimics the process of whole-eye development. In this study, we developed a rapid defined method to induce the differentiation of multi-zone ocular cells (MZOCs) from human induced pluripotent stem cells, which specifically experienced the key progenitor stages of anterior neuroectoderm and eye field stem cells by 2...
February 2, 2019: Stem Cells and Development
Wentao Jiang, Li Zhang, Qingjun Guo, Honghai Wang, Ming Ma, Jisan Sun, Chiyi Chen
The purpose of this study was to explore potential biomarkers in the diagnosis of hepatocellular carcinoma (HCC) based on RNA-seq. The microarray data GSE98269 were downloaded from the GEO database, including the miRNA, mRNA and lncRNA expression profiles of 3 HCC tissues and 3 normal liver tissues from 3 HCC patients. The limma package was used to identify the differentially expressed miRNAs (DEMs) and the differentially expressed lncRNAs in HCC tissues compared with normal liver tissues. Database of DAVID, KEGG PATHWAY and Reactome were used to perform the functional and pathway enrichment...
January 24, 2019: Pathology Oncology Research: POR
Wenpu Ma, Qingjun Dou, Xin Ha
PURPOSE: The aim of this study was to investigate the mechanism of let-7a-5p in osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in postmenopausal osteoporosis (PMOP) mice. METHODS: A mouse model of PMOP was established and osteoporosis model was identified by micro-CT scan. BMSCs in the sham group and PMOP group were cultured and osteogenic differentiation was induced. The expression of let-7a-5p in BMSCs was detected by qRT-PCR, and BMSCs was induced by osteogenic differentiation in sham and PMOP group...
January 16, 2019: Biochemical and Biophysical Research Communications
Zhenyu Shu, Xiaoyong Shen, Shiqing Xin, Qingjun Chang, Jieqing Feng, Ladislav Kavan, Ligang Liu
Shape segmentation is a fundamental problem in shape analysis. Previous research shows that prior knowledge helps to improve the segmentation accuracy and quality. However, completely labeling each 3D shape in a large training data set requires a heavy manual workload. In this paper, we propose a novel weakly-supervised algorithm for segmenting 3D shapes using deep learning. Our method jointly propagates information from scribbles to unlabeled faces and learns deep neural network parameters. Therefore, it does not rely on completely labeled training shapes and only needs a really simple and convenient scribble-based partially labeling process, instead of the extremely time-consuming and tedious fully labeling processes...
January 10, 2019: IEEE Transactions on Visualization and Computer Graphics
Qingjun Kong, Lingling Zhang, Peipei An, Jianrui Qi, Xing Yu, Jun Lu, Xueyan Ren
AIMS: As a natural antimicrobial agent, Melaleuca alternifolia oil (MAO) is generally recognized to be safe and effective in the inhibition of phytopathogenic fungi. Due to lack of comprehensive studies on MAO for controlling postharvest Aspergillus, we investigated the preservative mechanism of MAO and its components against Aspergillus ochraceus (A. ochraceus) in postharvest grapes to evaluate their potential effectiveness as fruit preservatives. METHODS AND RESULTS: In our study, the compositions in MAO were analyzed by gas chromatography-mass spectrometry...
January 5, 2019: Journal of Applied Microbiology
Qingjun Cao, Xueyan Liu, Fenghua Yang, Hua Wang
Epilepsy is a chronic brain disease caused by abnormal discharging in the brain, which induces momentary brain dysfunction. Cannabinoid 2 receptor (CB2R) is expressed in central nervous system (CNS) and serves an important role in the pathogenesis of CNS diseases. The aim of the present study was to explore the effects of CB2R activation on phosphoinositide 3-kinase (PI3K) 110α-protein kinase B (AKT) signaling in an astrocyte model of epilepsy. Rat CTX TNA2 astrocytes were treated with Mg free solution to establish a cell model of epilepsy and were subsequently treated with a CB2R agonist (JWH133) and antagonist (AM630)...
December 2018: Experimental and Therapeutic Medicine
Guijun Ren, Xiaoye Yuan, Xin Zhao, Qingchun Hao, Jinglin Cao, Yang Wang, Qingjun Gao, Jian Dou, Qiang Zeng
The aim of the present study was to investigate the characteristics and progression of intestinal injury at the anhepatic phase in portal hypertensive rats. A total of 120 healthy male Wistar rats were purchased, with 15 rats in the normal control group and 105 rats were assigned to establish a prehepatic portal hypertension model. The 105 model rats were further divided into seven treatment groups following ischemia-reperfusion. Meanwhile, portal vein pressure, the area of lower esophageal mucosal vein, endotoxin levels in portal vein blood and the level of malondialdehyde (MDA) and superoxide dismutase (SOD) were measured...
December 2018: Experimental and Therapeutic Medicine
Jisan Sun, Wentao Jiang, Dazhi Tian, Qingjun Guo, Zhongyang Shen
Purpose: Hepatocellular carcinoma (HCC) accounts for one of the most prevalent tumor types in the world and still lacks an effective treatment regimen. The EGFR tyrosine-kinase inhibitor icotinib is capable of inhibiting proliferation of several kinds of cancer cells, but its anticancer effect in HCC is still not verified. Methods: In the current study, ten HCC cell lines were selected to test their original EGFR-activation status and PDL1 protein level, and in vitro antiproliferation assays were also conducted to analyze the IC50 and further investigate the correlation between IC50 and protein level of phosphorylated EGFR and PDL1...
2018: OncoTargets and Therapy
Jia Li, Wenyu Feng, Huiping Lu, Yan Wei, Shiting Ma, Linfeng Wei, Qian Liu, Jinmin Zhao, Qingjun Wei, Jun Yao
In addition to being used to treat malaria, artemisinin (Art) can be used as an anti-inflammatory and antitumor agent. In this study, we evaluated the effects of Art on osteoclast formation and activation and on the development of breast cancer cells in bone. To evaluate the effect of Art on osteoclast differentiation in vitro, we treated bone marrow-derived macrophages (BMMs) with various concentrations of Art and evaluated the expression of genes and proteins involved in osteoclast formation. We also performed cell counting kit-8 assays to evaluate the toxicity of Art in BMMs and MDA-MB-231 cells...
December 7, 2018: Journal of Cellular Physiology
Zhenyu Zhao, Xin Wang, Yi Yu, Subo Yuan, Dan Jiang, Yujun Zhang, Teng Zhang, Wenhao Zhong, Qingjun Yuan, Luqi Huang
Dioscorea L., the largest genus of the family Dioscoreaceae with over 600 species, is not only an important food but also a medicinal plant. The identification and classification of Dioscorea L. is a rather difficult task. In this study, we sequenced five Dioscorea chloroplast genomes, and analyzed with four other chloroplast genomes of Dioscorea species from GenBank. The Dioscorea chloroplast genomes displayed the typical quadripartite structure of angiosperms, which consisted of a pair of inverted repeats separated by a large single-copy region, and a small single-copy region...
2018: PeerJ
Xiaoqiang Tong, Chaojie Jing, Zhaojun Dong, Na Zhang, Lijun Bi, Yanyan Wang, Hua Cai, Dongmin An, Xiaoxue Lian, Qiong Wang, Qingjun Zhou, Ying Guo, Yan Yan, Wenfu Yan
A homochiral open-framework fluorinated cobalt phosphate with a 2-fold interpenetrating diamond topology was ionothermally synthesized. The significant enantiomeric excess of the bulk product was confirmed by strong signals in its solid state circular dichroism (CD) spectrum.
December 7, 2018: Chemical Communications: Chem Comm
Lisi Zeng, Quanxing Liao, Zhaowei Zou, Yuefeng Wen, Jingshu Wang, Chang Liu, Qingjun He, Nuoqing Weng, Judeng Zeng, Hongsheng Tang, Runya Fang, Ziying Lei, Zhen Tang, Xianzi Yang, Shuzhong Cui
BACKGROUND/AIMS: The development of multidrug resistance (MDR), which results in disease recurrence and metastasis, is a crucial obstacle to successful chemotherapy for patients with gastric cancer (GC). Long non-coding RNAs (lncRNAs) have been found to play various roles in cancer. This study aimed to investigate the effect of XLOC_006753 on the development of MDR in GC cells. METHODS: The expression levels of XLOC_006753 in GC patients and MDR GC cell lines (SGC-7901/5-FU and SGC-7901/DDP cell line) were assessed by qRT-PCR...
November 27, 2018: Cellular Physiology and Biochemistry
Jun Lu, Keyu Kally Shi, Shuping Chen, Junqiao Wang, Amira Hassouna, Loretta Nicole White, Fabrice Merien, Mingyong Xie, Qingjun Kong, Jinyao Li, Tianlei Ying, William Lindsey White, Shaoping Nie
Fucoidan, the complex fucose-containing sulphated polysaccharide varies considerably in structure, composition, and bioactivity, depending on the source, species, seasonality, and extraction method. In this study, we examined five fucoidans extracted from the same seaweed species Undaria pinnatifida but from different geological locations, and compared them to the laboratory-grade fucoidan from Sigma (S). The five products differed in molecular composition. The amount of over 2 kDa low molecular weight fraction (LMWF) of the New Zealand crude fucoidan (S1) was larger than that of S, and this fraction was unique, compared to the other four fucoidans...
November 22, 2018: Marine Drugs
Lingqing Wang, Xiaoxiao Han, Tao Liang, Qingjun Guo, Jing Li, Lijun Dai, Shiming Ding
Geochemical distribution of trace elements in sediments could reflect the impact of anthropogenic activities on environmental changes in aquatic ecosystems. In this study, rare earth elements (REEs) were used as geochemical tracers to study the environmental processes in a complex and dynamic aquatic environment. Both surface and core sediment samples were collected from Poyang Lake, the largest freshwater lake located in the middle-low region of the Yangtze River. Sediment samples were analyzed for their respective REE spatial distributions, fractionation, and co-occurrence patterns...
November 11, 2018: Chemosphere
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