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Epitheloid hemangioendothelioma

Amir Taefi, Karen Matsukuma, Eric Chak
No abstract text is available yet for this article.
March 31, 2018: Clinical Gastroenterology and Hepatology
Lekha K Nair, Anitha Das, Arun Kumar A S, V Ramachandran
INTRODUCTION: Epitheloid hemangioendothelioma is a rare vascular soft tissue tumour of intermediate malignant potential. The tumor affects any age group, and liver is the commonest internal organ affected. Bones as calvarium, spine, tibia and femur may also be affected. The lesion can be multifocal in the liver or the same bone itself and can metastasise to lungs. Here we report a rare case of epithelioid hemangioendothelioma involving tibia in a male infant, which regressed by itself without any treatment, after incisional biopsy over a period of one and half years...
January 2015: Journal of Orthopaedic Case Reports
Jaya Prakash Sugunaraj, Claire Pedroso, Shravan Kethireddy, Mohammed Mogri
Pulmonary epitheloid hemangioendothelioma (PEHE) is a rare, often incidentally diagnosed, endothelial tumor of the lung. We present a case of a young adult who presented with acute hypoxemic respiratory failure and severe pulmonary hypertension with subsequent imaging and tissue biopsy confirming a diagnosis of PEHE. We briefly highlight the unique clinical, radiographic and histopathologic aspects of this rare disease. We propose that PEHE should be considered in the differential diagnosis for acute hypoxemic respiratory failure associated with bilateral pulmonary cavitary nodules and bronchoscopy should be considered as an initial diagnostic test...
2015: Respiratory Medicine Case Reports
Denis Schallier, Berend-Jan Berendes, Pierre Lefesvre, Hendrik Everaert
A patient with a pleural epitheloid hemangio-endothelioma (EHE) who failed to respond to six cycles of initial chemotherapy with iphosphamide and epirubicine was treated with pazopanib in second-line. A significant subjective and objective metabolic response on (18)F-fluoro-deoxyglucose positron-emission tomography-computed tomography was noted. Based on this observation, the role of vasculoendothelial growth factor receptor inhibitors such as pazopanib (or other tyrosine kinase inhibitors), in the treatment of pleural EHE should be established through prospective collaborative studies as upfront medication and in combination with chemotherapy...
January 2016: Anticancer Research
Chuifeng Fan, Lianhe Yang, Xuyong Lin, Enhua Wang
Pseudomyogenic hemangioendothelioma is an extremely rare soft tissue tumor, also named as epithelioid sarcoma-like hemangioendothelioma, which occurs more frequently in young adult males. It was originally recognized as a variant of epitheloid sarcoma, however it is now concluded as a distinctive, rarely metastasizing endothelial neoplasm. We present a case of pseudomyogenic hemangioendothelioma in the lower limb in a 49-year-old female who has a long course of disease and suffered from twice local recurrences and lymph node affection of the tumor...
August 28, 2015: Diagnostic Pathology
Imran Nizami, Shamayel Mohammed, Mohei El Din Abouzied
We describe a case of pulmonary epitheloid hemangioendothelioma (PEH) in a 13 years old girl, the aggressive nature of the tumor in this particular case and the PET CT findings. PEH are rare tumors of vascular origin, first described by Dial and Liebow in 1975. This is an uncommon pulmonary neoplasm, 4 times more common in young women. This tumor can affect multiple organs (lung, liver, bones and soft tissue, skin, heart, central nervous system). However lung and liver represent 2 main locations. Clinical manifestations are variable; typically patients are asymptomatic, and PEH is detected on routine chest radiographs as bilateral small (1 cm or less) nodules in the lungs Diagnosis usually requires a surgical lung biopsy...
September 2014: Annals of Saudi Medicine
Bhargavan Sarojini Sreenivasan, Majo Ambooken, Mayeesh Radhakrishna, Joseph Sebastian
Epitheloid hemangioendothelioma (EHE) is an uncommon angiocentric neoplasm of intermediate malignant potential. This tumor is frequently seen in the lungs and liver, but its presentation in the oral cavity is rare. In the oral cavity, gingival region is the common sites of occurrence. We report a rare case of epitheloid hemangioendothelioma in a 48-year-old male, presenting as a growth in the upper anterior gingiva of five months duration along with a review of its clinicopathological and immunohistochemical characteristics...
March 2015: Iranian Journal of Medical Sciences
Mohammad M Al-Qattan, Ammar C Al-Rikabi
Epithelioid hemangioendotheliomas (EHEs) are known to have a variable malignant potential. EHEs are rarely seen in the hand and there is no consensus about their management. The options include excision, excision followed by adjuvant radiotherapy and amputation. In this paper, we report a case of EHE of a finger that was treated by excision. Although the tumor had ill-defined borders and there was histological evidence of tumor extension to all resection margins, no local recurrence or metastasis were noted during the 3 years of followup...
September 2014: Indian Journal of Orthopaedics
A Puri, M Pruthi, A Gulia
AIM: To evaluate morbidity, oncologic results and functional outcome in patients with malignant tumors of pelvis treated with limb sparing resection. METHODS: Between March 2002 and November 2010, 106 cases of non metastatic malignant pelvic tumors were treated with limb sparing resections of pelvis. Diagnosis included chondrosarcoma (65), Ewing's sarcoma (25), osteogenic sarcoma (10), synovial sarcoma (3) and malignant fibrous histiocytoma, high grade sarcoma, epitheloid hemangiothelioma (1 each)...
January 2014: European Journal of Surgical Oncology
Hayyam Kiratli, Berçin Tarlan, Sevket Ruacan
PURPOSE: To describe a case of an epitheloid hemangioendothelioma which is a tumor of endothelial origin with borderline malignancy between hemangioma and angiosarcoma and which is very rare in the orbit. METHODS: Clinical features, results of imaging and histopathological studies and postoperative clinical course of a 22-year-old female patient who presented with a gradual swelling of the left upper eyelid were reviewed. RESULTS: Magnetic resonance imaging studies suggested a solid lesion with moderate contrast enhancement in the palpebral lobe of the lacrimal gland...
April 2013: Orbit
Regina Pálföldi, Marianna Radács, Edit Csada, Zoltán Rózsavölgyi, László Tiszlavicz, Attila Somfay, Márta Gálfi
A 49-year-old female patient was admitted in July 2009 because of cough, weight loss and effort dyspnoe. Chest X-ray and CT showed multiple bilateral nodules which have been identified earlier and these nodules were unchanged. However, there was a new parenchymal lesion in the right upper lobe, and new right hilar and mediastinal lymphadenomegaly was also found. Sample was taken by bronchoscope and the pathological diagnosis was pulmonary epitheloid haemangioendothelioma. This rare endothelial tumor usually affects middle-aged patients with a female predominance and it presents with chest pain, effort dyspnoe, cough, sputum, or it may remain asymptomatic...
May 22, 2011: Orvosi Hetilap
Mayke Houtappel, Roos J Leguit, Vigfus Sigurdsson
A 58-year-old man presented at the dermatology outpatient clinic with a subcutaneous nodule on his left hand. The patient could not recall a previous injury. Excision revealed an epithelioid hemangioendothelioma, a rare and malignant vascular tumour, characterized by slow progression and often located on the upper and lower extremities. The patient was referred to a specialist group for soft-tissue tumours. He underwent excision, after which the wound was closed using a non-invasive adhesive wound closure. Since the excision was not very extensive, supplementary radiotherapy was given...
2010: Nederlands Tijdschrift Voor Geneeskunde
Tajana Filipec Kanizaj, Vesna Colić Cvrlje, Anna Mrzljak, Ika Kardum-Skelin, Dunja Sustercić, Dinko Segro, Denis Gustin, Branislav Kocman
Malignant hepatic epithelioid hemangioendothelioma (HEH) is a rare malignant tumor of vascular origin with unknown aetiology and a variable natural course. At the time of diagnosis, most patients present with multifocal tumours lesions that involve both liver lobes. From the therapeutic aspect, liver resection (LRx), liver transplantation (LTx), chemotherapy, radiotherapy, and/or immunotherapy have been used in the treatment of patients with HEH. However, because of the rarity of this tumor and its unpredictable natural history, it is impossible to assess the effectiveness of these respective therapies...
March 2010: Collegium Antropologicum
Shashideep Singhal, Shilpa Jain, Montish Singla, Ram Babu Pippal, Ranjana Gondal, Anil Agarwal, Premashis Kar
CASE REPORT: A 43-year-old woman presented with right upper abdominal pain, on and off for 3-4 years. One year prior to her presentation, a space-occupying lesion was found in the right lobe of the liver, which was suspected to be hemangioma, as the patient had history of combined oral contraceptive pill use for the last 15 years. On examination, she was thinly built and had pallor; abdominal examination revealed tender hepatomegaly 3 cm below the costal margin, smooth surface, sharp regular edge with left lobe enlargement, and no bruit...
2009: Journal of Gastrointestinal Cancer
E Honsová, H Gottfriedová, M Oliverius, P Trunecka
Primary hepatic epitheloid heamangioendothelioma (EHE) is a rare neoplasm of vascular origin. We present a retrospective study of 6 patients with EHE treated by liver transplantation that were monitored clinically for more than 3 years and had protocol biopsy samples taken at 1, 3, 5, 7, and 10 years posttransplant. None of the patients suffered from any form of viral or autoimmune hepatitis before or after the transplantation. Two patients had lung metastases detected by preoperative imaging. All tumours showed factor VIII, CD31, and CD34 strong positive staining...
2009: Prague Medical Report
Narmada P Gupta, Surendra B Kolla, Sabyasachi Panda, M C Sharma
Epitheloid hemangioendothelioma is an uncommon vascular neoplasm and has an unpredictable clinical behavior. It is characterized by round or spindle-shaped endothelial cells with cytoplasmic vacuolation. Most often, epitheloid hemangioendothelioma arise from the soft tissues of the upper and lower extremities and it has borderline malignant potential. We describe the first reported case of epitheloid hemangioendothelioma in the urinary bladder, which was treated by transurethral resection. The diagnosis was confirmed by immunohistochemistry...
April 2008: Indian Journal of Urology: IJU: Journal of the Urological Society of India
N Kalra, R Kochhar, K Vaiphei, V Virmani, T D Yadav, N Khandelwal
Epitheloid hemangioendothelioma (EHE) is a rare neoplasm of vascular origin known to arise in soft tissue, liver and lung. We describe a case of coexistent hepatic and pulmonary epitheloid hemangioendothelioma, proven on autopsy, and review the histological and radiological features of epitheloid hemangioendothelioma. The coexistence of hepatic with pulmonary EHE has been reported in only a few cases. Large confluent masses, peripheral location with capsular retraction, hypertrophy of uninvolved liver, invasion of portal and hepatic veins, enhancing margins and delayed enhancement and dense calcification are the typical features which provide a clue to diagnosis of hepatic EHE...
January 2009: Indian Journal of Cancer
Elvira Stacher, Ulrike Gruber-Mösenbacher, Iris Halbwedl, Angelo Paolo Dei Tos, Alberto Cavazza, Mauro Papotti, Lina Carvalho, Monika Huber, Leander Ermert, Helmut H Popper
Malignant epitheloid vascular tumors (epitheloid haemangioendotheliomas and angiosarcomas) of the lung are very rare lesions often posing difficulties in diagnosis. Due to their rare incidence no standardized therapy regimen is established. Surgical resection of the tumor is the mainstay of treatment, but in many cases, especially due to the multifocality of the tumor, negative resection margins cannot be achieved. A blockade of members of the vascular endothelial growth factor (VEGF) system either by antibodies for their ligands or by kinase inhibitors has been increasingly used for the therapy of solid tumors...
July 2009: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
B Chatelain, A Clairotte, E Euvrard, C Meyer, B Ricbourg
INTRODUCTION: Epitheloid hemangioendothelioma is a rare vascular tumor with a borderline malignancy and a potential risk for recurrence. It usually affects the soft tissue of extremities, the liver, and the lungs. The cervicofacial localization is rare. We report a very rare maxillary localization. CASE REPORT: An 8-year-old girl with no personal or family history was sent to us by her dentist for a painless ulceration of the right maxilla having developed months before...
February 2009: Revue de Stomatologie et de Chirurgie Maxillo-faciale
D Petrov, V Vlasov, V Stanoev, M Kostadinov, S Danon, G Kirova
OBJECTIVE: To study and evaluate clinic, diagnostics and operative treatment of patients with primary pulmonary sarcomas (PPS). MATERIAL AND METHODS: During 24 years period, a total of 49 patients underwent surgery for PPS. There were 29 male and 20 female with a mean age of 52.6 years. Main presenting complaints were shortness of breath, cough, chest pain, weight loss and haemoptysis. Correct preoperative diagnosis was obtained in 12 (24.48%) of the patients by bronchoscopy or percutaneous core biopsy...
2008: Khirurgiia
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