keyword
https://read.qxmd.com/read/37483744/glycyrrhizic-acid-glycosides-reduces-extensive-tripterygium-glycosides-induced-lipid-deposition-in-hepatocytes
#21
JOURNAL ARTICLE
Yifei Yang, Xiaotong Fu, Bing Xia, Liu Zhou, Haijing Zhang, Chun Li, Xiao Ye, Ting Liu
AIM: Tripterygium glycosides (TG) extracted from the plant Tripterygium wilfordii Hook F has been used to treat chronic kidney diseases for many years. However, hepatotoxicity limits its clinical application. Glycyrrhizic acid glycosides (GA) can reduce TG hepatotoxicity, however, further investigation into the underlying molecular mechanisms by which GA attenuates TG-induced hepatotoxicity is required. METHODS: Sprague‒Dawley rats were randomly divided into the control group, the TG groups (TG189 mg/kg group, TG472...
July 2023: Heliyon
https://read.qxmd.com/read/37454955/resveratrol-reverses-palmitic-acid-induced-cow-neutrophils-apoptosis-through-shifting-glucose-metabolism-into-lipid-metabolism-via-cav-1-cpt-1-mediated-fao-enhancement
#22
JOURNAL ARTICLE
Yansong Li, Yuming Zhang, Qinghua Deng, Jingdong Mao, Zhenwei Jia, Mingyu Tang, Yue Zhang, Junkang Zhao, Jiaojiao Chen, Yiru Wang, Ziying Feng, Xinbo Wang, Liyin Du
Elevated plasma nonesterified fatty acids (NEFAs) affect neutrophils function and longevity during the periparturient period in dairy cows. Previous research has shown that resveratrol (RSV) may protect cell viability from NEFA-induced damage by regulating energy metabolism. However, it is unclear whether RSV has a protective effect on palmitic acid (PA)-treated neutrophils. The aim of this study was to investigate the molecular regulatory mechanism of the protective effect of RSV on neutrophils. The results showed that treatment with high concentrations of RSV (50μM, 100μM) maintained neutrophils activity by inhibiting neutrophils apoptosis (P < 0...
July 14, 2023: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/37385578/lapatinib-ditosylate-rescues-motor-deficits-in-rotenone-intoxicated-rats-potential-repurposing-of-anti-cancer-drug-as-a-disease-modifying-agent-in-parkinson-s-disease
#23
JOURNAL ARTICLE
Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khatib
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor deficits induced by dopaminergic neuronal death in the substantia nigra (SN). Finding a successful neuroprotective therapy is still challenging despite improved knowledge of the etiology of PD and a variety of medications intended to reduce symptoms. Lapatinib (LAP), an FDA-approved anti-cancer medication, has been stated to exert its effect through the modulation of oxidative stress. Furthermore, recent studies display the neuroprotective effects of LAP in epilepsy, encephalomyelitis, and Alzheimer's disease in rodent models through the modulation of oxidative stress and ferroptosis...
June 28, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/37373168/acsl4-mediated-ferroptosis-and-its-potential-role-in-central-nervous-system-diseases-and-injuries
#24
REVIEW
Bowen Jia, Jing Li, Yiting Song, Chengliang Luo
As an iron-dependent regulated form of cell death, ferroptosis is characterized by iron-dependent lipid peroxidation and has been implicated in the occurrence and development of various diseases, including nervous system diseases and injuries. Ferroptosis has become a potential target for intervention in these diseases or injuries in relevant preclinical models. As a member of the Acyl-CoA synthetase long-chain family (ACSLs) that can convert saturated and unsaturated fatty acids, Acyl-CoA synthetase long-chain familymember4 (ACSL4) is involved in the regulation of arachidonic acid and eicosapentaenoic acid, thus leading to ferroptosis...
June 12, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37285607/genome-wide-association-study-of-red-blood-cell-fatty-acids-in-the-women-s-health-initiative-memory-study
#25
JOURNAL ARTICLE
Jason Westra, Carmen Annevelink, Tonya Orchard, Lifang Hou, William S Harris, Timothy D O'Connell, Gregory Shearer, Nathan Tintle
Despite their widespread associations with a wide variety of disease phenotypes, the genetics of red blood cell fatty acids remains understudied. We present one of the first genome-wide association studies of red blood cell fatty acid levels, using the Women's Health Initiative Memory study - a prospective cohort of N = 7,479 women aged 65-79. Approximately 9 million SNPs were measured directly or imputed and, in separate linear models adjusted for age and genetic principal components of ethnicity, SNPs were used to predict 28 different fatty acids...
July 2023: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://read.qxmd.com/read/37283372/biocontrol-potential-of-actinobacteria-against-pantoea-ananatis-the-causal-agent-of-maize-white-spot-disease
#26
JOURNAL ARTICLE
J C M Dornelas, P H F Carmo, U G P Lana, M A G Lana, C A O Paiva, I E Marriel
Pantoea ananatis is the causal agent of maize white spot, a foliar disease responsible for significant maize yield reduction worldwide, especially in Brazil. In general, the maize foliar diseases control involves the adoption of resistant genotypes and pesticides application. However, the use of agrochemicals can significantly cause increase production costs, damage to human health and negative environmental impacts. In this sense, the use of biological control agents has been considered among the most promising eco-friendly technologies for sustainable agriculture...
2023: Brazilian Journal of Biology
https://read.qxmd.com/read/37278223/synthesis-nmr-kinetics-and-dynamic-structure-of-a-17-mer-heptaloop-rna-hairpin-carrying-a-3-n-methyluridine-nucleotide-residue-in-the-loop-region
#27
JOURNAL ARTICLE
Cenk A Andac, Ulfert Hornemann, Ningur Noyanalpan, Thomas C Stringfellow
A 17-mer RNA hairpin (5'GGGAGU X AGCGGCUCCC3') carrying 3- N -methyluridine (m3U) at position X (m3U7-RNA), designed to represent the anticodon stem-loop (ACSL) region of tRNAs to study an open loop (O-state), was synthesized, purified by HPLC, and characterized by MALDI-ToF_MS and NMR methods. 1 H-NMR data revealed primary (P-state in 56.1%), secondary (S-state in 43.9%) and tertiary (∼5-6%) ACSL conformations. Exchange rate constant (kex ) for interconversion between P and S states is 112 sec-1 (<Δω ∼454 rad//sec), confirming a slow exchange regime between the two states...
June 6, 2023: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/37210761/loxblock-1-or-curcumin-attenuates-liver-pancreas-and-cardiac-ferroptosis-oxidative-stress-and-injury-in-ischemia-reperfusion-damaged-rats-by-facilitating-acsl-gpx4-signaling
#28
JOURNAL ARTICLE
Fatih Kar, Fatma Yıldız, Ceyhan Hacioglu, Ezgi Kar, Dilek Burukoglu Donmez, Hakan Senturk, Gungor Kanbak
In this study, the effects of the pretreatment of Curcumin and LoxBlock-1 on liver, pancreas, and cardiac dysfunction following Ischemia-Reperfusion-induced (IR) Acute Kidney Injury (AKI) were investigated through the mechanisms of oxidative stress and ferroptosis. Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) parameters in the tissue were analyzed to investigate the oxidative stress occurring in the liver, pancreas, and heart, and Acyl-Coa synthetase long-chain family member (ACSL4)...
May 18, 2023: Tissue & Cell
https://read.qxmd.com/read/37025414/proteomic-analysis-reveals-semaglutide-impacts-lipogenic-protein-expression-in-epididymal-adipose-tissue-of-obese-mice
#29
JOURNAL ARTICLE
Ruiyi Zhu, Shuchun Chen
BACKGROUND AND OBJECTIVES: Obesity is a global health problem with few pharmacologic options. Semaglutide is a glucagon-like peptide-1 (GLP-1) analogue that induces weight loss. Yet, the role of semaglutide in adipose tissue has not yet been examined. The following study investigated the mechanism of semaglutide on lipid metabolism by analyzing proteomics of epididymal white adipose tissue (eWAT) in obese mice. METHODS: A total of 36 C57BL/6JC mice were randomly divided into a normal-chow diet group (NCD, n = 12), high-fat diet (HFD, n = 12), and HFD+semaglutide group (Sema, n = 12)...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/36774839/integrated-proteomics-and-metabolomics-analysis-revealed-the-mechanisms-underlying-the-effect-of-irradiation-on-the-fat-quality-of-chinese-bacon
#30
JOURNAL ARTICLE
Ju Zhang, Tian Wang, Chunjie Yang, Ruixiao Wu, Linjie Xi, Wu Ding
Irradiation increases the security and storage period of preserved Chinese bacon; nevertheless, the biological mechanisms underlying the changes in fat quality caused by irradiation are unknown. We investigated the influence of irradiation on Chinese bacon by proteomic and metabolomic. We identified 24 proteins that participated in metabolism and 40 common differential metabolites enriched in 16 signalling pathways. Correlation analysis revealed that irradiation altered 11 pathways shared between the proteome and metabolome, including two lipid metabolism pathways...
January 3, 2023: Food Chemistry
https://read.qxmd.com/read/36671505/the-placentas-of-women-who-suffer-an-episode-of-psychosis-during-pregnancy-have-increased-lipid-peroxidation-with-evidence-of-ferroptosis
#31
JOURNAL ARTICLE
Miguel A Ortega, Oscar Fraile-Martinez, Cielo García-Montero, Rosa M Funes Moñux, Sonia Rodriguez-Martín, Coral Bravo, Juan A De Leon-Luis, Jose V Saz, Miguel A Saez, Luis G Guijarro, Guillermo Lahera, Fernando Mora, Sonia Fernandez-Rojo, Javier Quintero, Jorge Monserrat, Natalio García-Honduvilla, Julia Bujan, Melchor Alvarez-Mon, Miguel Angel Alvarez-Mon
Psychosis is a complex entity characterized by psychological, behavioral, and motor alterations resulting in a loss of contact with reality. Although it is not common, pregnancy can be a period in which a first episode of psychosis can manifest, entailing detrimental consequences for both the fetus and the mother. The pathophysiological basis and study of maternofetal wellbeing need to be further elucidated. Lipid peroxidation and ferroptosis are two phenomena that are tightly linked to the placental dysfunction commonly observed in different complications of pregnancy...
January 6, 2023: Biomolecules
https://read.qxmd.com/read/36661650/identification-of-differentially-expressed-genes-related-to-the-lipid-metabolism-of-esophageal-squamous-cell-carcinoma-by-integrated-bioinformatics-analysis
#32
JOURNAL ARTICLE
Meng-Ying Cui, Xing Yi, Dan-Xia Zhu, Jun Wu
PURPOSE: In recent years, lipid metabolism has been reprogrammed to meet the energy and substrate needs of tumorigenesis and development and is a potential new target for cancer treatment. However, the regulatory mechanism of lipid metabolism in esophageal squamous cell carcinoma is not well understood. METHODS: We first downloaded the esophageal squamous cell carcinoma (ESCC) gene dataset in the GEO and TCGA databases and analyzed the central differentially expressed genes (DEGs) of ESCC through bioinformatics...
December 20, 2022: Current Oncology
https://read.qxmd.com/read/36529627/prognostic-role-of-long-chain-acyl-coenzyme-a-synthetase-family-genes-in-patients-with-clear-cell-renal-cell-carcinoma-a-comprehensive-bioinformatics-analysis-confirmed-with-external-validation-cohorts
#33
JOURNAL ARTICLE
Mustafa Zafer Temiz, Aykut Colakerol, Salih Zeki Sonmez, Adem Gokce, Ibrahim Ogulcan Canitez, Sule Ozsoy, Engin Kandirali, Atilla Semercioz, Ahmet Yaser Muslumanoglu
INTRODUCTION: We aimed to determine the prognostic role of long-chain acyl-CoA synthetases (ACSLs) as a disease marker for kidney clear cell carcinoma (KIRC). PATIENTS AND METHODS: The Cancer Genome Atlas (TCGA) data were accessed via open access LinkedOmics database for KIRC. Provisional datasets were used for analysis as previously described and gene expression quantification data were downloaded. The corresponding clinical information of patients also were obtained from the database...
November 23, 2022: Clinical Genitourinary Cancer
https://read.qxmd.com/read/36527851/dietary-t-2-toxin-induces-transcriptomic-changes-in-hepatopancreas-of-chinese-mitten-crab-eriocheir-sinensis-via-nutrition-metabolism-and-apoptosis-related-pathways
#34
JOURNAL ARTICLE
Xiawei Yu, Caiyan Zhang, Keke Chen, Yuan Liu, Ying Deng, Wenbin Liu, Dingdong Zhang, Guangzhen Jiang, Xiangfei Li, Sib Sankar Giri, Se Chang Park, Cheng Chi
Long-term feed route exposure to T-2 toxin was proved to elicit growth retarding effects and induction of oxidative stress and apoptosis in Chinese mitten crab (Eriocheir sinensis). However, no study with a holistic perspective has been conducted to date to further describe the in-depth toxicological mechanism of T-2 toxin in E.sinensis. In this study, an RNA-Sequencing (RNA-seq) was used in this study to investigate the effects of feed supplementation with 0 mg/kg and 4 mg/kg T-2 toxin on the hepatopancreas transcriptome of E...
December 15, 2022: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/36507355/an-update-on-the-therapeutic-implications-of-long-chain-acyl-coenzyme-a-synthetases-in-nervous-system-diseases
#35
REVIEW
Zhimin Wu, Jun Sun, Zhi Liao, Jia Qiao, Chuan Chen, Cong Ling, Hui Wang
Long-chain acyl-coenzyme A synthetases (ACSLs) are a family of CoA synthetases that activate fatty acid (FA) with chain lengths of 12-20 carbon atoms by forming the acyl-AMP derivative in an isozyme-specific manner. This family mainly includes five members (ACSL1, ACSL3, ACSL4, ACSL5, and ACSL6), which are thought to have specific and different functions in FA metabolism and oxidative stress of mammals. Accumulating evidence shows that the dysfunction of ACSLs is likely to affect cell proliferation and lead to metabolic diseases in multiple organs and systems through different signaling pathways and molecular mechanisms...
2022: Frontiers in Neuroscience
https://read.qxmd.com/read/36497375/acsl3-and-acsl4-distinct-roles-in-ferroptosis-and-cancers
#36
REVIEW
Yufei Yang, Ting Zhu, Xu Wang, Fen Xiong, Zhangmin Hu, Xuehan Qiao, Xiao Yuan, Deqiang Wang
The long-chain fatty acyl CoA synthetase (ACSLs) family of enzymes contributes significantly to lipid metabolism and produces acyl-coenzyme A by catalyzing fatty acid oxidation. The dysregulation of ACSL3 and ACSL4, which belong to the five isoforms of ACSLs, plays a key role in cancer initiation, development, metastasis, and tumor immunity and may provide several possible therapeutic strategies. Moreover, ACSL3 and ACSL4 are crucial for ferroptosis, a non-apoptotic cell death triggered by the accumulation of membrane lipid peroxides due to iron overload...
November 29, 2022: Cancers
https://read.qxmd.com/read/36482895/transcript-variants-of-long-chain-acyl-coa-synthase-1-have-distinct-roles-in-sheep-lipid-metabolism
#37
JOURNAL ARTICLE
Yang Cao, Yongsheng Yu, Lichun Zhang, Yu Liu, Kaizhi Zheng, Sutian Wang, Haiguo Jin, Lixiang Liu, Yang Cao
Mutton has recently been identified to be a consumer favorite, and intermuscular fat is the key factor in determining meat tenderness. Long-chain acyl-CoA synthetase 1 (ACSL1) is a vital subtype of the ACSL family that is involved in the synthesis of lipids from acyl-CoA and the oxidation of fatty acids. The amplification of the ACSL1 gene using rapid amplification of cDNA ends revealed that the alternative polyadenylation (APA) results in two transcripts of the ACSL1 gene. Exon 18 had premature termination, resulting in a shorter CDS region...
2022: Frontiers in Genetics
https://read.qxmd.com/read/36407633/functional-study-of-cyp90a1-and-aldh3f1-gene-obtained-by-transcriptome-sequencing-analysis-of-brassica-napus-seedlings-treated-with-brassinolide
#38
JOURNAL ARTICLE
Qingqin Gan, Mingbao Luan, Maolong Hu, Zhongsong Liu, Zhenqian Zhang
Sclerotinia disease and weeds of Brassica napus greatly reduce crop yields. However, brassinolides can improve the resistance of plants to sclerotinia diseases and herbicides. In this study, we investigated the effects of brassinolide on the occurrence, physiological indices, yield, and gene expression of Fanming No. 1 seeds under sclerotinia and glufosinate stress. The results showed that soaking of the seeds in 0.015% brassinolide for 6 h reduced the incidence of sclerotinia by 10%. Additionally, in response to glufosinate stress at the seedling stage, the enzyme activities of catalase and superoxide dismutase increased by 9...
2022: Frontiers in Plant Science
https://read.qxmd.com/read/36338658/acsl3-is-a-potential-prognostic-biomarker-for-immune-infiltration-in-clear-cell-renal-cell-carcinoma
#39
JOURNAL ARTICLE
Chiyu Zhang, Honglin Hu, Ruizhen Huang, Gaomin Huang, Xiaoqing Xi
Objective: Long-chain acyl-coenzyme A synthases (ACSLs) catalyze the activation of fatty acid and are often dysregulated in malignancies. The purpose of this research was to figure out the ACSL3's prognostic value and mechanism in clear cell renal cell carcinoma (ccRCC). Methods: The expression of ACSL3 in ccRCC was investigated in this work using data from the GEO, TCGA, Oncomine and HPA databases. The expression differences of ACSL3 in the cell lines were further detected by qPCR and Western blot...
2022: Frontiers in Surgery
https://read.qxmd.com/read/36192773/acsl3-regulates-lipid-droplet-biogenesis-and-ferroptosis-sensitivity-in-clear-cell-renal-cell-carcinoma
#40
JOURNAL ARTICLE
Timothy D Klasson, Edward L LaGory, Hongjuan Zhao, Star K Huynh, Ioanna Papandreou, Eui Jung Moon, Amato J Giaccia
BACKGROUND: Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, possesses characteristic alterations to multiple metabolic pathways, including the accumulation of cytosolic lipid droplets. However, the pathways that drive lipid droplet accumulation in ccRCC cells and their importance to cancer biology remain poorly understood. METHODS: We sought to identify the carbon sources necessary for lipid droplet accumulation using Oil red O staining and isotope-tracing lipidomics...
October 3, 2022: Cancer & Metabolism
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