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https://read.qxmd.com/read/30770200/the-endometrium-during-and-after-ovarian-hyperstimulation-and-the-role-of-segmentation-of-infertility-treatment
#1
REVIEW
Pedro Montoya-Botero, Nikolaos P Polyzos
Controlled ovarian hyperstimulation (COH) is a crucial part of assisted reproductive technologies (ART) that resulted in a substantial increase in pregnancy rates from in vitro fertilization (IVF). However, in spite of the apparent benefit of COH on an increase in the number of follicles and the number of oocytes retrieved, allowing for extended embryo culture and enabling the selection of the best quality embryo for transfer, several reports has shown that the supraphysiologic hormonal levels may indeed have a detrimental effect at the endometrial level...
September 13, 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
https://read.qxmd.com/read/30755319/making-health-a-shared-value-lessons-from-nurse-designed-models-of-care
#2
Diana J Mason, Grant R Martsolf, Jennifer Sloan, Antonia Villarruel, Cheryl Sullivan
BACKGROUND: Nurse-designed models of community-based care reflect a broad definition of health; family- and community-centricity; relationships; and group and public health approaches. PURPOSE: To examine how nurse-designed models of care have addressed "making health a shared value" based on the framework of the Culture of Health. METHOD: A mixed-methods design included an online survey completed by 37 of 41 of "Edge Runners" (American Academy of Nursing-designated nurse innovators) and telephone interviews with 13 of the 37...
December 27, 2018: Nursing Outlook
https://read.qxmd.com/read/30719388/can-infrared-thermography-be-used-to-monitor-fatigue-during-exercise-a-case-study
#3
Vedran Hadžić, Brane Širok, Aleš Malneršič, Milan Čoh
Background: Infrared thermographic imaging (IRTG) is a safe and reliable technology used to monitor skin temperature. The main aim of our study was to evaluate the relationship between skin temperature changes and muscle fatigue in order to answer the main research question if IRTG can be used to monitor muscle fatigue. Methods: This was a case study performed on a 23-year-old trained middle distance runner. After warm-up the subject was exercising on the dynamometer for 7...
January 2019: Journal of Sport and Health Science
https://read.qxmd.com/read/30711590/high-resolution-prediction-of-organic-matter-concentration-with-hyperspectral-imaging-on-a-sediment-core
#4
Kévin Jacq, Yves Perrette, Bernard Fanget, Pierre Sabatier, Didier Coquin, Ruth Martinez-Lamas, Maxime Debret, Fabien Arnaud
In the case of environmental samples, the use of a chemometrics-based prediction model is highly challenging because of the difficulty in experimentally creating a well-ranged reference sample set. In this study, we present a methodology using short wave infrared hyperspectral imaging to create a partial least squares regression model on a cored sediment sample. It was applied to a sediment core of the well-known Lake Bourget (Western Alps, France) to develop and validate a model for downcore high resolution LOI550 measurements used as a proxy of the organic matter...
January 26, 2019: Science of the Total Environment
https://read.qxmd.com/read/30703687/interactions-of-graphene-derivatives-with-glutamate-neurotransmitter-a-parallel-first-principles-docking-investigation
#5
Mariana Zancan Tonel, Michael González-Durruthy, Ivana Zanella, Solange Binotto Fagan
Glutamate plays an important role in excitatory neurotransmission, learning, and memory processes, and under pathological conditions it is directly associated with several chronic neurological disorders, such as depression, epilepsy, schizophrenia, and Parkinson's. Therefore, the detection and quantification of Glutamate is important for the rapid diagnosis of these diseases. Using first principles and molecular docking simulations we have evaluated the energetic, structural, and binding properties of graphene derivatives, such as pristine graphene (pristine-Gr) and oxidized graphene with carboxylic (Gr-COOH), carbonyl (Gr-COH), hydroxyl (Gr-OH), and epoxy (-O-) groups interacting with the glutamate neurotransmitter...
January 22, 2019: Journal of Molecular Graphics & Modelling
https://read.qxmd.com/read/30700099/the-stock-performance-of-american-companies-investing-in-a-culture-of-health
#6
Ron Z Goetzel, Raymond Fabius, Enid Chung Roemer, Karen B Kent, Jeffrey Berko, Michael A Head, Rachel Mosher Henke
PURPOSE: We investigated the relationship between companies' efforts to build internal (COH-INT) and external cultures of health (COH-EXT) and their stock performance. DESIGN: We administered 2 surveys, which measure companies' programs, policies, and supports for improving the health of their employees and communities. We then compared the companies' stock performance to the Standard and Poor's (S&P) 500 Index from January 2013 through August 2017. SETTING: United States...
January 30, 2019: American Journal of Health Promotion: AJHP
https://read.qxmd.com/read/30645939/computational-in-vitro-toxicology-uncovers-chemical-structures-impairing-mitochondrial-membrane-potential
#7
David Dreier, Nancy D Denslow, Christopher J Martyniuk
Technological advances in molecular biology enable high-throughput screening (HTS) of large chemical libraries. These approaches have provided valuable toxicity data for many physiological responses, including mitochondrial dysfunction. While several quantitative structure-activity relationship (QSAR) models have been developed for mitochondrial dysfunction, there remains a need to identify specific chemical features associated with this response. Thus, the objective of this study was to identify chemical structures associated with altered mitochondrial membrane potential (MMP)...
January 15, 2019: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/30639464/ivf-procedures-are-not-but-subfertility-is-associated-with-neurological-condition-of-9-year-old-offspring
#8
Machiel Drenth Olivares, Derk B Kuiper, Maaike L Haadsma, Kirsten R Heineman, Maas Jan Heineman, Mijna Hadders-Algra
In vitro fertilization (IVF) is not associated with neurological abnormalities in offspring's early childhood. Yet, it is unclear whether this is also true for school age. Neither do we know the role of parental subfertility in offspring's neurological development. The present study examined neurological condition at 9 years of 57 singletons born after controlled ovarian hyperstimulation IVF (COH-IVF), 46 singletons born after modified natural cycle IVF (MNC-IVF) and 66 singletons born to subfertile parents after natural conception (Sub-NC)...
January 9, 2019: Early Human Development
https://read.qxmd.com/read/30637543/activation-of-nrf2-ho-1-pathway-protects-retinal-ganglion-cells-from-a-rat-chronic-ocular-hypertension-model-of-glaucoma
#9
Xue Wang, Zhi-Lan Yuan
OBJECTIVE: The objective of this work was to find out the effects of nuclear factor erythroid 2-related factor/heme oxygenase-1 (Nrf2/HO-1) pathway on retinal ganglion cell (RGC) injury in glaucoma. METHODS: The chronic ocular hypertension (COH) rat models of glaucoma were constructed, and intraocular pressure (IOP) and RGC numbers were detected at different time points. Additionally, rats were divided into normal group (normal control rats), model group (COH model rats), and model + tBHQ group (COH model rats treated with Nrf activator, tBHQ)...
January 12, 2019: International Ophthalmology
https://read.qxmd.com/read/30612423/vitamin-d-improves-the-outcome-of-in-vitro-fertilization-ivf-in-infertile-women-with-polycystic-ovary-syndrome-and-insulin-resistance
#10
Juan Zhao, Shan Liu, Yidan Wang, Peng Wang, Danni Qu, Minghui Liu, Wei Ma, Yuan Li
BACKGROUND: To investigate the effect of vitamin D supplementation upon the outcome of in vitro fertilization (IVF) in infertile women with polycystic ovarian syndrome (PCOS) and insulin resistance (IR). METHODS: Three hundred and five infertile patients with PCOS and insulin resistance undergoing IVF were included in this study. All participants underwent oral glucose tolerance test (OGTT). Insulin resistance was calculated by homeostasis model assessment. Vitamin D status was measured by assessing circulating levels of 25OH-VD in serum samples by radioimmunoassay...
January 4, 2019: Minerva Medica
https://read.qxmd.com/read/30607593/pgr-and-ptx3-gene-expression-in-cumulus-cells-from-obese-and-normal-weighting-women-after-administration-of-long-acting-recombinant-follicle-stimulating-hormone-for-controlled-ovarian-stimulation
#11
Tanja Burnik Papler, Eda Vrtačnik Bokal, Uršula Prosenc Zmrzljak, Martin Stimpfel, Antonio Simone Laganà, Fabio Ghezzi, Nina Jančar
PURPOSE: The present study aimed to determine clinical IVF parameters and gene expression in cumulus cells (CCs) in obese and normal weighting women after administration of 150 mcg of corifollitropin alfa for controlled ovarian hyperstimulation (COH). METHODS: 150 mcg of corifollitropin alfa and gonadotropin releasing hormone antagonist were used for COH. Analysis of CC gene expression was performed using quantitative real-time PCR. RESULTS: We did not find significant differences in biochemical and clinical pregnancy rates between obese and normal weighting women...
January 4, 2019: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/30607580/factors-inducing-decreased-oocyte-maturation-rate-a-retrospective-analysis-of-20-939-icsi-cycles
#12
Yihua Lin, Puyu Yang, Yanrong Chen, Jinliang Zhu, Xinyu Zhang, Caihong Ma
PURPOSE: Decreased oocyte maturation rate (OMR) is associated with worse clinical outcomes in IVF/ICSI cycles. The clinical features inducing decreased OMR remain unknown. The study is designed to explore the factors influencing the incidence of decreased OMR and its effects on clinical outcomes. METHODS: This is a retrospective case-control study analyzing data from 20,939 ICSI cycles in a reproductive center of university affiliated hospital from January 2015 to December 2017...
January 4, 2019: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/30606204/letrozole-associated-controlled-ovarian-hyperstimulation-in-breast-cancer-patients-versus-conventional-controlled-ovarian-hyperstimulation-in-infertile-patients-assessment-of-oocyte-quality-related-biomarkers
#13
Oranite Goldrat, Geraldine Van Den Steen, Eric Gonzalez-Merino, Julie Dechène, Christine Gervy, Anne Delbaere, Fabienne Devreker, Viviane De Maertelaer, Isabelle Demeestere
BACKGROUND: Fertility preservation (FP) protocols in case of breast cancer (BC) include mature oocyte cryopreservation following letrozole associated controlled ovarian hyperstimulation (Let-COH). To date, the impact of Let-COH on the follicular microenvironment has been poorly investigated, although a high androgen/estrogen ratio was previously associated with low oocyte quality. METHODS: In this prospective study, follicular fluid (FF) steroid levels (estradiol, testosterone, progesterone) and cumulus cell (CC) gene expression related to oocyte quality (HAS2, PTGS2, GREM1) were compared between 23 BC patients undergoing Let-COH for FP and 24 infertile patients undergoing conventional COH without letrozole...
January 3, 2019: Reproductive Biology and Endocrinology: RB&E
https://read.qxmd.com/read/30583826/-the-histopathology-and-immunohistochemistry-of-granular-cell-tumour-a-study-of-12-cases-with-a-brief-historical-note
#14
Carlos Ortiz-Hidalgo, Christian Lisette Frías-Soria
INTRODUCTION AND OBJECTIVE: Granular cell tumour (GCT) is a benign neoplasm of neural/schwannian origin, usually presenting as a single asymptomatic lesion, mainly located in the dermis and subcutaneous tissue or submucosa, although multiple tumours may occur. Microscopically, GCTs are composed of large cells with abundant eosinophilic, granular cytoplasm arranged in sheets, nests, cords or trabeculae. Based on the cytological characteristics and the presence of necrosis, three types are recognized: benign, atypical and malignant...
January 2019: Revista Española de Patología
https://read.qxmd.com/read/30557803/composition-and-origin-of-pm-2-5-in-mediterranean-countryside
#15
D Atzei, P Fermo, R Vecchi, M Fantauzzi, V Comite, G Valli, F Cocco, A Rossi
In this work PM2.5 was collected during winter and summer in a Sardinian village (Gonnostramatza, Italy) highly affected by biomass burning emissions. A multi-technique approach was adopted for the complete PM chemical characterization. The bulk characterization was performed by IC (Ion Chromatography), HPAEC (High-Performance Anion-Exchange Chromatography), TOT (Thermal Optical Transmittance) and ED-XRF (Energy-Dispersive X-Ray Fluorescence) while XPS (X-ray Photoelectron Spectroscopy) was used for the surface characterization...
December 8, 2018: Environmental Pollution
https://read.qxmd.com/read/30480769/in-vitro-maturation-in-subfertile-women-with-polycystic-ovarian-syndrome-undergoing-assisted-reproduction
#16
REVIEW
Charalampos S Siristatidis, Abha Maheshwari, Dennis Vaidakis, Siladitya Bhattacharya
BACKGROUND: Polycystic ovarian syndrome (PCOS) occurs in 4% to 7% of all women of reproductive age and 50% of women presenting with subfertility. Subfertility affects 15% to 20% of couples trying to conceive. A significant proportion of these women ultimately need assisted reproductive technology (ART). In vitro fertilisation (IVF) is one of the assisted reproduction techniques employed to raise the chances of achieving a pregnancy. For the standard IVF technique, stimulating follicle development and growth before oocyte retrieval is essential, for which a large number of different methods combining gonadotrophins with a gonadotrophin-releasing hormone (GnRH) agonist or antagonist are used...
November 15, 2018: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/30466259/valence-and-inner-electronic-excitation-ionization-and-fragmentation-of-perfluoropropionic-acid
#17
Yanina Berrueta Martínez, Yanina Belén Bava, Reinaldo Luiz Cavasso Filho, Mauricio Federico Erben, Rosana Mariel Romano, Carlos Omar Della Védova
The photoexcitation, photoionization and photofragmentation of gaseous CF3CF2C(O)OH were studied by means of synchrotron radiation in the valence and inner energy regions. Photofragmentation events were detected from 11.7 eV through formation of COH+, C2F4+ and the parent species M+. Since the vertical ionization potential has been reported at 11.94 eV, the starting energy used in this study, 11.7 eV, falls just inside the tale of the ionization band in the photoelectron spectra. Together, therefore, with the foremost ionization process, autoionization or adiabatic ionization cannot be discounted in order to explain the observed production of ions...
November 22, 2018: Journal of Physical Chemistry. A
https://read.qxmd.com/read/30446124/exploring-the-hydrogen-bond-structures-in-sodium-alginate-through-two-dimensional-correlation-infrared-spectroscopy
#18
Lei Hou, Peiyi Wu
In this paper, the heat-induced hydrogen bonding evolution in the sodium alginate (SA) film is explored mainly by FTIR spectroscopy in combination with perturbation correlation moving window (PCMW) technique and 2D correlation spectroscopy (2Dcos). Due to the strong hydrophilicity, hydrogen bonds formed between water molecules and polar groups (including OH and COO- ) along SA chains hold an predominant role at room temperature, which is believed to disrupt the inter/intra-molecular hydrogen bonding in SA chains...
February 1, 2019: Carbohydrate Polymers
https://read.qxmd.com/read/30430883/gnrh-antagonist-versus-follicular-phase-single-dose-gnrh-agonist-protocol-in-patients-of-normal-ovarian-responses-during-controlled-ovarian-stimulation
#19
Yudi Geng, Yang Xun, Shiqiao Hu, Qiaohong Lai, Lei Jin
OBJECTIVE: This study aims to explore the differences of the ovarian stimulation (OS) characteristics, laboratory, and clinical outcomes between follicular-phase single-dose gonadotropin-releasing hormone (GnRH) agonist protocol and GnRH antagonist protocol during controlled ovarian hyperstimulation (COH). METHODS: About 1883 consecutive IVF/ICSI fresh cycles of normal ovarian responders were retrospectively analyzed, with 1229 in the single-dose GnRH agonist protocol group and 654 in the GnRH antagonist protocol group at Reproductive Medical Center of Tongji Hospital from 1 January 2014 to 31 December 2017...
November 15, 2018: Gynecological Endocrinology
https://read.qxmd.com/read/30406448/could-polymorphisms-of-some-hormonal-receptor-genes-involved-in-folliculogenesis-help-in-predicting-patient-response-to-controlled-ovarian-stimulation
#20
Maruška Čuš, Veljko Vlaisavljević, Katja Repnik, Uroš Potočnik, Borut Kovačič
PURPOSE: The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in selected genes, responsible for hormonal regulation of folliculogenesis, are associated with response to controlled ovarian hyperstimulation (COH) and clinical characteristics of women enrolled in in vitro fertilization (IVF) programs. METHODS: In a cross-sectional study, 60 (IVF) patients underwent COH by using gonadotropin-releasing hormone (GnRH) antagonist and recombinant follicle-stimulating hormone (rFSH) protocol...
November 8, 2018: Journal of Assisted Reproduction and Genetics
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