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https://read.qxmd.com/read/30762998/-iron-deficiency-with-and-without-anemia-in-children-a-brief-update-for-caregivers
#1
Veneranda Mattiello, Stéphane Sizonenko, Fréderic Baleydier, Fanette Bernard, Manuel Diezi, Raffaele Renella
Non anemic iron deficiency (NAID) is the most common nutritional deficiency. Symptoms more frequently observed in children and adolescents include fatigue, delayed psychomotor development as well as decreased school and athletic performances. Iron treatment is effective in improving symptoms in older children and adolescents. In children under 2 years of age, there is currently no evidence of the efficacy of substitution therapy on development. Preemptive treatment is not justified considering the available evidence beyond premature or small newborns for gestational age and should only be initiated if a diagnosis of iron deficiency is confirmed...
February 13, 2019: Revue Médicale Suisse
https://read.qxmd.com/read/30761881/iron-supplementation-should-be-given-in-breath-holding-spells-regardless-of-anemia
#2
Gürkan Gürbüz, Peren Perk, Turgay Çokyaman, Özge Berfu Gürbüz
Background/aim: The purpose of this retrospective study was to determine the effectiveness of oral iron therapy in breath-holding spells and evaluation of electrocardiographical changes Materials and methods: Three hundred twelve children aged 1–48 months and diagnosed with breath-holding spells between January 2017 and April 2018 were included. Patients’ laboratory findings were compared with 100 patients who had one simple febrile seizure. Results: Cyanotic breath-holding spells were diagnosed in 85...
February 11, 2019: Turkish Journal of Medical Sciences
https://read.qxmd.com/read/30759887/a-randomized-feeding-trial-of-iron-biofortified-beans-on-school-children-in-mexico
#3
Julia L Finkelstein, Saurabh Mehta, Salvador Villalpando, Veronica Mundo-Rosas, Sarah V Luna, Maike Rahn, Teresa Shamah-Levy, Stephen E Beebe, Jere D Haas
Iron deficiency is a major public health problem worldwide, with the highest burden among children. The objective of this randomized efficacy feeding trial was to determine the effects of consuming iron-biofortified beans (Fe-Beans) on the iron status in children, compared to control beans (Control-Beans). A cluster-randomized trial of biofortified beans ( Phaseolus vulgaris L ), bred to enhance iron content, was conducted over 6 months. The participants were school-aged children ( n = 574; 5⁻12 years), attending 20 rural public boarding schools in the Mexican state of Oaxaca...
February 12, 2019: Nutrients
https://read.qxmd.com/read/30746372/celiac-crisis-a-rare-occurrence-in-adult-celiac-disease-a-systematic-review
#4
Daniel Vasile Balaban, Alina Dima, Ciprian Jurcut, Alina Popp, Mariana Jinga
BACKGROUND: Celiac crisis (CC), a potentially life-threatening condition, is one of the rare clinical presentations of celiac disease (CD). Several cases have been documented in the literature, mostly in children. AIM: To perform a review of CC cases reported in adult CD patients. METHODS: A systematic search of the literature was conducted in two databases, PubMed/MEDLINE and EMBASE, using the term "celiac crisis" and its variant "coeliac crisis", from January 1970 onwards...
February 6, 2019: World Journal of Clinical Cases
https://read.qxmd.com/read/30742355/high-burden-of-subclinical-cardiovascular-target-organ-damage-after-pediatric-liver-transplantation
#5
Nima Memaran, Bianca Borchert-Mörlins, Bernhard M W Schmidt, Rizky I Sugianto, Hannes Wilke, Ricarda Blöte, Ulrich Baumann, Elena Bauer, Anika von Wick, Norman Junge, Christoph Leiskau, Eva D Pfister, Daniela Thurn-Valsassina, Nicolas Richter, Imeke Goldschmidt, Anette Melk
Cardiovascular (CV) events account for 8% to 13% of deaths after liver transplantation (LT) in adulthood. Although CV risk factors are present, little is known about the prevalence of subclinical CV target organ damage in children after LT. The aim of this prospective observational study was to assess the prevalence of subclinical CV target organ damage in children after LT and to identify risk factors contributing to CV damage as potential targets for clinical intervention. In this study, 104 children after LT (54% female, 46% male, aged 11...
February 11, 2019: Liver Transplantation
https://read.qxmd.com/read/30740989/circulating-microparticles-in-children-with-sickle-cell-anemia-in-a-tertiary-center-in-upper-egypt
#6
Asmaa M Zahran, Khalid I Elsayh, Khaled Saad, Mostafa M Embaby, Mervat A M Youssef, Yasser F Abdel-Raheem, Shaban M Sror, Shereen M Galal, Helal F Hetta, Mohamed Diab Aboul-Khair, Mohamd A Alblihed, Amira Elhoufey
Sickle cell disease (SCD) is a genetically inherited hemolytic anemia increasingly appreciated as a chronic inflammatory condition and hypercoagulable state with high thrombotic risk. It is associated with disturbed immune phenotype and function and circulating microparticles (MPs) derived from multiple cell sources. This study was carried out to determine MPs profiles in patients with sickle cell anemia (either on hydroxyurea (HU) therapy or those with no disease-modifying therapy) and to compare these profiles with healthy children...
January 2019: Clinical and Applied Thrombosis/hemostasis
https://read.qxmd.com/read/30735503/multiple-micronutrient-status-and-predictors-of-anemia-in-young-children-aged-12-23-months-living-in-new-delhi-india
#7
Lisa A Houghton, Geeta Trilok-Kumar, Deborah McIntosh, Jillian J Haszard, Michelle J Harper, Malcolm Reid, Juergen Erhardt, Karl Bailey, Rosalind S Gibson
Anemia has been identified as a severe public health concern among young children in India, however, information on the prevalence of anemia attributed to micronutrient deficiencies is lacking. We aimed to assess multiple micronutrient status (iron, zinc, selenium, vitamin A, vitamin D, folate and vitamin B12) in young Indian children and to investigate the role of these seven micronutrients and other non-nutritional factors on hemoglobin concentrations and anemia. One-hundred and twenty children aged 12 to 23 months were included in a cross-sectional nutritional assessment survey, of which 77 children provided a blood sample...
2019: PloS One
https://read.qxmd.com/read/30734697/genetic-markers-of-benzimidazole-resistance-among-human-hookworms-necator-americanus-in-kintampo-north-municipality-ghana
#8
Ambrose R Orr, Josephine E Quagraine, Peter Suwondo, Santosh George, Lisa M Harrison, Fabio Pio Dornas, Benjamin Evans, Adalgisa Caccone, Debbie Humphries, Michael D Wilson, Michael Cappello
Hookworm infection causes anemia, malnutrition, and growth delay, especially in children living in sub-Saharan Africa. The World Health Organization recommends periodic mass drug administration (MDA) of anthelminthics to school-age children (SAC) as a means of reducing morbidity. Recently, questions have been raised about the effectiveness of MDA as a global control strategy for hookworms and other soil-transmitted helminths (STHs). Genomic DNA was extracted from Necator americanus hookworm eggs isolated from SAC enrolled in a cross-sectional study of STH epidemiology and deworming response in Kintampo North Municipality, Ghana...
February 2019: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/30734129/helicobacter-pylori-infection-in-children-an-overview-of-diagnostic-methods
#9
REVIEW
Parisa Sabbagh, Mostafa Javanian, Veerendra Koppolu, VeneelaKrishna Rekha Vasigala, Soheil Ebrahimpour
Children differ from adults regarding Helicobacter pylori (H. pylori) infection in many terms. H. pylori infection represents a key factor in the pathogenesis of duodenal ulcer and chronic gastritis in children. H. pylori infection causes some extraintestinal diseases as well as gastrointestinal diseases. Although, among these illnesses in children, symptoms like recurrent abdominal pain are not specific. Moreover, the role of the pathogen in the growth faltering, iron deficiency anemia, and asthma still remains controversial...
February 7, 2019: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/30733916/a-different-clinical-presentation-of-heiner-syndrome-the-case-of-diffuse-alveolar-hemorrhage-causing-massive-hemoptysis-and-hematemesis
#10
Ayse Selcan Koc, Asena Sucu, Umit Celik
Heiner syndrome is a non-IgE-mediated hypersensitivity to cow's milk, which often causes pulmonary disease in infants and young children. Patients often have symptoms of chronic or recurrent upper or lower respiratory tract infection. It has been reported that the Heiner's syndrome can cause recurrent pulmonary hemorrhage, and it is difficult to differentiate from the entity of idiopathic pulmonary hemosiderosis, another disease with recurrent pulmonary hemorrhage of unknown etiology usually occurring in the older children...
2019: Respiratory Medicine Case Reports
https://read.qxmd.com/read/30733275/rapid-growth-is-a-dominant-predictor-of-hepcidin-suppression-and-declining-ferritin-in-gambian-infants
#11
Andrew E Armitage, Schadrac C Agbla, Modupeh Betts, Ebrima A Sise, Momodou W Jallow, Ellen Sambou, Bakary Darboe, Archibald Worwui, George M Weinstock, Martin Antonio, Sant-Rayn Pasricha, Andrew M Prentice, Hal Drakesmith, Momodou K Darboe, Brenda Anna Kwambana-Adams
Iron deficiency and iron deficiency anemia are highly prevalent in low-income countries, especially among young children. Hepcidin is the major regulator of systemic iron homeostasis. It controls dietary iron absorption, dictates whether absorbed iron is made available in circulation for erythropoiesis and other iron-demanding processes, and predicts response to oral iron supplementation. Understanding how hepcidin is itself regulated is therefore important, especially in young children. We investigated how changes in iron-related parameters, inflammation and infection status, season and growth influenced plasma hepcidin and ferritin concentrations during infancy using longitudinal data from two birth-cohorts of rural Gambian infants (N=114 and N=193)...
February 7, 2019: Haematologica
https://read.qxmd.com/read/30721650/transspinal-delivery-of-drugs-by-transdermal-patch-back-of-neck-for-alzheimer-s-disease-a-new-route-of-administration
#12
Steven Lehrer, Peter H Rheinstein
NSAIDs may prevent Alzheimer's disease (AD) but have failed as a treatment, possibly because only 1-2% of an oral NSAID dose reaches the brain. This minuscule dose is enough to have a preventative effect on Alzheimer's disease but not to treat it. We propose a new route of administration for drugs to treat AD: transspinal delivery by transdermal patch over the back-of-neck/cervical spine. The drug would diffuse from the patch through the intervertebral spaces, penetrate the dura, enter the CSF, and reach the brain...
January 2019: Discovery Medicine
https://read.qxmd.com/read/30709626/reprogramming-of-bone-marrow-derived-mesenchymal-stromal-cells-to-human-induced-pluripotent-stem-cells-from-pediatric-patients-with-hematological-diseases-using-a-commercial-mrna-kit
#13
Irene Sfougataki, Ioannis Grafakos, Ioanna Varela, Anastasios Mitrakos, Angeliki Karagiannidou, Marianna Tzannoudaki, Myrto Poulou, Anny Mertzanian, Maria Roubelakis G, Kalliope Stefanaki, Joanne Traeger-Synodinos, Emmanuel Kanavakis, Vasiliki Kitra, Maria Tzetis, Evgenios Goussetis
The potential use of patient-specific induced pluripotent stem cells (hiPSCs) in the study and treatment of hematological diseases requires the setup of efficient and safe protocols for hiPSC generation. We aimed to adopt a reprogramming method for large-scale production of integration-free patient-specific hiPSC-lines in our stem cell processing laboratory, which supports a pediatric hematopoietic stem cell transplant unit located at a tertiary care children's hospital. We describe our 5-year experience in generation of hiPSC-lines from human bone marrow-derived mesenchymal stromal cells (BM-MSCs) using synthetic mRNAs encoding reprogramming factors...
January 24, 2019: Blood Cells, Molecules & Diseases
https://read.qxmd.com/read/30706046/engagement-in-agriculture-protects-against-food-insecurity-and-malnutrition-in-peri-urban-nepal
#14
Corrina Moucheraud, Ram K Chandyo, Sigrun Henjum, Tor A Strand, Manjeswori Ulak, Wafaie W Fawzi, Lindsey M Locks, Patrick Webb, Andrew L Thorne-Lyman
Background: Urbanization is occurring rapidly in many low- and middle-income countries, which may affect households' livelihoods, diet, and food security and nutritional outcomes. Objective: The main objective of our study was to explore whether agricultural activity among a peri-urban population in Nepal was associated with better or worse food household security, household and maternal dietary diversity, and nutritional outcomes for children and women. Methods: A cross-sectional survey was administered to 344 mother-child pairs in Bhaktapur district, Nepal, including data on household agricultural practices, livestock ownership, food security, dietary diversity and expenditures, anthropometric measurements of children (aged 5-6 y), maternal body mass index (BMI), and maternal anemia...
January 2019: Current developments in nutrition
https://read.qxmd.com/read/30704661/pediatric-screening-development-anemia-and-lead
#15
REVIEW
Sarah K Wood, Randi Sperling
Screening and prevention are important components of general pediatric health care. Infants and young children should be screened for iron deficiency anemia, lead poisoning, and developmental disorders as essential parts of the well-child visit. Developmental and behavioral screening early in childhood is necessary to identify developmental delays and facilitate timely treatment. Lead screening is recommended for at-risk pediatric patients to treat children with elevated lead levels. Infants and children are also at risk for iron deficiency anemia and must be screened appropriately...
March 2019: Primary Care
https://read.qxmd.com/read/30700948/heart-failure-in-ethiopian-children-mirroring-the-unmet-cardiac-services
#16
Bezaye Nigussie, Henok Tadele
Background: HeartFailure (HF) is a progressive clinical and pathophysiological syndrome caused by cardiovascular and noncardiovascular abnormalities. Childhood HF has not been well studied in Sub-Sharan Africa, particularly in Ethiopia. Hence, this study aimed at describing the pattern and outcome of pediatrics HF at a referral-teaching hospital. Methods: Medical records of 216 HF children aged 2 months to 14 years, and admitted between January 2014 and January 2016 were reviewed...
January 2019: Ethiopian Journal of Health Sciences
https://read.qxmd.com/read/30700693/association-of-appendicitis-helicobacter-pylori-positive-gastritis-and-thrombotic-thrombocytopenic-purpura-in-an-adolescent
#17
Adela Arapović, Sandra Prgomet, Marijan Saraga, Tanja Kovačević, Zoltán Prohászka, Ranka Despot, Eugenija Marušić, Josipa Radić
BACKGROUND Thrombotic thrombocytopenic purpura (TTP) in children is a rare life-threatening syndrome, characterized by microangiopathic hemolytic anemia, thrombocytopenia with renal dysfunction, neurologic symptoms, and fever. TTP is usually caused by deficient activity of von Willebrand factor cleaving protease (ADAMTS13), due to either gene mutations or acquired via anti-ADAMTS13 autoantibodies. It can be triggered by bone marrow or solid organ transplantation, cardiothoracic-, abdominal-, and orthopedic surgeries, infections including very rarely Helicobacter pylori infection...
January 31, 2019: American Journal of Case Reports
https://read.qxmd.com/read/30700016/anemia-and-iron-deficiency-in-children-with-chronic-kidney-disease-ckd-data-from-the-know-ped-ckd-study
#18
Keum Hwa Lee, Eujin Park, Hyun Jin Choi, Hee Gyung Kang, Il-Soo Ha, Hae Il Cheong, Young Seo Park, Heeyeon Cho, Kyoung Hee Han, Seong Heon Kim, Min Hyun Cho, Joo Hoon Lee, Jae Il Shin
Children with chronic kidney disease (CKD) are at high risk of anemia, an important risk factor for cardiovascular disease and poor quality of life. The present study used baseline data from the Korean cohort study for Outcome in patients With Pediatric Chronic Kidney Disease (KNOW-PedCKD). A Total of 437 patients was included in the analyses excluding missing data. The characteristics of patients with and without anemia and those of patients with and without iron deficiency were compared. Logistic regression analysis and Pearson correlation were conducted to evaluate associated risk factors and correlations in children with CKD...
January 29, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/30696314/effects-of-birth-spacing-on-adverse-childhood-health-outcomes-evidence-from-34-countries-in-sub-saharan-africa
#19
Sanni Yaya, Olalekan A Uthman, Michael Ekholuenetale, Ghose Bishwajit, Vissého Adjiwanou
BACKGROUND: Interpregnancy intervals (IPI) are independently associated with maternal, perinatal, infant and child outcomes. Birth spacing is a recommended tool to reduce adverse health outcomes especially among children. This study aims to determine the prevalence of adverse child health outcomes in sub-Saharan Africa (SSA) countries and to examine the association between the length of preceding birth interval child health outcomes. METHODS: Secondary data from Demographic and Health Survey (DHS) in 34 SSA countries with 299 065 births was used in this study...
January 29, 2019: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/30691686/clonal-hematopoiesis-pre-cancer-plus
#20
Alexander J Silver, Siddhartha Jaiswal
Clonal hematopoiesis is a common, age-related process in which a somatically mutated hematopoietic precursor gives rise to a genetically distinct subpopulation in the blood. This phenomenon has been observed in populations across the globe and, while virtually non-existent in children is estimated to affect >10% of the 70-and-older age group. The mutations are thought to occur in stem cells, which makes them pre-cancerous, and precursors to cancer stem cells. Many of the genes most commonly mutated in clonal hematopoiesis are also recurrently mutated in leukemia, genes such as DNMT3A, TET2, ASXL1, JAK2, and TP53...
2019: Advances in Cancer Research
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