keyword
https://read.qxmd.com/read/38378812/understanding-social-and-clinical-associations-with-unemployment-for-people-with-schizophrenia-and-bipolar-disorders-large-scale-health-records-study
#21
JOURNAL ARTICLE
Natasha Chilman, Dionne Laporte, Sarah Dorrington, Stephani L Hatch, Craig Morgan, Celestin Okoroji, Robert Stewart, Jayati Das-Munshi
PURPOSE: People with severe mental illness (SMI) experience high levels of unemployment. We aimed to better understand the associations between clinical, social, and demographic inequality indicators and unemployment. METHODS: Data were extracted from de-identified health records of people with SMI in contact with secondary mental health services in south London, UK. A Natural Language Processing text-mining application was applied to extract information on unemployment in the health records...
February 20, 2024: Social Psychiatry and Psychiatric Epidemiology
https://read.qxmd.com/read/38369499/how-changes-in-depression-severity-and-borderline-personality-disorder-intensity-are-linked-a-cohort-study-of-depressed-patients-with-and-without-borderline-personality-disorder
#22
JOURNAL ARTICLE
John J Söderholm, J Lumikukka Socada, Jesper Ekelund, Erkki Isometsä
BACKGROUND: Borderline personality disorder (BPD) is often complicated by comorbid major depressive episodes (MDEs), which can occur as part of major depressive disorder (MDD) or bipolar disorder (BD). Such comorbidity is related to worse outcomes in both disorders. Subsyndromal features of BPD are also common in depression. However, studies of simultaneous changes in BPD and depression severities are scarce, and their interactions are poorly understood. AIMS: Studying the associations between changes in BPD and depression symptoms over the course of an MDE...
February 19, 2024: Borderline Personality Disorder and Emotion Dysregulation
https://read.qxmd.com/read/38368745/transcriptome-profiling-as-a-biological-marker-for-bipolar-disorder-sub-phenotypes
#23
JOURNAL ARTICLE
Joanna Pawlak, Aleksandra Szczepankiewicz, Maria Skibińska, Beata Narożna, Paweł Kapelski, Przemysław Zakowicz, Karolina Gattner, Dominik Spałek, Łukasz Mech, Monika Dmitrzak-Węglarz
PURPOSE: Bipolar affective disorder (BP) causes major functional impairment and reduced quality of life not only for patients, but also for many close relatives. We aimed to investigate mRNA levels in BP patients to find differentially expressed genes linked to specific clinical course variants; assuming that several gene expression alterations might indicate vulnerability pathways for specific course and severity of the disease. MATERIALS: We searched for up- and down-regulated genes comparing patients with diagnosis of BP type I (BPI) vs type II (BPII), history of suicide attempts, psychotic symptoms, predominance of manic/hypomanic episodes, and history of numerous episodes and comorbidity of substance use disorders or anxiety disorders...
February 17, 2024: Advances in Medical Sciences
https://read.qxmd.com/read/38365101/psychiatric-disorders-and-mortality-due-to-external-causes-following-diagnosis-of-endometriosis-at-young-age-a-longitudinal-register-based-cohort-study-in-finland
#24
JOURNAL ARTICLE
Elina Rasp, Liisu Saavalainen, Anna But, Mika Gissler, Päivi Härkki, Oskari Heikinheimo, Kristiina Rönö
BACKGROUND: Endometriosis diagnosed in adults is associated with increased risk of various psychiatric disorders. However, little is known concerning psychiatric comorbidity and mortality due to external causes associated with endometriosis diagnosed at a young age. OBJECTIVE(S): In this longitudinal cohort study, we investigated the link between surgical diagnosis of endometriosis at a young age, and subsequent psychiatric disorders and mortality due to external causes...
February 14, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38359838/psilocybin-assisted-psychotherapy-for-treatment-resistant-depression-a-randomized-clinical-trial-evaluating-repeated-doses-of-psilocybin
#25
RANDOMIZED CONTROLLED TRIAL
Joshua D Rosenblat, Shakila Meshkat, Zoe Doyle, Erica Kaczmarek, Ryan M Brudner, Kevin Kratiuk, Rodrigo B Mansur, Christian Schulz-Quach, Rickinder Sethi, Amanda Abate, Shaun Ali, Jordan Bawks, Marc G Blainey, Elisa Brietzke, Victoria Cronin, Jessica Danilewitz, Shalini Dhawan, Anthony Di Fonzo, Melissa Di Fonzo, Pawel Drzadzewski, William Dunlop, Hajnalka Fiszter, Fabiano A Gomes, Smrita Grewal, Marisa Leon-Carlyle, Marilyn McCallum, Niki Mofidi, Hilary Offman, Jeremy Riva-Cambrin, Joel Schmidt, Mark Smolkin, Joan M Quinn, Andrea Zumrova, Michelle Marlborough, Roger S McIntyre
BACKGROUND: Psilocybin-assisted psychotherapy (PAP) has been associated with antidepressant effects. Trials to date have typically excluded participants with complex presentations. Our aim was to determine the feasibility of PAP in a complex population, including high levels of treatment resistance in major depressive and bipolar disorder and patients with baseline suicidality and significant comorbidity. We also evaluated flexible repeated doses over a 6-month period. METHODS: Adults with treatment-resistant depression as part of major depressive or bipolar II disorder without psychosis or a substance use disorder were eligible to participate...
March 8, 2024: Med
https://read.qxmd.com/read/38355785/key-subphenotypes-of-bipolar-disorder-are-differentially-associated-with-polygenic-liabilities-for-bipolar-disorder-schizophrenia-and-major-depressive-disorder
#26
JOURNAL ARTICLE
Jie Song, Lina Jonsson, Yi Lu, Sarah E Bergen, Robert Karlsson, Erik Smedler, Katherine Gordon-Smith, Ian Jones, Lisa Jones, Nick Craddock, Patrick F Sullivan, Paul Lichtenstein, Arianna Di Florio, Mikael Landén
Bipolar disorder (BD) features heterogenous clinical presentation and course of illness. It remains unclear how subphenotypes associate with genetic loadings of BD and related psychiatric disorders. We investigated associations between the subphenotypes and polygenic risk scores (PRS) for BD, schizophrenia, and major depressive disorder (MDD) in two BD cohorts from Sweden (N = 5180) and the UK (N = 2577). Participants were assessed through interviews and medical records for inter-episode remission, psychotic features during mood episodes, global assessment of functioning (GAF, function and symptom burden dimensions), and comorbid anxiety disorders...
February 14, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38343859/application-of-polygenic-scores-to-a-deeply-phenotyped-sample-enriched-for-substance-use-disorders-reveals-extensive-pleiotropy-with-psychiatric-and-medical-traits
#27
Emily E Hartwell, Zeal Jinwala, Jackson Milone, Sarah Ramirez, Joel Gelernter, Henry R Kranzler, Rachel L Kember
Co-occurring psychiatric, medical, and substance use disorders (SUDs) are common, but the complex pathways leading to such comorbidities are poorly understood. A greater understanding of genetic influences on this phenomenon could inform precision medicine efforts. We used the Yale-Penn dataset, a cross-sectional sample enriched for individuals with SUDs, to examine pleiotropic effects of genetic liability for psychiatric and medical traits. Participants completed an in-depth interview that provides information on demographics, environment, medical illnesses, and psychiatric and SUDs...
January 23, 2024: medRxiv
https://read.qxmd.com/read/38337367/the-impact-of-complex-ptsd-on-suicide-risk-in-patients-with-bipolar-disorder-a-cross-sectional-study
#28
JOURNAL ARTICLE
Anna Maria Iazzolino, Marta Valenza, Martina D'Angelo, Grazia Longobardi, Valeria Di Stefano, Giulia Visalli, Luca Steardo, Caterina Scuderi, Luca Steardo
BACKGROUND: Patients with bipolar disorder (BD) are more likely than the general population to experience traumatic events, particularly during childhood, and these may predict and be a risk factor for the development of complex PTSD (cPTSD). The presence of multiple traumas plays a relevant role from a psychopathological point of view, but little is known about the effect this may have on suicide attempts in patients with BD. METHODS: A cross-sectional study was conducted comparing socio-demographic and clinical characteristics, recruiting 344 patients diagnosed with BD I and II, screened for the presence (or absence) of cPTSD using the International Trauma Questionnaire (ITQ)...
January 24, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38334088/in-memoriam-professor-joseph-biederman-s-contributions-to-child-and-adolescent-psychiatry
#29
JOURNAL ARTICLE
Stephen V Faraone, Jeffrey H Newcorn, Janet Wozniak, Gagan Joshi, Barbara Coffey, Mai Uchida, Timothy Wilens, Craig Surman, Thomas J Spencer
OBJECTIVE: To provide an overview of Joe Biederman's contributions to child and adolescent psychiatry. METHOD: Nine colleagues described his contributions to: psychopharmacology, comorbidity and genetics, pediatric bipolar disorder, autism spectrum disorders, Tourette's and tic disorders, clinical and neuro biomarkers for pediatric mood disorders, executive functioning, and adult ADHD. RESULTS: Joe Biederman left us with many concrete indicators of his contributions to child and adolescent psychiatry...
February 9, 2024: Journal of Attention Disorders
https://read.qxmd.com/read/38332338/the-natural-history-of-lifetime-psychiatric-disorders-in-patients-with-obsessive-compulsive-disorder-followed-over-half-a-century
#30
JOURNAL ARTICLE
Isak Fredén Klenfeldt, Gunnar Skoog, Johan Skoog, Ingmar Skoog
OBJECTIVE: Few long-term studies have examined the life-time prevalence of comorbid psychiatric conditions in patients with obsessive-compulsive disorder (OCD). We therefore studied the frequency of comorbid psychiatric disorders, and their relation to onset and prognosis, in patients with OCD who were followed for almost half a century. METHODS: During 1947-1953, 285 OCD patients were admitted as inpatients to a university hospital in Gothenburg, Sweden. Among those, 251 (88%) accepted a structured comprehensive psychiatric examination in 1954-1956...
February 8, 2024: Acta Psychiatrica Scandinavica
https://read.qxmd.com/read/38331126/a-narrative-review-on-insomnia-and-hypersomnolence-within-major-depressive-disorder-and-bipolar-disorder-a-proposal-for-a-novel-psychometric-protocol
#31
REVIEW
Claudia Savia Guerrera, Francesco Maria Boccaccio, Simone Varrasi, Giuseppe Alessio Platania, Marinella Coco, Concetta Pirrone, Sabrina Castellano, Filippo Caraci, Raffaele Ferri, Giuseppe Lanza
Sleep disorders have become increasingly prevalent, with many adults worldwide reporting sleep dissatisfaction. Major Depressive Disorder (MDD) and Bipolar Disorder (BD) are common conditions associated with disrupted sleep patterns such as insomnia and hypersomnolence. These sleep disorders significantly affect the progression, severity, treatment, and outcome of unipolar and bipolar depression. While there is evidence of a connection between sleep disorders and depression, it remains unclear if sleep features differ between MDD and BD...
February 6, 2024: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/38330355/disinhibited-attachment-behavior-among-infants-reared-at-home-relations-to-maternal-severe-mental-illness-and-personality-disorder-symptoms
#32
JOURNAL ARTICLE
Sofie Stender, Kirstine A Davidsen, Karlen Lyons-Ruth, Susanne Harder
Disinhibited attachment behavior (DAB) among infants is persistent and associated with behavioral and relational problems throughout childhood and adolescence. Little is known about risk factors for DAB among infants reared at home, although studies have linked DAB with maternal psychiatric hospitalization and maternal borderline personality disorder. The aim of the current study was to further assess the association between DAB, maternal severe mental illness (SMI; schizophrenia, bipolar disorder, and depression), and maternal PD symptoms...
February 8, 2024: Personality Disorders
https://read.qxmd.com/read/38317665/association-of-chronic-obstructive-pulmonary-disease-with-risk-of-psychiatric-disorders-a-two-sample-mendelian-randomization-study
#33
JOURNAL ARTICLE
Qinxia Zhang, Haifu Zhang, Qinxing Xu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disorder often accompanied by comorbidities. Although the past few years have witnessed significant scientific progress, the potential relationship between COPD and mental illness remains a subject of debate. MATERIALS AND METHODS: We retrieved COPD data from the genome-wide association studies (GWAS) directory and data on mental illnesses, including Alzheimer's disease, schizophrenia, panic disorder, attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder, multiple disabilities, obsessive-compulsive disorder, post-traumatic stress disorder, and schizophrenia, from the Psychiatric Genomics Consortium...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38314515/the-predictive-effect-of-family-genetic-risk-scores-as-an-indirect-measure-of-causal-effects-of-one-disorder-on-another
#34
JOURNAL ARTICLE
Kenneth S Kendler, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
BACKGROUND: One potential cause of comorbidity is the direct causal effect of one disorder - A - on risk for subsequent onset of disorder B. Could genetic risk scores be utilized to test for such an effect? If disorder A causally impacts on risk for disorder B, then genetic risk for disorder A should be lower in cases of disorder A with v. without a prior onset of B. METHODS: In all individuals ( n = 905 736) born in Sweden from 1980 to 1990, from six psychiatric and drug use disorders (major depression, anxiety disorders, alcohol use disorder, drug use disorder, bipolar disorder, and schizophrenia), we formed 14 pairs of disorders A and B...
February 5, 2024: Psychological Medicine
https://read.qxmd.com/read/38309130/serious-mental-illness-is-associated-with-elevated-risk-of-hospital-readmission-in-veterans-with-heart-failure
#35
JOURNAL ARTICLE
Julia Browne, James L Rudolph, Lan Jiang, Thomas A Bayer, Zachary J Kunicki, Alyssa N De Vito, Melanie L Bozzay, John E McGeary, Catherine M Kelso, Wen-Chih Wu
OBJECTIVE: Adults with serious mental illness (SMI) have high rates of cardiovascular disease, particularly heart failure, which contribute to premature mortality. The aims were to examine 90- and 365-day all-cause medical or surgical hospital readmission in Veterans with SMI discharged from a heart failure hospitalization. The exploratory aim was to evaluate 180-day post-discharge engagement in cardiac rehabilitation, an effective intervention for heart failure. METHODS: This study used administrative data from the Veterans Health Administration (VHA) and Centers for Medicare & Medicaid Services between 2011 and 2019...
March 2024: Journal of Psychosomatic Research
https://read.qxmd.com/read/38304661/navigating-the-complexity-of-a-bipolar-pregnant-patient-with-multiple-comorbidities
#36
Paula Traugott, Adriana Medina, Jonathan M Parker
Bipolar disorder I (BDI) is a psychiatric disorder characterized by the occurrence of at least one manic episode. Within the scope of neurological disorders, epilepsy and psychogenic nonepileptic seizures (PNES) share clinical features and can be differentiated using electroencephalogram (EEG). Substance use disorder is a condition defined by impaired control, risky use, social impairment, and addictive behaviors. We present the case of a 20-year-old pregnant woman with BDI associated with a history of epilepsy, PNES, and polyvalent substance use...
January 2024: Curēus
https://read.qxmd.com/read/38300182/a-pathophysiological-approach-for-selecting-medications-to-treat-nociceptive-and-neuropathic-pain-in-servicemembers
#37
JOURNAL ARTICLE
Khan Thi Nguyen, Daniel W Beauchamp, Reginald B O'Hara
INTRODUCTION: The prevalence of chronic pain of service members (SMs) in the U.S. is estimated to be higher (roughly 31-44%) compared to that of civilian population (26%). This higher prevalence is likely due to the high physical demands related combat and training injuries that are not immediately resolved and worsen over time. Mental Health America reports that chronic pain can lead to other mental health conditions such as severe anxiety, depression, bipolar disorder, and post-traumatic stress disorder...
January 31, 2024: Military Medicine
https://read.qxmd.com/read/38294688/bipolar-adhd-comorbidity-screening-for-differences-in-neurocognition-and-virtual-reality-based-cognitive-performance
#38
JOURNAL ARTICLE
Andreas E Jespersen, Zacharias Obel, Anders Lumbye, Lars V Kessing, Kamilla W Miskowiak
OBJECTIVES: Identification of comorbid attention-deficit/hyperactivity disorder (ADHD) in patients with bipolar disorder (BD) is complicated by overlapping cognitive symptoms and methodological challenges. This cross-sectional study investigated whether virtual reality (VR)-based cognitive assessment that mimics daily life cognitive challenges can aid in the detection of sustained attention impairment in BD individuals with comorbid ADHD (BD + ADHD). METHODS: Forty-nine fully or partially remitted outpatients with BD, of whom 14 (24%) had BD + ADHD, were assessed with the Cognition Assessment in Virtual Reality (CAVIR) test, including a sustained attention test that involves distractions, and the Screen for Cognitive Impairment in Psychiatry (SCIP)...
January 31, 2024: Nordic Journal of Psychiatry
https://read.qxmd.com/read/38294521/excess-mortality-and-its-causes-among-older-adults-with-schizophrenia-versus-those-with-bipolar-disorder-and-major-depressive-disorder-a-5-year-prospective-multicenter-study
#39
JOURNAL ARTICLE
Nicolas Hoertel, Marina Sánchez-Rico, Sandra Abou Kassm, Benjamin Brami, Mark Olfson, Katayoun Rezaei, Valentin Scheer, Frédéric Limosin
Excess mortality observed in people with schizophrenia may persist in later life. The specific causes of increased mortality observed in older adults with schizophrenia and the potential influence of psychotropic medications remain partly unknown. We compared 5-year mortality and its causes of older adults with schizophrenia to bipolar disorder (BD) or major depressive disorder (MDD). We used a 5-year prospective cohort, including 564 older inpatients and outpatients with schizophrenia, BD or MDD (mean age: 67...
January 31, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38291410/chronic-kidney-disease-incidences-in-thai-outpatients-diagnosed-with-psychiatric-illnesses-receiving-lithium-maintenance-therapy-a-university-hospital-based-study
#40
JOURNAL ARTICLE
Jarurin Pitanupong, Chavisa Jittpratoom, Kanthee Anantapong
BACKGROUND: There has been no previous study in Thailand regarding the incidence of lithium-induced abnormal renal function. Hence, this study aimed to assess the effect of lithium maintenance therapy on chronic kidney disease, and associated factors among outpatients diagnosed with a psychiatric illness within Southern Thailand. METHODS: This was a retrospective study, using an information review from the electronic medical records of Songklanagarind Hospital computer system in the last ten years; from 1 January 2013 until 31 September 2022...
January 30, 2024: BMC Psychiatry
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