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"bipolar disorder","comorbidity"

Vinoomika Chandrasekaran, Sharon L Brennan-Olsen, Amanda L Stuart, Julie A Pasco, Michael Berk, Jason M Hodge, Lana J Williams
BACKGROUND: Bipolar disorder is a chronic, episodic mental illness, affecting around 2.4% of the population worldwide. Psychological and/or physiological comorbidities are a common consequence, and osteoporosis is one such possible comorbidity. Thus, this systematic review aimed to collate, evaluate, and discuss the literature examining the link between bipolar disorder and bone health. METHODS: We conducted an e-search of PubMed/OVID/MEDLINE, PsychINFO and CINAHL to identify studies that investigated associations between bipolar disorder and bone in adults aged ≥18...
February 6, 2019: Journal of Affective Disorders
D Łojko, M Stelmach-Mardas, A Suwalska
OBJECTIVE: As mood disorders and obesity are interrelated, and both are linked to increased morbidity and mortality, risk factors for obesity should be identified and closely monitored in patients with bipolar disorder (BD). The aim of this study was to determine the diet quality of BD patients and to investigate its putative associations with comorbid obesity and disorders of carbohydrate metabolism, as well as the relationship between diet and clinical features of BD. PATIENTS AND METHODS: Eating patterns in 113 euthymic BD patients and 160 healthy control subjects were assessed using data obtained from a food frequency questionnaire...
February 2019: European Review for Medical and Pharmacological Sciences
Dong Ik Park, Christoph W Turck
High comorbidity and complexity have precluded reliable diagnostic assessment and treatment of psychiatric disorders. Impaired molecular interactions may be relevant for underlying mechanisms of psychiatric disorders but by and large remain unknown. With the help of a number of publicly available databases and various technological tools, recent research has filled the paucity of information by generating a novel dataset of psychiatric interactomes. Different technological platforms including yeast two-hybrid screen, co-immunoprecipitation-coupled with mass spectrometry-based proteomics, and transcriptomics have been widely used in combination with cellular and molecular techniques to interrogate the psychiatric interactome...
2019: Advances in Experimental Medicine and Biology
Lavanya P Sharma, Y C Janardhan Reddy
Obsessive Compulsive Disorder (OCD) and Obsessive Compulsive Symptoms (OCS) are known to be highly comorbid with bipolar disorder and schizophrenia. Comorbid OCD/OCS influences the course of schizophrenia and bipolar disorder. There is also some evidence to suggest that a diagnosis of OCD may be associated with elevated risk for later development of psychosis and bipolar disorder. Comorbid OCD/OCS is associated with a greater severity of schizophrenia phenotype and poorer prognosis. In addition, certain atypical antipsychotics, clozapine in particular are known to induce or worsen OCS in schizophrenia...
January 2019: Indian Journal of Psychiatry
Lavanya Vedanarayanan, Ravindra Munoli, Girish Thunga, Sreedharan Nair, Pooja Poojari, Vijayanarayana Kunhikatta
Background and Aim: Treatment outcomes in bipolar disorder are highly variable, and several sociodemographic, clinical characteristics, and comorbidities play an important role. Early recognition of these factors will help the physicians to implement individualized treatment and a better clinical outcome. The present study was aimed at identifying the factors affecting treatment outcomes in bipolar disorder. Materials and Methods: All patients diagnosed with bipolar disorder as per diagnostic and statistical manual-IV criteria were included in the study...
January 2019: Indian Journal of Psychiatry
A Amerio, A Odone, S N Ghaemi
BACKGROUND: Apparent comorbidity between bipolar disorder (BD) and obsessive-compulsive disorder (OCD) is a common condition in psychiatry, but treatment of BD-OCD remains a clinical challenge. Although serotonin reuptake inhibitors (SRIs) are the first line treatment for OCD, they can induce mood instability in BD. An optimal treatment approach remains to be defined. METHODS: A systematic review was conducted on aripiprazole augmentation in treating comorbid BD-OCD patients...
February 6, 2019: Journal of Affective Disorders
Erik Pettersson, Henrik Larsson, Brian D'Onofrio, Catarina Almqvist, Paul Lichtenstein
Importance: It is unclear if the associations between fetal growth and later mental health conditions remain after controlling for familial factors and psychiatric comorbidity. Objective: To examine the associations between fetal growth and general and specific mental health conditions, controlling for familial factors. Design, Setting, and Participants: This register-based study conducted in Sweden analyzed 546 894 pairs of full siblings born between January 1, 1973, and December 31, 1998...
February 6, 2019: JAMA Psychiatry
Nicholas Zareifopoulos, Aggeliki Bellou, Agathi Spiropoulou, Kostas Spiropoulos
The disease burden associated with schizophrenia and bipolar disorder is substantial, with affected individuals having a shorter life expectancy and a high risk of severe physical comorbid conditions. These individuals are more likely to smoke and have a longer smoking history compared to the general population. Furthermore, use of antipsychotic drugs has also been linked to active smoking. Chronic obstructive pulmonary disease (COPD) is a respiratory condition affecting elderly individuals with a long smoking history, so it would be expected that individuals suffering from major mental disorders may exhibit a higher prevalence of COPD compared to the general population...
February 4, 2019: COPD
Mark Zimmerman, Caroline Balling, Kristy Dalrymple, Iwona Chelminski
OBJECTIVE: Borderline personality disorder (BPD) is a serious illness that is frequently underdiagnosed. A previous psychometric analysis of the 9 BPD criteria in DSM-IV/DSM-5 found that the affective instability criterion functioned well as a screen for the disorder. A limitation of that initial study was that the performance of the BPD criteria was examined in a diagnostically heterogeneous sample, including those with a low likelihood of having BPD. The present study from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project examined the operating characteristics of the BPD criteria in patients with major depressive disorder (MDD) and bipolar disorder...
January 15, 2019: Journal of Clinical Psychiatry
Lorena de la Fuente-Tomas, Belen Arranz, Gemma Safont, Pilar Sierra, Monica Sanchez-Autet, Ana Garcia-Blanco, Maria P Garcia-Portilla
INTRODUCTION: Bipolar disorder (BD) is a heterogeneous disorder needing personalized and shared decisions. We aimed to empirically develop a cluster-based classification that allocates patients according to their severity for helping clinicians in these processes. METHODS: Naturalistic, cross-sectional, multicenter study. We included 224 subjects with BD (DSM-IV-TR) under outpatient treatment from 4 sites in Spain. We obtained information on socio-demography, clinical course, psychopathology, cognition, functioning, vital signs, anthropometry and lab analysis...
2019: PloS One
Awais Aftab, Martha Sajatovic
Older adults are a rapidly growing group world-wide. Among the elderly, anxiety disorders are among the most common psychiatric disorders, but are highly under-recognized and under-treated in clinical settings. Anxiety comorbidity is also very common in individuals with bipolar disorder, and in older adults with bipolar disorder (OABD), anxiety symptoms may emerge in the setting of increased medical burden, cognitive decline, and social isolation. Clinicians evaluating older people with BD need to assess for anxiety comorbidity, recognizing the potential for under-recognition and overlap with conditions that are relative to aging such as increased medical burden and cognitive impairment...
January 22, 2019: Bipolar Disorders
Andrea Amerio, Matteo Tonna, Anna Odone
BACKGROUND: Apparent comorbidity between bipolar disorder (BD) and obsessive-compulsive disorder (OCD) is a common condition in psychiatry and it has important nosological and therapeutic implications. Although antidepressantsare the first line treatment for OCD, they can induce mood instability in BD. An optimal treatment approach remains to be defined. METHODS: Longitudinal clinical observation of three severe OCD patients who developed a manic episode during treatment with different classes of antidepressants...
January 15, 2019: Acta Bio-medica: Atenei Parmensis
Rikinkumar S Patel, Geetha Manikkara, Amit Chopra
Background and objectives: The quality of life and disease outcomes in bipolar patients, including increased risk of psychiatric hospitalizations and suicide, are adversely affected by the presence of borderline personality disorder (BPD). Our study aims to determine the impact of BPD on the inpatient outcomes of bipolar disorder patients. Methods : We used Nationwide Inpatient Sample from the US hospitals and identified cases with bipolar disorder and comorbid BPD (N = 268,232) and controls with bipolar disorder only (N = 242,379), using the International Classification of Diseases, 9th Revision, and Clinical Modification codes...
January 14, 2019: Medicina
Aliya M Lucatch, Alexandria S Coles, Kevin P Hill, Tony P George
Purpose of review: The present review will provide an overview of the neurobiology, epidemiology, clinical impact, and treatment of cannabis use disorder (CUD) in mood disorders. Recent findings: Patients with mood disorders including major depressive disorder (MDD) and bipolar disorder (BD) have higher rates of cannabis use, and CUD compared to the general population. Reasons for this association are not clear, nor are the putative therapeutic effects of cannabis use, or its components delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), in these illnesses...
September 2018: Current Addiction Reports
Sanna Pallaskorpi, Kirsi Suominen, Tom Rosenström, Outi Mantere, Petri Arvilommi, Hanna Valtonen, Sami Leppämäki, Aitana García-Estela, Iria Grande, Francesc Colom, Eduard Vieta, Erkki Isometsä
BACKGROUND: Patients with bipolar disorder (BD) differ in their relative predominance of types of episodes, yielding predominant polarity, which has important treatment implications. However, few prospective studies of predominant polarity exist. METHODS: In the Jorvi Bipolar Study (JoBS), a regionally representative cohort of 191 BD I and BD II in- and outpatients was followed for five years using life-chart methodology. Differences between depressive (DP), manic (MP), and no predominant polarity (NP) groups were examined regarding time ill, incidence of suicide attempts, and comorbidity...
December 25, 2018: Journal of Affective Disorders
Mamidipalli Sai Spoorthy, Subho Chakrabarti, Sandeep Grover
Over the last three decades burgeoning research has shown that anxiety disorder comorbidity is not only highly prevalent in bipolar disorder (BD), but it also adversely impacts the course, outcome, and treatment of BD. The present review provides an overview of the current trends in research on comorbid anxiety and BDs based on prior reviews and meta-analyses ( n = 103), epidemiological surveys, and large-scale clinical studies. The results reiterated the fact that at least half of those with BD are likely to develop an anxiety disorder in their lifetimes and a third of them will manifest an anxiety disorder at any point of time...
January 4, 2019: World Journal of Psychiatry
Marc J Weintraub, David A Axelson, Robert A Kowatch, Christopher D Schneck, David J Miklowitz
BACKGROUND: While family interventions have shown efficacy in improving mood symptoms and family functioning in pediatric bipolar disorder, few studies have examined the effects of comorbid psychiatric conditions on patients' symptomatic or functional responses to treatment. METHODS: 145 adolescents with bipolar I or II disorder were randomly assigned to family-focused therapy (FFT-A) or a brief psychoeducational therapy (enhanced care; EC) and followed over 2 years...
December 25, 2018: Journal of Affective Disorders
Basak Sahin, Ikbal Inanli, Ali M Calıskan, Sema Uysal
OBJECTIVES: To evaluate the relationship between the expression level and biologic role of YKL-40 in bipolar disorder (BD). METHODS: This case-control study was conducted in the Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey in 2015. One hundred and four patients diagnosed as having bipolar disorder (DSM5 criteria), and 96 participants were included as healthy controls in this study. A human YKL-40 enzyme-linked immunosorbent assay (ELISA) kit was used to measure the serum YKL-40 levels...
January 2019: Saudi Medical Journal
Sandeep Grover, Swapnajeet Sahoo, Swati Chaudhary, Subho Chakrabarti, Ritu Nehra, Ajit Avasthi
This study aimed to estimate the gender differences, family size and fertility rate among patients with Bipolar disorder (BD). 219 patients diagnosed with BD, who were married for at least 3 years and aged more than 25 years were assessed clinically for the course of illness as per the NIMH-life chart. Fertility and infertility were assessed based on the information on number of living children, abortions and medical termination of pregnancies. Significantly higher proportion of male patients had comorbid substance dependence while females had significantly higher prevalence of physical comorbidity...
December 30, 2018: Psychiatry Research
D Sikkens, R F Riemersma-Van der Lek, Y Meesters, R A Schoevers, B C M Haarman
BACKGROUND: The combination of sleep deprivation and light therapy, called combined chronotherapy, may yield positive short- and long-term results, even in patients with treatment resistant depression (TRD). The implementation of combined chronotherapy in daily clinical practice is rare. This study describes the implementation and the effectiveness in a clinical setting. METHODS: Twenty six depressed patients with unipolar or bipolar depression received combined chronotherapy consisting of three nights of sleep deprivation with alternating recovery nights, light therapy, and continuation of antidepressant medication...
December 25, 2018: Journal of Affective Disorders
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