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Zhenyu Wang, Qiang Zhang, Yunong Yue, Jiawen Xu, Wei Xu, Xinhu Sun, Yanqiu Chen, Jin Jiang, Yu Liu
Materials with tunable and high strain sensitivities have a great potential to be used in next-generation flexible electronic devices. Conventional methods, which focus on tailoring the material composition to obtain controllable sensitivities, face the issues of complicated fabrication process and unstability, restricting their use in real applications. In this work, we propose the idea of tuning the sensitivities through precisely controlled micro-structures. Based on 3D printing technique, we successfully fabricate graphene/polydimethylsiloxane composites with long-range ordered porous structures...
March 22, 2019: Nanotechnology
Nabarun Polley, Supratim Basak, Roland Hass, Claudia Pacholski
A simple, convenient, and inexpensive method to fabricate optical fiber based biosensors which utilize periodic hole arrays in gold films for signal transduction is reported. The process of hole array formation mainly relies on self-assembly of hydrogel microgels in combination with chemical gold film deposition and subsequent transfer of the perforated film onto an optical fiber tip. In the fabrication process solely chemical wet lab techniques are used, avoiding cost-intensive instrumentation or clean room facilities...
March 12, 2019: Biosensors & Bioelectronics
Qingchuan Ma, Etsuko Kobayashi, Junchen Wang, Kazuaki Hara, Hideyuki Suenaga, Ichiro Sakuma, Ken Masamune
BACKGROUND: Human-related factors affect the accuracy and safety of the oral and maxillofacial surgery (OMS). This study proposed an autonomous surgical system aiming to conduct the OMS under the assistance and surveillance of the surgeon. METHODS: A markerless navigation module and a compact OMS robot were seamlessly integrated into this system. The specifications of each module and the working concept of the system were elaborated in this paper. A drilling experiment was conducted on five 3D printed mandible models to test the pose detecting capability and evaluate the operational performance...
March 22, 2019: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
Tan Sui, Enrico Salvati, Hongjia Zhang, Kirill Nyaza, Fedor S Senatov, Alexei I Salimon, Alexander M Korsunsky
Polylactide (PLA)-hydroxyapatite (HAp) composite components have attracted extensive attentions for a variety of biomedical applications. This study seeks to explore how the biocompatible PLA matrix and the bioactive HAp fillers respond to thermo-mechanical environment of a PLA-HAp composite manufactured by 3D printing using Fused Filament Fabrication (FFF). The insight is obtained by in situ synchrotron small- and wide- angle X-ray scattering (SAXS/WAXS) techniques. The thermo-mechanical cyclic loading tests (0-20 MPa, 22-56 °C) revealed strain softening (Mullins effect) of PLA-HAp composite at both room and elevated temperatures (<56 °C), which can be attributed primarily to the non-linear deformation of PLA nanometre-scale lamellar structure...
March 2019: Journal of Advanced Research
Chen-Yu Ding, Xue-Han Yi, Chang-Zhen Jiang, Hao Xu, Xiao-Rong Yan, Yuan-Long Zhang, De-Zhi Kang, Zhang-Ya Lin
BACKGROUND: The teaching of endoscopic endonasal surgery has always been difficult because of the complex structure of the nasal cavity, and the unique endoscopic view angle and endoscopic surgical tools. In this study, we have designed a 3D printed multi-color model for training of endoscopic endonasal surgery, and obtained preliminary application results. METHODS: The 3D printed model contained facial skin, bony skeleton, internal carotid artery, turbinate, optic chiasm, and a special sellar base with appropriate colors...
2019: American Journal of Translational Research
P A Coucke
Additive manufacturing is creating a real revolution in every sector of human activity, including health care. The main reasons are a reduction of manufacturing cost, of waste production, and of energy consumption. In the health care sector, it offers unique production opportunities for medical material, especially in low-income and emerging countries. However, as the 3D (bio-)printing techniques evolve, there are more and more viable alternatives for total or partial organ replacement in order to restore function...
March 2019: Revue Médicale de Liège
Michelle E Howell, Christine S Booth, Sharmin M Sikich, Tomáš Helikar, Rebecca L Roston, Brian A Couch, Karin van Dijk
Understanding the relationship between molecular structure and function represents an important goal of undergraduate life sciences. Although evidence suggests that handling physical models supports gains in student understanding of structure-function relationships, such models have not been widely implemented in biochemistry classrooms. Three-dimensional (3D) printing represents an emerging cost-effective means of producing molecular models to help students investigate structure-function concepts. We developed three interactive learning modules with dynamic 3D printed models to help biochemistry students visualize biomolecular structures and address particular misconceptions...
March 21, 2019: Biochemistry and Molecular Biology Education
Hong-Beom Kwon, Seong-Jae Yoo, Ui-Seon Hong, Kyungtae Kim, Jangseop Han, Min-Ki Kim, Dong-Hyun Kang, Jungho Hwang, Yong-Jun Kim
To monitor airborne nanoparticles at a particular point of interest sensitively and accurately, we developed a compact and inexpensive but highly-precise nanoparticle detection system. The proposed system, based on nucleation light-scattering, consists of two components: a microelectromechanical system (MEMS)-based particle growth chip that grows nanoparticles to micro-sized droplets through condensation and a miniaturized optical particle counter (mini-OPC) that detects individual grown droplets using a light-scattering method...
March 21, 2019: Lab on a Chip
Anna Archetti, Evgenii Glushkov, Christian Sieben, Anton Stroganov, Aleksandra Radenovic, Suliana Manley
Super-resolution microscopies based on the localization of single molecules have been widely adopted due to their demonstrated performance and their accessibility resulting from open software and simple hardware. The PAINT method for localization microscopy offers improved resolution over photoswitching methods, since it is less prone to sparse sampling of structures and provides higher localization precision. Here, we show that waveguides enable increased throughput and data quality for PAINT, by generating a highly uniform ~100 × 2000 µm2 area evanescent field for TIRF illumination...
March 20, 2019: Nature Communications
Maisa R P Araújo, Livia L Sa-Barreto, Tais Gratieri, Guilherme M Gelfuso, Marcilio Cunha-Filho
The pharmaceutical industry is set to join the fourth industrial revolution with the 3D printing of medicines. The application of 3D printers in compounding pharmacies will turn them into digital pharmacies, wrapping up the telemedicine care cycle and definitively modifying the pharmacotherapeutic treatment of patients. Fused deposition modeling 3D printing technology melts extruded drug-loaded filaments into any dosage form; and allows the obtainment of flexible dosages with different shapes, multiple active pharmaceutical ingredients and modulated drug release kinetics-in other words, offering customized medicine...
March 19, 2019: Pharmaceutics
Diana Chioibasu, Alexandru Achim, Camelia Popescu, George E Stan, Iuliana Pasuk, Monica Enculescu, Stefana Iosub, Liviu Duta, Andrei Popescu
Laser melting deposition is a 3D printing method usually studied for the manufacturing of machine parts in the industry. However, for the medical sector, although feasible, applications and actual products taking advantage of this technique are only scarcely reported. Therefore, in this study, Ti6Al4V orthopedic implants in the form of plates were 3D printed by laser melting deposition. Tuning of the laser power, scanning speed and powder feed rate was conducted, in order to obtain a continuous deposition after a single laser pass and to diminish unwanted blown powder, stuck in the vicinity of the printed elements...
March 19, 2019: Materials
A Qu, J J Wang, Y L Jiang, H T Sun, P Jiang, Z Ji, F X Guo, J H Fan, W Y Li
Objective: To compare the difference of preoperative planning parameters between 3D-printing non-coplanar template (3D-PNCT) and 3D-printing coplanar template (3D-PCT) in the treatment of pelvic wall recurrent gynecological malignant tumor with radioactive seeds implantation, and to guide the clinical application. Methods: From January 2016 to March 2018, 33 patients with pelvic wall recurrent gynecological malignant tumor were treated with radioactive seeds implantation assisted by 3D-printing template and in Peking University Third Hospital...
March 19, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Morteza Amini, Andreas Reisinger, Dieter H Pahr
Natural bone microstructure has shown to be the most efficient choice for the bone scaffold design. However, there are several process parameters involved in the generation of a microCT-based 3D-printed (3DP) bone. In this study, the effect of selected parameters on the reproducibility of mechanical properties of a 3DP trabecular bone structure is investigated. MicroCT images of a distal radial sample were used to reconstruct a 3D ROI of trabecular bone. Nine tensile tests on bulk material and 54 compression tests on 8...
March 20, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Raquel Moya-Costa, Gloria Cuenca-Bescós, Blanca Bauluz
We have developed a protocol for reconstructing 3D models of the skulls of extinct species of small mammals. For the first time, the reconstruction uses fragments of fossils from a mixture of different specimens and from related extant species. We use free software and commercial computers to make the process reproducible and usable for the scientific community. We present a semi-quantitative protocol to face the problem of making 3D reconstructions of fossil species that are incomplete in the fossil record and/or represented by a mixture of different individuals, as usually occurs with small vertebrates...
2019: PloS One
Ashley D Knight, Peter P Anderson, Mark D Beachler, Christopher L Dearth, Louise M Hassinger, Brad D Hendershot, Todd J Sleeman, Peter C Liacouras
No abstract text is available yet for this article.
April 2019: American Journal of Physical Medicine & Rehabilitation
Zhongliang Jiang, Rajib Shaha, Kun Jiang, Ralph McBride, Carl Frick, John Oakey
Controlled cell delivery has shown some promising outcomes compared with traditional cell delivery approaches over the past decades, and strategies focused on optimization or engineering of controlled cell delivery have been intensively studied. In this report, we demonstrate the fabrication of a 3D printed hydrogel scaffold infused with degradable PEGPLA/NB composite hydrogel core for controlled cell delivery with improved cell viability and facile tunability. The 3D printed poly(ethylene glycol) diacrylate (PEGDA) scaffold with specifically designed architectures can provide mechanical support while allowing bidirectional diffusion of small molecules, thus permitting structural integrity and long-term cell viability...
March 15, 2019: IEEE Transactions on Nanobioscience
Agata Blasiak, Thomas H M Guerin, Daniel B L Teh, In Hong Yang, Amit Lahiri, Nitish V Thakor
Ability to direct neuronal growth not only carries great potential for treating neural conditions -e.g. bridging traumatically shattered connections - but would also be an exquisite tool for bionic applications that require physical interface between neurons and electronics. A testing platform is needed to better understand axonal guidance in the context of a specific in-vivo application. Versatility of 3D printing technology allows tailoring to researcher needs, both in-vitro and in-vivo. In this study we establish a fibro-neuronal co-culture inspired by our neural interface research, and demonstrate axon alignment on a texturized substrate fabricated with a common, versatile 3D-printing set-up...
March 15, 2019: IEEE Transactions on Nanobioscience
Lauren M Shepard, Kelsey N Sommer, Erin Angel, Vijay Iyer, Michael F Wilson, Frank J Rybicki, Dimitrios Mitsouras, Sabee Molloi, Ciprian N Ionita
We developed three-dimensionally (3D) printed patient-specific coronary phantoms that are capable of sustaining physiological flow and pressure conditions. We assessed the accuracy of these phantoms from coronary CT acquisition, benchtop experimentation, and CT-FFR software. Five patients with coronary artery disease underwent 320-detector row coronary CT angiography (CCTA) (Aquilion ONE, Canon Medical Systems) and a catheter lab procedure to measure fractional flow reserve (FFR). The aortic root and three main coronary arteries were segmented (Vitrea, Vital Images) and 3D printed (Eden 260V, Stratasys)...
April 2019: Journal of Medical Imaging
Shin Hau Bong, Behzad Nematollahi, Ali Nazari, Ming Xia, Jay Sanjayan
Since the initial introduction of geopolymers, these materials have been characterised as environmentally-friendly sustainable substitutes for ordinary Portland cement (OPC). There is a routine increase in the application of geopolymers, especially in advanced technologies. Because of its better rheological characteristics compared to OPC, geopolymers are appropriate materials for extrusion-based 3D printing technologies. This paper focuses on the optimisation of an ambient temperature cured geopolymer for 3D printing construction applications...
March 18, 2019: Materials
Sulaiman Khan, David Newport, Stéphane Le Calvé
A simple deep-ultraviolet (UV) absorption spectrophotometer based on ultraviolet light-emitting diode (UV LED) was developed for the detection of air-borne toluene with a good sensitivity. A fiber-coupled deep UV-LED was employed as a light source, and a spectrometer was used as a detector with a gas cell in between. 3D printed opto-fluidics connectors were designed to integrate the gas flow with UV light. Two types of hollow core waveguides (HCW) were tested as gas cells: a glass capillary tube with aluminum-coated inner walls and an aluminum capillary tube...
March 18, 2019: Micromachines
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