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Keywords brain memory neurotrophins and...

brain memory neurotrophins and receptors

https://read.qxmd.com/read/35625880/brain-derived-neurotropic-factor-in-neurodegenerative-disorders
#21
REVIEW
Abdallah Mohammad Ibrahim, Lalita Chauhan, Aditi Bhardwaj, Anjali Sharma, Faizana Fayaz, Bhumika Kumar, Mohamed Alhashmi, Noora AlHajri, Md Sabir Alam, Faheem Hyder Pottoo
Globally, neurodegenerative diseases cause a significant degree of disability and distress. Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role in the development and maintenance of various nerve roles and is associated with the family of neurotrophins, including neuronal growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). BDNF has affinity with tropomyosin receptor kinase B (TrKB), which is found in the brain in large amounts and is expressed in several cells...
May 16, 2022: Biomedicines
https://read.qxmd.com/read/35622266/effects-of-omega-3-fatty-acid-supplementation-during-chronic-maternal-hypoxia-on-behavioral-disorders-in-male-rat-offspring-the-role-of-trk-family-and-oxidative-stress
#22
JOURNAL ARTICLE
Zohreh Ghotbeddin, Kaveh Khazaeel, Mohammad-Reza Tabandeh, Maryam Aliheydari, Hooshyar Yaghoubi
Maternal hypoxia due to a lack of blood flow and insufficient oxygen supply in the brain leads to behavioral disorders in adult offspring. Fish oil includes docosahexaenoic acid (DHA), a significant component of membrane phospholipids of nerve cells, which improved cognition, and memory. Trk family receptors are activated by hypoxic induction factor (HIF), and are involved in the neurotrophin's protective effects at the cellular level. Here we studied the biochemical, and molecular mechanisms of the protective effect of fish oil during the chronic maternal hypoxia model on behavioral responses in male rat offspring...
May 27, 2022: Metabolic Brain Disease
https://read.qxmd.com/read/35316814/interleukin-10-attenuates-behavioral-immune-and-neurotrophin-changes-induced-by-chronic-central-administration-of-interleukin-1%C3%AE-in-rats
#23
JOURNAL ARTICLE
Yong-Ping Zhang, Yu-Yu Li, Cai Zhang, Ya-Jun Li, Bai-Ping Liu, Yan Zhang, Ju-Da Lin, Cai Song
BACKGROUND: Activated microglia can trigger pro-inflammatory cytokine releases and neuroinflammation, which may inhibit astrocytes to produce neurotrophins and anti-inflammatory factors. Both eventually lead to neuron apoptosis or death. Furthermore, effective antidepressant or anti-dementia treatments can reduce pro-inflammatory cytokines, while enhance interleukin (IL)-10 production. However, the underline mechanism by which IL-10 modulates glial cell function, hence improves cognitive impairment or depression-like behavior is unknown...
March 22, 2022: Neuroimmunomodulation
https://read.qxmd.com/read/35128708/regulation-of-ampar-trafficking-in-synaptic-plasticity-by-bdnf-and-the-impact-of-neurodegenerative-disease
#24
REVIEW
Joyce Keifer
Research demonstrates that the neural mechanisms underlying synaptic plasticity and learning and memory involve mobilization of AMPA-type neurotransmitter receptors at glutamatergic synaptic contacts, and that these mechanisms are targeted during neurodegenerative disease. Strengthening neural transmission occurs with insertion of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) into synapses while weakening results from receptor withdrawal. A key player in the trafficking of AMPARs during plasticity and learning is the brain-derived neurotrophic factor (BDNF) signaling system...
February 7, 2022: Journal of Neuroscience Research
https://read.qxmd.com/read/34974125/pleiotropic-effects-of-bdnf-on-the-cerebellum-and-hippocampus-implications-for-neurodevelopmental-disorders
#25
REVIEW
Serena Camuso, Piergiorgio La Rosa, Maria Teresa Fiorenza, Sonia Canterini
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the mammalian brain, essential not only to the development of the central nervous system but also to synaptic plasticity. BDNF is present in various brain areas, but highest levels of expression are seen in the cerebellum and hippocampus. After birth, BDNF acts in the cerebellum as a mitogenic and chemotactic factor, stimulating the cerebellar granule cell precursors to proliferate, migrate and maturate, while in the hippocampus BDNF plays a fundamental role in synaptic transmission and plasticity, representing a key regulator for the long-term potentiation, learning and memory...
February 2022: Neurobiology of Disease
https://read.qxmd.com/read/34639085/prongf-involvement-in-the-adult-neurogenesis-dysfunction-in-alzheimer-s-disease
#26
JOURNAL ARTICLE
Bolanle Fatimat Olabiyi, Catherine Fleitas, Bahira Zammou, Isidro Ferrer, Claire Rampon, Joaquim Egea, Carme Espinet
In recent decades, neurogenesis in the adult brain has been well demonstrated in a number of animal species, including humans. Interestingly, work with rodents has shown that adult neurogenesis in the dentate gyrus (DG) of the hippocampus is vital for some cognitive aspects, as increasing neurogenesis improves memory, while its disruption triggers the opposite effect. Adult neurogenesis declines with age and has been suggested to play a role in impaired progressive learning and memory loss seen in Alzheimer's disease (AD)...
October 4, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/34558255/brain-derived-neurotrophic-factor-in-gastroenterology-oncology-short-review-of-current-literature
#27
REVIEW
Tomasz Antoni Guzel, Katarzyna Mech, Marek Wroński, Katarzyna Gerkowicz, Agata Bednarczyk, Weronika Adamczyk, Monika Radecka, Maciej Słodkowski
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophins group which plays a crucial role in brain development and neurogenesis. In the hypothalamus it is described as playing a role in energy metabolism and feeding behaviour. The hippocampal concentration of BDNF is believed to play an important role in learning and memory, it has a protective role in neurodegeneration and stress responses. BDNF is also known to take part in many other processes, e.g. angiogenesis, proliferation, cell migration and apoptosis...
September 16, 2021: Annals of Agricultural and Environmental Medicine: AAEM
https://read.qxmd.com/read/34470044/probdnf-dependence-of-ltd-and-fear-extinction-learning-in-the-amygdala-of-adult-mice
#28
JOURNAL ARTICLE
Xiaoyun Ma, Harish Vuyyuru, Thomas Munsch, Thomas Endres, Volkmar Lessmann, Susanne Meis
Neurotrophins are secreted proteins that control survival, differentiation, and synaptic plasticity. While mature neurotrophins regulate these functions via tyrosine kinase signaling (Trk), uncleaved pro-neurotrophins bind preferentially to the p75 neurotrophin receptor (p75NTR) and often exert opposite effects to those of mature neurotrophins. In the amygdala, brain-derived neurotrophic factor (BDNF) enables long-term potentiation as well as fear and fear extinction learning. In the present study, we focused on the impact of mature BDNF and proBDNF signaling on long-term depression (LTD) in the lateral amygdala (LA)...
March 30, 2022: Cerebral Cortex
https://read.qxmd.com/read/34440751/effects-of-reactive-oxygen-and-nitrogen-species-on-trka-expression-and-signalling-implications-for-prongf-in-aging-and-alzheimer-s-disease
#29
REVIEW
Erika Kropf, Margaret Fahnestock
Nerve growth factor (NGF) and its precursor form, proNGF, are critical for neuronal survival and cognitive function. In the brain, proNGF is the only detectable form of NGF. Dysregulation of proNGF in the brain is implicated in age-related memory loss and Alzheimer's disease (AD). AD is characterized by early and progressive degeneration of the basal forebrain, an area critical for learning, memory, and attention. Learning and memory deficits in AD are associated with loss of proNGF survival signalling and impaired retrograde transport of proNGF to the basal forebrain...
August 4, 2021: Cells
https://read.qxmd.com/read/34440640/identification-of-novel-positive-allosteric-modulators-of-neurotrophin-receptors-for-the-treatment-of-cognitive-dysfunction
#30
JOURNAL ARTICLE
Märta Dahlström, Nather Madjid, Gunnar Nordvall, Magnus M Halldin, Erika Vazquez-Juarez, Maria Lindskog, Johan Sandin, Bengt Winblad, Maria Eriksdotter, Pontus Forsell
Alzheimer's disease (AD) is the most common neurodegenerative disorder and results in severe neurodegeneration and progressive cognitive decline. Neurotrophins are growth factors involved in the development and survival of neurons, but also in underlying mechanisms for memory formation such as hippocampal long-term potentiation. Our aim was to identify small molecules with stimulatory effects on the signaling of two neurotrophins, the nerve growth factor (NGF) and the brain derived neurotrophic factor (BDNF)...
July 23, 2021: Cells
https://read.qxmd.com/read/34424488/investigation-of-the-molecular-role-of-brain-derived-neurotrophic-factor-in-alzheimer-s-disease
#31
REVIEW
Pragya Girotra, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Simona Bungau
Brain-derived neurotrophic factor (BDNF), or abrineurin, is a member of the neurotrophin family of growth factors that acts on both the central and peripheral nervous systems. BDNF is also well known for its cardinal role in normal neural maturation. It binds to at least two receptors at the cell surface known as tyrosine kinase B (TrkB) and p75NTR . Additional neurotrophins that are anatomically linked with BDNF include neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), and nerve growth factor (NGF). It is evident that BDNF levels in patients with Alzheimer's disease (AD) are altered...
February 2022: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/34358930/paternal-fenvalerate-exposure-transgenerationally-impairs-cognition-and-hippocampus-in-female-offspring
#32
JOURNAL ARTICLE
Feng Zhan, Ye-Cheng Wang, Quan-Mei Liu, Meng-Juan Guo, Hui-Min Zhu, Chi Zhang, De-Xiang Xu, Xiu-Hong Meng
The impairments of maternal fenvalerate exposure have been well documented in previous study, but little was known about the effects of paternal fenvalerate exposure. The current study aimed to assess the effects of paternal fenvalerate exposure on spatial cognition and hippocampus across generations. Adult male mice (F0) were orally administered with fenvalerate (0, 2 or 20 mg/kg) for 5 weeks. F0 males were mated with untreated-females to generate F1 generation. F1 males were mated with F1 control females to generate F2 generation...
October 15, 2021: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/34199883/peptides-derived-from-growth-factors-to-treat-alzheimer-s-disease
#33
REVIEW
Suzanne Gascon, Jessica Jann, Chloé Langlois-Blais, Mélanie Plourde, Christine Lavoie, Nathalie Faucheux
Alzheimer's disease (AD) is a devastating neurodegenerative disease characterized by progressive neuron losses in memory-related brain structures. The classical features of AD are a dysregulation of the cholinergic system, the accumulation of amyloid plaques, and neurofibrillary tangles. Unfortunately, current treatments are unable to cure or even delay the progression of the disease. Therefore, new therapeutic strategies have emerged, such as the exogenous administration of neurotrophic factors (e.g., NGF and BDNF) that are deficient or dysregulated in AD...
June 4, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/33984602/plasmalogen-attenuates-the-development-of-hepatic-steatosis-and-cognitive-deficit-through-mechanism-involving-p75ntr-inhibition
#34
JOURNAL ARTICLE
Yanjun Liu, Peixu Cong, Tao Zhang, Rui Wang, Xiaoxu Wang, Junyi Liu, Xinceng Wang, Jie Xu, Yuming Wang, Jingfeng Wang, Changhu Xue
Emerging evidence suggests that the reduction of ethanolamine plasmalogen (PlsEtn) is associated with in Alzheimer's disease and metabolic diseases. However, the mechanistic bases for PlsEtn on the these diseases are not well understood. Plasmalogens are primarily synthesized in the liver and enriched in brain. To this end, the present study sought to investigate the potential role of PlsEtn on steatohepatitis and memory impairments and its underlying mechanism. Here we show that peroxisome dysfunction and impairment of PlsEtn synthesis pathway occurs in both of hippocampus and liver, resulting in the decrease of PlsEtn level in APP/PS1 mice and HFD-fed mice...
July 2021: Redox Biology
https://read.qxmd.com/read/33966253/maternal-subclinical-hypothyroidism-in-rats-impairs-spatial-learning-and-memory-in-offspring-by-disrupting-balance-of-the-trka-p75-ntr-signal-pathway
#35
JOURNAL ARTICLE
Fan Zhang, Xinyue Lin, Aihua Liu, Jian Chen, Zhongyan Shan, Weiping Teng, Xiaohui Yu
Maternal subclinical hypothyroidism (SCH) during pregnancy can adversely affect the neurodevelopment of the offspring. The balance of nerve growth factor (NGF)-related tropomyosin receptor kinase A/p75 neurotrophin receptor (TrkA/p75NTR ) signaling in the hippocampus is important in brain development, and whether it affects cognitive function in maternal SCH's offspring is not clear. In this study, we found that compared with the control (CON) group, expression of proliferation-related proteins [NGF, p-TrkA, phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2) and phospho-cAMP response element-binding protein (p-CREB)] decreased in the hippocampus of the offspring in the SCH group, overt hypothyroidism (OHT) group, and the group with levothyroxine (L-T4 ) treatment for SCH from gestational day 17 (E17)...
September 2021: Molecular Neurobiology
https://read.qxmd.com/read/33935645/depletion-of-trkb-receptors-from-adult-serotonergic-neurons-increases-brain-serotonin-levels-enhances-energy-metabolism-and-impairs-learning-and-memory
#36
JOURNAL ARTICLE
Madhusmita P Sahu, Yago Pazos-Boubeta, Anna Steinzeig, Katja Kaurinkoski, Michela Palmisano, Olgierd Borowecki, Timo Petteri Piepponen, Eero Castrén
Neurotrophin brain-derived neurotrophic factor (BDNF) and neurotransmitter serotonin (5-HT) regulate each other and have been implicated in several neuronal mechanisms, including neuroplasticity. We have investigated the effects of BDNF on serotonergic neurons by deleting BDNF receptor TrkB from serotonergic neurons in the adult brain. The transgenic mice show increased 5-HT and Tph2 levels with abnormal behavioral phenotype. In spite of increased food intake, the transgenic mice are significantly leaner than their wildtype littermates, which may be due to increased metabolic activity...
2021: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/33899577/investigating-the-effect-of-crocin-on-memory-deficits-induced-by-total-sleep-deprivation-tsd-with-respect-to-the-bdnf-trkb-and-erk-levels-in-the-hippocampus-of-male-wistar-rats
#37
JOURNAL ARTICLE
Malihe Looti Bashiyan, Mohammad Nasehi, Salar Vaseghi, Solmaz Khalifeh
BACKGROUND: Sleep deprivation (SD) induces cognitive impairments such as memory deficit. Brain-derived neurotrophic factor (BDNF) is considered as the most critical neurotrophin in the central nervous system that is involved in sleep and memory. The main receptor of BDNF, tropomyosin receptor kinase B (TrkB), is dramatically expressed in the hippocampus. Also, extracellular signal-regulated kinase (ERK) has a significant role in memory function. Crocin is a carotenoid chemical compound and the active component of the flower Crocus sativus L...
April 25, 2021: Journal of Psychopharmacology
https://read.qxmd.com/read/33666886/the-neurotrophic-like-effect-of-carvacrol-perspective-for-axonal-and-synaptic-regeneration
#38
JOURNAL ARTICLE
Flávia Malvestio Sisti, Neife Aparecida Guinaim Dos Santos, Lilian do Amaral, Antonio Cardozo Dos Santos
Carvacrol (CARV) is a phytochemical widely used as flavoring, preservative, and fragrance in food and cosmetic industries. CARV is able to cross the blood-brain barrier (BBB) and has demonstrated protective potential against neurodegenerative diseases by several mechanisms, including antioxidant, anti-inflammatory, anticholinesterase, and antiapoptotic effects. However, it is not known whether CARV is able to modulate axonal and synaptic plasticity, crucial events in cognition, memory, and learning. Abnormalities in axonal and synaptic plasticity, low levels of neurotrophins, and bioenergetic failure have been associated with the pathogenesis of neurodegenerative diseases, including Parkinson's (PD) and Alzheimer's diseases (ADs)...
June 2021: Neurotoxicity Research
https://read.qxmd.com/read/33643311/tissue-specificity-of-antibodies-raised-against-trkb-and-p75-ntr-receptors-implications-for-platelets-as-models-of-neurodegenerative-diseases
#39
JOURNAL ARTICLE
Samuel Fleury, Imane Boukhatem, Jessica Le Blanc, Mélanie Welman, Marie Lordkipanidzé
Platelets and neurons share many similarities including comparable secretory granule types with homologous calcium-dependent secretory mechanisms as well as internalization, sequestration and secretion of many neurotransmitters. Thus, platelets present a high potential to be used as peripheral biomarkers to reflect neuronal pathologies. The brain-derived neurotrophic factor (BDNF) acts as a neuronal growth factor involved in learning and memory through the binding of two receptors, the tropomyosin receptor kinase B (TrkB) and the 75 kDa pan-neurotrophic receptor (p75NTR )...
2021: Frontiers in Immunology
https://read.qxmd.com/read/33610667/exercise-and-pharmacological-inhibition-of-histone-deacetylase-improves-cognitive-function-accompanied-by-an-increase-of-gene-expressions-crucial-for-neuronal-plasticity-in-the-hippocampus
#40
JOURNAL ARTICLE
Mika Kitahara, Takahiro Inoue, Hiroki Mani, Yasuyuki Takamatsu, Ryo Ikegami, Harukazu Tohyama, Hiroshi Maejima
Exercise is recognized to increase the expression of neurotrophic genes in the hippocampus and prevent cognitive impairment. Histone deacetylase (HDAC) inhibitor acetylate histones and enhance gene transcription in epigenetic regulation. HDAC inhibitors are expected to be an efficacious pharmacological treatment for cognitive function. This study aimed to examine the effect of HDAC inhibitors and exercise on epigenetic markers and neurotrophic gene expression in the hippocampus to find a more enriched brain conditioning for cognitive function based on the synergic effects of pharmacological treatment and behavioral therapy...
February 18, 2021: Neuroscience Letters
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