keyword
https://read.qxmd.com/read/38460431/bright-daylight-produces-negative-effects-on-affective-and-cognitive-outcomes-in-nocturnal-rats
#1
JOURNAL ARTICLE
James T Sangma, Zothanmawii Renthlei, Amit K Trivedi
The daily light/dark cycle affects animals' learning, memory, and cognition. Exposure to insufficient daylight illumination negatively impacts emotion and cognition, leading to seasonal affective disorder characterized by depression, anxiety, low motivation, and cognitive impairment in diurnal animals. However, how this affects memory, learning, and cognition in nocturnal rodents is largely unknown. Here, we studied the effect of daytime light illuminance on memory, learning, cognition, and expression of mRNA levels in the hippocampus, thalamus, and cortex, the higher-order learning centers...
March 6, 2024: Journal of Photochemistry and Photobiology. B, Biology
https://read.qxmd.com/read/38328140/vagus-nerve-stimulation-vns-modulates-synaptic-plasticity-in-the-rat-infralimbic-cortex-via-trk-b-receptor-activation-to-reduce-drug-seeking
#2
Christopher M Driskill, Jessica E Childs, Aarron J Phensy, Sierra R Rodriguez, John T O'Brien, Kathy L Lindquist, Aurian Naderi, Bogdan Bordieanu, Jacqueline F McGinty, Sven Kroener
UNLABELLED: Drugs of abuse cause changes in the prefrontal cortex (PFC) and associated regions that impair inhibitory control over drug-seeking. Breaking the contingencies between drug-associated cues and the delivery of the reward during extinction learning reduces relapse. Vagus nerve stimulation (VNS) has previously been shown to enhance extinction learning and reduce drug-seeking. Here we determined the effects of VNS-mediated release of brain-derived neurotrophic factor (BDNF) on extinction and cue-induced reinstatement in rats trained to self-administer cocaine...
January 26, 2024: bioRxiv
https://read.qxmd.com/read/38211776/neurotrophin-3-into-the-insular-cortex-strengthens-conditioned-taste-aversion-memory
#3
JOURNAL ARTICLE
María G Briones-Vidal, Salma E Reyes-García, Martha L Escobar
Memory consolidation is an essential process of long-term memory formation. Neurotrophins have been suggested as key regulators of activity dependent changes in the synaptic efficacy and morphology, which are considered the downstream mechanisms of memory consolidation. The neurotrophin 3 (NT-3), a member of the neurotrophin family, and its high affinity receptor TrkC, are widely expressed in the insular cortex (IC), a region with a critical role in the consolidation of the conditioned taste aversion (CTA) paradigm, in which an animal associates a novel taste with nausea...
January 9, 2024: Behavioural Brain Research
https://read.qxmd.com/read/36948022/glp-1-agonist-liraglutide-prevents-mk%C3%A2-801-induced-schizophrenia%C3%A2-like-behaviors-and-bdnf-creb-p-creb-trk-b-expressions-in-the-hippocampus-and-prefrontal-cortex-in-balb-c-mice
#4
JOURNAL ARTICLE
Meltem Donmez Kutlu, Seda Kose, Kubra Akillioglu
Glucagon-like peptide 1 (GLP-1) agonists are among the agents that can be used to treat type 2 diabetes mellitus, and they have also been reported to have neuroprotective effects. This study examined the effects of GLP-1 agonist Liraglutide on CREB, BDNF, Trk-B expression and emotional/cognitive behaviors in an experimental schizophrenia-like behavior model induced by MK-801. MK-801 (0.25 mg/kg, 0.1 ml/kg body weight) and/or Liraglutide (300 mcg/kg) were injected intraperitoneally once a day for 7 weeks into 8-10 weeks old male Balb/c mice (n = 78)...
March 20, 2023: Behavioural Brain Research
https://read.qxmd.com/read/35622266/effects-of-omega-3-fatty-acid-supplementation-during-chronic-maternal-hypoxia-on-behavioral-disorders-in-male-rat-offspring-the-role-of-trk-family-and-oxidative-stress
#5
JOURNAL ARTICLE
Zohreh Ghotbeddin, Kaveh Khazaeel, Mohammad-Reza Tabandeh, Maryam Aliheydari, Hooshyar Yaghoubi
Maternal hypoxia due to a lack of blood flow and insufficient oxygen supply in the brain leads to behavioral disorders in adult offspring. Fish oil includes docosahexaenoic acid (DHA), a significant component of membrane phospholipids of nerve cells, which improved cognition, and memory. Trk family receptors are activated by hypoxic induction factor (HIF), and are involved in the neurotrophin's protective effects at the cellular level. Here we studied the biochemical, and molecular mechanisms of the protective effect of fish oil during the chronic maternal hypoxia model on behavioral responses in male rat offspring...
May 27, 2022: Metabolic Brain Disease
https://read.qxmd.com/read/35316814/interleukin-10-attenuates-behavioral-immune-and-neurotrophin-changes-induced-by-chronic-central-administration-of-interleukin-1%C3%AE-in-rats
#6
JOURNAL ARTICLE
Yong-Ping Zhang, Yu-Yu Li, Cai Zhang, Ya-Jun Li, Bai-Ping Liu, Yan Zhang, Ju-Da Lin, Cai Song
BACKGROUND: Activated microglia can trigger pro-inflammatory cytokine releases and neuroinflammation, which may inhibit astrocytes to produce neurotrophins and anti-inflammatory factors. Both eventually lead to neuron apoptosis or death. Furthermore, effective antidepressant or anti-dementia treatments can reduce pro-inflammatory cytokines, while enhance interleukin (IL)-10 production. However, the underline mechanism by which IL-10 modulates glial cell function, hence improves cognitive impairment or depression-like behavior is unknown...
March 22, 2022: Neuroimmunomodulation
https://read.qxmd.com/read/34746842/high-fat-diet-associated-cognitive-decline-is-zinc-finger-protein-1-zpr1-the-molecular-connection
#7
REVIEW
Mythri Chittilla, Nuraly S Akimbekov, Mohammed S Razzaque
Zinc finger protein 1 (ZPR1) is required for cellular replication and viability. Recently, ZPR1 variant rs964184 has been repeatedly linked to high plasma triglyceride levels, metabolic syndrome, type 2 diabetes mellitus (T2DM), and nonalcoholic fatty liver disease (NAFLD), suggesting its involvement in lipid metabolism. This article attempts to explain how ZPR1 contributes to the mechanism of high-fat diet-associated cognitive decline through three premises: i) high-fat diet results in cognitive decline, ii) ZPR1 deficiency also results in cognitive decline, and iii) high-fat diet results in ZPR1 deficiency...
2021: Current research in physiology
https://read.qxmd.com/read/34470044/probdnf-dependence-of-ltd-and-fear-extinction-learning-in-the-amygdala-of-adult-mice
#8
JOURNAL ARTICLE
Xiaoyun Ma, Harish Vuyyuru, Thomas Munsch, Thomas Endres, Volkmar Lessmann, Susanne Meis
Neurotrophins are secreted proteins that control survival, differentiation, and synaptic plasticity. While mature neurotrophins regulate these functions via tyrosine kinase signaling (Trk), uncleaved pro-neurotrophins bind preferentially to the p75 neurotrophin receptor (p75NTR) and often exert opposite effects to those of mature neurotrophins. In the amygdala, brain-derived neurotrophic factor (BDNF) enables long-term potentiation as well as fear and fear extinction learning. In the present study, we focused on the impact of mature BDNF and proBDNF signaling on long-term depression (LTD) in the lateral amygdala (LA)...
March 30, 2022: Cerebral Cortex
https://read.qxmd.com/read/34440640/identification-of-novel-positive-allosteric-modulators-of-neurotrophin-receptors-for-the-treatment-of-cognitive-dysfunction
#9
JOURNAL ARTICLE
Märta Dahlström, Nather Madjid, Gunnar Nordvall, Magnus M Halldin, Erika Vazquez-Juarez, Maria Lindskog, Johan Sandin, Bengt Winblad, Maria Eriksdotter, Pontus Forsell
Alzheimer's disease (AD) is the most common neurodegenerative disorder and results in severe neurodegeneration and progressive cognitive decline. Neurotrophins are growth factors involved in the development and survival of neurons, but also in underlying mechanisms for memory formation such as hippocampal long-term potentiation. Our aim was to identify small molecules with stimulatory effects on the signaling of two neurotrophins, the nerve growth factor (NGF) and the brain derived neurotrophic factor (BDNF)...
July 23, 2021: Cells
https://read.qxmd.com/read/34299040/molecular-basis-of-late-life-depression
#10
REVIEW
Chien-Yi Kuo, Chieh-Hsin Lin, Hsien-Yuan Lane
Late-life depression (LLD), compared to depression at a young age, is more likely to have poor prognosis and high risk of progression to dementia. A recent systemic review and meta-analysis of the present antidepressants for LLD showed that the treatment response rate was 48% and the remission rate was only 33.7%, thus implying the need to improve the treatment with other approaches in the future. Recently, agents modulating the glutamatergic system have been tested for mental disorders such as schizophrenia, dementia, and depressive disorder...
July 10, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/33915201/effects-of-morphine-and-maternal-care-on-behaviors-and-protein-expression-of-male-offspring
#11
JOURNAL ARTICLE
Ardeshir Akbarabadi, Mitra-Sadat Sadat-Shirazi, Mohamed Kabbaj, Setareh Nouri Zadeh-Tehrani, Solmaz Khalifeh, Fardad Pirri, Mohammad-Reza Zarrindast
Genes and environment interact during development to alter gene expression and behavior. Parental morphine exposure before conception has devastating effects on the offspring. In the present study, we evaluated the role of maternal care in the intergenerational effect of maternal morphine exposure. Female rats received morphine or saline for ten days and were drugfree for another ten days. Thereafter, they were allowed to mate with drug-naïve male rats. When pups were born, they were cross-fostered to assess the contribution of maternal care versus morphine effects on the offspring...
July 1, 2021: Neuroscience
https://read.qxmd.com/read/33549684/the-role-of-pro-and-mature-neurotrophins-in-the-depression
#12
REVIEW
Ying Xue, Hongyan Liang, Rui Yang, Kunhong Deng, Mimi Tang, Mengqi Zhang
Neurotrophic factors, which can provide nutritional support to neurons and neuronal cells, also played an important role in their proliferation and survival. As signaling molecules, it also mediated the learning, memory and other activities in the brain. The latest study shows that neurotrophic factors have diametrically opposing effects of the pro- and mature form through distinct receptors. In this review, we summarize the different forms of neurotrophic factors, related receptors, and the corresponding biological effects...
April 23, 2021: Behavioural Brain Research
https://read.qxmd.com/read/33146738/rottlerin-bdnf-and-the-impairment-of-inhibitory-avoidance-memory
#13
JOURNAL ARTICLE
Wan-Ling Huang, Ming-Heng Hsiung, Wen Dai, Sherry Shu-Jung Hu
RATIONALE AND OBJECTIVE: As a eukaryotic elongation factor 2 kinase (eEF2K) inhibitor and a mitochondrial uncoupler, oncologists have extensively studied rottlerin. Neuroscientists, however, have accumulated scarce data on the role of rottlerin in affective and cognitive functions. Only two prior studies have, respectively, documented its antidepressant-like effect and how it impairs psychostimulant-supported memory. Whether or not rottlerin would affect aversive memory remains unknown...
November 4, 2020: Psychopharmacology
https://read.qxmd.com/read/32765787/effects-of-vortioxetine-on-depression-model-rats-and-expression-of-bdnf-and-trk-b-in-hippocampus
#14
JOURNAL ARTICLE
Baomin Sun, Yanhua Lv, Hua Xu, Chunhua Qi, Cuiping Li, Pengfei Liu
Effects of Vortioxetine on the expression of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (Trk B) in hippocampus of depressive rats were investigated. Forty-five SD rats were randomly divided into three groups: model control, Vortioxetine and normal control group, with 15 rats in each group. The changes of body mass were recorded within 5 weeks, and the open field test, sugar water preference test and Morris water maze test were performed to evaluate the behavior and mental status of the rats...
September 2020: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/31573411/effects-of-the-application-of-general-anesthesia-with-propofol-during-the-early-stage-of-pregnancy-on-brain-development-and-function-of-sd-rat-offspring-and-the-intervention-of-dha
#15
JOURNAL ARTICLE
Xiangming Yu, Fei Ma, Xingnian Cao, Xiaodi Ma, Chenhu Hu
Objective : To investigate the effects of propofol used in early pregnancy on brain development and function of offspring, and further to explore the effects of docosahexaenoic acid (DHA) intervention. Methods : Forty pregnant rats were randomly divided into four groups: control group (C), propofol group (P), DHA intervention group (D), and propofol + DHA group (P + D). The DHA treatment was before propofol was administered. Morris water maze test was performed 30 days after delivery. The levels of amyloid beta (Aβ), IL-1β and reactive oxygen species (ROS) in hippocampus were detected by enzyme-linked immunosorbent assay (ELISA)...
November 2019: Neurological Research
https://read.qxmd.com/read/31417375/infralimbic-estradiol-enhances-neuronal-excitability-and-facilitates-extinction-of-cocaine-seeking-in-female-rats-via-a-bdnf-trkb-mechanism
#16
JOURNAL ARTICLE
Hanna Yousuf, Chad W Smies, Madalyn Hafenbreidel, Jennifer J Tuscher, Ashley M Fortress, Karyn M Frick, Devin Mueller
Women are more susceptible to developing cocaine dependence than men, but paradoxically, are more responsive to treatment. The potent estrogen, 17β-estradiol (E2 ), mediates these effects by augmenting cocaine seeking but also promoting extinction of cocaine seeking through E2 's memory-enhancing functions. Although we have previously shown that E2 facilitates extinction, the neuroanatomical locus of action and underlying mechanisms are unknown. Here we demonstrate that E2 infused directly into the infralimbic-medial prefrontal cortex (IL-mPFC), a region critical for extinction consolidation, enhances extinction of cocaine seeking in ovariectomized (OVX) female rats...
2019: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/30547417/trkb-regulates-n-methyl-d-aspartate-receptor-signaling-by-uncoupling-and-recruiting-the-brain-specific-guanine-nucleotide-exchange-factor-rasgrf1
#17
JOURNAL ARTICLE
Asghar Talebian, Kim Robinson-Brookes, Susan O Meakin
Brain-derived neurotrophic factor (BDNF) facilitates multiple aspects of neuronal differentiation and cellular physiology by activating the high-affinity receptor tyrosine kinase, TrkB. While it is known that both BDNF and TrkB modulate cellular processes involved in learning and memory, exactly how TrkB cross-talks and modulates signaling downstream of excitatory ionotropic receptors, such as the NMDA receptor (NMDAR), are not well understood. A model that we have investigated involves the signaling molecule RasGrf1, a guanine nucleotide exchange factor for both Ras and Rac...
January 2019: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/30496785/environmental-enrichment-improves-long-term-memory-impairment-and-aberrant-synaptic-plasticity-by-bdnf-trkb-signaling-in-nerve-injured-mice
#18
JOURNAL ARTICLE
Xing-Ming Wang, Wei Pan, Ning Xu, Zhi-Qiang Zhou, Guang-Fen Zhang, Jin-Chun Shen
Nerve injury can induce memory impairment in mice. The aim of this research is to study the effect of environmental enrichment (EE) on long-term memory impairment in nerve-injured mice and the underlying mechanisms. Adult male C57BL/6 mice were received sham or chronic constriction injury (CCI) operation and reared in a standard environment (SE) or EE for 4 weeks after the operation. The pain threshold, long-term memory, expression of brain-derived neurotrophic factor (BDNF) and synaptic plasticity in hippocampus were determined...
February 16, 2019: Neuroscience Letters
https://read.qxmd.com/read/29781786/sitagliptin-rescues-memory-deficits-in-parkinsonian-rats-via-upregulating-bdnf-to-prevent-neuron-and-dendritic-spine-loss
#19
JOURNAL ARTICLE
Jing Li, Shuhu Zhang, Chenye Li, Mei Li, Lan Ma
OBJECTIVES: Parkinson's disease (PD) is a neurodegenerative disease with high morbidity among adults worldwide that causes tremendous trouble to people's lives. The purpose of this study was to investigate the impact of sitagliptin on PD and its potential mechanism. METHODS: First, the memory of rats in each group was evaluated with the Morris water maze (MWM) test and the passive avoidance test. Then, both brain-derived neurotrophic factor (BDNF) protein and mRNA levels were detected by ELISA and qPCR assays, respectively...
September 2018: Neurological Research
https://read.qxmd.com/read/29661832/kinase-activity-in-the-olfactory-bulb-is-required-for-odor-memory-consolidation
#20
JOURNAL ARTICLE
Michelle T Tong, Tae-Young P Kim, Thomas A Cleland
Long-term fear memory formation in the hippocampus and neocortex depends upon brain-derived neurotrophic factor (BDNF) signaling after acquisition. Incremental, appetitive odor discrimination learning is thought to depend substantially on the differentiation of adult-born neurons within the olfactory bulb (OB)-a process that is closely associated with BDNF signaling. We sought to elucidate the role of neurotrophin signaling within the OB on odor memory consolidation. Male mice were trained on odor-reward associative discriminations after bilateral infusion of the kinase inhibitor K252a, or vehicle control, into the OB...
May 2018: Learning & Memory
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