keyword
https://read.qxmd.com/read/38230791/multifaceted-approach-toward-mapping-out-the-anticancer-properties-of-small-molecules-via-in%C3%A2-vitro-evaluation-on-melanoma-and-nonmelanoma-skin-cancer-cells-and-in-silico-target-fishing
#1
JOURNAL ARTICLE
Samuel T Boateng, Tithi Roy, Mercy E Agbo, Md Ashiq Mahmud, Sergette Banang-Mbeumi, Roxane-Cherille N Chamcheu, Rajesh K Yadav, Marion Bramwell, Long K Pham, Danny D Dang, Keith E Jackson, Bolni Marius Nagalo, Ronald A Hill, Tatiana Efimova, Jean Fotie, Jean Christopher Chamcheu
Melanoma and nonmelanoma skin cancers are among the most prevalent and most lethal forms of skin cancers. To identify new lead compounds with potential anticancer properties for further optimization, in vitro assays combined with in-silico target fishing and docking have been used to identify and further map out the antiproliferative and potential mode of action of molecules from a small library of compounds previously prepared in our laboratory. From screening these compounds in vitro against A375, SK-MEL-28, A431, and SCC-12 skin cancer cell lines, 35 displayed antiproliferative activities at the micromolar level, with the majority being primarily potent against the A431 and SCC-12 squamous carcinoma cell lines...
January 2024: Chemical Biology & Drug Design
https://read.qxmd.com/read/37093456/advances-in-the-expression-and-function-of-fyn-in-different-human-tumors
#2
REVIEW
Changqing Liu, Shan Li, Yunlian Tang
The tyrosine kinase Fyn is a member of the SRC family of kinases, and its sustained activation is closely linked to tumor cell migration, proliferation, and cell metabolism. Recently, Fyn has been found to be expressed in various tumor tissues, and the expression and function of Fyn vary between tumors, with Fyn acting as an oncogene to promote proliferation and metastasis in some tumors. This article summarizes the recent studies on the role of Fyn in different human tumors, focusing on the role of Fyn in melanoma, breast cancer, glioma, lung cancer, and peripheral T-cell lymphoma in order to provide a basis for future research and targeted therapy in different human tumors...
April 24, 2023: Clinical & Translational Oncology
https://read.qxmd.com/read/36672292/immune-pathways-with-aging-characteristics-improve-immunotherapy-benefits-and-drug-prediction-in-human-cancer
#3
JOURNAL ARTICLE
Xinyue Wang, Shuang Guo, Hanxiao Zhou, Yue Sun, Jing Gan, Yakun Zhang, Wen Zheng, Caiyu Zhang, Xiaoxi Zhao, Jiebin Xiao, Li Wang, Yue Gao, Shangwei Ning
(1) Background: Perturbation of immune-related pathways can make substantial contributions to cancer. However, whether and how the aging process affects immune-related pathways during tumorigenesis remains largely unexplored. (2) Methods: Here, we comprehensively investigated the immune-related genes and pathways among 25 cancer types using genomic and transcriptomic data. (3) Results: We identified several pathways that showed aging-related characteristics in various cancers, further validated by conventional aging-related gene sets...
January 4, 2023: Cancers
https://read.qxmd.com/read/36498797/screening-and-identification-of-key-biomarkers-in-metastatic-uveal-melanoma-evidence-from-a-bioinformatic-analysis
#4
JOURNAL ARTICLE
Tan Wang, Zixing Wang, Jingyuan Yang, Youxin Chen, Hanyi Min
PURPOSE: To identify key biomarkers in the metastasis of uveal melanoma (UM). METHODS: The microarray datasets GSE27831 and GSE22138 were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified, and functional enrichment analyses were performed. A protein-protein interaction network was constructed, and four algorithms were performed to increase the reliability of hub genes. Biomarker analysis and metastasis-free survival analysis were performed to screen and verify prognostic hub genes...
December 5, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/36255654/cartilage-oligomeric-matrix-protein-acts-as-a-molecular-biomarker-in-multiple-cancer-types
#5
JOURNAL ARTICLE
Bingjie Guo, Yajing Wang, Wenyu Liu, Sailong Zhang
PURPOSE: The main function of cartilage oligomeric matrix protein (COMP) is to maintain the synthesis and stability of the extracellular matrix by interacting with collagen. At present, there are relatively few studies on the role of this protein in tumors. This study aimed to explore the relationship between COMP and pan-cancer, and analyzed its diagnostic and prognostic value. METHODS: The Cancer Genome Atlas database, the Genotype-Tissue Expression database and the Cancer Cell Line Encyclopedia database was used for gene expression analysis...
October 18, 2022: Clinical & Translational Oncology
https://read.qxmd.com/read/34552568/novel-insights-into-cellular-changes-in-hpv8-e7-positive-keratinocytes-a-transcriptomic-and-proteomic-analysis
#6
JOURNAL ARTICLE
Matthias Kirschberg, Adnan Shahzad Syed, Hanife Güler Dönmez, Sandra Heuser, Astrid Wilbrand-Hennes, Angel Alonso, Martin Hufbauer, Baki Akgül
Human papillomavirus type 8 (HPV8) is associated with the development of non-melanoma skin cancer. In the past we already delved into the mechanisms involved in keratinocyte invasion, showing that the viral E7 oncoprotein is a key player that drives invasion of basal keratinocytes controlled by the extracellular protein fibronectin. To unravel further downstream effects in E7 expressing keratinocytes we now aimed at characterizing gene and protein/phosphoprotein alterations to narrow down on key cellular targets of HPV8-E7...
2021: Frontiers in Microbiology
https://read.qxmd.com/read/33619323/correction-to-the-phosphorylation-of-cd147-by-fyn-plays-a-critical-role-for-melanoma-cells-growth-and-metastasis
#7
Xu Zhang, Zunnan Huang, Yeye Guo, Ta Xiao, Ling Tang, Shuang Zhao, Lisha Wu, Juan Su, Weiqi Zeng, Hongbin Huang, Zheng Li, Juan Tao, Jianda Zhou, Xiang Chen, Cong Peng
No abstract text is available yet for this article.
March 2021: Oncogene
https://read.qxmd.com/read/32918219/molecular-biology-of-basal-and-squamous-cell-carcinomas
#8
REVIEW
Lars Boeckmann, Marie Christine Martens, Steffen Emmert
The prevalent keratinocyte-derived neoplasms of the skin are basal cell carcinoma and squamous cell carcinoma. Both so-called non-melanoma skin cancers comprise the most common cancers in humans by far. Common risk factors for both tumor entities include sun exposure, DNA repair deficiencies leading to chromosomal instability, or immunosuppression. Yet, fundamental differences in the development of the two different entities have been and are currently unveiled. The constitutive activation of the sonic hedgehog signaling pathway by acquired mutations in the PTCH and SMO genes appears to represent the early basal cell carcinoma developmental determinant...
2020: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/32565740/a-novel-chalcone-derivative-suppresses-melanoma-cell-growth-through-targeting-fyn-stat3-pathway
#9
JOURNAL ARTICLE
Ling Tang, Jing Long, Keke Li, Xu Zhang, Xiang Chen, Cong Peng
BACKGROUND: Fyn has been documented to have oncogenic features in multiple tumors, which might be a potential therapeutic target, however, few studies on the function role of Fyn and its specific inhibitors in melanoma. METHODS: We investigated the impacts of Fyn and its inhibitor Lj-1-60 on melanoma through bioinformatics analysis, western blot, cell viability, cell cycle and apoptosis and xenograft tumor model as well as immunohistochemical staining. Pull-down and in vitro kinase assay were used to demonstrate Lj-1-60 targeting Fyn...
2020: Cancer Cell International
https://read.qxmd.com/read/32291412/the-phosphorylation-of-cd147-by-fyn-plays-a-critical-role-for-melanoma-cells-growth-and-metastasis
#10
JOURNAL ARTICLE
Xu Zhang, Zunnan Huang, Yeye Guo, Ta Xiao, Ling Tang, Shuang Zhao, Lisha Wu, Juan Su, Weiqi Zeng, Hongbin Huang, Zheng Li, Juan Tao, Jianda Zhou, Xiang Chen, Cong Peng
CD147, also known as extracellular matrix metalloproteinase inducer (EMMPRIN), is a transmembrane glycoprotein that is highly expressed in tumor cells, particularly melanoma cells, and plays critical roles in tumor cell metastasis through the regulation of matrix metalloprotease (MMP) expression. In this study, we identified Fyn as a novel interacting protein of CD147. Fyn is a member of the Src family of nonreceptor tyrosine kinases that regulates diverse physiological processes, such as T lymphocyte differentiation, through the TCR signaling pathway...
May 2020: Oncogene
https://read.qxmd.com/read/29578129/dna-methylation-and-uveal-melanoma
#11
REVIEW
Zhi-Kun Yang, Jing-Yun Yang, Zhuo-Zai Xu, Wei-Hong Yu
OBJECTIVE: The objective of the study was to summarize the role of DNA methylation in the development and metastasis of uveal melanoma (UM). DATA SOURCES: The relevant studies in MEDLINE were searched. STUDY SELECTION: In this review, we performed a comprehensive literature search in MEDLINE using "uveal melanoma" AND ("DNA methylation" OR "epigenetics") for original research/review articles published before February 2018 on the relationship between DNA methylation and UM...
April 5, 2018: Chinese Medical Journal
https://read.qxmd.com/read/29374752/photocarcinogenesis-and-skin-cancer-prevention-strategies-an-update
#12
REVIEW
Marie Christine Martens, Christina Seebode, Janin Lehmann, Steffen Emmert
UV radiation is acknowledged as the primary cause of photocarcinogenesis and therefore contributes to the development of skin cancer entities such as squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and melanoma. Typical DNA photoproducts and indirect DNA damage caused by reactive oxygen species are the result of UV radiation. UV-induced DNA damage is repaired by nucleotide excision repair, which consequently counteracts the development of mutations and skin carcinogenesis. Tumour-suppressor genes are inactivated by mutation and growth-promoting pathways are activated leading to disruption of cell-cycle progression...
February 2018: Anticancer Research
https://read.qxmd.com/read/26751795/src-family-tyrosine-kinase-signaling-regulates-filgap-through-association-with-rbm10
#13
JOURNAL ARTICLE
Hazuki Yamada, Koji Tsutsumi, Yuki Nakazawa, Yoshio Shibagaki, Seisuke Hattori, Yasutaka Ohta
FilGAP is a Rac-specific GTPase-activating protein (GAP) that suppresses lamellae formation. In this study, we have identified RBM10 (RNA Binding Motif domain protein 10) as a FilGAP-interacting protein. Although RBM10 is mostly localized in the nuclei in human melanoma A7 cells, forced expression of Src family tyrosine kinase Fyn induced translocation of RBM10 from nucleus into cell peripheries where RBM10 and FilGAP are co-localized. The translocation of RBM10 from nucleus appears to require catalytic activity of Fyn since kinase-negative Fyn mutant failed to induce translocation of RBM10 in A7 cells...
2016: PloS One
https://read.qxmd.com/read/26305432/fyn-is-an-important-molecule-in-cancer-pathogenesis-and-drug-resistance
#14
REVIEW
Daniel Elias, Henrik J Ditzel
Fyn is a non-receptor tyrosine kinase that belongs to the Src family kinases (SFKs) which under normal physiological conditions is involved in signal transduction pathways in the nervous system, as well as the development and activation of T lymphocytes. In cancer, Fyn contributes to the development and progression of several cancer types through its involvement in the control of cell growth, death, morphogenic transformation and cellular motility. Enhanced expression and/or activation of Fyn is observed in various cancers, including melanoma, glioblastoma, squamous cell carcinoma, prostate and breast cancers...
October 2015: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/25961655/masitinib-for-the-treatment-of-mild-to-moderate-alzheimer-s-disease
#15
REVIEW
Jaume Folch, Dmitry Petrov, Miren Ettcheto, Ignacio Pedrós, Sonia Abad, Carlos Beas-Zarate, Alberto Lazarowski, Miguel Marin, Jordi Olloquequi, Carme Auladell, Antoni Camins
Alzheimer's disease (AD) is a degenerative neurological disorder that is the most common cause of dementia and disability in older patients. Available treatments are symptomatic in nature and are only sufficient to improve the quality of life of AD patients temporarily. A potential strategy, currently under investigation, is to target cell-signaling pathways associated with neurodegeneration, in order to decrease neuroinflammation, excitotoxicity, and to improve cognitive functions. Current review centers on the role of neuroinflammation and the specific contribution of mast cells to AD pathophysiology...
June 2015: Expert Review of Neurotherapeutics
https://read.qxmd.com/read/25450268/identification-of-melanoma-biomarkers-based-on-network-modules-by-integrating-the-human-signaling-network-with-microarrays
#16
JOURNAL ARTICLE
Chunyun Huang, Youyu Sheng, Jack Jia, Lianjun Chen
BACKGROUND: Melanoma is a leading cause of cancer death. Thus, accurate prognostic biomarkers that will assist rational treatment planning need to be identified. METHODS: Microarray analysis of melanoma and normal tissue samples was performed to identify differentially expressed modules (DEMs) from the signaling network and ultimately detect molecular markers to support histological examination. Network motifs were extracted from the human signaling network. Then, significant expression-correlation differential modules were identified by comparing the network module expression-correlation differential scores under normal and disease conditions using the gene expression datasets...
November 2014: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/24973819/the-transcription-factor-irf1-dictates-the-il-21-dependent-anticancer-functions-of-th9-cells
#17
JOURNAL ARTICLE
Frédérique Végran, Hélène Berger, Romain Boidot, Grégoire Mignot, Mélanie Bruchard, Magalie Dosset, Fanny Chalmin, Cédric Rébé, Valentin Dérangère, Bernhard Ryffel, Masashi Kato, Armelle Prévost-Blondel, François Ghiringhelli, Lionel Apetoh
The TH9 subset of helper T cells was initially shown to contribute to the induction of autoimmune and allergic diseases, but subsequent evidence has suggested that these cells also exert antitumor activities. However, the molecular events that account for their effector properties are elusive. Here we found that the transcription factor IRF1 enhanced the effector function of TH9 cells and dictated their anticancer properties. Under TH9-skewing conditions, interleukin 1β (IL-1β) induced phosphorylation of the transcription factor STAT1 and subsequent expression of IRF1, which bound to the promoters of Il9 and Il21 and enhanced secretion of the cytokines IL-9 and IL-21 from TH9 cells...
August 2014: Nature Immunology
https://read.qxmd.com/read/24597767/expression-analysis-of-genes-and-pathways-associated-with-liver-metastases-of-the-uveal-melanoma
#18
JOURNAL ARTICLE
Yuanyuan Zhang, Yong Yang, Lei Chen, Jianhong Zhang
BACKGROUND: Uveal melanoma is an aggressive cancer which has a high percentage metastasizing to the liver, with a worse prognosis. Identification of patients at high risk of metastases may provide information for early detection of metastases and treatment. METHODS: Expression profiling of ocular tumor tissues from 46 liver metastatic uveal melanoma samples and 45 non-metastatic uveal melanoma samples were got from GEO database. Bioinformatic analyses such as the Gene Oncology and Kyoto Encyclopedia of Genes and Genomes were used to identify genes and pathways specifically associated with liver metastases of the uveal melanoma...
March 5, 2014: BMC Medical Genetics
https://read.qxmd.com/read/23915951/immunoglobulin-e-induces-vegf-production-in-mast-cells-and-potentiates-their-pro-tumorigenic-actions-through-a-fyn-kinase-dependent-mechanism
#19
JOURNAL ARTICLE
Guillermina Yanek Jiménez-Andrade, Alfredo Ibarra-Sánchez, Diana González, Mónica Lamas, Claudia González-Espinosa
BACKGROUND: High concentrations of plasmatic IgE have been related to distinct systemic inflammatory conditions that frequently predispose individuals to hypersensitivity reactions. Although effects of IgE have been suggested to relay on the low-intensity activation of distinct effector elements of the immune system, such as mast cells (MC), experimental evidence on the role of IgE-induced production of inflammatory mediators on specific pathologies is scarce. MC are an important component in tumor microenvironment where they seem to secrete a number of immunomodulatory and angiogenic mediators, such as the Vascular Endothelial Growth Factor (VEGF) by not well-described mechanisms...
August 2, 2013: Journal of Hematology & Oncology
https://read.qxmd.com/read/23405030/human-kinome-analysis-reveals-novel-kinases-contributing-to-virus-infection-and-retinoic-acid-inducible-gene-i-induced-type-i-and-type-iii-ifn-gene-expression
#20
JOURNAL ARTICLE
Laura Nousiainen, Maarit Sillanpää, Miao Jiang, James Thompson, Jussi Taipale, Ilkka Julkunen
Activation of host innate antiviral responses are mediated by retinoic-acid inducible gene I (RIG-I)-like receptors, RIG-I and melanoma differentiation-associated gene 5, and TLRs 3, 7, 8 and 9, recognising different types of viral nucleic acids. The major components of the RIG-I- and TLR pathways have putatively been identified, but previously unrecognised kinases may contribute to virus infection-induced activation of the IFN response. Here, we screened a human kinase cDNA library, termed the kinome, using an IFN-λ1 promoter-driven luciferase reporter assay in HEK293 cells during Sendai virus infection...
October 2013: Innate Immunity
keyword
keyword
158893
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.