Samuel T Boateng, Tithi Roy, Mercy E Agbo, Md Ashiq Mahmud, Sergette Banang-Mbeumi, Roxane-Cherille N Chamcheu, Rajesh K Yadav, Marion Bramwell, Long K Pham, Danny D Dang, Keith E Jackson, Bolni Marius Nagalo, Ronald A Hill, Tatiana Efimova, Jean Fotie, Jean Christopher Chamcheu
Melanoma and nonmelanoma skin cancers are among the most prevalent and most lethal forms of skin cancers. To identify new lead compounds with potential anticancer properties for further optimization, in vitro assays combined with in-silico target fishing and docking have been used to identify and further map out the antiproliferative and potential mode of action of molecules from a small library of compounds previously prepared in our laboratory. From screening these compounds in vitro against A375, SK-MEL-28, A431, and SCC-12 skin cancer cell lines, 35 displayed antiproliferative activities at the micromolar level, with the majority being primarily potent against the A431 and SCC-12 squamous carcinoma cell lines...
January 2024: Chemical Biology & Drug Design