Lu-Lin Liu, Zhong-Rui Liu, Lu-Jun Cao, Jun Wang, San-Ming Huang, Shui-Gen Hu, Yi-Zhong Yang, Dong-Sheng Li, Wei-Wei Cao, Qing-Bao Zeng, Sheng Huang, Qiong Wu, Jian-Hua Xiao, Wu-Yang Liu, Yao-Sheng Xiao
OBJECTIVE: Iron accumulation is associated with osteoporosis. This study aims to explore the effect of chronic iron accumulation induced by hepcidin1 deficiency on aging osteoporosis. METHODS: Iron accumulation in hepcidin1 knockout aging mice was assessed by atomic absorption spectroscopy and Perl's staining. Bone microarchitecture was observed using Micro-CT. Hepcidin, ferritin, oxidative stress, and markers of bone turnover in serum were detected by enzyme-linked immunosorbent assay...
January 12, 2024: Journal of Orthopaedic Surgery and Research