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Oxidative Stress Osteoporosis

Xiao-Chen Ma, Si-Yu Zhu, Miao-Miao Luo, Xue-Chao Hu, Cheng Peng, He Huang, Lu-Jing Ren
Menaquinone-7 (MK-7) plays an important role in blood clotting, cardiovascular disease and anti-osteoporosis, and has been wildly used in the food additives and pharmaceutical industries. The aim of this study was to investigate the mechanism of menaquinone-7 biosynthesis in response to different oxygen supplies in Bacillus natto. The differences of fermentation performance, intracellular metabolites, oxidative stress reaction and enzyme activities of Bacillus natto R127 were analyzed under different KLa. Glycerol consumption rate and MK-7 yield at 24...
February 13, 2019: Bioprocess and Biosystems Engineering
Maria Almeida, Ryan M Porter
The sirtuin family of NAD+ -dependent protein deacetylases promotes longevity and counteract age-related diseases. One of the major targets of Sirtuins are the FoxO family of transcription factors. FoxOs play a major role in the adaptation of cells to a variety of stressors such as oxidative stress and growth factor deprivation. Studies with murine models of cell-specific loss- or gain-of-function of Sirtuins or FoxOs and with Sirtuin1 stimulators have provided novel insights into the function and signaling of these proteins on the skeleton...
February 6, 2019: Bone
Jian Cheng, Haohao Wang, Zhida Zhang, Keyong Liang
Introduction: Oxidative stress is currently proposed as a risk factor associated with the development and progression of osteoporosis. Here, the effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glycoside (THSG) on oxidative damage was investigated in an osteoblast-like MC3T3-E1 cell model. Material and methods: In this study, MC3T3-E1 cells were treated with hydrogen peroxide (H2 O2 ) (100 µM) and THSG (20, 50 and 100 μM), and alkaline phosphatase (ALP). ROS and MDA levels were measured using specific kits...
January 2019: Archives of Medical Science: AMS
Li-Wei Lin, Fan-Hsuan Tsai, Wan-Cheng Lan, Yih-Dih Cheng, Sheng-Chi Lee, Chi-Rei Wu
The roots of Achyranthes bidentata Blume (AB) is commonly used in the treatment of osteoporosis and dementia in traditional Chinese medicine. Pharmacological reports evidenced that AB possessed anti-osteoarthritis effects. However, there is little literature about the anti-dementia activities of AB. The present study was designed to prepare steroid-enriched fraction of AB (ABS) and investigate whether ABS can protect from cognitive dysfunction and neuroinflammation against Aβ 1-40-induced Alzheimer's disease (AD) model in rats...
January 21, 2019: Molecular Neurobiology
Qinghe Geng, Haiyan Gao, Renlei Yang, Kaijin Guo, Dengshun Miao
Accumulating studies have shown that oxidative stress increases with aging, which is related to the pathophysiology of postmenopausal osteoporosis. Pyrroloquinoline quinone (PQQ) is a natural anti-oxidant with anti-oxidative and anti-aging effects. However, it is unclear whether PQQ has a protective role against estrogen deficiency-induced osteoporosis. Here, we evaluated the efficacy of PQQ on bone mineral density, bone microarchitecture, bone turnover and biomechanical strength in ovariectomy (OVX)-induced osteoporosis mouse model...
2019: International Journal of Biological Sciences
Rui Zuo, Minghan Liu, Yanqiu Wang, Jie Li, Wenkai Wang, Junlong Wu, Chao Sun, Bin Li, Ziwen Wang, Weiren Lan, Chao Zhang, Chunmeng Shi, Yue Zhou
BACKGROUND: Radiotherapy to cancer patients is inevitably accompanied by normal tissue injury, and the bone is one of the most commonly damaged tissues. Damage to bone marrow mesenchymal stem cells (BM-MSCs) induced by radiation is thought to be a major cause of radiation-induced bone loss. Exosomes exhibit great therapeutic potential in the treatment of osteoporosis, but whether exosomes are involved in radiation-induced bone loss has not been thoroughly elucidated to date. The main purpose of this study is to investigate the role of exosomes derived from BM-MSCs in restoring recipient BM-MSC function and alleviating radiation-induced bone loss...
January 15, 2019: Stem Cell Research & Therapy
Xiao-Rong Ma, Yong Wang, Yong-Chang Sun
BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is associated with a higher prevalence of osteoporosis. However, the underlying mechanisms linking OSAHS with bone loss are still unclear. The aim of this study was to investigate the changes of receptor activator of nuclear factor-κB ligand (RANKL, an osteoclastogenesis-promoting factor) and osteoprotegerin (OPG, the decoy receptor for RANKL), oxidative stress and bone metabolism markers in OSAHS, in order to understand the potential mechanisms underlying bone loss in OSAHS patients...
January 5, 2019: Chinese Medical Journal
Fatemeh Goshadrou, Afsaneh Arefi Oskouie, Maryam Eslami, BiBi Fatemeh Nobakht Mothlagh Ghoochani
Objectives: Alzheimer's disease (AD) is dysfunction of the central nervous system and as a neurodegenerative disease. The objective of this work is to investigate metabolic profiling in the serum of animal models of AD compared to healthy controls and then to peruse the role of ghrelin as a therapeutic approach for the AD. Materials and Methods: Nuclear magnetic resonance (NMR) technique was used for identification of metabolites that are differentially expressed in the serum of a rat model of the AD with or without ghrelin treatment...
December 2018: Iranian Journal of Basic Medical Sciences
Yu-Ting Tseng, Wan-Jung Lin, Wan-Hsuan Chang, Yi-Ching Lo
Loganin, a major iridoid glycoside obtained from fruits of Cornus officinalis, possesses anti-inflammatory, antitumor, antidiabetic, and osteoporosis prevention effects. Loganin has been linked to neuroprotection in several models of neurodegeneration, including Parkinson's disease (PD). However, mechanisms underlying the neuroprotective effects of loganin are still mostly unknown. Here, we demonstrated the protective effects of loganin against PD mimetic toxin 1-methyl-4-phenylpyridinium (MPP+ ) and the important roles of insulin-like growth factor 1 receptor (IGF-1R) and glucagon-like peptide 1 receptor (GLP-1R) in the neuroprotective mechanisms of loganin...
December 16, 2018: Phytotherapy Research: PTR
Emma O'Donnell, Jennifer L Scheid, Sarah L West, Mary Jane De Souza
In estrogen deficient postmenopausal women, osteoporosis shares a common link with cardiovascular disease risk, including endothelial dysfunction. The current study sought to examine associations between bone mineral density (BMD) and endothelial function in estrogen deficient premenopausal women with exercise-associated menstrual disturbances. Recreationally trained women (24.3±0.8 years; overall mean±SEM) who were estrogen deficient (amenorrheic or eumenorrheic anovulatory cycles; E2Def; n=13) or estrogen replete (eumenorrheic ovulatory cycles; E2Rep; n=14) were studied...
December 12, 2018: Scandinavian Journal of Medicine & Science in Sports
Hui Liu, Yonghui Dong, Yutong Gao, Liming Zhao, Cong Cai, Dahu Qi, Meipeng Zhu, Libo Zhao, Changyu Liu, Fengjing Guo, Jun Xiao, Hui Huang
Destructive bone diseases caused by osteolysis are increasing in incidence. They are characterized by an excessive imbalance of osteoclast formation and activation. During osteolysis, the activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways are triggered by receptor activator of NF-κB ligand (RANKL), inflammatory factors, and oxidative stress. Previous studies have indicated that the common flavanone glycoside compound hesperetin exhibits anti-inflammatory and antioxidant activity by inhibition of NF-κB and MAPK signaling pathways...
December 11, 2018: Journal of Cellular Physiology
Mahdieh Abbasalizad Farhangi, Mahdi Najafi
AIMS: Recently, the clinical importance of total antioxidant capacity (TAC) and its protective role against several chronic diseases like cardiovascular disease, osteoporosis and several types of cancers has been reported. However, its association with cardio-metabolic risk factors among patients candidate for coronary artery bypass graft surgery (CABG) has not been evaluated yet. CABG is associated with increased oxidative stress and free radicals; so, the current study was aimed to evaluate the potential association of TAC with cardiovascular risk factors among patients candidate for CABG...
2018: PloS One
Romina H Aspera-Werz, Sabrina Ehnert, Daniel Heid, Sheng Zhu, Tao Chen, Bianca Braun, Vrinda Sreekumar, Christian Arnscheidt, Andreas K Nussler
Cigarette smoking has been identified as a major risk factor for osteoporosis decades ago. Several studies have shown a direct relationship between cigarette smoking, decreased bone mineral density, and impaired fracture healing. However, the mechanisms behind impaired fracture healing and cigarette smoking are yet to be elucidated. Migration and osteogenesis of mesenchymal stem/stromal cells (MSCs) into the fracture site play a vital role in the process of fracture healing. In human nicotine, the most pharmacologically active and major addictive component present in tobacco gets rapidly metabolized to the more stable cotinine...
2018: Oxidative Medicine and Cellular Longevity
Arijit Nath, Máté András Molnár, Attila Csighy, Kornélia Kőszegi, Ildikó Galambos, Klára Pásztorné Huszár, András Koris, Gyula Vatai
Lactose-based prebiotics are synthesized by enzymatic- or microbial- biotransformation of lactose and have unique functional values. In this comprehensive review article, the biochemical mechanisms of controlling osteoporosis, blood-lipid, and glucose levels by lactose-based prebiotics and symbiosis with probiotics are reported along with the results of clinical investigations. Interaction between lactose-based prebiotics and probiotics reduces osteoporosis by (a) transforming insoluble inorganic salts to soluble and increasing their absorption to gut wall; (b) maintaining and protecting mineral absorption surface in the intestine; (c) increasing the expression of calcium-binding proteins in the gut wall; (d) remodeling osteoclasts and osteoblasts formation; (e) releasing bone modulating factors; and (f) degrading mineral complexing phytic acid...
December 3, 2018: Medicina
Nam-Hui Yim, Min Jung Gu, Hee Ra Park, Youn-Hwan Hwang, Jin Yeul Ma
BACKGROUND: Sagunja-tang (SGT) is widely used in traditional herbal medicine to treat immune system and gastrointestinal disorders and reportedly has protective effects against inflammation, cancer, and osteoporosis. In this study, we fermented SGT with different Latobacillus strains and investigated the change in phytochemical compositions in SGT and enhancement of it neuroprotective effects in SH-SY5Y human neuroblastoma. METHODS: Marker components, including ginsenoside Rg1 , glycyrrhizin, liquiritin, liquiritigenin, atractylenolide I, atractylenolide II, atractylenolide III, and pachymic acid, in SGT, were qualitatively and quantitatively analyzed using high-performance liquid chromatography-diode array detection and liquid chromatography-mass spectrometry...
November 28, 2018: BMC Complementary and Alternative Medicine
Chenyue Liu, Ruyuan Zhu, Haixia Liu, Lin Li, Beibei Chen, Qiangqiang Jia, Lili Wang, Rufeng Ma, Simin Tian, Min Wang, Min Fu, Jianzhao Niu, Alexander N Orekhov, Sihua Gao, Dongwei Zhang, Baosheng Zhao
Purpose: The present study is aimed to explore whether the aqueous extract of Mori Folium (MF) exhibits bone protective effect by regulating calcium and redox homeostasis in diabetic rats, and to identify the signaling pathways involved in this process. Methods: Diabetic rats were established using high-sugar and high-fat diet and streptozotocin (STZ) (30 mg/kg for 3 consecutive days). The serum levels of osteocalcin (OC), insulin-like growth factor-1 (IGF-1), tartrate-resistant acid phosphatase (TRAP), phosphorus (P), calcium (Ca), 1,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ], parathormone (PTH), advanced glycation end products (AGEs), superoxide dismutase (SOD), and malondialdehyde (MDA), total antioxidant capacity (TAC), 8-hydroxy-2'-deoxyguanosine (8-OH-dG), and interleukin 6 (IL-6) were determined by ELISA or biochemical assays...
2018: Frontiers in Pharmacology
Jingyao Zhang, Yun Chen, Huiqin Luo, Linlin Sun, Mengting Xu, Jin Yu, Qigang Zhou, Guoliang Meng, Shengju Yang
As the most abundant natural flavonoid in rattan tea, dihydromyricetin (DMY) has shown a wide range of pharmacological effects. In addition to the general characteristics of flavonoids, DMY has the effects of cardioprotection, anti-diabetes, hepatoprotection, neuroprotection, anti-tumor, and dermatoprotection. DMY was also applied for the treatment of bacterial infection, osteoporosis, asthma, kidney injury, nephrotoxicity and so on. These effects to some extent enrich the understanding about the role of DMY in disease prevention and therapy...
2018: Frontiers in Pharmacology
Maryam Bayat, Mohammad Hossein Dabbaghmanesh, Farhad Koohpeyma, Marzieh Mahmoodi, Nima Montazeri-Najafabady, Marzieh Bakhshayeshkaram
Bone fragility, despite relatively high BMD values, is an important complication related to insulin resistance and oxidative stress in diabetes mellitus type 1. The present study aimed to compare the effects of soy milk (SM), soy milk containing Lactobacillus casei (PSM), and soy milk enriched with Lactobacillus casei and omega-3 (OPSM) on the stereology of the tibia and vertebra, and antioxidant activity in type 1 diabetic rats. Sixty-five male Sprague Dawley rats were randomly assigned into 5 groups of 13 animals each...
November 8, 2018: Probiotics and Antimicrobial Proteins
Neelam Kaushal, Divya Vohora, Rajinder K Jalali, Sujeet Jha
BACKGROUND AND OBJECTIVE: Osteoporosis is a common bone disorder that increases susceptibility to fragility bone fractures. The clinical and public health repercussions of osteoporosis are huge due to the morbidity, mortality, and cost of medical care linked with fragility fractures. Clinical assessment of osteoporotic risk factors can help to identify candidates at an early stage that will benefit from medical intervention and potentially lowering the morbidity and mortality seen with fractures and complications...
November 2, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Xingzhi Jing, Ting Du, Kun Chen, Jiachao Guo, Wei Xiang, Xudong Yao, Kai Sun, Yaping Ye, Fengjing Guo
Iron overload is common in patients with diseases such as hemoglobinopathies, hereditary hemochromatosis or elderly men and postmenopausal women. This disorder is frequently associated with bone loss and recently has been considered as an independent risk factor for osteoporosis. By excess reactive oxygen species (ROS) production through Fenton reaction, iron could induce osteoblast apoptosis, inhibit osteoblast osteogenic differentiation. Moreover, Iron could also promote osteoclasts differentiation and bone absorption...
November 1, 2018: Journal of Cellular Physiology
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