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Aging Review

Florian Zweipfenning, Sandra P Toelle, Christina Gerth-Kahlert
BACKGROUND: Evaluation and comparison of the ocular phenotype in patients diagnosed with tuberous sclerosis complex (TSC). Analysis of ocular complications during follow-up. PATIENTS AND METHODS: A retrospective chart review was performed of patients with TSC who had received an ocular examination at the eye clinic of the University Hospital Zurich. Data were analysed on visual acuity (VA) assessment, refraction, anterior and posterior eye examination including the distinction of different types of hamartomas and, when available, visual fields...
February 14, 2019: Klinische Monatsblätter Für Augenheilkunde
Gang Seok Jeon, Jae Ryong Han
PURPOSE: To assess treatment efficacy of scleral buckling surgery with wide-field surgical microscope and 27-gauge (G) chandelier illumination for rhegmatogenous retinal detachment (RRD). METHODS: This study is a retrospective chart review of 29 eyes in 29 patients with RRD who underwent scleral buckling surgery with a wide-field surgical microscope and 27-G chandelier illumination fiber inserted into the sclera at the pars plana. Results are expressed as mean ± standard deviation...
February 14, 2019: Ophthalmologica. Journal International D'ophtalmologie
Tae-Joon Kim, Jee Eun Yoon, Jung A Park, Seung Ku Lee, Min Kyung Chu, Kwang Ik Yang, Won-Joo Kim, Seong-Ho Park, Robert J Thomas, Chol Shin, Chang-Ho Yun
BACKGROUND: Restless legs syndrome (RLS) is a common sleep disorder, although it has a low prevalence in Asian populations. However, the reported RLS prevalence in -Korean adults is mostly 4.5-12.1%, which is higher than that reported in other Asian populations. This study aimed to diagnose RLS and exclude mimicking conditions in 2 independent samples of Korean adults, and to compare its prevalence to that from previous studies performed in Asian countries. METHODS: Study populations included a (1) nationwide stratified random sample (n = 2,824; age 19-79 years) and (2) community-based cohort (n = 2,685; age 47-79 years)...
February 14, 2019: Neuroepidemiology
John R Giudicessi, Michael J Ackerman
BACKGROUND: Catecholamingergic polymorphic ventricular tachycardia (CPVT) is characterized by adrenergically-induced VT, syncope, and sudden cardiac arrest (SCA). In the absence of structural disease, exercise-provoked premature ventricular contractions in bigeminy/couplets and non-sustained VT are highly predictive of CPVT. OBJECTIVE: To determine the number of missed/delayed CPVT diagnoses attributable to exercise testing oversights in a cohort of young SCA survivors...
February 11, 2019: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Francesco Doglietto, Francesco Belotti, Carlotta Ginevra Nucci, Elena Roca, Pier Paolo Mattogno, Francesca Zappa, Karol Migliorati, Pier Paolo Panciani, Giannantonio Spena, Claudio Cereda, Claudio Cornali, Marco Maria Fontanella
BACKGROUND: Three-dimensional (3D), high-definition (HD) endoscopy has been recently introduced in neurosurgery and its value extensively discussed in endonasal skull base surgery. There is no reported clinical series on the use of a recent 3D-HD ventriculoscope. OBJECTIVE: Aim of this study is to describe our initial experience with this novel device. METHODS: Patients consecutively operated on from June 2016 to June 2018 with a 3D-HD ventriculoscope were prospectively collected...
February 11, 2019: World Neurosurgery
Faliang Gao, Min Li, Zheng Wang, Lingfei Shi, Lin Lou, Jia Zhou
OBJECTIVE: To explore the efficacy and safety of Gamma Knife Radiosurgery (GKRS) for meningiomas in neurofibromatosis Type 2 (NF2) patients . METHODS: A series of 35 consecutive patients with 99 meningiomas in our department were retrospectively included from Jan 2000 to Dec 2015. Clinical records, MR image and follow-up data were reviewed. RESULTS: A total of 35 patients(25 females and 10 males) with 99 NF2-associated meningiomas were identified...
February 11, 2019: World Neurosurgery
Atahualpa Cauê Paim Strapasson, Ápio Cláudio Martins Antunes, Paulo Petry Oppitz, Marcos Dalsin, Carlos Roberto de Mello Rieder
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for patients suffering from Parkinson's disease (PD). One of its adverse events is the development of postoperative confusion. OBJECTIVE: To report the incidence and associated factors of postoperative confusion after STN-DBS surgery Methods: retrospective cohort study by chart review of patients with PD, who underwent STN-DBS surgery in a Brazilian public academic hospital from January 2013 to October 2017...
February 11, 2019: World Neurosurgery
Federica Guicciardi, Laura Atzori, Angelo Valerio Marzano, Simona Tavecchio, Giampiero Girolomoni, Chiara Colato, Axel Patrice Villani, Jean Kanitakis, Christina Mitteldorf, Rosanna Satta, Bernard Cribier, Laurence Gusdorf, Maria Teresa Rossi, Piergiacomo Calzavara-Pinton, Isabel Bielsa, Maria Teresa Fernandez-Figueras, Werner Kempf, Giorgio Filosa, Luca Pilloni, Franco Rongioletti
BACKGROUND: Clinical and pathological criteria to distinguish drug-induced subacute lupus erythematosus (DI-SCLE) from idiopathic (I-SCLE) are controversial. OBJECTIVE: Aim of the survey was a retrospective analysis of a consistent number of iatrogenous and idiopathic SCLE cases, by means of clinical and histopathological investigation. METHODS: Eleven European University Dermatology Units collected all diagnosed cases from January 2000 to December 2016...
February 11, 2019: Journal of the American Academy of Dermatology
Diogo Trigo, André Nadais, Odete A B da Cruz E Silva
Protein aggregation is normally associated with amyloidosis, namely motor neurone, Alzheimer's, Parkinson's or prion diseases. However, recent results have unveiled a concept of gradual increase of protein aggregation associated with the ageing process, apparently not necessarily associated with pathological conditions. Given that protein aggregation is sufficient to activate stress-response and inflammation, impairing protein synthesis and quality control mechanisms, the former is assumed to negatively affect cellular metabolism and behaviour...
February 11, 2019: Ageing Research Reviews
Sarah N Bowe, C Alessandra Colaianni, Alisa Yamasaki, Brian M Cummings, Christopher J Hartnick
Importance: Health care organizations are complex and evolving systems. To date, longitudinal evaluation to ensure the sustainability of quality improvement (QI) initiatives has been missing from the otolaryngology literature. We sought to reassess perioperative management of laryngotracheal reconstruction, which requires adequate sedation. Objective: Using principles of continuous QI, the objectives of this study were to (1) describe step-by-step methods to sustain QI efforts and (2) revisit a series of process, outcome, and balance measures for sedation weaning management following implementation of a new electronic health record (EHR)...
February 14, 2019: JAMA Otolaryngology—Head & Neck Surgery
Judit Bajor, Zsolt Szakács, Nelli Farkas, Péter Hegyi, Anita Illés, Margit Solymár, Erika Pétervári, Márta Balaskó, Gabriella Pár, Patrícia Sarlós, Ákos Szűcs, József Czimmer, Kata Szemes, Orsolya Huszár, Péter Varjú, Áron Vincze
BACKGROUND AND AIMS: Experimental data suggest that the HLA-DQ2 gene dose has a strong quantitative effect on clinical outcomes and severity of celiac disease (CD). We aimed to conduct a meta-analysis with systematic review to investigate the association between HLA-DQB1*02 gene doses and the characteristics of CD. METHODS: We searched seven medical databases for studies discussing HLA-DQB1 gene dose in CD and various disease characteristics, such as clinical presentation, histology, age at diagnosis, and comorbidities...
2019: PloS One
Keiko Azuma, Xue Tan, Shotaro Asano, Kimiko Shimizu, Asako Ogawa, Tatsuya Inoue, Hiroshi Murata, Ryo Asaoka, Ryo Obata
Pachychoroid neovasculopathy (PNV) shares some anatomical features with other pachychoroid spectrum diseases, but little is known about the characteristics on the treatment with anti-vascular endothelial growth factor (VEGF). We investigated the effect of choroidal structure and responses to anti-VEGF on the prognosis of pachychoroid neovasculopathy (PNV) and other types of neovascular age-related macular degeneration (non-PNV). Twenty-one eyes with PNV and 34 eyes with non-PNV who had anti-VEGF treatment were retrospectively reviewed...
2019: PloS One
Lorene Zerah, René-Sosata Bun, Sylvie Guillo, Jean-Philippe Collet, Dominique Bonnet-Zamponi, Florence Tubach
BACKGROUND: Oral antithrombotic (AT) drugs, which include antiplatelet and anticoagulant therapies, are widely implicated in serious preventable bleeding events. Avoiding inappropriate oral AT combinations is a major concern. Numerous practical guidelines have been released; a document to enhance prescriptions of oral AT combinations for adults would be of great help. OBJECTIVE: To synthesize guidelines on the prescription of oral AT combinations in adults and to create a prescription support-tool for clinicians about chronic management (≥ one month) of oral AT combinations...
2019: PloS One
Mona Doshani, Mark Weng, Kelly L Moore, José R Romero, Noele P Nelson
Hepatitis A (HepA) vaccination is recommended routinely for children at age 12-23 months, for persons who are at increased risk for hepatitis A virus (HAV) infection, and for any person wishing to obtain immunity. Persons at increased risk for HAV infection include international travelers to areas with high or intermediate hepatitis A endemicity, men who have sex with men, users of injection and noninjection drugs, persons with chronic liver disease, person with clotting factor disorders, persons who work with HAV-infected primates or with HAV in a research laboratory setting, and persons who anticipate close contact with an international adoptee from a country of high or interme-diate endemicity (1-3)...
February 15, 2019: MMWR. Morbidity and Mortality Weekly Report
Jenny Carter
PRACTICAL RELEVANCE: Systemic hypertension is common in older cats and can result in damage to organs with a rich arteriolar supply such as the eyes, kidneys, myocardium and brain. Hypertensive disease in these organs is known as target organ damage (TOD). Disease in the eye resulting from hypertension is the most easily identifiable form of TOD and can often be the reason the cat is presented to the veterinarian. Routine blood pressure measurement and fundic examination allows cats with hypertensive ocular lesions to be detected early in the course of the disease, when the lesions have the best chance of responding to treatment...
January 2019: Journal of Feline Medicine and Surgery
Charana Perera, Sue Patterson, George Bruxner
OBJECTIVES: To describe prescription of sodium valproate (SV) for bipolar mood disorder to potentially child-bearing women within one public mental health service and describe risks of fetal exposure, and safe prescribing practices among psychiatrists. METHODS: A 24-month retrospective chart review with descriptive analysis; narrative review of literature and guidelines. RESULTS: Review of 383 charts demonstrated prescription of valproate to 20% of 98 women aged 15-45, with little evidence of advice regarding risk and contraception...
February 14, 2019: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Elsa Gonzalez Nguyen-Tang, Paloma Parvex, Alexandra Goischke, Alexandra Wilhelm-Bals
Vitamin D deficiency is increasing in Switzerland. If cases of rickets are scarce, pediatricians are often dealing with patients presenting vitamin D deficiency. The increase in vitamin D deficiency is certainly due to modification of life habits in recent decades. Clinical presentation varies according to age and severity of deficit. Treatments differ based on the level of vitamin D deficiency and symptoms. Vitamin D deficiency rickets is the most common cause of rickets and is predominantly seen in patients with risks factors They are other types of rickets like pseudo-vitamin D deficiency and hypophosphatemic rickets that the clinician needs to recognize...
February 13, 2019: Revue Médicale Suisse
Manish Kumar, Javed Mostafa
Integration of electronic health records (EHRs) in the national health care systems of low- and middle-income countries (LMICs) is vital for achieving the United Nations Sustainable Development Goal of ensuring healthy lives and promoting well-being for all people of all ages. National EHR systems are increasing, but mostly in developed countries. Besides, there is limited research evidence on successful strategies for ensuring integration of national EHRs in the health care systems of LMICs. To fill this evidence gap, a comprehensive survey of literature was conducted using scientific electronic databases-PubMed, SCOPUS, Web of Science, and Global Health-and consultations with international experts...
February 14, 2019: International Journal of Health Planning and Management
Iqbal Al-Zirqi, Anne Kjersti Daltveit, Siri Vangen
INTRODUCTION: Complete uterine rupture, a rare peripartum complication, is often associated with a catastrophic outcome for both mother and child. However, few studies have investigated large data sets to evaluate maternal outcomes after complete ruptures, particularly in unscarred uteri. This paucity of studies is partly due to the rarity of both the event and the serious outcomes, such as peripartum hysterectomy and maternal death. The incidence of uterine rupture is expected to increase, due to increasing cesarean section rates worldwide...
February 14, 2019: Acta Obstetricia et Gynecologica Scandinavica
Jung K Mok, Evan D Sheha, Andre M Samuel, Steven J McAnany, Avani S Vaishnav, Todd J Albert, Catherine Himo Gang, Sheeraz Qureshi
STUDY DESIGN: This was a retrospective cohort study. OBJECTIVES: The main objectives of this study were to identify epidemiological trends, differences, and complications in patients undergoing surgical treatment for single-level cervical radiculopathy (SLCR). SUMMARY OF BACKGROUND DATA: SLCR that fails nonoperative management is effectively treated with either anterior cervical discectomy and fusion (ACDF), cervical disc replacement (CDR), or posterior cervical foraminotomy (PCF)...
February 12, 2019: Clinical Spine Surgery
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