keyword
https://read.qxmd.com/read/38185768/protective-topical-dual-sided-nanofibrous-hemostatic-dressing-using-mussel-and-silk-proteins-with-multifunctionality-of-hemostasis-and-anti-bacterial-infiltration
#21
JOURNAL ARTICLE
Jaeyun Lee, Eunjin Kim, Ki-Joo Kim, Jong Won Rhie, Kye Il Joo, Hyung Joon Cha
Topical hemostatic agents are preferred for application to sensitive bleeding sites because of their immediate locoregional effects with less tissue damage. However, the majority of commercial hemostatic agents fail to provide stable tissue adhesion to bleeding wounds or act as physical barriers against contaminants. Hence, it has become necessary to investigate biologically favorable materials that can be applied and left within the body post-surgery. In this study, a dual-sided nanofibrous dressing for topical hemostasis is electrospun using a combination of two protein materials: bioengineered mussel adhesive protein (MAP) and silk fibroin (SF)...
January 7, 2024: Small
https://read.qxmd.com/read/38182562/quick-model-based-viscoelastic-clot-strength-predictions-from-blood-protein-concentrations-for-cybermedical-coagulation-control
#22
JOURNAL ARTICLE
Damon E Ghetmiri, Alessia J Venturi, Mitchell J Cohen, Amor A Menezes
Cybermedical systems that regulate patient clotting in real time with personalized blood product delivery will improve treatment outcomes. These systems will harness popular viscoelastic assays of clot strength such as thromboelastography (TEG), which help evaluate coagulation status in numerous conditions: major surgery (e.g., heart, vascular, hip fracture, and trauma); liver cirrhosis and transplants; COVID-19; ICU stays; sepsis; obstetrics; diabetes; and coagulopathies like hemophilia. But these measurements are time-consuming, and thus impractical for urgent care and automated coagulation control...
January 5, 2024: Nature Communications
https://read.qxmd.com/read/38166815/prediction-of-injury-localization-in-preoperative-patients-with-gastrointestinal-perforation-a-multiomics-model-analysis
#23
JOURNAL ARTICLE
Pingxia Lu, Yue Luo, Ziling Ying, Junrong Zhang, Xiaoxian Tu, Lihong Chen, Xianqiang Chen, Yingping Cao, Zhengyuan Huang
BACKGROUND: The location of gastrointestinal perforation is essential for severity evaluation and optimizing the treatment approach. We aimed to retrospectively analyze the clinical characteristics, laboratory parameters, and imaging features of patients with gastrointestinal perforation and construct a predictive model to distinguish the location of upper and lower gastrointestinal perforation. METHODS: A total of 367 patients with gastrointestinal perforation admitted to the department of emergency surgery in Fujian Medical University Union Hospital between March 2014 and December 2020 were collected...
January 2, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38122860/platelet-function-testing-and-clinical-outcomes-in-peripheral-arterial-disease-systematic-review-and-narrative-synthesis
#24
REVIEW
Aman Kankaria, Monica Majumdar, Sonia Lee, Ryan P Hall, Sasha P Suarez Ferreira, Ivy Lee, Shiv S Patel, Samuel Jessula, Mario D'Oria, Anahita Dua
OBJECTIVE: This systematic review aims to comprehensively assess the contemporary literature on platelet function testing (PFT) in individuals undergoing revascularization therapy for peripheral arterial disease (PAD). The goal is to identify whether PFT can aid in detecting antiplatelet resistance, predicting post-procedural thrombotic complications, and informing tailored treatment strategies. METHODS: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a literature review was conducted using PubMed databases...
December 18, 2023: Journal of Vascular Surgery
https://read.qxmd.com/read/38116119/polymorphic-short-tandem-repeats-make-widespread-contributions-to-blood-and-serum-traits
#25
JOURNAL ARTICLE
Jonathan Margoliash, Shai Fuchs, Yang Li, Xuan Zhang, Arya Massarat, Alon Goren, Melissa Gymrek
Short tandem repeats (STRs) are genomic regions consisting of repeated sequences of 1-6 bp in succession. Single-nucleotide polymorphism (SNP)-based genome-wide association studies (GWASs) do not fully capture STR effects. To study these effects, we imputed 445,720 STRs into genotype arrays from 408,153 White British UK Biobank participants and tested for association with 44 blood phenotypes. Using two fine-mapping methods, we identify 119 candidate causal STR-trait associations and estimate that STRs account for 5...
December 13, 2023: Cell Genom
https://read.qxmd.com/read/38077825/platelets-of-covid-19-patients-display-mitochondrial-dysfunction-oxidative-stress-and-energy-metabolism-failure-compatible-with-cell-death
#26
JOURNAL ARTICLE
Valentine Léopold, Osoul Chouchane, Joe M Butler, Alex R Schuurman, Erik H A Michels, Justin de Brabander, Bauke V Schomakers, Michel van Weeghel, Daisy I Picavet-Havik, Anita E Grootemaat, Renée A Douma, Tom D Y Reijnders, Augustijn M Klarenbeek, Brent Appelman, W Joost Wiersinga, Nicole N van der Wel, Jeroen den Dunnen, Riekelt H Houtkooper, Cornelis Van't Veer, Tom van der Poll
BACKGROUND: Alterations in platelet function have been implicated in the pathophysiology of COVID-19 since the beginning of the pandemic. While early reports linked hyperactivated platelets to thromboembolic events in COVID-19, subsequent investigations demonstrated hyporeactive platelets with a procoagulant phenotype. Mitochondria are important for energy metabolism and the function of platelets. OBJECTIVES: Here, we sought to map the energy metabolism of platelets in a cohort of noncritically ill COVID-19 patients and assess platelet mitochondrial function, activation status, and responsiveness to external stimuli...
October 2023: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38077814/characterization-of-copy-number-variants-in-a-large-cohort-of-patients-with-von-willebrand-disease-reveals-a-relationship-between-disrupted-regions-and-disease-type
#27
JOURNAL ARTICLE
Brooke Sadler, Pamela A Christopherson, Crystal L Perry, Daniel B Bellissimo, Sandra L Haberichter, Gabe Haller, Lilian Antunes, Veronica H Flood, Jorge Di Paola, Robert R Montgomery
BACKGROUND: Genetic analysis for von Willebrand disease (VWD) commonly utilizes DNA sequencing to identify variants in the von Willebrand factor ( VWF ) gene; however, this technique cannot always detect copy-number variants (CNVs). Additional mapping of CNVs in patients with VWD is needed. OBJECTIVES: This study aimed to characterize CNVs in a large sample of VWF mutation-negative VWD patients. METHODS: To determine the role of CNVs in VWD, a VWF high-resolution comparative genomic hybridization array was custom-designed to avoid multiple sequence variations, repeated sequences, and the VWF pseudogene...
October 2023: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38075556/critical-shifts-in-lipid-metabolism-promote-megakaryocyte-differentiation-and-proplatelet-formation
#28
JOURNAL ARTICLE
Bianca de Jonckheere, Ferdinand Kollotzek, Patrick Münzer, Vanessa Göb, Melina Fischer, Kristina Mott, Cristina Coman, Nina Nicole Troppmair, Mailin-Christin Manke, Monika Zdanyte, Tobias Harm, Manuel Sigle, Dominik Kopczynski, Andrea Bileck, Christopher Gerner, Nils Hoffmann, David Heinzmann, Alice Assinger, Meinrad Gawaz, David Stegner, Harald Schulze, Oliver Borst, Robert Ahrends
During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multiomics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation. Data reveal that MK differentiation is driven by an increased fatty acyl import and de novo lipid synthesis, resulting in an anionic membrane phenotype. Pharmacological perturbation of fatty acid import and phospholipid synthesis blocked membrane remodeling and directly reduced MK polyploidization and proplatelet formation resulting in thrombocytopenia...
September 2023: Nat Cardiovasc Res
https://read.qxmd.com/read/38046948/research-and-publication-trends-on-knee-osteoarthritis-and-cellular-senescence-a-bibliometric-analysis
#29
JOURNAL ARTICLE
Shuai Wang, Jiyong Yang, Ruian Xiang, Congcong Li, Junyi Li, Xingxing Shen, Wengang Liu, Xuemeng Xu
Background: Cellular senescence is associated with age-related pathological changes, senescent cells promote the development of knee osteoarthritis. A better understanding between knee osteoarthritis and cellular senescence may enhance the effectiveness of therapies that aim to slow or stop the progression of this disease. Purpose: This study aimed to systematically analyze and visualize the publication trends, research frontiers and current research hotspots of knee osteoarthritis and cellular senescence by using bibliometrics...
2023: Frontiers in Physiology
https://read.qxmd.com/read/38039722/towards-a-greater-understanding-of-reduced-response-to-aspirin-in-children-with-congenital-heart-disease-post-cardiac-surgery-using-immature-platelet-fraction
#30
JOURNAL ARTICLE
Irene E Regan, Dermot Cox, Sean T Kelleher, Beatrice Nolan, Kathryn Shaw, Owen P Smith, Colin J McMahon
OBJECTIVE: A high platelet turnover rate may produce a population of platelets that confers an inadequate response to aspirin. We aimed to investigate the relationship between residual platelet aggregation and platelet turnover in paediatric cardiology patients on aspirin monotherapy by evaluating the fraction of immature platelets as a marker for turnover and secondly to test the predictive value of the immature platelet fraction (IPF) to classify patients as responsive or non-responsive to aspirin...
November 22, 2023: Thrombosis Research
https://read.qxmd.com/read/38031649/comparison-of-blood-parameters-according-to-fecal-detection-of-mycobacterium-avium-subspecies-paratuberculosis-in-subclinically-infected-holstein-cattle
#31
JOURNAL ARTICLE
Seungmin Ha, Seogjin Kang, Mooyoung Jung, Sang Bum Kim, Han Gyu Lee, Hong-Tae Park, Jun Ho Lee, Ki Choon Choi, Jinho Park, Ui-Hyung Kim, Han Sang Yoo
BACKGROUND: Mycobacterium avium subspecies paratuberculosis (MAP) causes a chronic and progressive granulomatous enteritis and economic losses in dairy cattle in subclinical stages. Subclinical infection in cattle can be detected using serum MAP antibody enzyme-linked immunosorbent assay (ELISA) and fecal polymerase chain reaction (PCR) tests. OBJECTIVES: To investigate the differences in blood parameters, according to the detection of MAP using serum antibody ELISA and fecal PCR tests...
September 2023: Journal of Veterinary Science
https://read.qxmd.com/read/38025153/novel-dosing-and-monitoring-of-aspirin-in-infants-with-systemic-to-pulmonary-artery-shunt-physiology-the-soprano-study
#32
JOURNAL ARTICLE
Joshua W Branstetter, Gary Woods, Hania Zaki, Nicole Coolidge, Tawanda Zinyandu, Subhadra Shashidharan, Alaa Aljiffry
OBJECTIVES: Provision of pulmonary blood flow with a systemic-to-pulmonary artery shunt is essential in some patients with cyanotic congenital heart disease. Traditionally, aspirin (ASA) has been used to prevent thrombosis. We evaluated ASA dosing with 2 separate antiplatelet monitoring tests for accuracy and reliability. METHODS: This is a retrospective, pre-post intervention single center study. Two cohorts were evaluated; the pre-intervention group used thromboelastography platelet mapping (TPM) and post-intervention used VerifyNow aspirin reactivity unit (ARU) monitoring...
2023: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/38018274/a-prediction-model-for-the-progression-from-gestational-hypertension-to-pre-eclampsia-complicated-with-hellp-syndrome
#33
JOURNAL ARTICLE
Zhaoqi Li, Ying Dai, Lin Yun, Wei Guo
OBJECTIVE: HELLP syndrome is a severe complication of hypertensive disorders of pregnancy that can cause multiple organ dysfunction and maternal death in a short period of time. Although HELLP syndrome is more common in patients with pre-eclampsia (PE), there is currently no effective way to identify high-risk individuals who may progress from gestational hypertension (GH) to PE complicated with HELLP syndrome. This study aimed to establish and validate a prediction model for PE complicated with HELLP syndrome, providing a basis for early detection and identification of high-risk individuals in clinical practice...
November 28, 2023: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38011031/pilot-study-of-frozen-platelet-extracellular-vesicles-as-a-therapeutic-agent-in-hemorrhagic-shock-in-rats
#34
JOURNAL ARTICLE
Samantha Durbin, Lindsey Loss, Lydia Buzzard, Karen Minoza, Marissa Beiling, Carmen Karsonovich, Moqing Liu, Joseph Garay, Alexander Fields, Michael Mathews, Benjamin Kuhn, Keith Moskowitz, Byron Miyazawa, Alpa Trivedi, Lucy Kornblith, Michael Fitzpatrick, Shibani Pati, Martin Schreiber
BACKGROUND: Hemorrhage accounts for the most preventable deaths after trauma. Resuscitation is guided by studies that demonstrate improved outcomes in patients receiving whole blood or balanced administration of blood products. Platelets present a logistical challenge due to short shelf life and need for refrigeration. Platelet derived extracellular vesicles (PEVs) are a possible platelet alternative. PEVs are secreted from platelets, have hemostatic effects and mitigate inflammation and vascular injury, similar to platelets...
November 27, 2023: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/37975828/visualizing-a-nanoscale-lubricant-layer-under-blood-flow
#35
JOURNAL ARTICLE
Jun Ki Hong, Isaac J Gresham, Dan Daniel, Anna Waterhouse, Chiara Neto
Tethered-liquid perfluorocarbons (TLPs) are a class of liquid-infused surfaces with the ability to reduce blood clot formation (thrombosis) on blood-contacting medical devices. TLP comprises a tethered perfluorocarbon (TP) infused with a liquid perfluorocarbon (LP); this LP must be retained to maintain the antithrombotic properties of the layer. However, the stability of the LP layer remains in question, particularly for medical devices under blood flow. In this study, the lubricant thickness is spatially mapped and quantified in situ through confocal dual-wavelength reflection interference contrast microscopy...
November 17, 2023: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/37960778/fgf2-and-ptpn11-play-a-role-in-cerebral-injury-caused-by-sevoflurane-anesthesia
#36
JOURNAL ARTICLE
Lin Zhang, Lingyan Xu
Sevoflurane is a new inhaled anesthetic, which has better physical properties than the existing inhalational anesthetics, rapid induction, less tissue uptake, and faster recovery. Sevoflurane can directly dilators cerebral blood vessels and increase cerebral blood flow, but it also reduces cerebral oxygen metabolism rate, thereby reducing cerebral blood flow. However, the role of Fgf2 and Ptpn11 in cerebral injury caused by sevoflurane anesthesia remains unclear. The sevoflurane anesthesia brain tissue datasets GSE139220 and GSE141242 were downloaded from gene expression omnibus (GEO)...
November 10, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37929515/convalescent-plasma-therapy-in-critically-%C3%A4-ll-covid-19-patients-a-retrospective-cohort-study
#37
JOURNAL ARTICLE
M S Sevdi, K Erkalp, A Ozalp, F G Ozcan, S Demirgan, O Akyol, H C Guneyli, M C Tunali, A Selcan
BACKGROUND: Convalescent plasma (CP) therapy can be defined as a passive immunity transfer approach involving the administration of plasma for therapeutic purposes to inpatients hospitalized due to an active virus infection. Passive immunity antibodies can reduce target organ damage and directly neutralize the responsible pathogens. A limited number of studies on the use of CP have reported that critically ill patients can benefit from CP therapy. AIM: We aimed in this study as the outcomes of CP therapy in critically ill coronavirus disease 2019 (COVID-19) patients in intensive care unit (ICU) and determine the differences between the recovery and mortality groups...
October 2023: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/37904396/roles-of-dscc1-and-gins1-in-gastric-cancer
#38
JOURNAL ARTICLE
Shiyang Hou, Jie Zhang, Xiaoqian Chi, Xiaowei Li, Qijun Zhang, Chunbo Kang, Haifeng Shan
Gastric carcinoma is a common malignant tumor originating from gastric mucosal epithelium. However, role of DS-cell cycle-dependent protein 1 (DSCC1) and GINS1 in gastric carcinoma remains unclear. The gastric carcinoma datasets GSE79973 and GSE118916 were downloaded from gene expression omnibus. Multiple datasets were merged and batched. Differentially expressed genes (DEGs) were screened and weighted gene co-expression network analysis was performed. Functional enrichment analysis, gene set enrichment analysis and immune infiltration analysis were performed...
October 27, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37893432/artificial-intelligence-and-neurosurgery-tracking-antiplatelet-response-patterns-for-endovascular-intervention
#39
REVIEW
Khushi Saigal, Anmol Bharat Patel, Brandon Lucke-Wold
Platelets play a critical role in blood clotting and the development of arterial blockages. Antiplatelet therapy is vital for preventing recurring events in conditions like coronary artery disease and strokes. However, there is a lack of comprehensive guidelines for using antiplatelet agents in elective neurosurgery. Continuing therapy during surgery poses a bleeding risk, while discontinuing it before surgery increases the risk of thrombosis. Discontinuation is recommended in neurosurgical settings but carries an elevated risk of ischemic events...
September 25, 2023: Medicina
https://read.qxmd.com/read/37889065/pathogenetic-dichotomy-in-angioleiomyoma
#40
JOURNAL ARTICLE
Ioannis Panagopoulos, Kristin Andersen, Marta Brunetti, Ludmila Gorunova, Ilyá Kostolomov, Wanja Kildal, Hanne Regine Hognestad, Ingvild Lobmaier, Francesca Micci, Sverre Heim
BACKGROUND/AIM: Angioleiomyoma is a benign tumor, occurs at any age, and arises most frequently in the lower extremities. Genetic information on angioleiomyomas is restricted to six reported abnormal karyotypes, losses in chromosome 22 and gains in Xq found by comparative genomic hybridization, and mutation analysis of notch receptor 2 (NOTCH2), NOTCH3, platelet-derived growth factor receptor beta (PDGFRB), and mediator complex subunit 12 (MED12) in a few tumors. Herein, we report the genetic findings in another three angioleiomyomas...
2023: Cancer Genomics & Proteomics
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