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Neutrophils to lymphocytes ratio

Ramazan Topaktaş, Ahmet Ürkmez, Emre Tokuç, Mehmet Akyüz, Musab A Kutluhan
OBJECTIVE: The pathophysiology of urethral stricture and its recurrence remains vague and one of the important causes is progressive infl ammation. It has been shown in recent years that the neutrophil / lymphocyte ratio is a marker of systemic infl ammation and is associated with prognosis in many cardiovascular diseases, malignancies and chronic infl ammatory diseases. We assessed simple systemic infl ammation markers preoperatively and surgical techniques for urethral stricture recurrence after urethroplasty...
February 15, 2019: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Marco Racioppi, Luca Di Gianfrancesco, Mauro Ragonese, Giuseppe Palermo, Emilio Sacco, Pier Francesco Bassi
OBJECTIVES: To evaluate the neutrophil-to-lymphocyte ratio (NLR) as a prognostic factor for response of high risk non muscle invasive bladder cancer (HRNMIBC) treated with BCG therapy. MATERIALS AND METHODS: Between March 2010 and February 2014 in a tertiary center 100 consecutive patients with newly diagnosed HRNMIBC were retrospectively analyzed. Patients were divided according to NLR value: 46 patients with NLR value less than 3 (NLR < 3 group), and 54 patients with NLR value more than 3 (NLR ≥ 3 group)...
November 3, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Ali Zeynal Abidin Tak, Yildizhan Sengül
Background and purpose: Although essential tremor (ET) is the most common cause of tremor, the pathology and underlying mechanisms have not fully understood yet. In addition to kinetic tremor, patients may present several types of tremor, gait ataxia, hearing deficits and eye movement abnormalities. Non-motor symptoms and signs have also added to definition of ET. There is significant evidence indicating the neurodegenerative nature of the disease. New studies indicate that inflammation may have a place in the etiology...
January 30, 2019: Ideggyógyászati Szemle
Ryun Ha, Byeoung Woo Lim, Dong Hyun Kim, Jung Woo Park, Chang Hyun Cho, Ju Hyoung Lee
BACKGROUND AND OBJECTIVES: No consensus has been reached regarding the optimum treatment or factors affecting prognosis in pediatric idiopathic sudden sensorineural hearing loss (ISSNHL) due to its rarity. In the present study, treatment outcomes and prognostic factors of ISSNHL were investigated in pediatric patients who underwent steroid therapy. SUBJECTS: and Methods: Forty-two patients diagnosed with ISSNHL were enrolled in this retrospective study and compared with 39 normal healthy controls with respect to demography and complete blood cell count test results...
February 11, 2019: International Journal of Pediatric Otorhinolaryngology
Yakup Bozkaya, Bediz Kurt, Fatih Gürler
BACKGROUND: This study aims to investigate the prognostic value of the ratio of hemoglobin-RDW (HRR) at diagnosis, in terms of overall survival (OS) and progression-free survival in patients with advanced non-small cell lung cancer (NSCLC). METHODS: Patients with metastatic NCCLC who attended two separate medical oncology clinics between April 2013 and December 2017 were retrospectively screened. HRR was calculated as Hgb (g/dL) divided by the RDW (%). Patients were assigned to either the low HRR group or high HRR group...
February 19, 2019: International Journal of Clinical Oncology
Francisco Valga, Tania Monzón, Fernando Henriquez, Gloria Antón-Pérez
No abstract text is available yet for this article.
February 16, 2019: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Li Zhou, Dong-Mei Xiao, Wen Qin, Bin-Hua Xie, Ting-Hui Wang, Hua Huang, Bao-Jing Zhao, Xi Han, Qing-Qing Sun, Xiu-Di Wu, Han Cen
BACKGROUND: Emerging evidence indicates that some hematological markers have critical value in evaluating treatment response. This study was performed to determine the clinical value of hemoglobin (Hb), platelet (Plt), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in rheumatoid arthritis (RA) patients treated with tocilizumab (TCZ). METHODS: Fifty-two RA patients receiving TCZ were recruited and followed for 6 months. The values of abovementioned hematological markers were collected...
February 19, 2019: Journal of Clinical Laboratory Analysis
Faustino Mollinedo
Neutrophils are the first responders to inflammation and infection. Recently, an elevated neutrophil-to-lymphocyte ratio has generally become a prognostic indicator of poor overall survival in cancer. Accordingly, heterogeneous ill-defined neutrophil-like populations have been increasingly recognized as important players in cancer development. In addition, neutrophil granule proteins released upon cell activation have been associated with tumor progression; this differential granule mobilization may allow neutrophils - and possibly associated cancer cells - to leave the bloodstream and enter inflamed/infected tissues...
February 15, 2019: Trends in Immunology
Zihou Liu, Shunjun Wang, Yongqiang Wang, Ningbo Zhou, Jie Shu, Christof Stamm, Meng Jiang, Fanyan Luo
BACKGROUND AND AIMS: Density may indicate some tissue characteristics and help reveal the role of epicardial adipose tissue (EAT) in coronary artery disease (CAD). Therefore, we assessed the association of EAT density with the coronary artery plaque burden in patients presenting with chest pain. METHODS: This retrospective cohort study comprised 614 patients (mean age 61 ± 9 years, 61% males) with a high cardiovascular disease risk, who underwent cardiac computed tomography angiography...
February 6, 2019: Atherosclerosis
Viera Jančinová, Katarína Drábiková, Zdenko Killinger, Silvia Pažoureková, Radomír Nosáľ, Juraj Payer
The relationship between inflammation and formation of reactive oxygen species (ROS) is still not completely understood and excessive inflammatory reaction is attributed to increased yet also to reduced ROS formation. To compare ROS formation in severe and low inflammation, neutrophil oxidative burst was analyzed in rheumatic patients before and during therapy with TNFα- or interleukin-6 receptor-neutralizing antibodies. Intracellular and extracellular ROS productions were evaluated on the basis of luminol- and isoluminol-enhanced chemiluminescence in isolated peripheral neutrophils...
February 15, 2019: International Immunopharmacology
Zhichao Wang, Chi Liu, Hong Fang
Major advances in coronary interventional techniques and pharmacotherapy as well as the use of drug-eluting stents (DESs) have considerably reduced the risk of in-stent restenosis (ISR). However, ISR remains a major clinical challenge. Inflammation and platelet activation are important processes that underlie the pathophysiology of ISR. Parameters related to blood cells, entailing both cell count and morphology, are useful markers of the inflammatory response and platelet activation in clinical practice. Recent studies have highlighted several new combined or derived parameters related to blood cells that independently predict ISR after DES implantation...
February 17, 2019: Angiology
B E Bass, T Tsai, H Yang, V Perez, D Holzgraefe, J Chewning, J W Frank, C V Maxwell
A study was conducted using 3 groups of gestating gilts and sows (n = 98) to determine the effects of Pichia guilliermondii (Pg), a whole cell inactivated yeast product (CitriStim; ADM Alliance Nutrition), on performance and immune parameters of dams and litters. Within 24 h of breeding, gilts and sows were allotted to 1 of 3 treatments consisting of a control (SC) diet or SC diet supplemented with 0.1 (S1) or 0.2% (S2) Pg. Dietary treatments were maintained through lactation. Colostrum and milk (d 14) samples were collected for IgA, IgG, and IgM analysis...
February 16, 2019: Journal of Animal Science
Maria Silvia Cona, Mara Lecchi, Sara Cresta, Silvia Damian, Michele Del Vecchio, Andrea Necchi, Marta Maria Poggi, Daniele Raggi, Giovanni Randon, Raffaele Ratta, Diego Signorelli, Claudio Vernieri, Filippo de Braud, Paolo Verderio, Massimo Di Nicola
Predictive biomarkers of response to immune-checkpoint inhibitors (ICIs) are an urgent clinical need. The aim of this study is to identify manageable parameters to use in clinical practice to select patients with higher probability of response to ICIs. Two-hundred-and-seventy-one consecutive metastatic solid tumor patients, treated from 2013 until 2017 with anti- Programmed death-ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) ICIs, were evaluated for baseline lactate dehydrogenase (LDH) serum level, performance status (PS), age, neutrophil-lymphocyte ratio, type of immunotherapy, number of metastatic sites, histology, and sex...
February 14, 2019: Cancers
Sasarman Vasile Aurelian, Molnar Adrian, Octavian Andercou, Schjoth Bruno, Oprea Alexandru, Trifan Catalin, Bindea Dan
BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) has recently emerged as a useful predictor of cardiovascular risk and adverse outcomes. According to previous studies, an NLR > 5 has the highest sensitivity and specificity for postoperative morbidity and mortality in cardiovascular disease. This study aims to evaluate the NLR in cases of unruptured (uAAA) and ruptured (rAAA) infrarenal abdominal aortic aneurysm (AAA) and to assess the role of NLR as a prognostic marker of 30-day mortality in patients with unruptured and ruptured AAA who underwent surgical repair...
February 12, 2019: Annals of Vascular Surgery
Vasundhara Kain, William Van Der Pol, Nithya Mariappan, Aftab Ahmad, Peter Eipers, Deanna L Gibson, Cecile Gladine, Claire Vigor, Thierry Durand, Casey Morrow, Ganesh V Halade
Calorie-dense obesogenic diet (OBD) is a prime risk factor for cardiovascular disease in aging. However, increasing age coupled with changes in the diet can affect the interaction of intestinal microbiota influencing the immune system, which can lead to chronic inflammation. How age and calorie-enriched OBD interact with microbial flora and impact leukocyte profiling is currently under investigated. Here, we tested the interorgan hypothesis to determine whether OBD in young and aging mice alters the gut microbe composition and the splenic leukocyte profile in acute heart failure (HF)...
February 15, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Tawfik Khoury, Saleh Daher, Muhammad Massarwa, David Hakimian, Ariel A Benson, Elez Viener, Raymond Farah, Amir Mari, Wadi Hazou, Anas Kadah, Wisam Sbeit, Mahmud Mahamid, Eran Israeli
BACKGROUND AND AIMS: A majority of acutely-ill Crohn's disease (CD) patients who present to Emergency Department (ED) will undergo an abdominal CT to rule out disease complications. We aimed to generate a simple non-invasive scoring model to predict the presence of an intra-abdominal abscess in CD patients in the ED. METHODS: We performed a retrospective case control study at four Israeli hospitals from January-1 st-2010 to May-30 th-2018. Inclusion criteria included patients with an established diagnosis of CD that had cross-sectional abdominal imaging performed...
February 14, 2019: Journal of Crohn's & Colitis
Aysun Yildiz Altun, İsmail Demirel, Esef Bolat, Sibel Özcan, Serdar Altun, Ahmet Aksu, Azize Beştaş
BACKGROUND: Postoperative nausea and vomiting (PONV) is one of the most common complications during the postoperative period. In the literature, there are many factors associated with PONV risk, but it is claimed that inflammation increases this risk. The neutrophil-to-lymphocyte ratio (NLR) is a cheap parameter to use in the diagnosis and follow-up of systemic inflammatory diseases. In this study, we aimed to investigate whether the preoperative NLR was a marker for PONV and to determine its relation with antiemetic use...
February 14, 2019: Aesthetic Plastic Surgery
Şafak Özer Balın, Ayşe Sağmak Tartar, Ayhan Akbulut
Background: Brucellosis is a zoonosis that affects several systems, especially with the osteoarticular involvement. Objectives: This study aims to compare the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), mean platelet volume (MPV) and red blood cell distribution (RDW) in patients with the osteoarticular involvement and those with non-localised brucellosis and evaluate their predictive value for the diagnosis of osteoarticular brucellosis...
December 2018: African Health Sciences
Manabu Kawai, Seiko Hirono, Ken-Ichi Okada, Motoki Miyazawa, Atsushi Shimizu, Yuji Kitahata, Ryohei Kobayashi, Masaki Ueno, Shinya Hayami, Kensuke Tanioka, Hiroki Yamaue
BACKGROUND: The impact of systemic immune inflammatory markers to predict survival in patients receiving neoadjuvant therapy for borderline resectable pancreatic cancer has not been sufficiently investigated. This study aims to evaluate whether systemic immune inflammatory markers after neoadjuvant therapy followed by pancreatectomy become preoperative prognostic factors to predict survival in patients with borderline resectable pancreatic cancer. METHODS: We retrospectively reviewed 67 borderline resectable pancreatic cancer patients receiving neoadjuvant therapy and 58 borderline resectable pancreatic cancer patients undergoing upfront surgery between 2010 and 2016...
February 11, 2019: Surgery
Pei-Hsun Sung, Kuan-Hung Chen, Hung-Sheng Lin, Chi-Hsiang Chu, John Y Chiang, Hon-Kan Yip
Despite left ventricular (LV) dysfunction increases the risk of incidental acute ischemic stroke (AIS), the association between LV function and severity of neurological deficits after AIS remains unclear. Between November 2015 and October 1017, a total of 99 AIS patients were prospectively enrolled and categorized into two groups based on National Institute of Health Stroke Scale (NIHSS). The AIS patients with NIHSS <6 were allocated into Group 1 ( n = 50) and those with NIHSS ≥6 were into Group 2 ( n = 49)...
February 5, 2019: Journal of Clinical Medicine
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