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Linda Dirven, Jaap C Reijneveld, Martin J B Taphoorn, Corneel Coens, Samy A El-Badawy, Tzahala Tzuk-Shina, Jose Bravo-Marques, Michael Back, Lukas J A Stalpers, Roger Stupp, Brigitta G Baumert, Clemens Seidel
BACKGROUND: It is currently unknown whether increasing radiotherapy volume has a negative impact on the health-related quality of life (HRQoL) of low-grade glioma (LGG) patients in the short-term. The aim was to examine if the size of the target volume is independently associated with HRQoL. METHODS: We included patients who were treated with radiotherapy in XXXX study, and who completed baseline HRQoL assessment. HRQoL was measured at baseline and every 3 months thereafter until progression, using the EORTC QLQ-C30 and QLQ-BN20 questionnaires...
February 1, 2019: International Journal of Radiation Oncology, Biology, Physics
Tesfaye Abera Gudeta, Tilahun Mekonnen Regassa
Background: Disorders of pregnancy induced hypertensive are a major health problem in the obstetric population as they are one of the leading causes of maternal and perinatal morbidity and mortality. The World Health Organization estimates that at least one woman dies every seven minutes from complications of hypertensive disorders of pregnancy. The objective of this study is to assess pregnancy induced hypertension and its associated factors among women attending delivery service at Mizan-Tepi University Teaching Hospital, Gebretsadikshawo Hospital and Tepi General Hospital...
January 2019: Ethiopian Journal of Health Sciences
Macey L Henderson, Alvin G Thomas, Ann K Eno, Madeleine M Waldram, Jaclyn Bannon, Allan B Massie, Michael A Levan, Dorry L Segev, Adam W Bingaman
BACKGROUND: Every year, more than 5500 healthy people in the United States donate a kidney for the medical benefit of another person. The Organ Procurement and Transplantation Network (OPTN) requires transplant hospitals to monitor living kidney donors (LKDs) for 2 years postdonation. However, the majority (115/202, 57%) of transplant hospitals in the United States continue to fail to meet nationally mandated requirements for LKD follow-up. A novel method for collecting LKD follow-up is needed to ease both the transplant hospital-level and patient-level burden...
January 15, 2019: JMIR Research Protocols
David Cella, Viktor Grünwald, Bernard Escudier, Hans J Hammers, Saby George, Paul Nathan, Marc-Oliver Grimm, Brian I Rini, Justin Doan, Cristina Ivanescu, Jean Paty, Sabeen Mekan, Robert J Motzer
BACKGROUND: In the ongoing phase 3, CheckMate 214 trial, nivolumab plus ipilimumab improved overall survival compared with sunitinib in patients with intermediate or poor risk, previously untreated, advanced renal cell carcinoma. We aimed to assess whether health-related quality of life (HRQoL) could be used to further describe the benefit-risk profile of nivolumab plus ipilimumab versus sunitinib. METHODS: In the phase 3, randomised, controlled, CheckMate 214 trial, patients aged 18 years and older with previously untreated, advanced or metastatic renal cell carcinoma with a clear-cell component were recruited from 175 hospitals and cancer centres in 28 countries...
January 15, 2019: Lancet Oncology
Tanvi Aggarwal, Mridula Goswami, Jatinder Kaur Dhillon
AIM: The present study was conducted with the aim to assess the effectiveness of Oral Health Education programme on Oral Health Status of visually impaired children in New Delhi. A specially designed oral health educational programme consisting of audio aid, Braille booklet and individualized training was implemented to educate and motivate visually impaired children for maintaining their oral health. METHODS AND RESULTS: A total sample size of 120 children in the age group of 5-15 years was selected and questionnaire based on WHO criteria 2013 was administrated...
January 16, 2019: Special Care in Dentistry
Gulshan Ara, Mansura Khanam, Ahmed Shafiqur Rahman, Zhahirul Islam, Shahriar Farhad, Kazi Istiaque Sanin, Sihan Sadat Khan, Mohammad Mahbobor Rahman, Herma Majoor, Tahmeed Ahmed
Micronutrient deficiency is one of the biggest public health concerns in Bangladesh. As per World Health Organisation (WHO) in the 2016 report, 40% women of reproductive age suffer from anaemia. According to the National Micronutrient Survey 2011-2012, 57% women suffer from zinc deficiency. The objective of the present study was to determine the effectiveness of fortified rice (FFR in addressing anaemia and zinc deficiency among vulnerable women. Baseline and endline surveys were conducted among female Vulnerable Group Development (VDG) beneficiaries in five districts in Bangladesh before and after 12 months of FFR distribution...
2019: PloS One
Jaymie A Henry
More than three years have passed since the publication of the Lancet Commission on Global Surgery and its recommendations on scaling up surgery in sub-Saharan Africa (SSA). An important gap, the voice of the districts as well as lack of contextualized research, has been noted in its support of national surgical plans that run the risk of being at best, aspirational. Moreover, a 'one-size-fits-all approach' may not adequately address country-specific challenges on the ground. There is a need to redirect attention, effort, and funding in creating a global mechanism to gather baseline country information documenting every single district level government health facility's ability and readiness to provide safe surgical, obstetric, trauma, and anesthesia care using the World Health Organization (WHO) Service Availability and Readiness Assessment (SARA) tool to aid in directing country-specific efforts in surgical systems strengthening and ensuring that a basic package of essential surgical and anesthesia services is made available to each citizen with adequate financial protection by 2030...
August 25, 2018: International Journal of Health Policy and Management
Nina Godtfredsen, Tina Brandt Sørensen, Marie Lavesen, Birthe Pors, Lone Sander Dalsgaard, Jens Dollerup, Ove Grann
Background: The positive impact of pulmonary rehabilitation (PR) in patients with COPD is well documented. However, little is known regarding the effect of this treatment in community-based settings. Since 2007, all Danish municipalities have been offering PR to patients with moderate to severe COPD, whereas patients with very severe disease or those suffering from many comorbidities were referred to outpatient hospital-based PR. Objective: To analyze the effect of a standardized PR program conducted in a community-based setting on exercise capacity and health-related quality of life (HRQoL)...
2019: International Journal of Chronic Obstructive Pulmonary Disease
Jeffrey A Sparks, Éilis J O'Reilly, Medha Barbhaiya, Sara K Tedeschi, Susan Malspeis, Bing Lu, Walter C Willett, Karen H Costenbader, Elizabeth W Karlson
BACKGROUND: Prior studies suggest that fish may be protective for rheumatoid arthritis (RA) risk perhaps through the anti-inflammatory effect of omega-3 fatty acid, but this relationship has not been clearly established. Therefore, we investigated fish intake and RA risk by serologic status, age of onset, and smoking using a prospective cohort study with large sample size, repeated measures of dietary intake, and lengthy follow-up. METHODS: We studied fish intake and RA risk among 166,013 women in two prospective cohorts, the Nurses' Health Study (NHS, 1984-2014) and NHSII (1991-2015)...
January 5, 2019: BMC Musculoskeletal Disorders
Song Liu, Yanbin Zhu, Lin Wang, Wei Chen, Xiaolin Zhang, Yingze Zhang
PURPOSE: The literature lacks population-based epidemiologic studies on the incidence and risk factors for traumatic foot fractures. The purpose of this study was to update information concerning the incidence of foot fractures in China and to identify associated risk factors. METHODS: All the data on foot fractures were available from the China National Fracture Survey (CNFS), which was conducted between January and May in 2015. A total of 8 provinces, 24 urban cities and 24 rural counties in China were selected, using stratified random sampling and the probability proportional to size method...
2018: PloS One
Helen J Curtis, Richard Croker, Alex J Walker, Georgia C Richards, Jane Quinlan, Ben Goldacre
BACKGROUND: There is a call for greater monitoring of opioid prescribing in the UK, particularly of strong opioids in chronic pain, for which there is little evidence of clinical benefit. We aimed to comprehensively assess trends and variation in opioid prescribing in primary care in England, from 1998 to 2018, and to assess factors associated with high-dose opioid prescribing behaviour in general practices. METHODS: We did a retrospective database study using open data sources on prescribing for all general practices in England...
February 2019: Lancet Psychiatry
Susan K Roethke, Joanne C Ryan, Sarah Yenser Wood
CASE STUDY Tom, a 75-year-old white male, was recently diagnosed with metastatic renal cell carcinoma (RCC; Tom's case is not an actual clinical case but has been developed by the authors as an exemplar). Two years prior, he had undergone a left partial (laparoscopic) nephrectomy for clear cell RCC. At that time, he had a stage 3 disease (the tumor extended into perinephric tissues but not into the ipsilateral adrenal gland and not beyond Gerota's fascia [, 2016]), and regularly (every 3-6 months) scheduled surveillance imaging did not show metastatic disease...
January 2018: Journal of the Advanced Practitioner in Oncology
Aleena M Wojcieszek, Emily Shepherd, Philippa Middleton, Zohra S Lassi, Trish Wilson, Margaret M Murphy, Alexander Ep Heazell, David A Ellwood, Robert M Silver, Vicki Flenady
BACKGROUND: Stillbirth affects at least 2.6 million families worldwide every year and has enduring consequences for parents and health services. Parents entering a subsequent pregnancy following stillbirth face a risk of stillbirth recurrence, alongside increased risks of other adverse pregnancy outcomes and psychosocial challenges. These parents may benefit from a range of interventions to optimise their short- and longer-term medical health and psychosocial well-being. OBJECTIVES: To assess the effects of different interventions or models of care prior to and during subsequent pregnancies following stillbirth on maternal, fetal, neonatal and family health outcomes, and health service utilisation...
December 17, 2018: Cochrane Database of Systematic Reviews
Nipun Shrestha, Katriina T Kukkonen-Harjula, Jos H Verbeek, Sharea Ijaz, Veerle Hermans, Zeljko Pedisic
BACKGROUND: A large number of people are employed in sedentary occupations. Physical inactivity and excessive sitting at workplaces have been linked to increased risk of cardiovascular disease, obesity, and all-cause mortality. OBJECTIVES: To evaluate the effectiveness of workplace interventions to reduce sitting at work compared to no intervention or alternative interventions. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL, OSH UPDATE, PsycINFO, ClinicalTrials...
December 17, 2018: Cochrane Database of Systematic Reviews
Xia Meng, Michael J Garay, David J Diner, Olga V Kalashnikova, Jin Xu, Yang Liu
Research efforts to better characterize the differential toxicity of PM2.5 (particles with aerodynamic diameters less than or equal to 2.5 μm) speciation are often hindered by the sparse or non-existent coverage of ground monitors. The Multi-angle Imaging SpectroRadiometer (MISR) aboard NASA's Terra satellite is one of few satellite aerosol sensors providing information of aerosol shape, size and extinction globally for a long and continuous period that can be used to estimate PM2.5 speciation concentrations since year 2000...
May 2018: Atmospheric Environment
Ingridt Hildegard Vogler, Daniela Frizon Alfieri, Heloisa Damazio Bruna Gianjacomo, Elaine Regina Delicato de Almeida, Edna Maria Vissoci Reiche
The cascade of care for people living with HIV infection (PLHIV) describes steps in diagnosis, linkage and retention in care, as well as the provision and success of combination antiretroviral therapy (cART). The aim of this study was to evaluate the rates regarding the retention in care, on cART, and suppressed viral load for PLHIV attended at a Brazilian public health network. Data on PLHIV from 116 cities of Paraná, Southern Brazil, attended from 2012 to 2015, were retrospectively collected through the Laboratory Tests Control System (SISCEL)...
November 29, 2018: Cadernos de Saúde Pública
Hong Liang, Ann M Vuong, Changchun Xie, Glenys M Webster, Andreas Sjödin, Wei Yuan, Maohua Miao, Joseph M Braun, Kim N Dietrich, Kimberly Yolton, Bruce P Lanphear, Aimin Chen
BACKGROUND: Polybrominated diphenyl ethers (PBDEs) exist extensively in the environment and human beings. PBDE concentrations are higher in children than adults. A previous study found that prenatal PBDE exposure was associated with decreased reading skills in children; however, evidence is limited on the potential impact of childhood exposure to PBDEs. The study examined the association between childhood PBDE exposures and reading ability in children at ages 5 and 8 years. METHODS: The study included 230 children from an ongoing prospective pregnancy and birth cohort study, the Health Outcomes and Measures of Environment (HOME) Study, conducted in Cincinnati, Ohio...
November 28, 2018: Environment International
Chinedum O Ojinnaka, Colleen Heflin
The Supplemental Nutrition Assistance Program (SNAP) is a public policy program that aims to reduce food insecurity-a social determinant of health that has been associated with suboptimal blood pressure control in the United States. The aim of the article was to explore the association between SNAP benefit timing and size and probability of hypertension-related emergency department (ED) claims. This study used the SNAP data from the Missouri's Department of Social Services for January 2010 to December 2013 linked to Medicaid ED claims data...
October 12, 2018: Journal of the American Society of Hypertension: JASH
Junhua Zhang
Every child deserves a fair chance in life. However, migrant children are at higher risk of developing mental health problems. The problem of migrant children who have left their hukou registration place for 6 months or longer with their parents from rural areas to cities in China has become a unique social issue in the social transformation of China. However, even up to this day, little is known about life satisfaction of migrant children in small and medium-sized cities. To investigate the current situation of migrant children's life satisfaction, several scales including Chinese Adolescent Students' Life Satisfaction Questionnaire, Social Economic Status Scale, Social Support Rating Scale and big five inventory were used to obtain data on 142 migrant children and 165 local primary school students...
2018: Child & Adolescent Social Work Journal: C & A
Carmen Domínguez-Baleón, Luis F Gutiérrez-Mondragón, Adrián I Campos-González, Miguel E Rentería
Background: With around 800,000 people taking their own lives every year, suicide is a growing health concern. Understanding the factors that underlie suicidality and identifying specific variables associated with increased risk is paramount for increasing our understanding of suicide etiology. Neuroimaging methods that enable the investigation of structural and functional brain markers in vivo are a promising tool in suicide research. Although a number of studies in clinical samples have been published to date, evidence about neuroimaging correlates for suicidality remains controversial...
2018: Frontiers in Psychiatry
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