Charles Washington, Matthew Dapas, Arjun Biddanda, Kevin M Magnaye, Ivy Aneas, Britney A Helling, Brooke Szczesny, Meher Preethi Boorgula, Margaret A Taub, Eimear Kenny, Rasika A Mathias, Kathleen C Barnes, Gurjit K Khurana Hershey, Carolyn M Kercsmar, Jessica D Gereige, Melanie Makhija, Rebecca S Gruchalla, Michelle A Gill, Andrew H Liu, Deepa Rastogi, William Busse, Peter J Gergen, Cynthia M Visness, Diane R Gold, Tina Hartert, Christine C Johnson, Robert F Lemanske, Fernando D Martinez, Rachel L Miller, Dennis Ownby, Christine M Seroogy, Anne L Wright, Edward M Zoratti, Leonard B Bacharier, Meyer Kattan, George T O'Connor, Robert A Wood, Marcelo A Nobrega, Matthew C Altman, Daniel J Jackson, James E Gern, Christopher G McKennan, Carole Ober
BACKGROUND: Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry. METHODS: We tested for association with haplotypes at the most replicated and significant childhood-onset asthma locus at 17q12-q21 and asthma in European American and African American children. Following this, we used whole-genome sequencing data from 1060 African American and 100 European American individuals to identify novel variants on a high-risk African American-specific haplotype...
September 29, 2022: Genome Medicine