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Urinary albumin excretion

Rie Oka, Akihiro Nomura, Ayaka Yasugi, Mitsuhiro Kometani, Yuko Gondoh, Kenichi Yoshimura, Takashi Yoneda
INTRODUCTION: Nutritional intervention is effective in improving glycemic control in patients with type 2 diabetes but requires large inputs of manpower. Recent improvements in photo analysis technology facilitated by artificial intelligence (AI) and remote communication technologies have enabled automated evaluations of nutrient intakes. AI- and mobile-supported nutritional intervention is expected to be an alternative approach to conventional in-person nutritional intervention, but with less human resources, although supporting evidence is not yet complete...
March 15, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Mingzheng Yang, Lin Kan, Lianye Wu, Yingchun Zhu, Qing Wang
The present study observed the effect of baicalin on blood glucose and renal function in patients with diabetic nephropathy and explored its mechanism of action. A total of 95 patients diagnosed with diabetic nephropathy by clinical and laboratory examinations were selected and randomly divided into a control and treatment group. The control group included 45 patients who were treated with routine symptomatic treatment. The remaining 50 patients in the treatment group received baicalin, in addition to routine symptomatic treatment...
March 2019: Experimental and Therapeutic Medicine
Ayumi Kaji, Yoshitaka Hashimoto, Yukiko Kobayashi, Sayori Wada, Masashi Kuwahata, Masahiro Yamazaki, Michiaki Fukui
AIMS: Diabetic kidney disease is an important problem in individuals with diabetes. The effect of dietary protein intake on the renal function of patients with diabetes is controversial. Here we sought to clarify the association between dietary protein intake and changes in the urinary albumin excretion (UAE) or estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes. PATIENTS AND METHODS: In this retrospective cohort study, we included 144 patients (70 men, mean ± standard deviation of age 64 ± 10 years, and median (interquartile range) of UAE 15...
March 12, 2019: Diabetes/metabolism Research and Reviews
Tatsumi Moriya, Takahiro Yamagishi, Madoka Matsubara, Motoshi Ouchi
AIMS: The aim of the present study was to explore the relationship between changes in renal structure in patients with type 2 diabetes at an early stage of diabetic nephropathy using serial renal biopsies, and change in renal function. METHODS: The study population comprised 10 patients with type 2 diabetes with normo- or microalbuminuria at baseline. Light and electron microscopy-based morphometric analyses were performed to quantitatively evaluate glomerular and interstitial structural changes...
February 10, 2019: Journal of Diabetes and its Complications
Chanadda Chinthammit, Amanda Harrington, Ann Wild, Shepin Werner, Kevin Boesen, Ann M Taylor, Terri L Warholak
BACKGROUND: Renin-angiotensin system (RAS) antagonists are recommended for people with diabetes and hypertension or with elevated urinary albumin excretion. RAS antagonists are beneficial for some, yet clinically inappropriate for others. The percentage of patients for whom RASs are clinically inappropriate has not been compared across health plans. OBJECTIVES: To (a) identify reasons why RAS therapy was not recommended and (b) compare exception percentages between health plans...
March 2019: Journal of Managed Care & Specialty Pharmacy
Yun-Ru Lai, Wen-Chan Chiu, Chih-Cheng Huang, Nai-Wen Tsai, Hung-Chen Wang, Wei-Che Lin, Ben-Chung Cheng, Yu-Jih Su, Chih-Min Su, Sheng-Yuan Hsiao, Cheng-Hsien Lu
Variability in HbA1c is associated with a higher risk of cardiovascular disease and microvascular complications in patients with type 2 diabetes. The present study evaluated the severity of somatic nerve dysfunction at different stages of chronic glycemic impairment, and its correlation with different cardio-metabolic parameters. The study was conducted on 223 patients with type 2 diabetes. We calculated the intrapersonal mean, standard deviation (SD), and coefficient of variation of HbA1c for each patient using all measurements obtained for 3 years prior to the study...
2019: Frontiers in Neuroscience
Yuko Kikuchi, Mariko Matsuo, Chiaki Nabeta, Asuka Akahoshi, Hisanori Minami
Crohn's disease is a type of inflammatory bowel disease of unknown etiology. Administration of indomethacin (Indo) to rats induces acute mucosal lesions similar to those observed in Crohn's disease patients, but the damage can be prevented by feeding the animals an elemental diet (ED). In this study, we examined changes in intestinal macroscopic appearance, permeability, and immunoglobulin production after administration of Indo to male Sprague-Dawley rats fed normal lab chow or an ED. Intestinal damage was induced by subcutaneous injection of Indo on two successive days...
2019: Journal of Nutritional Science and Vitaminology
James P Corsetti, Stephan J L Bakker, Ronald T Gansevoort, Eke G Gruppen, Margery A Connelly, Charles E Sparks, Robin P F Dullaart
Lipoproteins containing apolipoprotein B modify associations of elevated urinary albumin excretion (UAE) with cardiovascular disease (CVD). Additionally, it is known that elevated UAE alters high-density lipoprotein functionality. Accordingly, we examined whether HDL features might also modify UAE-associated CVD. Multivariable Cox proportional-hazards modeling was performed on participants of the PREVEND (Prevention of Renal and Vascular Endstage Disease) study at the baseline screening with standard lipid/lipoprotein analyses and, three-to-four years later (second screen), with nuclear magnetic resonance lipoprotein analyses focusing on HDL parameters including HDL particle (HDL-P) and apolipoprotein A-I concentrations...
February 23, 2019: International Journal of Molecular Sciences
Samy A Khodeir, Hanaa I Okda, Heba M Abdalal
Most chronic kidney disease (CKD) biomarkers in the current clinical use are not sensitive enough and cannot be used to identify the early stage of the disease. Klotho is a transmembrane protein predominantly expressed in the renal tubules and implicated in managing phosphate homeostasis, together with fibroblast growth factor-23 (FGF-23); a bone-derived protein that increases urinary phosphate excretion. The present study was carried out on 50 patients CKD with different etiologies referred to the Internal Medicine Department and Out Patient Clinic of Tanta University Hospitals and 30 apparently healthy individuals of matched age and sex as a control group...
January 2019: Saudi Journal of Kidney Diseases and Transplantation
J Q Li, X Han, M J Zhang, X B Li, G J Liu, J Q Zhang, Z J Liu
Objective: To investigate and analyze the actual intake of protein and energy in adult patients with severe burns during post burn days (PBDs) 3 to 14. Methods: Records of 52 adult patients with severe burns [37 males and 15 females, (37±9) years old], admitted to the Department of Plastic Surgery and Burns of Tianjin First Central Hospital from January 1st 2011 to December 31st 2017 and meeting the study inclusion criteria, were retrospectively analyzed. Nutrition intake from routes of oral diet, enteral nutrition preparations, and parenteral nutrition preparations of patients during PBDs 3 to 14 were obtained from critical care records...
February 20, 2019: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Wen-Wen Han, Li-Jun Tang, Xiang-Lei Kong, Huan Yang, Dong-Mei Xu
The present study aimed to explore the correlation between the dynamic serum levels of phospholipase A2 receptor (PLA2R), aldose reductase (AR) and superoxide dismutase 2(SOD2) antibodies with disease activity and treatment response in patients with idiopathic membranous nephropathy (IMN). The present study included 56 patients with IMN who were diagnosed through a renal biopsy and presenting with nephrotic syndrome. The patients were divided into two treatment groups: One treated with cyclophosphamide (CTX) and one with tacrolimus (FK506)...
March 2019: Experimental and Therapeutic Medicine
Kengo Kidokoro, David Z I Cherney, Andrea Bozovic, Hajime Nagasu, Minoru Satoh, Eiichiro Kanda, Tamaki Sasaki, Naoki Kashihara
BACKGROUND: Sodium glucose cotransporter 2 (SGLT2) inhibitors may reduce kidney hyperfiltration, thereby preventing diabetic kidney disease (DKD) progression, which may in turn reduce cardiovascular risk, including heart failure. However, the mechanisms that regulate renal function responses to SGLT2 inhibition are not yet fully understood. We explored the renal protective effects of SGLT2 inhibition with empagliflozin (Empa), with a focus on glomerular hemodynamic effects and tubuloglomerular feedback (TGF) using in vivo multiphoton microscope (MPM) imaging techniques...
February 18, 2019: Circulation
Deniz Özalp Kızılay, Semra Şen, Betül Ersoy
Objective: In this study we aimed to assess the association between serum uric acid (SUA) concentration and metabolic syndrome (MetS) parameters and insulin resistance (IR). Our second aim was evaluate whether hyperuricemia is related with renal injury and cardiovascular risk in obese (OB) and overweight(OW) children. Methods: This study was conducted on 128 OB/OW children and adolescents (ages: 8-18 years), of whom 52 (40%) with SUA elevation (SUA persantile>75), 76 with (60%) normal SUA level (SUAL)...
February 14, 2019: Journal of Clinical Research in Pediatric Endocrinology
Robert G Hahn, Markus Zdolsek, Emma Hasselgren, Joachim Zdolsek, Håkan Björne
AIMS: A population kinetic model was developed for the body fluid shifts occurring when 20% albumin is given by intravenous infusion. The aim was to study whether its efficacy to expand the plasma volume is impaired after major surgery. METHODS: An intravenous infusion of 3 mL/kg 20% albumin over 30 min was given to 15 volunteers and to 15 patients on the first day after major open abdominal surgery. Blood samples and urine were collected during 5 hours. Mixed-effect modeling software was used to develop a fluid volume kinetic model, using blood hemoglobin and urine excretion the estimate body fluid shifts, to which individual-specific covariates were added in sequence...
February 12, 2019: British Journal of Clinical Pharmacology
Kenta Imaruoka, Yuji Oe, Tomofumi Fushima, Emiko Sato, Akiyo Sekimoto, Hiroshi Sato, Junichi Sugawara, Sadayoshi Ito, Nobuyuki Takahashi
Systemic lupus erythematosus (SLE) increases the risk of preterm birth and preeclampsia (PE). The flares of SLE during pregnancy or after delivery are also problematic. We have previously demonstrated that nicotinamide (NAM), a non-teratogenic amide of vitamin B3, reduces inflammation and oxidative stress and improves PE-like phenotype and pregnancy outcomes in the mouse models of PE. The present study aimed to establish a model to investigate the pregnancy outcomes and flares of SLE in pregnant mice with SLE and to examine whether NAM is beneficial to pregnant mice with SLE...
February 7, 2019: Biochemical and Biophysical Research Communications
Dan Dong, Ting-Ting Fan, Ying-Shi Ji, Jin-Yu Yu, Shan Wu, Li Zhang
PURPOSE: Podocytes are terminally differentiated cells lining the Bowman's capsule. Podocytes are critical for the proper glomerular filtration barrier function. At the same time, autophagy is crucial for maintaining podocyte homeostasis and insufficient autophagy could cause podocyte loss and proteinuria that is commonly observed in diabetic nephropathy (DN). METHODS: In this study, we investigated the role of spironolactone in podocyte loss and autophagy. DN model was established in male Sprague-Dawley rats using high-fat diet and low-dose streptozotocin...
February 8, 2019: International Urology and Nephrology
Sebastián Jaurretche, Germán R Perez, Graciela Venera
Renal involvement is associated with a greater morbidity and mortality in Fabry disease. Pathological albuminuria, the first Fabry nephropathy clinical manifestation, can occur from early childhood, although histological lesions such as tubulo-interstitial fibrosis and glomerulosclerosis are present or may precede the onset of pathological albuminuria. In renal cells, exposure to Lyso-Gb3 is correlated with increased expression of Transforming Growth Factor- β eta (TGF- β ). miR-21, miR-192, and miR-433 that promote fibrosis are activated by TGF- β , and miR-29 and miR-200 that suppress fibrosis are inhibited by TGF- β ...
2019: Case Reports in Nephrology
Adam V Wisnewski, Ala F Nassar, Jian Liu, Dhimiter Bello
Biomonitoring methylene dipheny diisocyanate (MDI) in urine may be useful in industrial hygiene and exposure surveillance approaches toward disease (occupational asthma) prevention, and in understanding pathways by which internalized chemical is excreted. We explored possible urine biomarkers of MDI exposure in mice after respiratory tract exposure to MDI, as glutathione (GSH) reaction products (MDI-GSH), and after skin exposure to MDI dissolved in acetone. LC-MS analyses of urine identified a unique 543.29 m/z [M+H]+ ion from MDI exposed mice, but not controls...
February 6, 2019: Chemical Research in Toxicology
Alfonso Farías-Basulto, Héctor Ramón Martínez-Ramírez, Erika Fabiola Gómez-García, Alfonso Martín Cueto-Manzano, Laura Cortés-Sanabria, Luis Eduardo Hernández-Ramos, Guadalupe Ramírez-López, Francisco Mendoza-Carrera
INTRODUCTION: Diabetic nephropathy is a leading cause of chronic kidney disease (CKD). In diabetes, changes in serum levels of both soluble alpha Klotho (sKL) and fibroblast growth factor 23 (FGF-23) have been associated with CKD progression. OBJECTIVE: To evaluate the associations of circulating levels of sKL and FGF-23 with the presence of early nephropathy (EN) in diabetic patients. METHODS: A cross-sectional study in 136 Mexicans with type 2 diabetes mellitus (T2DM)...
February 1, 2019: Archives of Medical Research
Naro Ohashi, Sayaka Ishigaki, Shinsuke Isobe, Takashi Matsuyama, Taichi Sato, Tomoyuki Fujikura, Takayuki Tsuji, Akihiko Kato, Hideo Yasuda
Objective Salt loading induces renal damage independently of blood pressure (BP) elevation via reactive oxygen species and sympathetic activity. Melatonin, a hormone that regulates the circadian rhythm, has multiple functions, including anti-oxidant effects and the inhibition of sympathetic activity. We have shown that impaired melatonin secretion is associated with renal damage in chronic kidney disease (CKD) patients. However, the associations between salt loading, melatonin secretion, and urinary albumin and protein have not been clarified...
February 1, 2019: Internal Medicine
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