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Short course radiotherapy

M Taffurelli, A Pellegrini, I Meattini, L Orzalesi, C Tinterri, M Roncella, D Terribile, F Caruso, G Tazzioli, G Pollini, D Friedman, C Mariotti, E Cianchetti, C Cabula, R Thomas, C Cedolini, F Rovera, M Grassi, G Lucani, A Cappella, M Bortul, G Stacul, F Scarabeo, E Procaccini, V Galimberti
BACKGROUND: Breast angiosarcoma is a malignant mesenchymal neoplasm, which accounts for approximately 2% of all soft tissue sarcomas. Secondary breast angiosarcoma (SBA) may be related to chronic lymphedema after a mastectomy with lymph node dissection (Stewart Treves syndrome) and previous radiotherapy for complications from breast radiation treatment. It is a very rare condition; therefore, diagnosis and management are still a challenge. METHODS: The ANISC collected SBA data by means of a survey sent to all Italian breast centres in the ANISC...
March 7, 2019: Breast: Official Journal of the European Society of Mastology
Mohamed Shelan, Seline Odermatt, Beat Bojaxhiu, Daniel P Nguyen, George N Thalmann, Daniel M Aebersold, Alan Dal Pra
Purpose: To retrospectively assess clinical outcomes and toxicity profile of prostate cancer patients treated with delayed dose-escalated image-guided salvage radiotherapy (SRT) for macroscopic local recurrence after radical prostatectomy (RP). Material and Methods: We report on a cohort of 69 consecutive patients with local recurrence after RP and no evidence of regional or distant metastasis who were referred for salvage radiotherapy between 2007 and 2016. SRT consisted of 64-66 Gy (2 Gy/fraction) to the prostatic bed followed by dose escalation to 72-74 Gy (2Gy/fraction) to the macroscopic disease...
2019: Frontiers in Oncology
Nikoletta K Pianou, Petros Z Stavrou, Evangelia Vlontzou, Phivi Rondogianni, Demetrios N Exarhos, Ioannis E Datseris
Prostate cancer (PCa) is the most common solid cancer affecting men worldwide. Serum prostate-specific antigen (PSA) is at present the most commonly used biomarker for PCa screening, as well as a reliable marker of disease recurrence after initial treatment. Bone metastases (BM) are present in advanced stages of the disease. Imaging of BM is important not only for localization and characterization, but also to evaluate their size and number, as well as to follow-up the disease during and after therapy. Bone metastases formation is triggered by cancer initiating cells in the bone marrow and is facilitated by the release of several growth factors...
March 5, 2019: Hellenic Journal of Nuclear Medicine
Corrado Spatola, Giuseppe Privitera, Roberto Milazzotto, Alessandra Tocco, Grazia Acquaviva, Francesco Marletta, Lorenza Marino, Alfio Di Grazia, Rosalba Salvo, Giovanni Cartia, Angelo Platania, Laura Molino, Anna Santacaterina, Marilena Mattace Raso, Pasquale Frosina, Roberto Ianni, Michele Bono, Luca Liardo, Salvatore Bonanno, Leonarda La Paglia, Manuela Federico, Ivan Fazio, Gianluca Mortellaro, Giuseppe Ferrera, Antonella Tripoli, Giovanna Evangelista, Antonino Daidone, Giampaolo Biti, Marco Badalamenti, Lucia Ognibene, Alberto Cacciola, Silvana Parisi, Stefano Pergolizzi
AIM: To conduct a survey among Sicilian centers of radiation oncology belonging to Associazione Italiana di Radioterapia ed Oncologia Clinica (AIRO), to record the different methods of integration of radio-chemotherapy both in neoadjuvant and adjuvant settings, to evaluate surgical procedures in relation to the sphincter preservation and to report the different toxicity profiles of the treatment strategies. METHODS: A questionnaire was sent at the end of 2017 to all the radiation oncology centers of Sicily region in order to collect the data from individual centers and the treatment characteristics retrospectively over the previous 5 years, from 2012 to 2016...
February 26, 2019: La Radiologia Medica
Amar U Kishan, Audrey Dang, Alan J Katz, Constantine A Mantz, Sean P Collins, Nima Aghdam, Fang-I Chu, Irving D Kaplan, Limor Appelbaum, Donald B Fuller, Robert M Meier, D Andrew Loblaw, Patrick Cheung, Huong T Pham, Narek Shaverdian, Naomi Jiang, Ye Yuan, Hilary Bagshaw, Nicolas Prionas, Mark K Buyyounouski, Daniel E Spratt, Patrick W Linson, Robert L Hong, Nicholas G Nickols, Michael L Steinberg, Patrick A Kupelian, Christopher R King
Importance: Stereotactic body radiotherapy harnesses improvements in technology to allow the completion of a course of external beam radiotherapy treatment for prostate cancer in the span of 4 to 5 treatment sessions. Although mounting short-term data support this approach, long-term outcomes have been sparsely reported. Objective: To assess long-term outcomes after stereotactic body radiotherapy for low-risk and intermediate-risk prostate cancer. Design, Setting, and Participants: This cohort study analyzed individual patient data from 2142 men enrolled in 10 single-institution phase 2 trials and 2 multi-institutional phase 2 trials of stereotactic body radiotherapy for low-risk and intermediate-risk prostate cancer between January 1, 2000, and December 31, 2012...
February 1, 2019: JAMA network open
Hiroko Kitanosono, Masakatsu Motomura, Hiroki Tomita, Hiroshi Iwanaga, Naoki Iwanaga, Takashi Irioka, Hirokazu Shiraishi, Akira Tsujino
A 63-year-old female who developed dizziness, diplopia and subsequent gait disturbance from September X-1 year was analyzed. The first neurological findings in May X year revealed cerebellar ataxia, weakness in the proximal limbs, decreased tendon reflexes, and autonomic symptoms (ADL:mRS 3). Furthermore, an incremental phenomenon was observed in the repetitive nerve stimulation test, and she was diagnosed with Lambert-Eaton myasthenic syndrome (LEMS) based on the serum P/Q-type calcium channel (VGCC) antibody positivity...
February 2019: Brain and Nerve, Shinkei Kenkyū No Shinpo
Angeliki Kotti, Annica Holmqvist, Maria Albertsson, Xiao-Feng Sun
OBJECTIVES: Increasing evidence suggests that statins may have antitumor effects but their role in rectal cancer appears inconclusive. The aim of this study was to investigate whether statins may have an impact on survival of older and younger patients with rectal cancer. MATERIALS AND METHODS: This study included 238 patients ≥70 years and 227 patients <70 years old, from the Southeast Health Care Region of Sweden, who were diagnosed with rectal adenocarcinoma between 2004 and 2013...
January 25, 2019: Journal of Geriatric Oncology
John Boyages, Lesley Baker
Radiation therapy (RT) is an important component of breast cancer treatment that reduces local recurrence and improves survival after breast conservation. Breast conservation rates have increased significantly since the late 1980s and techniques have improved with greater awareness of the impact of radiation on the heart. An overview of randomized controlled trials of breast conservation using standard whole breast irradiation, whole breast hypofractionation, accelerated partial breast irradiation (APBI) and intraoperative radiation are reviewed...
December 2018: Gland Surgery
Sotaro Otake, Taichiro Goto
Oligometastatic disease is defined as "a condition with a few metastases arising from tumors that have not acquired a potential for widespread metastases." Its behavior suggests a transitional malignant state somewhere between localized and metastatic cancer. Treatment of oligometastatic disease is expected to achieve long-term local control and to improve survival. Historically, patients with oligometastases have often undergone surgical resection since it was anecdotally believed that surgical resection could result in progression-free or overall survival benefits...
January 23, 2019: Cancers
Alice M Couwenberg, Johannes P M Burbach, Martijn P W Intven, Esther C J Consten, Anandi H W Schiphorst, Anke B Smits, Niels A T Wijffels, Joost T Heikens, Miriam Koopman, Wilhemina M U van Grevenstein, Helena M Verkooijen
BACKGROUND: Neoadjuvant chemoradiation with delayed surgery (CRT-DS) and short-course radiotherapy with immediate surgery (SCRT-IS) are two commonly used treatment strategies for rectal cancer. However, the optimal treatment strategy for patients with intermediate-risk rectal cancer remains a discussion. This study compares quality of life (QOL) between SCRT-IS and CRT-DS from diagnosis until 24 months after treatment. METHODS: In a prospective colorectal cancer cohort, rectal cancer patients with clinical stage T2-3N0-2M0 undergoing SCRT-IS or CRT-DS between 2013 and 2017 were identified...
January 18, 2019: Acta Oncologica
Brandon C Chapman, Karyn Goodman, Patrick Hosokawa, Ana Gleisner, Michelle L Cowan, Elisa Birnbaum, Jon D Vogel
BACKGROUND: Randomized controlled trials have demonstrated comparable survival outcomes for short-course (SCRT) and long-course neoadjuvant radiotherapy (LCRT) in patients with rectal cancer. METHODS: Using the National Cancer Data Base (2004-2015), a propensity score was used to match 188 patients with rectal cancer receiving SCRT to 376 patients receiving LCRT. Perioperative, oncologic, and survival outcomes were compared. RESULTS: Patient and clinical tumor characteristics were similar between groups...
January 13, 2019: Journal of Surgical Oncology
Jesper Carl, Dirk Rades, Claudia Doemer, Cornelia Setter, Jürgen Dunst, Niels Henrik Holländer
BACKGROUND: This study was conducted to investigate a new short-course radiotherapy regimen for patients with metastatic hormone refractory prostate cancer (HRPC) presenting with a dominant debilitating symptom. METHODS / DESIGN: This is an international, multi-center single arm prospective feasibility study that aims to include 34 patients with HRPC and a dominant debilitating symptom. The dominant symptomatic lesion will receive 4 × 5 Gy of high-precision radiotherapy, and the most aggressive part of the lesion 4 × 7 Gy using a simultaneous integrated boost technique...
January 10, 2019: Radiation Oncology
Rachel Glicksman, Noelia Sanmamed, John Thoms, Alexandre R Zlotta, Antonio Finelli, Theodorus van der Kwast, Joan Sweet, Michael Jewett, Laurence H Klotz, Tara Rosewall, Neil E Fleshner, Robert G Bristow, Padraig Warde, Alejandro Berlin
BACKGROUND: Neoadjuvant radiotherapy (RT) improves disease control in various cancers, and has become an established oncologic treatment strategy. During 2001-2004, we conducted a phase I pilot study assessing the role of short-course pre-operative RT (PreORT) for men with unfavourable intermediate- and high-risk localized prostate cancer. Herein, we present long-term follow-up toxicity and oncologic outcomes. MATERIALS AND METHODS: Eligible patients had histologically proven prostate cancer, cT1-T2N0M0 disease, PSA >15-35 ng/ml regardless of Gleason score, or PSA 10-15 ng/ml with Gleason score ≥7...
January 6, 2019: International Journal of Radiation Oncology, Biology, Physics
Lucas Gomes Sapienza, Matthew Stephen Ning, Anuja Jhingran, Lilie L Lin, Caio Raposo Leão, Bruna Bueno da Silva, Antônio Cássio de Assis Pellizzon, Maria José Leite Gomes, Glauco Baiocchi
Purpose: To compare and evaluate the utility of varying hemostatic radiotherapy prescriptions for emergent palliation of bleeding tumors. Materials and methods: This retrospective study analyzed 112 consecutive patients treated with radiotherapy for emergent palliation of bleeding tumors at an academic institution. Study endpoints included: primary bleeding control; re-bleeding rate after initial control; treatment interruption rate; overall survival; and death within 30 days of treatment...
January 2019: Clinical and Translational Radiation Oncology
Amy Downing, Adam W Glaser, Paul J Finan, Penny Wright, James D Thomas, Alexandra Gilbert, Jessica Corner, Mike Richards, Eva Ja Morris, David Sebag-Montefiore
BACKGROUND: There is a growing population of cancer survivors at risk of treatment-related morbidity. This study investigates how potentially curative rectal cancer treatment influences subsequent function and health-related quality of life (HRQL) using data from a large-scale survey of patient-reported outcomes. METHODS: All individuals 12-36 months post-diagnosis of colorectal cancer in England were sent a survey in January 2013. The survey responses were linked with cancer registration, hospital admissions and radiotherapy data through the National Cancer Registration and Analysis Service...
December 13, 2018: International Journal of Radiation Oncology, Biology, Physics
P Han, F Y Liang, R H Chen, Q Cai, S T Yu, M R Luo, Y J Su, J Y Wang, X M Huang
Objective: Surgery is one of the salvage treatments for recurrent nasopharyngeal carcinoma. The safety and efficacy of Da Vinci's robotic surgery was preliminarily investigated to resect recurrent nasopharyngeal cancer after one-course radiotherapy. Method: Since Oct 2017, Da Vinci surgery system was used to complete the operation of locally recurrent nasopharyngeal carcinoma including two approaches, such as trans oral with soft palate incision and trans oral and nose with soft palate suspended. Result: Ten patients underwent robotic nasopharyngectomy, The median operation time was 90 minutes, median follow-up time was 6 months, and all patients had clear resection margins...
July 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Yuhong Dai, Hong Qiu
Malignant acute abdomen is a emergency with abrupt onset, rapid progress and often a complex etiology, presenting difficulties for treatment and high mortality. Therefore, multidisciplinary team (MDT) treatment modality is required. Compared with single-discipline diagnosis and treatment modality, diagnosis made from MDT discussion is more accurate, where specialists can improve efficiency and quality of the treatment through better communication. A good MDT can cover all stages from the diagnosis to the assessment and treatment of the disease, and combine them into a more coherent process...
November 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Luca Bertamini, Jacopo Nanni, Giovanni Marconi, Mariachiara Abbenante, Valentina Robustelli, Francesco Bacci, Antonella Matti, Stefania Paolini, Chiara Sartor, Silvia Lo Monaco, Maria Chiara Fontana, Stefano De Polo, Michele Cavo, Antonio Curti, Giovanni Martinelli, Cristina Papayannidis
BACKGROUND: Extramedullary involvement of B-cell Acute Lymphoblastic Leukemia (EM-ALL) is a rare occurrence, characterized by dismal outcome and the absence of a defined and shared therapeutic approach. In the landscape of innovative compounds, inotuzumab ozogamicin (IO) is a promising drug, whose mechanism of action relies on the killing of CD22 positive leukemic cells, through the delivery, after cell binding, of a molecule of calicheamicin. CASE PRESENTATION: We report two cases of CD22 positive relapsed EM-ALL treated with IO, obtained as compassionate use...
November 15, 2018: BMC Cancer
Neil Chevli, Gary D Lewis, Todd A Swanson
CONTEXT: Patients with locoregional anal carcinoma who don't qualify for standard definitive chemoradiation are candidates for a short course of palliative hypofractionated radiotherapy such as QUAD Shot. METHODS: A 57-year-old man with massive locoregional squamous cell carcinoma of the anal canal was treated with QUAD Shot (14.8 Gy in 4 fractions over 2 consecutive days) repeated every 4 weeks for a total of 2 courses. RESULTS: He reported symptomatic relief following each course of radiation...
November 4, 2018: Journal of Pain and Symptom Management
K-S Jeng, C-C Huang, C-S Chung, C-K Lin, C-J Teng, P-W Shueng, K-H Chen
The effective treatment for hepatocellular carcinoma (HCC) with American Joint Committee on Cancer stage IIIB remains controversial and challenging because of the high recurrence rate after resection and low survival rate. The median survival of those with macroscopic portal vein tumor thrombus (PVTT) is short. We reported such a case which received liver transplantation (LT) after successful consecutive downstaging therapies. A 40-year-old man with alcohol related liver cirrhosis and repeated esophageal varices bleeding had HCC with tumor thrombi in right main portal vein and the second portal branch of segment VI (stage IIIB)...
November 2018: Transplantation Proceedings
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