Ravi Chauhan, Ashna Gupta, Lakshay Malhotra, Ajaz A Bhat, Raj K Pandita, Tariq Masoodi, Gunjan Dagar, Hana Q Sadida, Sara K Al-Marzooqi, Atul Batra, Sameer Bakhshi, Mehar Chand Sharma, Pranay Tanwar, Shah Alam Khan, Ethayathulla Abdul Samath, Shahab Uddin, Ammira S Al-Shabeeb Akil, Mohammad Haris, Muzafar A Macha, Tej K Pandita, Mayank Singh
BACKGROUND: Osteosarcoma is a type of bone cancer that predominantly affects young individuals, including children and adolescents. The disease progresses through heterogeneous genetic alterations, and patients often develop pulmonary metastases even after the primary tumors have been surgically removed. Ubiquitin-specific peptidases (USPs) regulate several critical cellular processes, such as cell cycle progression, transcriptional activation, and signal transduction. Various studies have revealed the significance of USP37 in the regulation of replication stress and oncogenesis...
April 28, 2023: Journal of Translational Medicine