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Pulmonary metastasis of osteosarcoma

Valeria Carina, Viviana Costa, Maria Sartori, Daniele Bellavia, Angela De Luca, Lavinia Raimondi, Milena Fini, Gianluca Giavaresi
Osteosarcoma (OS) is a primary bone sarcoma, manifesting as osteogenesis by malignant cells. Nowadays, patients' quality of life has been improved, however continuing high rates of limb amputation, pulmonary metastasis and drug toxicity, remain unresolved issues. Thus, effective osteosarcoma therapies are still required. Recently, the potentialities of biophysical treatments in osteosarcoma have been evaluated and seem to offer a promising future, thanks in this field as they are less invasive. Several approaches have been investigated such as hyperthermia (HT), high intensity focused ultrasound (HIFU), low intensity pulsed ultrasound (LIPUS) and sono- and photodynamic therapies (SDT, PDT)...
March 12, 2019: Cancers
Yoko Yamamoto, Ryu Kanzaki, Takashi Kanou, Naoko Ose, Soichiro Funaki, Yasushi Shintani, Masato Minami, Hidetatsu Outani, Satoshi Takenaka, Kenichiro Hamada, Hideki Yoshikawa, Meinoshin Okumura
BACKGROUND: The prognostic factors of pulmonary metastasectomy in patients with osteosarcoma and soft tissue sarcoma remain controversial. The purpose of our analysis was to explore the prognostic factors and outcomes of patients with osteosarcoma and soft tissue sarcoma who underwent pulmonary metastasectomy at our institution. METHODS: We reviewed the data of 44 patients who underwent resection of pulmonary metastases from 1996 to 2016 at our institution. The Kaplan-Meier method, log-rank test and multivariate Cox hazard model were used for comparison and survival analyses...
February 26, 2019: International Journal of Clinical Oncology
Motonari Nomura, Nino Rainusso, Yi-Chien Lee, Brian Dawson, Cristian Coarfa, Ruolan Han, Jeffrey L Larson, Ryan Shuck, Lyazat Kurenbekova, Jason T Yustein
BACKGROUND: The Wnt/β-catenin pathway is closely associated with osteosarcoma (OS) development and metastatic progression. We investigated the antitumor activity of Tegavivint, a novel β-catenin/transducing β-like protein 1 (TBL1) inhibitor, against OS employing in vitro, ex vivo and in vivo cell line and patient-derived xenograft (PDX) models that recapitulate high risk disease. METHODS: The antitumor efficacy of Tegavivint was evaluated in vitro using established OS and PDX-derived cell lines...
February 21, 2019: Journal of the National Cancer Institute
Christopher R Lamb, James Whitlock, Andrew T L Foster-Yeow
In order to estimate the prevalence of pulmonary nodules in dogs with nonpulmonary malignant neoplasia, medical record descriptions of CT findings in dogs diagnosed with nonpulmonary malignant neoplasia were reviewed retrospectively. A total of 536 dogs were sampled from a single hospital. For malignant neoplasms with >10 affected individuals, prevalence of multiple pulmonary nodules at first CT was hemangiosarcoma 24 of 58 (41%), osteosarcoma 14 of 55 (26%), carcinoma 20 of 80 (25%), histiocytic sarcoma five of twenty-one (24%), soft tissue sarcoma 13 of 57 (23%), adenocarcinoma 11 of 60 (18%), melanoma five of thirty-seven (14%), lymphoma 10 of 76 (13%), mast cell tumor two of forty-seven (4%), and squamous cell carcinoma zero of seventeen (0%)...
February 19, 2019: Veterinary Radiology & Ultrasound
Yilong Dai, Yifu Tang, Xuemei Xu, Zhongwei Luo, Yu Zhang, Zhaohui Li, Zhangyuan Lin, Shushan Zhao, Min Zeng, Buhua Sun, Liang Cheng, Jianxi Zhu, Zeng Xiong, Haitao Long, Yong Zhu, Kun Yu
Osteosarcoma is a malignant primary bone tumor, which often associates with pulmonary metastasis. The radical surgery of osteosarcoma often requires internal orthopedic implants. Therefore, implants with antitumor properties should be developed. Magnesium (Mg) and its alloys possess great potential as orthopedic materials, given their biodegradable properties, superior osteogenesis performance, and antitumor features. However, problems arise with their uncontrolled degradation rates and their unknown antitumor mechanisms...
February 19, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Jisheng Sui, Guoqiang Shao, Lulu Zhang, Pengjun Zhang, Ting Bu, Qingqiang Yao, Liming Wang
Objective: To investigate the value of integrin α v β 3 targeted microPET/CT imaging with 68 Ga-NODAGA-RGD 2 as radiotracer for the detection of osteosarcoma and theranostics of osteosarcoma lung metastasis. Methods: The 68 Ga-NODAGA-RGD 2 and 177 Lu-NODAGA-RGD 2 were prepared via one-step method and their stability and integrin α v β 3 binding specificity were investigated in vitro . Forty-one nude mice were injected with human MG63 osteosarcoma to established the animal model bearing subcutaneous osteosarcoma ( n =21), osteosarcoma in tibia ( n =5), and osteosarcoma pulmonary metastatic ( n =15)...
February 1, 2019: Chinese Journal of Reparative and Reconstructive Surgery
Sita S Withers, Daniel York, Jin W Choi, Kevin D Woolard, Renee Laufer-Amorim, Ellen E Sparger, Jenna H Burton, Stephen J McSorley, Arta M Monjazeb, William J Murphy, Robert J Canter, Robert B Rebhun
Our lack of understanding of the immune microenvironment in canine osteosarcoma (cOSA) has limited the identification of potential immunotherapeutic targets. In particular, our ability to utilize readily available tissue from a dog's primary tumor to predict the type and extent of immune response in their pulmonary metastatic lesions is unknown. We therefore collected 21 matched pairs of primary tumors and pulmonary metastatic lesions from dogs with OSA and performed immunohistochemistry to quantify T lymphocyte (CD3), FOXP3+ cell, B lymphocyte (Pax-5), and CD204+ macrophage infiltration...
January 25, 2019: Veterinary and Comparative Oncology
Changkun Huang, Xuan Zhu, Wei Xiong, Xiaokun Zhao, Ran Xu
RATIONALE: Primary osteosarcoma of the kidney is a very rare subtype of renal neoplasms. There are only 27 cases reported in the literature since 1936. In addition, it has a high risk of metastasis and very low survival rate. PATIENT'S CONCERNS: In this report, we present a case of unique large osteosarcoma originated from the left kidney (21 cm × 18 cm × 11 cm) with lung metastasis. A 48-year-old female patient presented with intermittent abdominal distension and gross hematuria...
January 2019: Medicine (Baltimore)
Xue-Feng Tang, Ya Cao, Dong-Bin Peng, Guo-Sheng Zhao, Ying Zeng, Zi-Ran Gao, Yang-Fan Lv, Qiao-Nan Guo
Background: Notch signaling abnormalities are associated with the development of various tumors, including hematopoietic and epithelium-derived tumors. However, the role of Notch signaling in tumors originating from mesenchymal cells is unclear. The effect of Notch3 expression on the prognosis of osteosarcoma and its role and mechanism in osteosarcoma cells have never been reported. Materials and methods: In this study, we performed a clinicopathological analysis of 70 cases of osteosarcoma, with primary focus on survival...
2019: Cancer Management and Research
Seongjae Choi, Ye-In Oh, Keun-Ho Park, Jeong-Seok Lee, Jin-Hyung Shim, Byung-Jae Kang
Limb-sparing surgery is one of the surgical options for dogs with distal radial osteosarcoma (OSA). This case report highlights the novel application of a three-dimensional (3D)-printed patient-specific polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) scaffold in limb-sparing surgery in a dog with distal radial OSA. The outcomes evaluated included postoperative gait analysis, complications, local recurrence of tumor, metastasis, and survival time. Post-operative gait evaluation showed significant improvement in limb function, including increased weight distribution and decreased asymmetry...
January 18, 2019: Journal of Veterinary Medical Science
Francisco Villanueva, Hector Araya, Pedro Briceño, Nelson Varela, Andres Stevenson, Sofia Jerez, Fabian Tempio, Jonas Chnaiderman, Carola Perez, Milena Villarroel, Emma Concha, Farzaneh Khani, Roman Thaler, Flavio Salazar-Onfray, Gary S Stein, Andre J van Wijnen, Mario Galindo
Osteosarcomas are bone tumors that frequently metastasize to the lung. Aberrant expression of the transcription factor, runt-related transcription factor 2 (RUNX2), is a key pathological feature in osteosarcoma and associated with loss of p53 and miR-34 expression. Elevated RUNX2 may transcriptionally activate genes mediating tumor progression and metastasis, including the RUNX2 target gene osteopontin (OPN/SPP1). This gene encodes a secreted matricellular protein produced by osteoblasts to regulate bone matrix remodeling and tissue calcification...
January 13, 2019: Journal of Cellular Physiology
M A Clara-Altamirano, D Y García-Ortega, A Maciel-Miranda, H Martínez-Said, J L Martínez-Tlahuel, C H S Caro-Sánchez, G C García-Ruíz, M Cuellar-Hubbe
Dedifferentiated parosteal osteosarcoma is a variant in which a high grade osteosarcoma coexists with a parosteal osteosarcoma. We report the case of a 20-year-old female patient who presented with six months of evolution of pain and functional limitation of the right forearm, with no apparent cause; radiographs were performed, observing a tumoral lesion in the diaphysis of the right ulna. Physical examination showed pain upon palpation in the diaphysis of the ulna and limitation of prone-supination. Axial computed tomography of the thorax revealed metastatic disease in the upper lobe of the left lung...
May 2018: Acta Ortopédica Mexicana
Jared I Baum, Owen T Skinner, Sarah E Boston
This report describes a domestic shorthair cat with fracture-associated osteosarcoma 11 years after injury. A left hind limb amputation was performed using coxofemoral disarticulation. No intravenous cytotoxic chemotherapy was used after surgery. Pulmonary metastasis was identified 3 months after amputation. Fracture-associated osteosarcoma may occur in the cat more than 10 years after initial injury.
October 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
Yang Su, Yan Zhou, Yuan-Jue Sun, Ya-Ling Wang, Jun-Yi Yin, Yu-Jing Huang, Jian-Jun Zhang, Ai-Na He, Kun Han, Hui-Zhen Zhang, Yang Yao, Xiao-Bin Lv, Hai-Yan Hu
Osteosarcoma (OS), which is the most common primary malignant bone tumor, has a high incidence of pulmonary metastasis. CCL18 (C-C motif chemokine ligand 18), which is secreted by tumor-associated macrophages (TAMs), has been found to be increased in various tumors and is associated with tumor metastasis. However, the role of CCL18 in OS remains unclear. Here, we evaluated the effect of CCL18 on the OS cell lines MG63 and 143B and explored its potential mechanisms. We found that CCL18 enhanced the proliferation and migration of OS cells and upregulated UCA1 through transcription factor EP300...
November 13, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Jie Wang, Di Wang, Xiaohui Niu, Zhijie Wang, Cheng-Li Song, Zhen Huang, Ke-Neng Chen, Jianchun Duan, Hua Bai, Jiachen Xu, Jun Zhao, Yu Wang, Minglei Zhuo, X Sunney Xie, Xiaozheng Kang, Yanhua Tian, Liangliang Cai, Jie-Fei Han, Tongtong An, Yu Sun, Shugeng Gao, Jun Zhao, Jianming Ying, Luhua Wang, Jie He
Osteosarcoma (OS) is the most common primary bone malignancy, and the lung is the most frequent site of metastasis. The limited understanding of the tumoral heterogeneity and evolutionary process of genomic alterations in pulmonary metastatic osteosarcoma impedes development of novel therapeutic strategies. Here we systematically illustrate the genomic disparities between primary tumors (PT) and corresponding pulmonary metastatic tumors (MT) by multiregional whole-exome and whole-genome sequencing in 86 tumor regions from 10 OS patients...
November 2, 2018: Cancer Research
Xiaodong Chen, Min Deng, Xinshe Zhou, Xuyi Wang, Yuchen Ye, Jun Zhu, Huafeng Jiang, Xiaotian Chen, Wenju Zha
OBJECTIVE: Osteosarcoma (OS) is one of the most common malignancies of bone. This study was aimed to explore the anti-metastatic effect of euxanthone on OS. MATERIALS AND METHODS: Adhesion assay and Transwell assay were used to examine the effect of euxanthone on adhesion, migration and invasion of OS cells. COX-2-over-expressing plasmid was applied to transfect OS cells to assess whether COX-2 affects the anti-metastatic function of euxanthone. PDCD4 knockdown and miR-21 mimic were applied to assess whether euxanthone suppresses the transactivation of c-jun via modulating miR-21-PDCD4 signaling...
October 17, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Jie Xu, Wei Guo, Lu Xie
BACKGROUND: The combination of gemcitabine and docetaxel (GT) has been demonstrated to be effective against various types of solid tumors, including sarcoma. However, the regimen has not been confirmed in large, well-designed clinical trials in refractory metastatic osteosarcoma. METHODS: We retrospectively reviewed the records of patients with refractory metastatic osteosarcoma at Peking University People's Hospital who were treated with gemcitabine (1000 mg/m2 ) intravenously (IV) on Day 1 and Day 8, and docetaxel (75 mg/m2 ) IV on Day 8, repeated every 21 days...
October 16, 2018: BMC Cancer
Xiuxin Han, Fengting Liu, Chao Zhang, Zhiwu Ren, Lili Li, Guowen Wang
Osteosarcoma (OS) patients often exhibit pulmonary metastasis, which results in high patient mortality. Our present study established the doxorubicin (Dox) resistant human OS MG-63 and HOS cells and named them MG-63/Dox and HOS/Dox, respectively. The Dox resistant OS cells had greater invasion ability than that of parental cells. The expression of ZEB1, while not FOXM1, Snail, HIF-1α, or Sp1, was significantly increased in Dox resistant OS cells. Silencing of ZEB1 can attenuate the metastasis and increase Dox sensitivity of MG-63/Dox and HOS/Dox cells...
October 11, 2018: Biological Chemistry
Dylan C Dean, Shen Shen, Francis J Hornicek, Zhenfeng Duan
Although the investigation into biomarkers specific for pulmonary metastasis within osteosarcoma (OS) has recently expanded, their usage within the clinic remains sparse. The current screening protocol after any OS diagnosis includes a chest CT scan; however, metastatic lung nodules frequently go undetected and remain the primary cause of death in OS. Recently, screening technologies such as liquid biopsy and next-generation sequencing have revealed a promising array of biomarkers with predictive and diagnostic value for the pulmonary metastasis associated with OS...
August 31, 2018: Cancer Metastasis Reviews
María Tereza Nieto-Coronel, Allan David López-Vásquez, Diana Marroquín-Flores, Sandy Ruiz-Cruz, Jorge Luis Martínez-Tláhuel, Jaime De la Garza-Salazar
Osteosarcoma is the most common primary malignancy of bone in children and young adults, the highest incidence peak is during adolescence and doesn't have any gender predominance. The main site of metastasis are the lungs and extrapulmonary cases are occasional. The incidence of metastasis in the Central Nervous System (CNS) is 2-6.5%, increase to 10-15% in patients with pulmonary metastases. Therefore, metastatic disease of the CNS is rare and the information on such patients is limited. Here, we describe a case of a 20-year old patient diagnosed with osteosarcoma in the left distal femur stage IIB, he developed pulmonary disease, during palliative chemotherapy experienced relapse to the brain classified as recursive partitioning analysis (RPA) class II, and was treated with external radiotherapy (30 Gy in 10 fractions) and later he had a poor evolution and died...
July 2018: Reports of Practical Oncology and Radiotherapy
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