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Maristela P Freire, Doroti de Oliveira Garcia, Ana Paula Cury, Gabriela R Francisco, Nathamy F Dos Santos, Fernanda Spadão, Maria Fernanda Campagnari Bueno, Carlos Henrique Camargo, Flavio J de Paula, Flavia Rossi, Willian C Nahas, Elias David-Neto, Ligia C Pierrotti
Kidney transplant recipients are at risk for infections due to carbapenem-resistant Enterobacteriaceae (CRE). Polymyxin-resistant CRE (PR-CRE) infections are especially difficult to treat. The aim of this study was to characterize PR-CRE infections among kidney transplant recipients and identify risk factors for treatment failure. This retrospective cohort study involved all kidney transplant recipients with PR-CRE infection between 2013 and 2017 at our center. Minimal inhibitory concentrations for polymyxin B were determined by broth microdilution...
January 24, 2019: European Journal of Clinical Microbiology & Infectious Diseases
Yasushi Suzuki, Masahiro Kojika, Hisaho Sato, Yoshihiro Inoue, Shigeatsu Endo
Direct hemoperfusion with polymyxin B-immobilized fiber (PMX-DHP) has been widely used for severe sepsis and septic shock. However, data are limited regarding the clinical experience and efficacy of PMX-DHP for septic shock resulting from urinary tract infection (UTI). At our institution, 15 patients with septic shock resulting from a UTI received PMX-DHP from January 2013 to July 2017. The cause of the urosepsis was mainly obstructive pyelonephritis secondary to ureterolithiasis or neurogenic bladder. Average Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores were 25...
September 12, 2018: Therapeutic Apheresis and Dialysis
B G Rodrigues Dos Santos, E S Amaral, P F C B C Fernandes, C M C Oliveira, J L N Rodrigues, L V Perdigão Neto, E S Girão
BACKGROUND: Carbapenem-resistant Enterobacteriaceae (CRE) are emerging pathogens. Recent publications have shown that renal transplant recipients are a population at risk for CRE infections. Management of these infections in this population is complex, requiring frequent use of nephrotoxic antimicrobial agents. Differentiating between urinary tract infection (UTI) and surgical site infection (SSI) in renal transplant recipients is sometimes difficult. The aim of this study was to describe CRE UTIs and SSIs in renal transplant recipients and to evaluate the impact of these infections on renal graft and patient survival...
July 2016: Transplantation Proceedings
Asghar Habibi, Ramin Honarmand
BACKGROUND: Putative virulence factors are responsible for the pathogenicity of UTIs caused by Pseudomonas aeruginosa (P. aeruginosa). Resistance of P. aeruginosa to commonly used antibiotics is caused by the extreme overprescription of those antibiotics. OBJECTIVES: The goal of the present study was to investigate the prevalence of virulence factors and the antibiotic resistance patterns of P. aeruginosa isolates in UTI cases in Iran. PATIENTS AND METHODS: Two hundred and fifty urine samples were collected from patients who suffered from UTIs...
December 2015: Iranian Red Crescent Medical Journal
Ming-Che Liu, Kuan-Ting Kuo, Hsiung-Fei Chien, Yi-Lin Tsai, Shwu-Jen Liaw
Proteus mirabilis is a common human pathogen causing recurrent or persistent urinary tract infections (UTIs). The underlying mechanisms for P. mirabilis to establish UTIs are not fully elucidated. In this study, we showed that loss of the sigma factor E (RpoE), mediating extracytoplasmic stress responses, decreased fimbria expression, survival in macrophages, cell invasion, and colonization in mice but increased the interleukin-8 (IL-8) expression of urothelial cells and swarming motility. This is the first study to demonstrate that RpoE modulated expression of MR/P fimbriae by regulating mrpI, a gene encoding a recombinase controlling the orientation of MR/P fimbria promoter...
March 2015: Infection and Immunity
Manjula N G, Girish C Math, Kavita Nagshetty, Shripad A Patil, Subhashchandra M Gaddad, Channappa T Shivannavar
BACKGROUND: Klebsiella pneumoniae possess a new problem to health care professionals worldwide, which complicates and limits therapeutic options. It is one of the leading nosocomial bacterial pathogens, and the present study aims to determine the prevalence of ESβL producing K. pneumoniae isolates with their antibiotic susceptibility pattern in urine samples of the pregnant women with UTI. MATERIALS AND METHODS: Using standard isolation and identification procedures a total of 41 isolates were obtained from 417 midstream urine samples of pregnant women with suspected UTI in Karnataka...
October 2014: Journal of Clinical and Diagnostic Research: JCDR
Po-Ren Hsueh, Daryl J Hoban, Yehuda Carmeli, Shey-Ying Chen, Sunita Desikan, Marissa Alejandria, Wen-Chien Ko, Tran Quang Binh
Urinary tract infections (UTIs) are among the most prevalent infectious diseases in the general population. They cause a substantial financial burden in the community and are associated with significant morbidity and mortality, particularly in hospitals. With increased rates of antimicrobial resistance, especially in the Asia-Pacific region, treatment of complicated UTIs (cUTIs) can be challenging for clinicians. Consideration of an optimal antimicrobial agent should be based on local resistance patterns, patient-specific factors, pharmacokinetic and pharmacodynamic principles, and cost...
August 2011: Journal of Infection
Young Kyoung Park, Gyu Hong Lee, Jin Yang Baek, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song, Kwan Soo Ko
We investigated the characteristics of a total of 96 Acinetobacter spp. isolates that were shown to cause bacteremia and urinary tract infections (UTIs) from 10 university hospitals located in various regions of Korea from November 2006 to August 2007. The antimicrobial susceptibilities of these isolates were determined using a broth microdilution method, and the species were identified using molecular identification. In addition, we performed multilocus sequence typing for Acinetobacter baumannii subgroup A isolates...
June 2010: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Andrew A Pastewski, Patricia Caruso, Addison R Parris, Ramon Dizon, Robert Kopec, Shobha Sharma, Suri Mayer, Monica Ghitan, Edward K Chapnick
BACKGROUND: Parenteral polymyxin use declined after the 1960s, due to safety concerns. An increase in multidrug-resistant (MDR) gram-negative infections and a shortage of new agents have prompted increased use of parenteral polymyxin. OBJECTIVE: To describe our clinical experience with parenteral polymyxin B for MDR gram-negative bacteremia and urinary tract infection (UTI). METHODS: Paper pharmacy records were used to identify patients aged 18 years or older, presence of MDR gram-negative bacteremia or UTI, and use of parenteral polymyxin B for at least 48 hours...
September 2008: Annals of Pharmacotherapy
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