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Sertraline hemodialysis

Magdalene M Assimon, M Alan Brookhart, Jennifer E Flythe
BACKGROUND: Individuals receiving maintenance hemodialysis may be particularly susceptible to the lethal cardiac consequences of drug-induced QT prolongation because they have a substantial cardiovascular disease burden and high level of polypharmacy, as well as recurrent exposure to electrolyte shifts during dialysis. Electrophysiologic data indicate that among the selective serotonin reuptake inhibitors (SSRIs), citalopram and escitalopram prolong the QT interval to the greatest extent...
March 18, 2019: Journal of the American Society of Nephrology: JASN
Rajnish Mehrotra, Daniel Cukor, Mark Unruh, Tessa Rue, Patrick Heagerty, Scott D Cohen, Laura M Dember, Yaminette Diaz-Linhart, Amelia Dubovsky, Tom Greene, Nancy Grote, Nancy Kutner, Madhukar H Trivedi, Davin K Quinn, Nisha Ver Halen, Steven D Weisbord, Bessie A Young, Paul L Kimmel, S Susan Hedayati
Background: Although depression is common among patients receiving maintenance hemodialysis, data on their acceptance of treatment and on the comparative efficacy of various therapies are limited. Objective: To determine the effect of an engagement interview on treatment acceptance (phase 1) and to compare the efficacy of cognitive behavioral therapy (CBT) versus sertraline (phase 2) for treating depression in patients receiving hemodialysis. Design: Multicenter, parallel-group, open-label, randomized controlled trial...
February 26, 2019: Annals of Internal Medicine
Narges Sadat Zahed, Marjan Sharifi, Mahdi Karimi, Hajar Nikbakht
Introduction: Depression is the most prevalent psychological problem among hemodialysis (HD) patients. Inflammatory factors have been reported to play an important role in the pathogenesis of depression. The association between depression and inflammatory factors was established in chronic kidney disease (CKD) patients. Sertraline, a selective serotonin reuptake inhibitor (SSRI) antidepressant, decreases serum levels of inflammatory factors in patients with depression. Objectives: This study was designed to assess the effect of sertraline on serum concentration of C-reactive protein (CRP), hemoglobin and albumin of depressed hemodialysis (HD) patients...
2017: Journal of Renal Injury Prevention
Maryam Pakfetrat, Leila Malekmakan, Noushin Hashemi, Taraneh Tadayon
INTRODUCTION: Uremic pruritus is an undesirable complication of end stage renal disease (ESRD). In spite of introduction of many treatments for this complication, it has no certain cure. The aim of this study was to assess sertraline effect on uremic pruritus. METHODS: In the present clinical trial study, we randomly divided our patients into two groups; trial group that received sertraline and control group that consumed placebo. We measured the severity of pruritus by two scoring systems (visual analogue scale and DUO) at the beginning and during the study with a-2-week interval...
January 2018: Hemodialysis International
Karin Friedli, Ayman Guirguis, Michael Almond, Clara Day, Joseph Chilcot, Maria Da Silva-Gane, Andrew Davenport, Naomi A Fineberg, Benjamin Spencer, David Wellsted, Ken Farrington
BACKGROUND AND OBJECTIVES: Depression is common in patients on hemodialysis, but data on the benefits and risks of antidepressants in this setting are limited. We conducted a multicenter, randomized, double-blind, placebo-controlled trial of sertraline over 6 months in patients on hemodialysis with depression to determine study feasibility, safety, and effectiveness. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Patients on hemodialysis at five United Kingdom renal centers completed the Beck Depression Inventory II...
February 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
S Susan Hedayati, Divya M Daniel, Scott Cohen, Bryan Comstock, Daniel Cukor, Yaminette Diaz-Linhart, Laura M Dember, Amelia Dubovsky, Tom Greene, Nancy Grote, Patrick Heagerty, Wayne Katon, Paul L Kimmel, Nancy Kutner, Lori Linke, Davin Quinn, Tessa Rue, Madhukar H Trivedi, Mark Unruh, Steven Weisbord, Bessie A Young, Rajnish Mehrotra
Major Depressive Disorder (MDD) is highly prevalent in patients with End Stage Renal Disease (ESRD) treated with maintenance hemodialysis (HD). Despite the high prevalence and robust data demonstrating an independent association between depression and poor clinical and patient-reported outcomes, MDD is under-treated when identified in such patients. This may in part be due to the paucity of evidence confirming the safety and efficacy of treatments for depression in this population. It is also unclear whether HD patients are interested in receiving treatment for depression...
March 2016: Contemporary Clinical Trials
Effat Razeghi, Simin Dashti-Khavidaki, Samira Nassiri, Rozita Abolghassemi, Hossein Khalili, Seyed Saeed Hashemi Nazari, Mohammad Ali Mansournia, Mohammad Taraz
INTRODUCTION: Intradialytic hypotension (IDH) has been reported in 15% to 50% of hemodialysis patients and increases patients morbidity and mortality. Some small noncontrolled studies evaluated the effect of sertraline on IDH with conflicting results. This study is a randomized crossover controlled trial on the effectiveness of sertraline to reduce IDH. MATERIALS AND METHODS: Patients on hemodialysis who suffered IDH in at least 50% of their dialysis sessions were enrolled...
July 2015: Iranian Journal of Kidney Diseases
Mohammad Taraz, Mohammad-Reza Khatami, Simin Dashti-Khavidaki, Shahin Akhonzadeh, Ahmad-Ali Noorbala, Padideh Ghaeli, Saeideh Taraz
BACKGROUND: This study was designed to assess the effect of sertraline on serum concentrations of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), IL-10 and high-sensitivity C-reactive protein (hs-CRP) of depressed hemodialysis (HD) patients. METHODS: During a randomized, double-blind, placebo-controlled trial, fifty depressed HD patients were allocated to receive sertraline or placebo for 12 weeks. Patients' depression was assessed using Beck Depression Inventory-second edition (BDI-II)...
November 2013: International Immunopharmacology
Mansor Shakiba, Hoshang Sanadgol, Hamid Reza Azmoude, Mohamad Ali Mashhadi, Hassan Sharifi
Background. Although uremic pruritus is a common and upsetting problem of chronic kidney disease, there is no approved treatment for it. This study was undertaken to find the efficiency of sertraline as a possible treatment for uremic pruritus. Methods. 19 ESRD patients under hemodialysis with severe chronic pruritus were randomly selected to participate in this before-after clinical trial. Before and after starting treatment with sertraline, a detailed pruritus history was obtained and pruritus graded by the 30-item inventory of pruritus that patients based on priorities grade allocated to 3 classes...
2012: International Journal of Nephrology
S Turk, H Atalay, L Altintepe, I Güney, N Okudan, H Z Tonbul, H Gökbel, R Kücür, M Yeksan, A Yildiz
BACKGROUND: Despite some improvements in dialysis therapies, depression still remains an important problem in chronic hemodialysis (HD) patients. In this study, we aimed to investigate the association of depression and its treatment with quality of life (QOL) in HD patients. PATIENTS AND METHODS: 97 HD patients (52 male, 45 female, mean age 55 +/- 16 years) were enrolled. All patients had been dialyzed for more than 6 months. In order to evaluate QOL of the patients, a short form of Medical Outcomes Study (SF-36) was used...
February 2006: Clinical Nephrology
Ahmet Ugur Yalcin, Gulmira Kudaiberdieva, Garip Sahin, Bulent Gorenek, Nevbahar Akcar, Serhat Kuskus, Figen Bayrak, Bilgin Timuralp
BACKGROUND/AIMS: It was previously shown that sertraline hydrochloride treatment improved hemodynamic parameters of patients with dialysis induced hypotension (DIH). The aim of this study was to examine the effect of sertraline on the autonomic functions of patients with DIH. METHODS: Ten patients with DIH, 10 hemodialysis patients without DIH and 10 healthy control subjects were included into the study. All of the patients were treated with sertraline 50 mg per day for 4 weeks...
January 2003: Nephron. Physiology
Ahmet Uğur Yalcin, Garip Sahin, Mehmet Erol, Cengiz Bal
BACKGROUND: Recently some pathogenetic parallels have been drawn between dialysis-induced hypotension and disorders characterized by hemodynamic instability due to autonomic dysfunction, such as neurocardiogenic syncope and idiopathic orthostatic hypotension. Several studies have shown that central serotonergic pathways participate in the abnormal response, and selective serotonin reuptake inhibitors improve the symptoms of patients with neurocardiogenic syncope or idiopathic orthostatic hypotension...
2002: Blood Purification
S Dheenan, J Venkatesan, B P Grubb, W L Henrich
Hemodialysis hypotension (HH) is a very common disorder and has a multifactorial etiology. Autonomic dysfunction occurs in up to 50% of patients with end-stage renal disease (ESRD) and plays a key role in HH in some patients. Sertraline hydrochloride, a central nervous system serotonin reuptake inhibitor, has been shown to be an effective treatment of hypotension caused by autonomic dysfunction in disorders such as neurocardiogenic syncope and idiopathic orthostatic hypotension. This study sought to determine whether sertraline was effective in ameliorating HH...
April 1998: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
M H Schwenk, M A Verga, J D Wagner
Sertraline is an antidepressant which selectively inhibits the neuronal uptake of serotonin in the central nervous system. The pharmacokinetics of sertraline in end-stage renal disease (ESRD) and the effect of hemodialysis on sertraline clearance is unknown. A dose of 100 mg sertraline was administered to two anuric hemodialysis patients after hemodialysis. During the next hemodialysis session, simultaneous pre- and post dialyzer blood samples were obtained at the start of and hourly throughout dialysis until completion...
August 1995: Clinical Nephrology
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