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https://read.qxmd.com/read/30747853/outcomes-in-older-kidney-transplant-recipients-after-prior-non-kidney-transplants
#1
Christine E Haugen, Xun Luo, Courtenay M Holscher, Mary G Bowring, Sandra R DiBrito, Jacqueline Garonzik-Wang, Mara McAdams-DeMarco, Dorry L Segev
BACKGROUND: Recipients of non-kidney solid organ transplants (nkSOT) are living longer, and 11-18% will develop ESRD. While our general inclination is to treat nkSOT recipients who develop ESRD with a kidney transplant (KT), an increasing number are developing ESRD at an older age where KT may not be the most appropriate treatment. It is possible that the risk of older age and prior nkSOT might synergize to make KT too risky, but this has never been explored. METHODS: To examine death-censored graft loss and mortality for KT recipients with and without prior nkSOT, we used Scientific Registry of Transplant Recipients data to identify 42,089 older (age ≥65) KT recipients between 1995 and 2016...
February 4, 2019: Transplantation
https://read.qxmd.com/read/30746135/mortality-risk-after-herpes-zoster-infection-in-end-stage-renal-disease-patients
#2
John H Ahn, Jennifer L Waller, Stephanie L Baer, Rhonda E Colombo, Mufaddal F Kheda, N Stanley Nahman, Jake E Turrentine
Background: End-stage renal disease (ESRD) patients have increased risk of developing herpes zoster (zoster) compared with the general population, but mortality risk is unknown. We assessed the risk of mortality in hospitalized ESRD patients with a diagnosis of zoster from the inpatient hospital files (as opposed to outpatient records) of the United States Renal Data System. Methods: This study analyzed incident ESRD patients from 2006 to 2009. Based on an International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code of zoster infection, we determined 2-year mortality following an inpatient diagnosis...
February 2019: Clinical Kidney Journal
https://read.qxmd.com/read/30743320/outcomes-of-end-stage-renal-disease-patients-on-the-waiting-list-for-deceased-donor-kidney-transplantation-a-single-center-study
#3
Hong Jae Jeon, Hong Jin Bae, Young Rok Ham, Dae Eun Choi, Ki Ryang Na, Moon-Sang Ahn, Kang Wook Lee
Background: Kidney transplantation is an effective renal replacement therapy for patients with end-stage renal disease (ESRD). In this study, we assessed the impact of the baseline characteristics and comorbidities of ESRD patients on the probability of deceased donor kidney transplantation (DDKT) and evaluated the morbidity and mortality during the time spent waiting. Methods: The study population consisted of 544 ESRD patients on the waiting list for DDKT at Chungnam National University Hospital in South Korea between February 2000 and October 2015...
February 11, 2019: Kidney Research and Clinical Practice
https://read.qxmd.com/read/30737754/efficacy-and-safety-of-dual-blockade-of-the-renin-angiotensin-aldosterone-system-in-diabetic-kidney-disease-a-meta-analysis
#4
REVIEW
Yanhuan Feng, Rongshuang Huang, Janet Kavanagh, Lingzhi Li, Xiaoxi Zeng, Yi Li, Ping Fu
INTRODUCTION: Current guidelines recommend renin-angiotensin-aldosterone system (RAAS) inhibitors in the treatment of diabetic kidney disease (DKD). However, evidence suggests that the combined use of RAAS blockers may be associated with increased rates of adverse events. OBJECTIVES: Our objective was to examine the efficacy and safety of dual blockade of the RAAS in patients with DKD. METHODS: This was a systematic review and meta-analysis of randomized controlled trials (RCTs) published between January 1990 and January 2018 sourced via the PubMed, EMBASE, and Cochrane Library databases...
February 9, 2019: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://read.qxmd.com/read/30736969/three-years-experience-of-dialysis-event-surveillance
#5
Rehab R Abdelfattah, Suliman Al-Jumaah, Lutfi Al-Korbi, Tahani Al-Qahtani
BACKGROUND: The main study aim was to track infections, evaluate performance, and identify opportunities for improved practice since infections, especially those associated with multidrug-resistant organisms, are the second most common cause of death among end-stage renal disease patients. METHODS: This study describes the establishment of baseline dialysis event surveillance at a large dialysis center. Every month, the dialysis center staff reported the total number of maintenance hemodialysis patients to the department of infection control and hospital epidemiology...
February 5, 2019: American Journal of Infection Control
https://read.qxmd.com/read/30732176/risk-factors-associated-with-outcomes-of-peritoneal-dialysis-in-taiwan-an-analysis-using-a-competing-risk-model
#6
Hsiao-Ling Chen, Der-Cherng Tarng, Lian-Hua Huang
Peritoneal dialysis (PD) is one option for renal replacement therapy in patients with end-stage renal disease (ESRD). Maintenance of the PD catheter is an important issue for patient outcomes and quality of life. The aim of this retrospective cohort study is to clarify the risk factors of technique failure and outcomes at a single institute in Taiwan.The study enrolled ESRD patients who had received PD catheters in a tertiary hospital in northern Taiwan. Using a competing risks regression model, we reviewed clinical data and analyzed them in terms of the time to technical failure and clinical outcomes, including PD-related peritonitis and mortality...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30724445/associations-of-microvascular-dysfunction-with-cardiovascular-outcomes-the-cardiac-endothelial-function-and-arterial-stiffness-in-esrd-ceres-cohort
#7
Amrita Ayer, Claire Mills, Catherine Donovan, Robert H Christenson, Peter Ganz, Ruth F Dubin
INTRODUCTION: Patients with end-stage renal disease (ESRD) have reduced endothelial function, but whether macro- and microvascular endothelial function correlate with baseline risk factors and cardiovascular outcomes in this population is not well understood. METHODS: Among 146 participants of the Cardiac, Endothelial Function and Arterial Stiffness in ESRD (CERES) study, we evaluated macro- and microvascular endothelial dysfunction as flow-mediated dilation (FMD) and velocity time integral (VTI), respectively...
February 6, 2019: Hemodialysis International
https://read.qxmd.com/read/30714322/beliefs-about-medicines-in-dialysis-patients-and-after-renal-transplantation
#8
Sarah H Drangsholt, Ulrik W Cappelen, Nanna von der Lippe, Aud Høieggen, Ingrid Os, Fredrik B Brekke
INTRODUCTION: Patients with end-stage renal disease are burdened by a complex medication regimen, but little is known about the belief about medicine among dialysis- and renal transplant (RTX) patients. Patients' beliefs about medicines may influence drug adherence and thereby affect morbidity and mortality. The aim of the present study was to assess the beliefs about medicine in dialysis as well as after RTX. METHODS: In a prospective study, 301 dialysis patients were followed for up to 5...
February 4, 2019: Hemodialysis International
https://read.qxmd.com/read/30692239/cumulative-risk-of-end-stage-renal-disease-among-patients-with-type-2-diabetes-a-nationwide-inception-cohort-study
#9
Patrik Finne, Per-Henrik Groop, Martti Arffman, Marjo Kervinen, Jaakko Helve, Carola Grönhagen-Riska, Reijo Sund
OBJECTIVE: To estimate long-term cumulative risk of end-stage renal disease (ESRD) after diagnosis of type 2 diabetes. RESEARCH DESIGN AND METHODS: This nationwide population-based inception cohort study included 421,429 patients with type 2 diabetes diagnosed in 1990-2011; patients were followed until the end of 2013. Data linkage between several national health care registers in Finland, covering 100% of the population, enabled the inclusion of almost all inhabitants who started taking diabetes medication or were hospitalized for diabetes...
January 28, 2019: Diabetes Care
https://read.qxmd.com/read/30692035/factors-associated-with-withdrawal-from-dialysis-therapy-in-incident-hemodialysis-patients-aged-80-years-or-older
#10
Gang Jee Ko, Yoshitsugu Obi, Tae Ik Chang, Melissa Soohoo, Rieko Eriguchi, Soo Jeong Choi, Daniel L Gillen, Csaba P Kovesdy, Elani Streja, Kamyar Kalantar-Zadeh, Connie M Rhee
OBJECTIVES: Among kidney disease patients ≥80 years progressing to end-stage renal disease, there is growing interest in conservative nondialytic management approaches. However, among those who have initiated hemodialysis, little is known about the impact of withdrawal from dialysis on mortality, nor the patient characteristics associated with withdrawal from dialysis. STUDY DESIGN: Historical cohort study. SETTING AND PARTICIPANTS: We examined 133,162 incident hemodialysis patients receiving care within a large national dialysis organization from 2007 to 2011...
January 25, 2019: Journal of the American Medical Directors Association
https://read.qxmd.com/read/30686286/maintenance-therapy-for-lupus-nephritis-with-mycophenolate-mofetil-or-azathioprine-a-meta-analysis
#11
Jin Deng, Huan Xie, Lin Zhu, Lei Luo, Hongping Xie
AIM: Maintenance therapy for lupus nephritis (LN) remains controversial. This meta-analysis of randomized controlled trials (RCTs) describes the comparative benefits and safety of mycophenolate mofetil (MMF) versus azathioprine (AZA) as maintenance therapy in patients with LN. MATERIALS AND METHODS: RCTs that compared the maintenance regimens of MMF and AZA in the treatment of LN were included. Outcomes were mortality, end-stage renal disease (ESRD), renal relapse, doubling of serum creatinine, and adverse effects...
January 28, 2019: Clinical Nephrology
https://read.qxmd.com/read/30683904/stc-1-ameliorates-renal-injury-in-diabetic-nephropathy-by-inhibiting-the-expression-of-bnip3-through-the-ampk-sirt3-pathway
#12
Zhiwen Liu, Hong Liu, Li Xiao, Guoyong Liu, Lin Sun, Liyu He
Diabetic kidney disease (DKD) is the leading cause of morbidity and mortality in individuals with diabetes, and it is the leading cause of end-stage renal disease (ESRD) worldwide. Stanniocalcin-1 (STC-1) is present in various tissues, and it has antioxidant and anti-apoptotic activities, which play a role in kidney protection, including diabetic nephropathy (DN). However, the mechanism that underlies these effects remains unknown. This study suggests that STC-1 ameliorates oxidative stress and cell apoptosis in the kidneys of db/db mice and high glucose (HG)-treated BUMPT cells by inhibiting Bnip3 expression through AMPK/Sirt3 pathway activation...
January 25, 2019: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://read.qxmd.com/read/30682846/the-risk-of-stroke-in-kidney-transplant-recipients-with-end-stage-kidney-disease
#13
Shih-Ting Huang, Tung-Min Yu, Ya-Wen Chuang, Mu-Chi Chung, Chen-Yu Wang, Pin-Kuei Fu, Tai-Yuan Ke, Chi-Yuan Li, Cheng-Li Lin, Ming-Ju Wu, Chia-Hung Kao
Background : The incidence of stroke after kidney transplantation is poorly understood. Our study aimed to determine the incidence and predictors of stroke as well as mortality from stroke in kidney transplant recipients (KTRs). Methods : This retrospective cohort study used the National Health Insurance Research Database in Taiwan to study KTRs ( N = 4635), patients with end-stage renal disease (ESRD; N = 69,297), and patients from the general population who were chronic kidney disease (CKD)-free and matched by comorbidities ( N = 69,297) for the years 2000 through 2010...
January 24, 2019: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/30681261/chronic-kidney-disease-is-associated-with-increased-mortality-and-procedural-complications-in-transcatheter-aortic-valve-replacement-a-systematic-review-and-meta-analysis
#14
Pattara Rattanawong, Chanavuth Kanitsoraphan, Jakrin Kewcharoen, Tanawan Riangwiwat, Pitchaporn Chongyangyuenvong, Wasawat Vutthikraivit, Santhosh R Mannem, Eugene H Chung
OBJECTIVE: We performed a systematic review and meta-analysis to explore the association between chronic kidney disease (CKD) and mortality and procedural complications in transcatheter aortic valve replacement (TAVR). BACKGROUND: The impact of varying stages of CKD or end-stage renal disease (ESRD) on patients receiving TAVR is not clearly identified. METHODS: We searched the databases of MEDLINE and EMBASE from inception to May 2018. Included studies were published TAVR studies that compared the risk of mortality and procedural complications in CKD patients compared to control patients...
January 25, 2019: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/30679380/excess-deaths-attributable-to-influenza-like-illness-in-the-esrd-population
#15
David T Gilbertson, Kenneth J Rothman, Glenn M Chertow, Brian D Bradbury, M Alan Brookhart, Jiannong Liu, Wolfgang C Winkelmayer, Til Stürmer, Keri L Monda, Charles A Herzog, Akhtar Ashfaq, Allan J Collins, James B Wetmore
BACKGROUND: Morbidity and mortality vary seasonally. Timing and severity of influenza seasons contribute to those patterns, especially among vulnerable populations such as patients with ESRD. However, the extent to which influenza-like illness (ILI), a syndrome comprising a range of potentially serious respiratory tract infections, contributes to mortality in patients with ESRD has not been quantified. METHODS: We used data from the Centers for Disease Control and Prevention (CDC) Outpatient Influenza-like Illness Surveillance Network and Centers for Medicare and Medicaid Services ESRD death data from 2000 to 2013...
January 24, 2019: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/30678696/the-aftermath-of-acute-kidney-injury-a-narrative-review-of-long-term-mortality-and-renal-function
#16
REVIEW
Gijs Fortrie, Hilde R H de Geus, Michiel G H Betjes
Acute kidney injury (AKI) is a frequent complication of hospitalization and is associated with an increased risk of chronic kidney disease (CKD), end-stage renal disease (ESRD), and mortality. While AKI is a known risk factor for short-term adverse outcomes, more recent data suggest that the risk of mortality and renal dysfunction extends far beyond hospital discharge. However, determining whether this risk applies to all patients who experience an episode of AKI is difficult. The magnitude of this risk seems highly dependent on the presence of comorbid conditions, including cardiovascular disease, hypertension, diabetes mellitus, preexisting CKD, and renal recovery...
January 24, 2019: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/30677763/clinical-outcomes-of-arteriovenous-access-in-incident-hemodialysis-patients-with-medicare-coverage-2012-2014
#17
Lauren C Bylsma, Heidi Reichert, Shawn M Gage, Prabir Roy-Chaudhury, Robert J Nordyke, Jon Fryzek, Shannon L M Dahl, Theodore Lithgow, Jeffrey H Lawson
BACKGROUND: Chronic hemodialysis requires a mode of vascular access through an arteriovenous fistula (AVF), a prosthetic arteriovenous graft (AVG), or a central venous catheter (CVC). AVF is recommended over AVG or CVC due to increased patency and decreased intervention rates for those that mature. AVG are preferred over CVC due to decreased infection and mortality risk. The aims of this study were to evaluate the lifespan of AVF and AVG in maturation, sustained access use, and abandonment...
2019: American Journal of Nephrology
https://read.qxmd.com/read/30675963/icodextrin-is-associated-with-a-lower-risk-of-atrial-fibrillation-in-peritoneal-dialysis-patients
#18
I-Kuan Wang, Tsung-Hsun Tsai, Shih-Shang Chang, Shih-Yi Lin, Tzung-Hai Yen, Cheng-Li Lin, Fung-Chang Sung
AIMS: Dialysis patients with atrial fibrillation (AF) are at 1.72-fold increased mortality risk. This study investigated whether peritoneal dialysis (PD) patients using icodextrin were at a reduced risk of AF. METHODS: From the Taiwan National Health Insurance database, we identified 4040 icodextrin users and 3517 non-users among 7557 patients newly diagnosed with end-stage renal disease undergoing PD f rom 2005 to 2011. The incidence of AF was compared between PD patients with and without icodextrin treatment by the end of 2011, with the hazard ratio (HR) of AF measured using Cox proportional hazards regression models...
January 24, 2019: Nephrology
https://read.qxmd.com/read/30674290/pregnancy-outcomes-in-women-with-kidney-transplant-metaanalysis-and-systematic-review
#19
Silvi Shah, Renganathan Lalgudi Venkatesan, Ayank Gupta, Maitrik K Sanghavi, Jeffrey Welge, Richard Johansen, Emily B Kean, Taranpreet Kaur, Anu Gupta, Tiffany J Grant, Prasoon Verma
BACKGROUND: Reproductive function in women with end stage renal disease generally improves after kidney transplant. However, pregnancy remains challenging due to the risk of adverse clinical outcomes. METHODS: We searched PubMed/MEDLINE, Elsevier EMBASE, Scopus, BIOSIS Previews, ISI Science Citation Index Expanded, and the Cochrane Central Register of Controlled Trials from date of inception through August 2017 for studies reporting pregnancy with kidney transplant...
January 23, 2019: BMC Nephrology
https://read.qxmd.com/read/30673974/generalizability-of-sprint-ckd-cohort-to-ckd-patients-referred-to-renal-clinics
#20
Roberto Minutolo, Luca De Nicola, Ciro Gallo, Paolo Chiodini, Michele Provenzano, Giuseppe Conte, Carlo Garofalo, Silvio Borrelli
BACKGROUND: The Systolic Blood Pressure Intervention Trial-CKD substudy (SPRINT-CKD) has suggested a lower blood pressure (BP) target in CKD patients. However, it is questionable whether the SPRINT-CKD results may be generalized to CKD patients under nephrology care. METHODS: To compare SPRINT-CKD cohort versus referred CKD patients in terms of patients' risk profile and outcomes, we pooled four prospective cohorts of consecutive CKD patients referred to 40 Italian renal clinics...
January 23, 2019: Journal of Nephrology
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