keyword
https://read.qxmd.com/read/38470176/preparation-of-the-myricetin-loaded-pegylated-niosomes-and-evaluation-of-their-in%C3%A2-vitro-anti-cancer-potentials
#1
JOURNAL ARTICLE
Hanieh Riazi, Mohammad Taghi Goodarzi, Masoud Homayouni Tabrizi, Majid Mozaffari, Ali Neamati
Several edible plants contain flavonoids, including myricetin (Myr), which perform a wide range of biological activities. Myr has antitumor properties against various tumor cells. In this study Myr-loaded PEGylated niosomes (Myr-PN) were prepared and their anti-cancer activities were evaluated in vitro. Myr-PNs were prepared as a tool for drug delivery to the tumor site. Myr-PN was characterized in terms of size, zeta potential, and functional groups using dynamic light scattering (DLS), Fourier-transform infrared spectroscopy (FTIR), and field emission scanning electron microscopy (SEM)...
March 12, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38265372/biological-activities-and-nanoparticle-synthesis-of-dioscorea-bulbifera-and-its-mechanistic-action-an-extensive-review
#2
JOURNAL ARTICLE
Sangilimuthu Alagar Yadav, Shiek Hasan, Suvathika Gnanaselvan, Santhoshraman Baskaran, Jayapragash G
BACKGROUND: Dioscorea bulbifera is commonly known as air potato present in the tropical and subtropical regions. It is a perennial climber traditionally used for various therapeutic purposes by traditional healers. This review explores various medicinal uses of D. bulbifera and its active ingredients, as well as describes its nanoparticle synthesis for medical applications. METHODS: The Google Scholar search engine was used to conduct this comprehensive review along with the databases of the following publishers: Elsevier, Springer, Taylor and Francis, Bentham, and PubMed...
January 23, 2024: Pharmaceutical Nanotechnology
https://read.qxmd.com/read/37895651/biological-synthesis-of-copper-nanoparticles-using-edible-plant-allium-monanthum-characterization-of-antibacterial-antioxidant-and-anti-inflammatory-properties-using-in-silico-molecular-docking-analysis
#3
JOURNAL ARTICLE
Hyo Shim Han, Jeong Sung Jung, Young-Il Jeong, Ki Choon Choi
This study prepared copper nanoparticles using an edible leaf extract from A. monanthum (AM-CuNPs) via eco-friendly green synthesis techniques. The size, shape, crystalline nature and functional groups of the synthesized AM-CuNP particles were analyzed by a UV-VIS spectrophotometer and SEM, EDX, TEM, XRD and FT-IR instrumentation. The synthesized AM-CuNPs had spherical shapes with sizes in the range of 30-80 nm and were crystalline in nature. In addition, the AM-CuNPs were synthesized using various bioactive sources, including flavonoids, phenolic acids, alkaloids and sugars that were present in an aqueous broth of A...
October 12, 2023: Materials
https://read.qxmd.com/read/37839226/antimicrobial-films-fabricated-with-myricetin-nanoparticles-and-chitosan-derivation-microgels-for-killing-pathogenic-bacteria-in-drinking-water
#4
JOURNAL ARTICLE
Yu Zhu, Xu Zhang, Enze Sun, Jiang Wu, Jiaxiang Guo, Anboyuan Lv, Xiaozhou Li, Ke Wang, Lin Wang
Pathogenic bacteria in drinking water threaten human health and life. In the work, antimicrobial films composed of myricetin@tannic acid (My@TA) nanoparticles (NPs) and chitosan derivation microgels were developed to kill pathogenic bacteria in drinking water. Hydrophobic My was first made into water soluble My@TA NPs using a solvent exchange method with TA as stabilizer. Polymeric microgels of carboxymethyl chitosan (CMCS)/hydroxypropyltrimethyl ammonium chloride chitosan (HACC) were then fabricated with a blending method...
October 12, 2023: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/37769767/design-of-flavonol-loaded-cationic-gold-nanoparticles-with-enhanced-antioxidant-and-antibacterial-activities-and-their-interaction-with-proteins
#5
JOURNAL ARTICLE
Xiangrong Li, Ruonan Xu, Li Shi, Tianjun Ni
In this work, four structurally similar flavonols (galangin, kaempferol, quercetin and myricetin) were coated on the surface of (11-mercaptoundecyl)-N,N,N-trimethylammonium bromide (MUTAB)‑gold nanoparticles (AuNPs) by two-step phase transfer and self-assembly, and the cationic MUTAB- AuNPs coated with flavonols (flavonol-MUTAB-AuNPs) were designed. Free radical scavenging and antibacterial experiments show that flavonol-MUTAB-AuNPs greatly improve the scavenging effect on DPPH, hydroxyl and superoxide anion radicals, and significantly enhance the inhibition effect on Staphylococcus aureus and Escherichia coli compared with flavonols and AuNPs...
September 26, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37651612/kinetics-of-flavonoid-degradation-and-controlled-release-from-functionalized-magnetic-nanoparticles
#6
JOURNAL ARTICLE
Anja Sadžak, Mihael Eraković, Suzana Šegota
Flavonoids are naturally occurring antioxidants that have been shown to protect cell membranes from oxidative stress and have a potential use in photodynamic cancer treatment. However, they degrade at physiological pH values, which is often neglected in drug release studies. Kinetic study of flavonoid oxidation can help to understand the mechanism of degradation and to correctly analyze flavonoid release data. Additionally, the incorporation of flavonoids into magnetic nanocarriers can be utilized to mitigate degradation and overcome their low solubility, while the release can be controlled using magnetic fields (MFs)...
August 31, 2023: Molecular Pharmaceutics
https://read.qxmd.com/read/37418933/myricetin-encapsulated-chitosan-nanoformulation-for-management-of-type-2-diabetes-preparation-optimization-characterization-and-in-vivo-activity
#7
JOURNAL ARTICLE
Mansi Upadhyay, Ramakrishna V Hosur, Abhishek Jha, Kanchan Bharti, Pramod S Mali, Akash Kumar Jha, Brahmeshwar Mishra, Ashutosh Kumar
Type 2 diabetes mellitus (T2DM) is a serious and alarming disease attracting widespread attention. It is not a single metabolic disease; over time, it leads to serious disorders, namely, diabetic nephropathy, neuropathy, retinopathy and several cardiovascular, hepatocellular complications. The increase in T2DM cases in recent times has attracted significant attention. Currently, the medications available have side effects, and injectables are painful, causing trauma to the patients. Therefore, it is imperative to come up with oral delivery...
June 30, 2023: Biomater Adv
https://read.qxmd.com/read/37291144/predicting-the-storage-time-of-green-tea-by-myricetin-based-on-surface-enhanced-raman-spectroscopy
#8
JOURNAL ARTICLE
Mengxuan Xiao, Yingqi Chen, Fangling Zheng, Qi An, Mingji Xiao, Huiqiang Wang, Luqing Li, Qianying Dai
The quality of green tea changes rapidly due to the oxidation and degradation of polyphenols during storage. Herein, a simple and fast Surface-enhanced Raman spectroscopy (SERS) strategy was established to predict changes in green tea during storage. Raman spectra of green tea with different storage times (2020-2015) were acquired by SERS with silver nanoparticles. The PCA-SVM model was established based on SERS to quickly predict the storage time of green tea, and the accuracy of the prediction set was 97...
June 9, 2023: NPJ science of food
https://read.qxmd.com/read/36998600/polyphenols-can-improve-resin-dentin-bond-durability-by-promoting-amorphous-calcium-phosphate-nanoparticles-to-backfill-the-dentin-matrix
#9
JOURNAL ARTICLE
Beibei Wang, Fei Han, Ran You, Chen Chen, Haifeng Xie
OBJECTIVE: To investigate the effects of proanthocyanidins (PA), myricetin, resveratrol, and kaempferol on the modification of dentin collagen and the inhibition of matrix metalloproteinase (MMP) activity, and to evaluate their contributions to the biomimetic remineralization and resin-dentin bonding performance. METHODS: Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and in situ zymography were applied to verify the collagen modification and MMP activity inhibition induced by these four polyphenols...
2023: International Journal of Nanomedicine
https://read.qxmd.com/read/36985836/some-nanocarrier-s-properties-and-chemical-interaction-mechanisms-with-flavones
#10
REVIEW
Cecilia Espíndola
Flavones such as 7,8-dihydroxyflavone (tropoflavin), 5,6,7-trihydroxyflavone (baicalein), 3',4',5,6-tetrahydroxyflavone (luteolin), 3,3',4',5,5',7-hexahydroxyflavone (myricetin) , 4',5,7-trihydroxyflavone (apigenin), and 5,7-dihydroxyflavone (chrysin) are important both for their presence in natural products and for their pharmacological applications. However, due to their chemical characteristics and their metabolic processes, they have low solubility and low bioavailability. Knowledge about the physicochemical properties of nanocarriers and the possible mechanisms of covalent and non-covalent interaction between nanoparticles (NPs) and drugs is essential for the design of nanocarriers to improve the bioavailability of molecules with pharmacological potential, such as tropoflavin, baicalein, luteolin, myricetin, apigenin, and chrysin...
March 22, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36949384/antimicrobial-potential-of-myricetin-coated-zinc-oxide-nanocomposite-against-drug-resistant-clostridium-perfringens
#11
JOURNAL ARTICLE
Nada H Gomaa, Norhan K Abd El-Aziz, El-Sayed Y El-Naenaeey, Walaa S Abdelaziz, Alaa H Sewid
BACKGROUND: Clostridium perfringens (C. perfringens) is an important pathogen in livestock animals and humans causing a wide array of systemic and enteric diseases. The current study was performed to investigate the inhibitory activity of myricetin (MYR), polyvinyl alcohol (PVA), and zinc oxide (ZnO) nanocomposite against growth and α-hemolysin of C. perfringens isolated from beef meat and chicken sources. RESULTS: The overall occurrence of C. perfringens was 29...
March 22, 2023: BMC Microbiology
https://read.qxmd.com/read/36771041/identifying-the-anti-mers-cov-and-anti-hcov-229e-potential-drugs-from-the-ginkgo-biloba-leaves-extract-and-its-eco-friendly-synthesis-of-silver-nanoparticles
#12
JOURNAL ARTICLE
Ezzat H Elshazly, Alyaa Nasr, Mohamed E Elnosary, Gamal A Gouda, Hassan Mohamed, Yuanda Song
The present study aimed to estimate the antiviral activities of Ginkgo biloba (GB) leaves extract and eco-friendly free silver nanoparticles (Ag NPs) against the MERS-CoV (Middle East respiratory syndrome-coronavirus) and HCoV-229E (human coronavirus 229E), as well as isolation and identification of phytochemicals from GB. Different solvents and high-performance liquid chromatography (HPLC) were used to extract and identify flavonoids and phenolic compounds from GB leaves. The green, silver nanoparticle synthesis was synthesized from GB leaves aqueous extract and investigated for their possible effects as anti-coronaviruses MERS-CoV and HCoV-229E using MTT assay protocol...
February 1, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36670250/ziziphus-spina-christi-extract-stabilized-novel-silver-nanoparticle-synthesis-for-combating-fusarium-oxysporum-causing-pepper-wilt-disease-in-vitro-and-in-vivo-studies
#13
JOURNAL ARTICLE
Amer M Abdelaziz, Mohammed A Elshaer, Mohamed A Abd-Elraheem, Omar M Omar M Ali, Muhammad I Haggag, Gharieb S El-Sayyad, Mohamed S Attia
The novelty of the present study is studying the ability of aqueous Ziziphus spina-christi leaves' extract (ZSCE) to produce eco-friendly and cost-effective silver nanoparticles (Ag NPs) against Fusarium wilt disease. Phytochemical screening of ZSCE by HPLC showed that they contain important antimicrobial substances such as Rutin, Naringin, Myricetin, Quercetin, Kaempferol, Hesperidin, Syringeic, Eugenol, Pyrogallol, Gallic and Ferulic. Characterization methods reveal a stable Ag NPs with a crystalline structure, spherical in shape with average particle size about 11...
January 21, 2023: Archives of Microbiology
https://read.qxmd.com/read/36567280/novel-nanotechnological-strategies-for-skin-anti-aging
#14
REVIEW
Sara Pozos-Nonato, Clara Luisa Domínguez-Delgado, Kenia Areli Campos-Santander, Allyson Amelia Benavides, Sandy María Pacheco-Ortin, Rosa Isabel Higuera-Piedrahita, Guillermo Resendiz-González, Eva María Molina-Trinidad
BACKGROUND: Nanoparticle formulations development for anti-aging treatment is increasing due to their multifunctional properties. These nanotechnological strategies can target cellular/ molecular pathways of the skin affected by the aging process. However, a review of these strategies is required to discuss their efficacy/safety and establish the needs for further research. OBJECTIVE: Innovative nanotechnological advances for skin anti-aging/rejuvenation are summarized and discussed in this work...
2023: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/36432115/-limoniastrum-monopetalum-mediated-nanoparticles-and-biomedicines-in-silico-study-and-molecular-prediction-of-biomolecules
#15
JOURNAL ARTICLE
Afrah E Mohammed, Sahar S Alghamdi, Nada K Alharbi, Fatma Alshehri, Rasha Saad Suliman, Fahad Al-Dhabaan, Maha Alharbi
An in silico approach applying computer-simulated models helps enhance biomedicines by sightseeing the pharmacology of potential therapeutics. Currently, an in silico study combined with in vitro assays investigated the antimicrobial ability of Limoniastrum monopetalum and silver nanoparticles (AgNPs) fabricated by its aid. AgNPs mediated by L. monopetalum were characterized using FTIR, TEM, SEM, and DLS. L. monopetalum metabolites were detected by QTOF-LCMS and assessed using an in silico study for pharmacological properties...
November 18, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36232319/synthesis-of-silver-nano-particles-using-myricetin-and-the-in-vitro-assessment-of-anti-colorectal-cancer-activity-in-silico-integration
#16
JOURNAL ARTICLE
Syed Tauqeer Anwer, Mohammad Mobashir, Omer I Fantoukh, Bushra Khan, Khalid Imtiyaz, Irshad Hussain Naqvi, M Moshahid Alam Rizvi
The creation of novel anticancer treatments for a variety of human illnesses, including different malignancies and dangerous microbes, also potentially depends on nanoparticles including silver. Recently, it has been successful to biologically synthesize metal nanoparticles using plant extracts. The natural flavonoid 3,3', 4', 5,5', and 7 hexahydroxyflavon (myricetin) has anticancer properties. There is not much known about the regulatory effects of myricetin on the possible cell fate-determination mechanisms (such as apoptosis/proliferation) in colorectal cancer...
September 20, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36093595/antioxidative-myricetin-enriched-nanoparticles-towards-acute-liver-injury
#17
JOURNAL ARTICLE
Tianyou Wang, Jianhua Zhang, Hengjie Zhang, Wanjie Bai, Jinhong Dong, Zhen Yang, Peng Yang, Zhipeng Gu, Yiwen Li, Xianchun Chen, Yuanting Xu
Acute liver injury (ALI) could severely destroy the liver function and cause inevitable damage to human health. Studies have demonstrated that excessive reactive oxygen species (ROS) and accompanying inflammatory factors play vital roles in the ALI disease. Herein, we fabricated a kind of nature-inspired myricetin-enriched nanomaterial via Michael addition and Schiff base reaction, which possessed uniform morphology, tunable component ratios, great stabilities, promising free radical scavenging abilities, biocompatibility and protective effects towards cells under oxidative stress...
September 12, 2022: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/35767106/myricetin-loaded-in-solid-lipid-nanoparticles-induces-apoptosis-in-the-ht-29-colorectal-cancer-cells-via-mitochondrial-dysfunction
#18
JOURNAL ARTICLE
Hadis Alidadi, Atefeh Ashtari, Azin Samimi, Masoud Ali Karami, Layasadat Khorsandi
BACKGROUND: Among the flavonoids, Myricetin (MCN) has negligible side effects and anti-cancer properties. However, the therapeutic potential of MCN has been limited mainly by its low bioavailability. Nanocarriers improve the bioavailability and stability of flavonoids. The toxic effects of MCN loaded in solid lipid nanoparticles (MCN-SLNs) on the HT-29 human colorectal cancer cells were investigated in this study. METHODS AND RESULTS: HT-29 cells were exposed to the 30 µmol MCN or MCN-SLNs for 24 h...
June 29, 2022: Molecular Biology Reports
https://read.qxmd.com/read/34974863/myricetin-based-self-assembled-nanoparticles-for-tumor-synergistic-therapy-by-antioxidation-pathway
#19
JOURNAL ARTICLE
Yumei Qian, Fang Zhao, Jing Wang, Hongxia Li, Lisheng Xu, Weiwei Wang, Weixiong Yu, Lingling Shan
Nanoplatforms are nano-scale systems that can transport different small molecular anticancer drugs or chemosensitization motif to accumulate in tumor cells without obvious side-effect in normal cells and achieve a synergistic therapy. In this paper the new self-assembled nanoparticles (NPs) merging doxorubicin (DOX) and myricetin (MYR) with ferric ions (Fe3+ ) and polyphenol was employed for forming the DOX@MYR-Fe3+ NP (FDMP NP). The FDMP NPs could reduce the DOX-induced toxicity in blood; and they could not cause damage to the heart and kidney tissues by the reasons that the MYR could enhance the anti-oxidation capability in normal cells, which resulted in preventing ROS-induced damage...
December 1, 2021: Journal of Biomedical Nanotechnology
https://read.qxmd.com/read/34868474/nanoparticle-carrier-co-delivery-of-complementary-antibiofilm-drugs-abrogates-dual-species-cariogenic-biofilm-formation-in-vitro
#20
JOURNAL ARTICLE
Guilherme Roncari Rocha, Kenneth R Sims, Baixue Xiao, Marlise I Klein, Danielle S W Benoit
Background: Dental caries is a multifactorial disease caused by pathogenic biofilm. In particular, Streptococcus mutans synthesizes biofilm exopolysaccharides, while Candida albicans is associated with the development of severe carious lesions. Aim: This study aimed to prevent the formation of S. mutans and C. albicans biofilms by exploiting pH-sensitive nanoparticle carriers (NPCs) with high affinity to exopolysaccharides to increase the substantivity of multi-targeted antibiofilm drugs introduced topically in vitro ...
2022: Journal of Oral Microbiology
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