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Saee Byel Kang, So Yeon Kong, Sang Do Shin, Young Sun Ro, Kyoung Jun Song, Ki Jeong Hong, Tae Han Kim
OBJECTIVES: There is growing evidence that optimal post-resuscitation treatment is a significant factor for overall survival and neurological outcomes in out-of-hospital cardiac arrest (OHCA). However, there is also growing evidence of disparities in treatments in vulnerable populations such as elderly individuals or patients with underlying diseases, including cancer. AIM: The aim of this study was to evaluate the influence of cancer status on post-resuscitation therapies among OHCA patients...
February 13, 2019: Resuscitation
Aldo L Schenone, Kevin Chen, Bashaer Gheyath, Nyal Borges, Manshi Li Bs Mss, Xiaofeng Wang, Abhijit Duggal, Venu Menon
Most important prognostic factors in the postcardiac arrest patients who underwent targeted temperature management (TTM) derive from the periarrest period. Whether early invasive hemodynamics predict survival or neurologic outcomes remains unknown. We retrospectively reviewed all comatose survivors of cardiac arrest who underwent TTM at the Coronary Intensive Care Unit of a Quaternary Center between January 2015 and June 2017. Patients were required to have a set of invasive hemodynamics available at initiation of TTM to be included...
January 24, 2019: American Journal of Cardiology
Maximiliano A Hawkes, Alejandro A Rabinstein
PURPOSE OF REVIEW: The purpose of this study is to provide an updated review on neurological prognostication in comatose patients after cardiac arrest in light of current targeted temperature management (TTM) strategies. RECENT FINDINGS: With improved pre-hospital and hospital care, death due to cardiac arrest is decreasing. Yet, most survivors have poor neurological outcomes. While TTM has demonstrated to improve neurological outcomes, it may cloud our prognostic accuracy...
February 9, 2019: Current Neurology and Neuroscience Reports
Jae Ho Jang, Won Bin Park, Yong Su Lim, Jea Yeon Choi, Jin Seong Cho, Jae-Hyug Woo, Woo Sung Choi, Hyuk Jun Yang, Sung Youl Hyun
This study aimed to determine whether the combination of procalcitonin (PCT) and S100B improves prognostic performance compared to either alone in cardiac arrest (CA) patients treated with targeted temperature management (TTM).We performed a prospective cohort study of CA patients treated with TTM. PCT and S100B levels were obtained at 0, 24, 48, and 72 hours after return of spontaneous circulation. The prognostic performance was analyzed using each marker and the combination of the 2 markers for predicting poor neurological outcome at 3 months and mortality at 14 days and 3 months...
February 2019: Medicine (Baltimore)
Colleen A Redding, David Goldberg, Kathleen M Weber, Hui-Qing Yin, Andrea L Paiva, Jane Burke-Miller, Mardge H Cohen, Joseph S Rossi
People with and at risk for HIV have high rates of smoking, increasing their morbidity and mortality. Effective cessation interventions are needed for this group. Transtheoretical model (TTM)-tailored interventions have demonstrated efficacy, but measures need cross-validation in this population. TTM cessation measures were evaluated in women smokers with and at risk for HIV (N = 111) from Chicago Women's Interagency HIV Study (WIHS). Confirmatory factor analyses evaluated measurement models. MANOVAs examined relationships between constructs and stage subgroups...
February 4, 2019: Translational Behavioral Medicine
DongHyun Lee, Ki Ok Ahn, Joohyun Suh, Si Young Jung
AIM: This study examined the influence of patient attributes and provider or organizational factors on the decision to apply targeted temperature management (TTM) to resuscitated out-of-hospital cardiac arrest (OHCA) patients. METHODS: A balanced factorial experiment was conducted among emergency medicine physicians (EMPs). Sixteen OHCA patient scenarios with balanced factors were presented. The balancing factors were dichotomous categories of patient age (45 ± 2 vs...
January 19, 2019: American Journal of Emergency Medicine
Kellie J Ryan, Karen E Skinner, Ancilla W Fernandes, Rajeshwari S Punekar, Melissa Pavilack, Mark S Walker, Noam A VanderWalde
This study examined real-world clinical outcomes such as progression-free survival (PFS), time to metastasis (TTM), overall survival (OS), and health-related quality of life (HRQOL) in patients with unresected stage III non-small cell lung cancer (NSCLC) treated in the community setting. A retrospective review of medical records extracted from 10 US community oncology practices was conducted. Eligible patients were adults diagnosed with stage III NSCLC from 1/1/2011 to 3/1/2016 without evidence of surgical resection within 6 months after stage III NSCLC diagnosis (index date)...
January 31, 2019: Medical Oncology
Florian Ebner, Susann Ullén, Anders Åneman, Tobias Cronberg, Niklas Mattsson, Hans Friberg, Christian Hassager, Jesper Kjærgaard, Michael Kuiper, Paolo Pelosi, Johan Undén, Matt P Wise, Jørn Wetterslev, Niklas Nielsen
OBJECTIVE: Exposure to hyperoxemia and hypoxemia is common in out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation (ROSC), but its effects on neurological outcome are uncertain, and study results are inconsistent. METHODS: Exploratory post hoc substudy of the Target Temperature Management (TTM) trial, including 939 patients after OHCA with return of spontaneous circulation (ROSC). The association between serial arterial partial pressures of oxygen (PaO2 ) during 37 h following ROSC and neurological outcome at 6 months, evaluated by Cerebral Performance Category (CPC), dichotomized to good (CPC 1-2) and poor (CPC 3-5), was investigated...
January 28, 2019: Critical Care: the Official Journal of the Critical Care Forum
Chuhuan He, Zhendong Li, Yibo Lei, Wenli Zou, Bingbing Suo
Stable doublet radical molecules have recently emerged as a promising new type of emitters in organic light-emitting diodes (OLEDs) to approach 100\% internal quantum efficiency. However, the detailed emission mechanism of these open-shell emitters remains elusive. Through theoretical model analysis and first-principle calculations, we unraveled the emission mechanism of a typical emitter, (4-N-carbazolyl-2,6-dichlorophenyl)bis(2,4,6-trichlorophenyl)methyl (TTM-1Cz). Our study showed that the electroluminescence arises from the first doublet excited state generated by injecting one electron into the singly occupied molecule orbital (SOMO) and one hole into the highest doubly occupied molecule orbital (HDMO)...
January 23, 2019: Journal of Physical Chemistry Letters
Faraaz Bhatti, Melissa Naiman, Alexander Tsarev, Erik Kulstad
Traumatic brain injury (TBI) is a leading cause of death in the United States, and represents 2.5 million Emergency Department attendances, admissions into hospital, and deaths. A range of temperature modulating devices have been used to proactively cool TBI patients; however, there are currently no uniform targeted temperature management (TTM) guidelines in this patient population. Esophageal temperature management (ETM) is a relatively new TTM modality and the purpose of this study is to determine whether ETM is effective in controlling core temperature in TBI cases...
January 18, 2019: Therapeutic Hypothermia and Temperature Management
Chih-Hung Lin, Chien-Hui Wen, Chia-Hsing Liu, Ching-Hsiu Yang
CONTEXT: Human epidermal growth factor receptor 2 (HER2) status of breast carcinomas is usually determined by immunohistochemical (IHC) staining and, if the IHC results are equivocal, in situ hybridization (ISH). Multiple ISH tests are sometimes required for multiple primary or metastatic tumors. A method for multiplex ISH test on tissues from multiple blocks is helpful in these situations. OBJECT: To evaluate the clinical application of transferred-tissue microarray (TTM) followed by a dual-probe HER2 fluorescence in situ hybridization (FISH)...
January 15, 2019: Applied Immunohistochemistry & Molecular Morphology: AIMM
İsmail Akaltun
Trichotillomania (TTM) is a disorder characterized by the individual pulling out his hair in a repetitive manner, resulting in significant hair loss, a feeling of tension before the hair pulling, and pleasure during it. Our understanding of the neurobiological basis of TTM is limited. However, the condition in all likelihood involves multiple pathways and a complex interaction between various genetic, psychological, and social factors. Vitamin D deficiency is thought to be linked to rickets in children and to a range of different diseases in adults, including osteoporosis, osteomalacia, cardiovascular diseases, cancer, dermatological diseases, and psychiatric disorders...
January 2019: Clinical Neuropharmacology
Woo Jin Joo, Kazuki Ide, Yohei Kawasaki, Chikashi Takeda, Tomotsugu Seki, Tomoko Usui, Koji Kawakami
AIM: Early enteral nutrition (EN) is recommended for critically ill patients; however, few reports have examined early EN for patients who received targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA). We investigated the effectiveness and safety of early EN for patients who received TTM after OHCA. METHODS: We used a nationwide Japanese administrative database to identify OHCA patients who received TTM from April 2008 to March 2017...
January 14, 2019: Resuscitation
Tae Han Kim, Young Sun Ro, Sang Do Shin, Kyoung Jun Song, Ki Jeong Hong, Jeong Ho Park, So Yeon Kong
BACKGROUND: We investigated the association of health insurance status with post-resuscitation care and neurological recovery in out-of-hospital cardiac arrest (OHCA) and whether the effects changed with age or gender. METHODS: Adult OHCAs with presumed cardiac etiology who had sustained ROSC from 2013 to 2016 were enrolled from the nationwide OHCA registry of Korea. Insurance status was categorized into 2 groups: National Health Insurance (NHI) and Medical Aid (MA)...
January 9, 2019: Resuscitation
Yi-Lin Chen, Leilei Zhang, Jin Song, Guoqing Jian, George Hirasaki, Keith Johnston, Sibani Lisa Biswal
The adsorption of a switchable cationic surfactant, N, N, N'-trimethyl- N'-tallow-1,3-diaminopropane (DTTM, Duomeen TTM), at the silica/aqueous solution interface is characterized using a quartz crystal microbalance with dissipation (QCM-D). The adsorption isotherms reveal that changes in the solution pH or salinity affect surfactant adsorption in competing ways. In particular, the combination of the degree of protonation of the surfactant and electrostatic interactions is responsible for surfactant adsorption...
January 14, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Nonglak Pagaiya, Pudtan Phanthunane, Adun Bamrung, Thinakorn Noree, Karnwarin Kongweerakul
BACKGROUND: For an effective health system, human resources for health (HRH) planning should be aligned with health system needs. To provide evidence-based information to support HRH plan and policy, we should develop strategies to quantify health workforce requirements and supply. The aim of this study is to project HRH requirements for the Thai health service system in 2026. HRH included in this study were doctors, dentists, nurses, pharmacists, medical technicians (MTs), physiotherapists (PTs), and Thai traditional medicine (TTM) practitioners...
January 8, 2019: Human Resources for Health
Seoyoun Park, Mee Ock Gu
PURPOSE: The purpose of this study was to develop and examine the effects of combined exercise program for older adults with sarcopenia based on transtheoretical model (TTM). METHODS: A non-equivalent control group with a pretest-posttest design was used. The subjects consisted of 43 older adults with sarcopenia in precontemplation stage, contemplation stage and preparation stage of TTM (experimental group: 22, control group: 21). The developed program consisted of 36 sessions for 12 weeks including combined exercise (60 minutes) and TTM based strategies for enhancing exercise behavior (10 minutes) per session...
December 2018: Journal of Korean Academy of Nursing
Jung Soo Park, Yeonho You, Jin Hong Min, Insool Yoo, Wonjoon Jeong, Yongchul Cho, Seung Ryu, Jinwoong Lee, Seung Whan Kim, Sung Uk Cho, Se Kwang Oh, Hong Joon Ahn, Junwan Lee, In Ho Lee
AIM: We aimed to evaluate the onset of severe blood-brain barrier (BBB) disruption using cerebrospinal fluid/serum albumin quotient (Qa) in cardiac arrest patients treated with target temperature management (TTM). METHODS: This was a prospective single-centre observational cohort study from October 2017 to September 2018 with the primary endpoint being the onset of severe BBB disruption, determined based on Qa in cardiac arrest patients treated with TTM. Enrolled patients were grouped according to neurologically good and poor outcomes using the cerebral performance category (CPC) at 3 months after return of spontaneous circulation (ROSC)...
October 26, 2018: Resuscitation
Chenxi Dai, Gang Chen, Bihua Chen, Juan Wang, Changlin Yin, Jianjie Wang, Yushun Gong, Liang Wei, Yuanyuan Huang, Yongqin Li
BACKGROUND: Transcranial direct current stimulation (tDCS) modulates neuronal activity and is a potential therapeutic tool for many neurological diseases. However, its beneficial effects on post cardiac arrest syndrome remains uncertain. OBJECTIVE/HYPOTHESIS: We investigated the effects of repetitive anodal tDCS on neurological outcome and survival in a ventricular fibrillation (VF) cardiac arrest rat model. METHODS: Cardiopulmonary resuscitation was initiated after 6 min of VF in 36 Sprague-Dawley rats...
December 27, 2018: Brain Stimulation
Amir Nili-Ahmadabadi, Parisa Alibolandi, Akram Ranjbar, Leila Mousavi, Hossein Nili-Ahmadabadi, Amir Larki-Harchegani, Davoud Ahmadimoghaddam, Navid Omidifar
Thymoquinone (TQ) is the main active constituent of Nigella sativa seeds. The objective of this study was to explore the protective effects of TQ on diazinon (DZN)-induced liver toxicity in the mouse model. The animals were divided into five groups of 6 each and treated intraperitoneally. Group 1 received the vehicle, group 2 was given 16 mg/kg DZN, group 3 received 5 mg/kg TQ, and groups 4 and 5 were treated with 1.25 and 5 mg/kg of TQ as well as 16 mg/kg DZN, respectively. Finally, butyrylcholinesterase (BChE), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) serum activity as well as nitric oxide (NO), lipid peroxidation (LPO), total antioxidant capacity (TAC), total thiol molecule (TTM), and histopathological experiments were evaluated in the liver samples...
December 2018: Research in Pharmaceutical Sciences
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