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https://read.qxmd.com/read/30759600/heavy-metal-pollution-and-potential-health-risks-of-commercially-available-chinese-herbal-medicines
#1
Zhongzhen Wang, Hongbin Wang, Haijuan Wang, Qinchun Li, Yang Li
A survey was conducted to investigate the pollution and health risks of copper (Cu), cadmium (Cd), lead (Pb), arsenic (As), mercury (Hg) and zinc (Zn) in 60 Chinese herbal medicines (CHMs) collected from a market in Kunming City, Yunnan Province, China. Furthermore, eight CHMs (Cyathulae radix, Drynariae rhizoma, Peucedani radix, Homalomenae rhizoma, Dryopteris setosa, Polygonati rhizoma, Lilii bulbus, and Linderae radix) containing high Cd concentrations were selected to further analyse their Cd chemical forms...
February 25, 2019: Science of the Total Environment
https://read.qxmd.com/read/30759179/estimating-the-importance-of-maize-root-hairs-in-low-phosphorus-conditions-and-under-drought
#2
Florian Klamer, Florian Vogel, Xuelian Li, Hinrich Bremer, Günter Neumann, Benjamin Neuhäuser, Frank Hochholdinger, Uwe Ludewig
Background and Aims: Root hairs are single-cell extensions of the epidermis that face into the soil and increase the root-soil contact surface. Root hairs enlarge the rhizosphere radially and are very important for taking up water and sparingly soluble nutrients, such as the poorly soil-mobile phosphate. In order to quantify the importance of root hairs for maize, a mutant and the corresponding wild type were compared. Methods: The rth2 maize mutant with very short root hairs was assayed for growth and phosphorus (P) acquisition in a slightly alkaline soil with low P and limited water supply in the absence of mycorrhization and with ample P supply...
February 12, 2019: Annals of Botany
https://read.qxmd.com/read/30725519/microfluidic-production-of-pyrophosphate-catalyzed-by-mineral-membranes-with-steep-ph-gradients
#3
Qingpu Wang, Laura M Barge, Oliver Steinbock
Pyrophosphate might have functioned as an energy storage/currency molecule on early Earth, essential for the emergence of life. Here we synthesized mineral membranes involving iron(II), iron(III), and other divalent metal cations (calcium, manganese, cobalt, copper, zinc, and nickel) and tested their ability to catalyze the formation of pyrophosphate from phosphate and acetyl phosphate across steep pH gradients in microfluidic devices. We studied the chemical compositions of the precipitate membranes (which included vivianite, goethite, and green rust) using in situ and ex situ micro-Raman spectroscopy...
February 6, 2019: Chemistry: a European Journal
https://read.qxmd.com/read/30717735/antioxidant-properties-of-milk-and-dairy-products-a-comprehensive-review-of-the-current-knowledge
#4
REVIEW
Imran Taj Khan, Muhammad Nadeem, Muhammad Imran, Rahman Ullah, Muhammad Ajmal, Muhammad Hayat Jaspal
Milk and dairy products are integral part of human nutrition and they are considered as the carriers of higher biological value proteins, calcium, essential fatty acids, amino acids, fat, water soluble vitamins and several bioactive compounds that are highly significant for several biochemical and physiological functions. In recent years, foods containing natural antioxidants are becoming popular all over the world as antioxidants can neutralize and scavenge the free radicals and their harmful effects, which are continuously produced in the biological body...
February 4, 2019: Lipids in Health and Disease
https://read.qxmd.com/read/30716983/effect-of-cold-storage-and-different-ions-on-the-thermal-resistance-of-b-cereus-nzas01-spores-analysis-of-differential-gene-expression-and-ion-exchange
#5
Aswathi Soni, Indrawati Oey, Patrick Silcock, Elizabeth Permina, Phil J Bremer
Bacillus cereus spores in food are able to survive pasteurization, and if conditions are favourable, subsequently germinate, grow and produce toxins causing food poisoning. The objectives of this study were to firstly determine the impact of cold storage and ion uptake on the thermal resistance of B. cereus spores and secondly to use differential gene expression to help elucidate possible molecular mechanisms for the changes detected in their thermal resistance. B. cereus spores were held at 4 °C in either 0...
February 2019: Food Research International
https://read.qxmd.com/read/30716564/layered-double-hydroxides-for-phosphorus-recovery-from-acidified-and-non-acidified-dewatered-sludge
#6
L Lundehøj, H C Jensen, L Wybrandt, U G Nielsen, M L Christensen, C A Quist-Jensen
Phosphate, which contains the essential element phosphorous (P), is a necessary fertilizer for agriculture, but the current phosphate deposits are running out and alternative sources are needed. Sludge obtained from wastewater treatment plants contains high concentrations of phosphorus and represents an alternative, sustainable source. In this study, sludge obtained from a wastewater treatment plant with biological and chemical phosphorus removal was acidified (pH = 3, 4, 5 and 6) to release orthophosphate followed by sequestration of the orthophosphate by a zinc aluminum layered double hydroxide (Zn2 Al-LDH)...
January 21, 2019: Water Research
https://read.qxmd.com/read/30689502/two-dna-binding-modes-of-a-zinc-metronidazole-and-biological-evaluation-as-a-potent-anti-cancer-agent
#7
Farhad Ahmadi, Nosaibeh Shabrandi, Leilah Hosseinzadeh, Homa Azizian
A complex of metronidazole (MTZ) with zinc ion was synthesized and characterized by UV-Vis, Fourier transform infrared (FT-IR), 1 H-NMR, X-ray crystallography and thermal gravimetric-differential thermal analysis (TG-DTA). The cytotoxicity effect of the synthesized complex investigated over SKNMC, A549, MCF-7, and MCDK cell lines and the results have shown that it has high cytotoxic potential over cancer cell lines. In order to clarify the mechanism of cell cytotoxicity, the oxidative stress and binding of the complex to the calf thymus-DNA studied by evaluating the intrinsic binding constant and defining thermodynamic parameters of complex over the DNA accompanying with in silico molecular modeling method...
January 28, 2019: Nucleosides, Nucleotides & Nucleic Acids
https://read.qxmd.com/read/30677499/controlled-release-of-dexamethasone-sodium-phosphate-with-biodegradable-nanoparticles-for-preventing-experimental-corneal-neovascularization
#8
Bing Wang, Yating Tang, Yumin Oh, Nicholas W Lamb, Shiyu Xia, Zheng Ding, Baiwei Chen, María J Suárez, Tuo Meng, Vineet Kulkarni, Charles G Eberhart, Laura M Ensign, Walter J Stark, Justin Hanes, Qingguo Xu
Corneal neovascularization (CNV) leads to the loss of corneal transparency and vision impairment, and can ultimately cause blindness. Topical corticosteroids are the first line treatment for suppressing CNV, but poor ocular bioavailability and rapid clearance of eye drops makes frequent administration necessary. Patient compliance with frequent eye drop regimens is poor. We developed biodegradable nanoparticles loaded with dexamethasone sodium phosphate (DSP) using zinc ion bridging, DSP-Zn-NP, with dense coatings of poly(ethylene glycol) (PEG)...
January 21, 2019: Nanomedicine: Nanotechnology, Biology, and Medicine
https://read.qxmd.com/read/30677043/gcm2-regulates-the-maintenance-of-parathyroid-cells-in-adult-mice
#9
Taku Yamada, Norifumi Tatsumi, Akane Anraku, Hideaki Suzuki, Sahoko Kamejima, Taketo Uchiyama, Ichiro Ohkido, Takashi Yokoo, Masataka Okabe
Glial cells missing homolog 2 (GCM2), a zinc finger-type transcription factor, is essential for the development of parathyroid glands. It is considered to be a master regulator because the glands do not form when Gcm2 is deficient. Remarkably, Gcm2 expression is maintained throughout the fetal stage and after birth. Considering the Gcm2 function in embryonic stages, it is predicted that Gcm2 maintains parathyroid cell differentiation and survival in adults. However, there is a lack of research regarding the function of Gcm2 in adulthood...
2019: PloS One
https://read.qxmd.com/read/30675452/complete-genome-sequence-of-caulobacter-flavus-rhgg3-t-a-type-species-of-the-genus-caulobacter-with-plant-growth-promoting-traits-and-heavy-metal-resistance
#10
Endong Yang, Leni Sun, Xiaoyuan Ding, Dongdong Sun, Jing Liu, Weiyun Wang
Caulobacter flavus RHGG3T , a novel type species in the genus Caulobacter , originally isolated from rhizosphere soil of watermelon ( Citrullus lanatus ), has the ability to improve the growth of watermelon seedling and tolerate heavy metals. In vitro, C. flavus RHGG3T was able to solubilize phosphate (80.56 mg L-1 ), produce indole-3-acetic acid (IAA) (11.58 mg L-1 ) and was resistant to multiple heavy metals (copper, zinc, cadmium, cobalt and lead). Inoculating watermelon with this strain increased shoot and root length by 22...
February 2019: 3 Biotech
https://read.qxmd.com/read/30672271/oriented-self-assembled-monolayer-of-zn-ii-tetraphenylporphyrin-on-tio2-electrode-for-photoelectrochemical-analysis
#11
Yue Zhou, Yi Shi, Feng-Bin Wang, Xing-Hua Xia
The photoelectrochemical performance of a zinc porphyrin sensitized TiO2 photoelectrode fabricated through the axial-coordination strategy has been studied. Zinc(II) tetraphenylporphyrin (TPPZn) was immobilized on the TiO2 electrode through the axial coordination reaction with surface pre-modified Methyl 4-(1H-imidazol-1-yl)benzoate (PhImMe). Spectral characterizations were carried out to confirm the robust interaction between TPPZn and PhImMe, while the chemical bonding of PhImMe on TiO2 surface has been evidenced by XPS measurement...
January 23, 2019: Analytical Chemistry
https://read.qxmd.com/read/30669269/in-vitro-degradation-of-absorbable-zinc-alloys-in-artificial-urine
#12
Sébastien Champagne, Ehsan Mostaed, Fariba Safizadeh, Edward Ghali, Maurizio Vedani, Hendra Hermawan
Absorbable metals have potential for making in-demand rigid temporary stents for the treatment of urinary tract obstruction, where polymers have reached their limits. In this work, in vitro degradation behavior of absorbable zinc alloys in artificial urine was studied using electrochemical methods and advanced surface characterization techniques with a comparison to a magnesium alloy. The results showed that pure zinc and its alloys (Zn⁻0.5Mg, Zn⁻1Mg, Zn⁻0.5Al) exhibited slower corrosion than pure magnesium and an Mg⁻2Zn⁻1Mn alloy...
January 18, 2019: Materials
https://read.qxmd.com/read/30665096/strong-mineralization-ability-of-strontium-zinc-silicate-formation-of-a-continuous-biomorphic-mineralized-layer-with-enhanced-osteogenic-activity
#13
Zhengjiang Xu, Jing Long, Ningfeng Zhang, Huijuan Cao, Wei Tang, Keda Shi, Xinluan Wang, Sergio Moya, Li Duan, Haobo Pan, Yuxiao Lai, Daping Wang, Guocheng Wang
Silica gel plays an important role in the formation of some biomorphic minerals (e.g. silica-carbonates) with morphologically complex micro/nanostructures in a pure inorganic system. Herein, we demonstrate the potential of strontium zinc silicate (Sr2 ZnSi2 O7 , SZnS) bioceramics as a biomorphic mineral "garden" due to its incongruent dissolution behavior. Briefly, the preferential release of Sr ions from SZnS leaves behind a silica-rich gel on the ceramic surface and leads to an alkaline pH in the localized area close to the silica-rich gel, providing a growth condition similar to that for the conventional synthesis of biomorphic minerals...
January 14, 2019: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/30660629/controlled-release-of-corticosteroid-with-biodegradable-nanoparticles-for-treating-experimental-autoimmune-uveitis
#14
Lixia Luo, Jin Yang, Yumin Oh, Matthew J Hartsock, Shiyu Xia, Yoo-Chun Kim, Zheng Ding, Tuo Meng, Charles G Eberhart, Laura Ensign, Jennifer E Thorne, Walter J Stark, Elia J Duh, Qingguo Xu, Justin Hanes
Noninfectious uveitis is a potentially blinding ocular condition that often requires treatment with corticosteroids to prevent inflammation-related ocular complications. Severe forms of uveitis such as panuveitis that affects the whole eye often require a combination of topical and either regional or systemic corticosteroid. Regional corticosteroids are currently delivered inside the eye by intravitreal injection (e.g. Ozurdex®, an intravitreal dexamethasone implant). Intravitreal injection is associated with rare but potentially serious side effects, including endophthalmitis, retinal and vitreous hemorrhage, and retinal detachment...
January 17, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30648870/metallo-cubosomes-zinc-functionalized-cubic-nanoparticles-for-therapeutic-nucleotide-delivery
#15
Behnoosh Tajik-Ahmadabad, Lucas Chollet, Jacinta White, Frances Separovic, Anastasios Polyzos
Development of an effective and potent RNA delivery system remains a challenge for the clinical application of RNA therapeutics. Herein, we describe the development of an RNA delivery platform derived from self-assembled bicontinuous cubic lyotropic liquid crystalline phases, functionalised with zinc co-ordinated lipids. These metallo-cubosomes were prepared from a series of novel lipidic zinc(II)-bis(dipicolylamine) (Zn2BDPA)) complexes admixed with glycerol monooleate (GMO). The zinc metallo-cubosomes showed the high affinity to siRNA through interaction between Zn2BDPA and the phosphate groups of RNA molecules...
January 16, 2019: Molecular Pharmaceutics
https://read.qxmd.com/read/30637572/loss-of-arabidopsis-halotolerance-2-like-ahl-a-3-phosphoadenosine-5-phosphate-phosphatase-suppresses-insensitive-response-of-arabidopsis-thaliana-ring-zinc-finger-1-atrzf1-mutant-to-abiotic-stress
#16
Da-Jeong Shin, Ji-Hee Min, Tinh Van Nguyen, Young-Min Kim, Cheol Soo Kim
Destruction of PAP phosphatase AHL suppresses atrzf1 phenotype in abiotic stress responses. AHL plays an intermediate role in the regulation of proline accumulation by PAP nucleotidase. Proline (Pro) metabolism is important for environmental responses, plant development, and growth. However, the role of Pro in abiotic stress process is unclear. Using atrzf1 (Arabidopsis thaliana ring zinc finger 1) mutant as a parental line for T-DNA tagging mutagenesis, we identified a suppressor mutant designated as proline content alterative 17 (pca17) that suppressed insensitivity of atrzf1 to abiotic stresses during early seedling growth...
January 12, 2019: Plant Molecular Biology
https://read.qxmd.com/read/30606572/chitosan-and-polyethylene-glycol-based-membranes-with-antibacterial-properties-for-tissue-regeneration
#17
Inês C Pereira, Ana S Duarte, Ana S Neto, J M F Ferreira
The prevention of microbial infections associated with implantable medical devices and superficial wounds represents one of the main research strategies in the field of biomaterials. The present study reports on the development of composite membranes of Chitosan (CS)-Polyethylene glycol (PEG) matrix, incorporating particles of biphasic calcium phosphate (BCP), zinc oxide (ZnO) and copper oxide (CuO). The properties that are relevant for intended applications in tissue regeneration and antibacterial coatings of implants were assessed...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30606515/effects-of-mgo-zno-sro-and-sio-2-in-tricalcium-phosphate-scaffolds-on-in-vitro-gene-expression-and-in-vivo-osteogenesis
#18
Dongxu Ke, Solaiman Tarafder, Sahar Vahabzadeh, Susmita Bose
β‑tricalcium phosphate (β‑TCP) is a versatile bioceramic for its use in many orthopedic and dental applications due to its excellent biocompatibility and biodegradability. Recently, the addition of additives to β‑TCP has been proven to improve bone repair and regeneration, however, the underlying mechanism of enhanced bone regeneration is still unknown. In this study, strontium oxide (SrO), silica (SiO2 ), magnesia (MgO), and zinc oxide (ZnO) were added to β‑TCP for dense discs fabrication followed by in vitro evaluation using a preosteoblast cell line...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30604584/highly-reversible-and-safe-zn-rechargeable-batteries-based-on-triethyl-phosphate-electrolyte
#19
Ahmad Naveed, Huijun Yang, Jun Yang, Yanna Nuli, Jiulin Wang
Zinc metal is an attractive anode material for next generation batteries. However, dendrite growth and limited Coulombic efficiency (CE) during cycling are the major roadblocks towards widespread commercialization of batteries employing Zn-anode. In this work, for the first time we report the adoption of triethyl phosphate (TEP) as a sole and co-solvent with aqueous electrolyte to obtain highly stable and dendrite-free Zn-anode. Stable Zn plating/stripping for over 3000 hours was obtained accompanied with a CE of 99...
January 2, 2019: Angewandte Chemie
https://read.qxmd.com/read/30600195/bone-marrow-derived-mesenchymal-stromal-cells-ameliorate-severe-acute-pancreatitis-in-rats-via-hemeoxygenase-1-mediated-anti-oxidant-and-anti-inflammatory-effects
#20
Zhilong Ma, Guodong Song, Dongbo Zhao, Dalu Liu, Xiaolei Liu, Yuxiang Dai, Zhigang He, Daohai Qian, Jian Gong, Hongbo Meng, B O Zhou, Tingsong Yang, Zhenshun Song
BACKGROUND AND AIMS: It has been previously verified that mesenchymal stromal cells (MSCs) have a good therapeutic effect on severe acute pancreatitis (SAP) and the potential for regeneration of damaged pancreatic tissue, but the exact molecular mechanism remains unclear. In this study, we demonstrated the therapeutic effect of bone morrow MSCs (BMSCs) on SAP, probably by targeting heme oxygenase-1 (HO-1). METHODS: Six hours after SAP induction, either phosphate-buffered saline (PBS) or BMSCs were transfused into the caudal vein of rats, zinc protoporphyrin (ZnPP) was administered intraperitoneally...
December 29, 2018: Cytotherapy
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