keyword
https://read.qxmd.com/read/35311615/clinician-guidelines-for-the-treatment-of-psychiatric-disorders-with-nutraceuticals-and-phytoceuticals-the-world-federation-of-societies-of-biological-psychiatry-wfsbp-and-canadian-network-for-mood-and-anxiety-treatments-canmat-taskforce
#1
JOURNAL ARTICLE
Jerome Sarris, Arun Ravindran, Lakshmi N Yatham, Wolfgang Marx, Julia J Rucklidge, Roger S McIntyre, Shahin Akhondzadeh, Francesco Benedetti, Constanza Caneo, Holger Cramer, Lachlan Cribb, Michael de Manincor, Olivia Dean, Andrea Camaz Deslandes, Marlene P Freeman, Bangalore Gangadhar, Brian H Harvey, Siegfried Kasper, James Lake, Adrian Lopresti, Lin Lu, Najwa-Joelle Metri, David Mischoulon, Chee H Ng, Daisuke Nishi, Roja Rahimi, Soraya Seedat, Justin Sinclair, Kuan-Pin Su, Zhang-Jin Zhang, Michael Berk
OBJECTIVES: The therapeutic use of nutrient-based 'nutraceuticals' and plant-based 'phytoceuticals' for the treatment of mental disorders is common; however, despite recent research progress, there have not been any updated global clinical guidelines since 2015. To address this, the World Federation of Societies of Biological Psychiatry (WFSBP) and the Canadian Network for Mood and Anxiety Disorders (CANMAT) convened an international taskforce involving 31 leading academics and clinicians from 15 countries, between 2019 and 2021...
July 2022: World Journal of Biological Psychiatry
https://read.qxmd.com/read/34953391/the-potential-use-of-folate-and-its-derivatives-in-treating-psychiatric-disorders-a-systematic-review
#2
REVIEW
Nelson Siu Kei Lam, Xin Xin Long, Xuegang Li, Mirette Saad, Florence Lim, James Cg Doery, Robert C Griffin, Cherrie Galletly
OBJECTIVES: To examine the strengths and limitations of existing data to provide guidance for the use of folate supplements as treatment, with or without other psychotropic medications, in various psychiatric disorders. To identify area for further research in terms of the biosynthesis of mechanism of folate and genetic variants in metabolic pathway in human. METHODS: A systematic review of published literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, to assess whether folate supplements are beneficial in certain psychiatric disorders (depression, bipolar disorder, schizophrenia, autism spectrum disorder, and attention deficit hyperactivity disorder)...
February 2022: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/31291206/l-methylfolate-calcium-supplementation-in-adolescents-and-children-a-retrospective-analysis
#3
JOURNAL ARTICLE
Michelle Rainka, Traci Aladeen, Erica Westphal, Jacqueline Meaney, Fran Gengo, Jessica Greger, Horacio Capote
Previous studies have shown l-methylfolate to be a safe and beneficial therapy for neuropsychiatric conditions, including major depressive disorder and schizophrenia in adults. The purpose of this study was to assess safety and describe patient experience using l-methylfolate calcium in a real-world pediatric and adolescent population. A retrospective chart review of patients (7 to 20 y of age, mean age 16 y) prescribed l-methylfolate calcium at a psychiatry clinic in Amherst, NY, between January 1, 2010 and November 10, 2015 was conducted...
July 2019: Journal of Psychiatric Practice
https://read.qxmd.com/read/29212788/l-methylfolate-cannot-yet-be-recommended-as-an-add-on-treatment-in-schizophrenia
#4
COMMENT
Błażej Misiak
No abstract text is available yet for this article.
February 2018: Evidence-based Mental Health
https://read.qxmd.com/read/28597528/enhancement-of-recovery-from-mental-illness-with-l-methylfolate-supplementation
#5
REVIEW
Gerald Martone
People suffering from depression, schizophrenia, and dementia often have measurably lower levels of serum folate compared to people not experiencing psychiatric disorders. Augmentation of SSRI and SNRI antidepressant medications with l-methylfolate has been demonstrated to increase their effectiveness and onset of action. Even the use of l-methylfolate as a stand-alone monotherapy has been observed to exert antidepressant properties. The role of folate in mental illness has been known for many decades, but the strategic use of l-methylfolate supplementation has not yet been accepted as a standard regimen...
April 2018: Perspectives in Psychiatric Care
https://read.qxmd.com/read/28289280/biochemical-physiological-and-clinical-effects-of-l-methylfolate-in-schizophrenia-a-randomized-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
J L Roffman, L J Petruzzi, A S Tanner, H E Brown, H Eryilmaz, N F Ho, M Giegold, N J Silverstein, T Bottiglieri, D S Manoach, J W Smoller, D C Henderson, D C Goff
Folic acid supplementation confers modest benefit in schizophrenia, but its effectiveness is influenced by common genetic variants in the folate pathway that hinder conversion to its active form. We examined physiological and clinical effects of l-methylfolate, the fully reduced and bioactive form of folate, in schizophrenia. In this randomized, double-blind trial, outpatients with schizophrenia (n=55) received l-methylfolate 15 mg or placebo for 12 weeks. Patients were maintained on stable doses of antipsychotic medications...
February 2018: Molecular Psychiatry
https://read.qxmd.com/read/27520898/effectiveness-of-add-on-l-methylfolate-therapy-in-a-complex-psychiatric-illness-with-mthfr-c677-t-genetic-polymorphism
#7
JOURNAL ARTICLE
Shailesh Jha, Pankaj Kumar, Rajesh Kumar, Aparna Das
The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene plays a central role in folate metabolism. Many studies have demonstrated an association between MTHFR C677 T variant with depression, schizophrenia and bipolar disorder as one of them being comorbid to other. This has justified the use of folate supplement in psychiatric disorders mainly depression but still not in various other comorbid complex psychiatric disorders. Here we have tried to show how the l-methylfolate in conjunction with the conventional psychotropic drugs can be useful in a state of such complex psychiatric phenomenon and comorbid diagnosis with genetic polymorphism of MTHFR C677 T mutation...
August 2016: Asian Journal of Psychiatry
https://read.qxmd.com/read/1974941/enhancement-of-recovery-from-psychiatric-illness-by-methylfolate
#8
RANDOMIZED CONTROLLED TRIAL
P S Godfrey, B K Toone, M W Carney, T G Flynn, T Bottiglieri, M Laundy, I Chanarin, E H Reynolds
41 (33%) of 123 patients with acute psychiatric disorders (DSM III diagnosis of major depression or schizophrenia) had borderline or definite folate deficiency (red-cell folate below 200 micrograms/l) and took part in a double-blind, placebo-controlled trial of methylfolate, 15 mg daily, for 6 months in addition to standard psychotropic treatment. Among both depressed and schizophrenic patients methylfolate significantly improved clinical and social recovery. The differences in outcome scores between methylfolate and placebo groups became greater with time...
August 18, 1990: Lancet
https://read.qxmd.com/read/1773245/enhancement-of-recovery-from-psychiatric-illness-by-methylfolate
#9
JOURNAL ARTICLE
A Procter
"41 (33%) of 123 patients with acute psychiatric disorders (DSM III diagnosis of major depression or schizophrenia) had borderline or definite folate deficiency (red-cell folate below 200 micrograms/l) and took part in a double-blind, placebo-controlled trial of methylfolate, 15 mg daily, for 6 months in addition to standard psychotropic treatment. Among both depressed and schizophrenic patients methylfolate significantly improved clinical and social recovery. The differences in outcome scores between methylfolate and placebo groups became greater with time...
August 1991: British Journal of Psychiatry
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