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E R Pesce, G L Blatch
Plasmodium falciparum displays a large and remarkable variety of heat shock protein 40 family members (PfHsp40s). The majority of the PfHsp40s are poorly characterized, and although the functions of some of them have been suggested, their exact mechanism of action is still elusive and their interacting partners and client proteins are unknown. The P. falciparum heat shock protein 70 family members (PfHsp70s) have been more extensively characterized than the PfHsp40s, with certain members shown to function as molecular chaperones...
August 2014: Parasitology
Simone Külzer, Sarah Charnaud, Tal Dagan, Jan Riedel, Pradipta Mandal, Eva R Pesce, Gregory L Blatch, Brendan S Crabb, Paul R Gilson, Jude M Przyborski
Malaria parasites modify their host cell, the mature human erythrocyte. We are interested in the molecules mediating these processes, and have recently described a family of parasite-encoded heat shock proteins (PfHsp40s) that are targeted to the host cell, and implicated in host cell modification. Hsp40s generally function as co-chaperones of members of the Hsp70 family, and until now it was thought that human Hsp70 acts as the PfHsp40 interaction partner within the host cell. Here we revise this hypothesis, and identify and characterize an exported parasite-encoded Hsp70, referred to as PfHsp70-x...
November 2012: Cellular Microbiology
Melissa Botha, Annette N Chiang, Patrick G Needham, Linda L Stephens, Heinrich C Hoppe, Simone Külzer, Jude M Przyborski, Klaus Lingelbach, Peter Wipf, Jeffrey L Brodsky, Addmore Shonhai, Gregory L Blatch
Heat shock protein 70 (Hsp70) and heat shock protein 40 (Hsp40) function as molecular chaperones during the folding and trafficking of proteins within most cell types. However, the Hsp70-Hsp40 chaperone partnerships within the malaria parasite, Plasmodium falciparum, have not been elucidated. Only one of the 43 P. falciparum Hsp40s is predicted to be a cytosolic, canonical Hsp40 (termed PfHsp40) capable of interacting with the major cytosolic P. falciparum-encoded Hsp70, PfHsp70. Consistent with this hypothesis, we found that PfHsp40 is upregulated under heat shock conditions in a similar pattern to PfHsp70...
July 2011: Cell Stress & Chaperones
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