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trophoblast invasion

Jufeng Wei, Yufen Fu, Xiaoling Mao, Yuhui Jing, Jiangbo Guo, Yuanhua Ye
OBJECTIVES: The purpose of this study was to investigate the expression of Filamin b in the placental placenta of patients with early or late onset pre-eclampsia (PE) and its potential effects on the pathophysiology of the disease. METHODS AND METHODS: Immunohistochemistry staining, western blot assays and real time PCR were used to detect the expression level of FLN-b. The expression levels of MMP-2, MMP-9 and ERK1/2 proteins from control and FLN-b-silenced JEG-3 cells were also detected by western blot and JEG-3 cell invasion...
2019: Ginekologia Polska
Carolina Vélez, Mariángeles Clauzure, Delia Williamson, Mirta A Koncurat, Tomás A Santa-Coloma, Claudio Barbeito
In pigs, given the type of epitheliochorial and non-invasive placenta, the trophoblast is in intimate contact with maternal tissues. The dialogue established between the conceptus and the endometrium involves, among others, the immune system, which minimizes the chances of rejection of the embryo and promotes the establishment of pregnancy. The aim of this work was to determine the concentration of IL-1β, IL-2 and IL-4 in sera and in extracts of maternal and fetal placenta from sows of different gestational periods...
January 25, 2019: Theriogenology
Ivo Brosens, Jan J Brosens, Joanne Muter, Patrick Puttemans, Giuseppe Benagiano
We explore the potential role of the endothelial lining of uteroplacental arteries in the pathogenesis of preeclampsia, a severe pregnancy disorder characterized by incomplete invasion of the uterine vasculature by extravillous trophoblast and angiogenic imbalance. In normal pregnancy, the endothelium disappears progressively from the uteroplacental arteries and is replaced by trophoblast and deposition of fibro-fibrinoid structure, underpinning the so-called physiological transformation of uterine spiral arteries...
February 6, 2019: American Journal of Obstetrics and Gynecology
Dandan Xie, Jingping Zhu, Qianqian Liu, Jun Li, Mengjiu Song, Kai Wang, Qian Zhou, Yuanhui Jia, Ting Li
Background and objective: Preeclampsia (PE) is a common disease during pregnancy. It is generally accepted that PE is closely associated with shallow placenta implantation caused by the dysfunction of trophoblast cells. Trophoblasts have been recognized to share histological and behavioral characteristics with cancer cells, and many lines of evidence have emphasized that histone deacetylases (HDACs) are therapeutic targets for cancer treatment with the most promising. However, the roles of HDACs have not been well established in preeclampsia...
February 2, 2019: American Journal of Hypertension
Zhao Xiaobo 赵肖波, He Qizhi, Wu Zhiping, Duan Tao
OBJECTIVE: Endoglin is expressed in human placenta and plays an important role in the pathogenesis of preeclampsia. Dysregulation of microRNAs in placental tissues has been recently suggested to be involved in the pathogenesis of preeclampsia. Until now, few studies have shed light on the correlation between endoglin and microRNAs, the latter of which may regulate the expression of ENG, a gene encoding endoglin, in placenta. In this study, we aim to investigate the regulation of ENG by microRNAs...
January 10, 2019: Pregnancy Hypertension
Ming Yu, Xinyuan Cui, Hao Wang, Jianwei Liu, Huamin Qin, Shuai Liu, Qiu Yan
INTRODUCTION: Trophoblast proliferation and invasion are essential for embryo implantation and placentation. Protein glycosylation is one of the most common and vital post-translational modifications, regulates protein physical and biochemical properties. FUT8 is the only known fucosyltransferase responsible for catalyzing α1,6-fucosylation in mammals, and α1,6-fucosylated glycoproteins are found to participate in various physiopathological processes. However, whether FUT8/α1,6-fucosylation modulates the functions of trophoblastic cells remains elusive...
January 2019: Placenta
Tine Graakjær Larsen, Rinat Hackmon, Daniel E Geraghty, Thomas Vauvert F Hviid
INTRODUCTION: The pathogenesis of preeclampsia may involve inadequate trophoblast invasion caused by excessive inhibition of uterine natural killer cells (uNK) by extravillous trophoblast cells (EVT). This may be the result of a combination of maternal killer-cell immunoglobin-like receptor (KIR) AA genotype and fetal human leukocyte antigen-C2 (HLA-C2) genotype. A few studies have reported a significantly increased frequency of the maternal KIR AA/fetal HLA-C2 combination in cases of preeclampsia compared to controls...
January 2019: Placenta
Shijian Lv, Na Wang, Hong Lv, Jieqiong Yang, Jianwei Liu, Wei-Ping Li, Cong Zhang, Zi-Jiang Chen
Recurrent miscarriage (RM) is currently defined as two or more losses of a clinically established intrauterine pregnancy. Despite years of research, RM continues to be a clinically frustrating challenge for patients and physicians, and its etiology remains poorly understood. Accumulating evidence has suggested that epigenetic modifications are involved in early embryogenesis, and defects in epigenetic patterning contribute to the development of RM. Here, we studied the role of enhancer of zeste homolog 2 (EZH2) in the pathogenesis of RM and found that the EZH2 expression was significantly decreased in the villi from women with RM compared with that in control villi...
December 22, 2018: Molecular Therapy. Nucleic Acids
Yanfen Zou, Shuhong Li, Dan Wu, Yetao Xu, Sailan Wang, Ying Jiang, Fang Liu, Ziyan Jiang, Hongmei Qu, Xiang Yu, Xiaoli Wang, Yuanli Wang, Lizhou Sun
Impairment spiral arteries remodelling was considered to be the underlying cause of pathogenesis of pre-eclampsia (PE). Resveratrol (RE) was reported that it could modulate cellar phenotype to ameliorate diverse human diseases. However, the biological function of RE in PE remains poorly understood. In this report, we investigated the effect of RE on trophoblast phenotype both in vivo and in vitro. We conducted MTT and transwell assays to explore cell proliferation and invasion events in HTR-8/SVneo. In mice model, the clinical characteristics of PE were established through the injection of NG-nitro-l-arginine methyl ester (L-NAME)...
February 1, 2019: Journal of Cellular and Molecular Medicine
Qiong Pan, Hui Yuan Niu, Long Fei Cheng, Xiao Qiong Li, Qi Gang Zhang, Ying Ning
No abstract text is available yet for this article.
December 15, 2018: Placenta
Xiaoling Liang, Yimei Jin, Hao Wang, Xinlu Meng, Zhongzhou Tan, Tao Huang, Shangrong Fan
Infertility has been a great challenge in reproductive medicine. At least 40% of human pregnancy losses are clinically unrecognized and occur because of embryo implantation failure. Identification of the proteins and biochemical factors involved in embryo implantation and that are essential for crosstalk between the embryo and uterus can further increase female fertility rates. The actin cytoskeleton and actin-binding proteins (ABPs) are of great importance for cell morphology and rearrangement, which is crucial for trophoblast adhesion and invasion...
January 31, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Omar Jiménez-Zarazúa, Lourdes N Vélez-Ramírez, José C Padilla-López, Juana R García-Ramírez, Pedro L González-Carillo, Jaime D Mondragón
Among the differential diagnoses that should be considered in acute respiratory failure (ARF) are infectious processes, autoimmune diseases, interstitial pulmonary fibrosis, and pulmonary neoplasia. Timely diagnosis of lung neoplasia is complicated in the early stages. An opportune diagnosis, as well as the specific treatment, decrease mortality. ARF occurs 1 in 500 pregnancies and is most common during the postpartum period. Among the specific etiologies that cause ARF during pregnancy that must be considered are: (1) preeclampsia; (2) embolism of amniotic fluid; (3) peripartum cardiomyopathy; and (4) trophoblastic embolism...
September 2018: Case Reports in Oncology
Xiaoyan Yu, Yan Zhang, Ping Yang, Xueli Gao, Yuping Wang
Preeclampsia (PE), a special type of hypertensive disorder complicating pregnancy (HDCP), is highly associated with the migratory and invasive capacity of extravillous trophoblasts (EVTs). Here, we aimed to study the functions of low-density lipoprotein receptor-related protein 6 (LRP6) in PE pathogenesis. A comparative analysis of cellular gene expressions between placenta tissues collected from PE patients and normal pregnant women showed that the expressions of LRP6, β-catenin and matrix metallopeptidases/TIMP metallopeptidase inhibitors (MMPs/TIMPs) ratio in placentas of PE patients were much lower than the normal...
January 23, 2019: Molecular and Cellular Probes
Piyush Chaudhary, Gosipatala Sunil Babu, Ranbir Chander Sobti, Satish Kumar Gupta
Hepatocyte growth factor (HGF) is reported to be down-regulated in pregnancy complications like intrauterine growth retardation and preeclampsia, which are associated with abnormal trophoblast migration/invasion. In this study, role of HGF and associated signaling pathways has been investigated in HTR-8/SVneo trophoblastic cells migration/invasion under normoxia (20% O2 ) and hypoxia (2% O2 ). HTR-8/SVneo cells exposed to hypoxia showed increase in migration and invasion as compared to cells incubated under normoxic conditions...
January 26, 2019: Journal of Cell Communication and Signaling
Jian Zhang, Hai Ma, Liu Yang, Hongchun Yang, Zhenxing He
OBJECTIVES: Overexpression of human trophoblast cell surface antigen 2 (Trop2) has been observed in many cancers; however, its roles in proliferation, apoptosis, migration, and invasion of hepatocellular carcinoma (HCC) remain unclear. Thus, this study aimed to characterize the function of Trop2 in HCC. METHODS: Trop2 protein expression was detected by immunohistochemistry in HCC tissues. Cell proliferation, apoptosis, and invasion were respectively measured by CCK-8, flow cytometry, Transwell, and wound healing assays...
January 24, 2019: Journal of International Medical Research
Yalan Xu, Lili Sui, Bintao Qiu, Xiuju Yin, Juntao Liu, Xiaohong Zhang
OBJECTIVES: The inadequate trophoblast invasion is associated with the development of preeclampsia (PE). Considering that annexin A4 (ANXA4) enhances tumor invasion, we aimed to explore the functional role of ANXA4 in trophoblast cells and to examine the underlying mechanism. METHODS: ANXA4 expression in PE placentas was analyzed using immunohistochemistry and Western blot. Cell proliferation, invasion, and apoptosis were determined using MTT assay, Transwell assay, and flow cytometry, respectively...
January 23, 2019: American Journal of Physiology. Cell Physiology
Kjell Haram, Jan Helge Mortensen, Ole Myking, Everett F Magann, John C Morrison
Oxidative stress is a consequence of a reduction in the antioxidant capacity and an excessive production of reactive oxygen and nitrogen species (ROS). Oxidative agents, which are overproduced due to ischemic-reperfusion injury in the placenta, may overwhelm the normal antioxidant activity. This imbalance is a key feature in the pathogenesis of preeclampsia. A decrease in glutathione peroxidase (GPX) activity is associated with the synthesis of vasoconstrictive eicosanoids such as F2-isoprostanes and thromboxane, which are known to be upregulated in preeclampsia...
January 19, 2019: Current Hypertension Reviews
Colette N Miller, Erica J Stewart, Samantha J Snow, Wanda C Williams, Judy H Richards, Leslie C Thompson, Mette C Schladweiler, Aimen K Farraj, Urmila P Kodavanti, Janice A Dye
Implantation is a sensitive window in reproductive development during which disruptions may increase the risk of adverse pregnancy outcomes including intrauterine growth restriction. Ozone exposure during implantation in rats reduces fetal weight near the end of gestation, potentially though impaired trophoblast migration and invasion and altered implantation. The current study characterized changes in ventilation, pulmonary injury, and circulating factors including hormonal, inflammatory, and metabolic markers related to exposure to ozone (0...
January 12, 2019: Toxicological Sciences: An Official Journal of the Society of Toxicology
Kai-Lun Hu, Hsun-Ming Chang, Hong-Cui Zhao, Yang Yu, Rong Li, Jie Qiao
BACKGROUND: Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH release, playing fundamental roles in female reproduction, which include the secretion of gonadotropins, puberty onset, brain sex differentiation, ovulation and the metabolic regulation of fertility...
January 11, 2019: Human Reproduction Update
Yuanyuan Liu, Liquan Wang, Hongjun Shi
Pre-eclampsia (PE) is a pregnancy-specific syndrome that is characterized by hypertension and proteinuria. The etiology of PE is not completely understood but is believed to involve placental insufficiency and maternal vascular damage. Growing evidence supports an important role for the apelin receptor (APJ) system in regulating cardiovascular physiology. There are two vertebrate APJ ligands, APELIN and ELABELA, both of which mediate vasodilatory functions. A recent study linked deficient ELABELA signaling and the development of PE, though the molecular mechanism remains largely unknown...
January 9, 2019: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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