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Yosuke Namba, Akihiko Oshita, Takashi Nishisaka, Maiko Namba, Tamito Sasaki, Yasuhiro Matsugu, Toshiyuki Itamoto
INTRODUCTION: A lymphoepithelial cyst (LEC) of the pancreas is a benign and rare lesion that is difficult to diagnose preoperatively based on imaging studies. PRESENTATION OF CASE: We report a case of a 49-year-old man who presented with weight loss and diarrhea. The serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels were slightly elevated to 6.7 ng/mL (reference value <5.0 ng/mL) and 45 U/mL (reference value <37 U/mL), respectively...
January 30, 2019: International Journal of Surgery Case Reports
Lise Charuaud, Emilie Jardé, Anne Jaffrézic, Marine Liotaud, Quentin Goyat, Fabien Mercier, Barbara Le Bot
In intensive livestock areas, veterinary pharmaceutical residues (VPRs) can occur in water resources, but also in tap water because treatment processes are not designed to remove these contaminants. The main objective of this study is to assess the occurrence of VPRs in water resources and tap waters in Brittany. As several identical compounds are used in both veterinary and human medicine, a toolbox (stanols and pharmaceuticals) is used to help determine the origin of contamination in the case of mixed-use molecules...
January 24, 2019: Science of the Total Environment
Si Li, Ruijie Zhang, Jingrun Hu, Wanzi Shi, Yuzhu Kuang, Xiaoyu Guo, Weiling Sun
Simultaneous elimination of antibiotics and antibiotic resistance genes (ARGs) is rarely investigated in full-scale riverine wetlands. Here, we compared the occurrence, abundance, and removal of 60 antibiotics and 27 ARGs in natural (Yeya Lake (YL)) and constructed (Bai River (BR)) riverine wetlands in Beijing, China. The concentrations of antibiotics in YL wetland were ND-51.9 ng/L in water and ND-37.9 ng/g in sediments. Significantly higher concentrations were found in BR wetland (ND-546 ng/L in water and ND-118 ng/g in sediments), which locates at the downstream of a reclaimed water treatment plant...
February 5, 2019: Science of the Total Environment
Ka Yan Ma, Jing Qin, Chia-Wei Lin, Tin-Yam Chan, Peter K L Ng, Ka Hou Chu, Ling Ming Tsang
Recent fossil calibrated molecular phylogenies have revealed that the Brachyura underwent rapid radiation during the Cretaceous and Early Tertiary, resulting in many early diverging lineages separated by short internodes that remain difficult to resolve. Here we present the first phylogenomic analyses of Brachyura using transcriptome data from 30 brachyuran species and 22 families. Analyses were carried out on a dataset containing 372 putative homologous loci (246,590 bps) and included data from 22 newly generated transcriptomes...
February 11, 2019: Molecular Phylogenetics and Evolution
Sonali Bose, Gregory B Diette, Han Woo, Kirsten Koehler, Karina Romero, Ana M Rule, Barbara Detrick, Emily Brigham, Meredith C McCormack, Nadia N Hansel
BACKGROUND: Indoor fine particulate air pollution (PM2.5 ) is linked to asthma morbidity; however, whether vitamin D status influences individual susceptibility to airborne exposures is unclear. OBJECTIVE: We aimed to determine if vitamin D modifies effects of indoor PM2.5 upon asthma symptoms in urban children. METHODS: 120 children aged 5-12 years with physician-diagnosed asthma were evaluated at baseline and every 3 months for 9 months...
February 11, 2019: Journal of Allergy and Clinical Immunology in Practice
Saeed Shokri, Seyyed Meisam Ebrahimi, Sanaz Ziaeipour, Reza Nejatbakhsh
Cryopreservation of sperms is common therapy but with multiple damages to sperms. The aim of this study was to assess the effect of insulin as a prosurvival factor on the most important functional parameters of human spermatozoa during cryopreservation. Semen samples were obtained from 15 normozoospermic men at age 25-40 years of old through masturbation. Cryopreservation of sperms was conducted along with adding 10, 100, 500 and 1000 (ng/ml) insulin and a control group was also considered by adding distilled water...
February 11, 2019: Cryobiology
Shuang Wang, Weimin Wang, Hong Li, Yuming Xing, Keyong Hou, Haiyang Li
Illegal drug smugglings and crimes have long been a global concern, and an apparatus which can identify drugs on-the-spot is urgently demanded by law enforcement. A thermal desorption acetone-assisted photoionization miniature ion trap mass spectrometer (TD-AAPI-ITMS) was developed for on-site and rapid identification of illegal drugs at checkpoints. Acetone was chosen for dopant assisted photoionization and the sensitivity of selected drugs was further enhanced with protonated analyte molecular ions [M+H]+...
February 14, 2019: Analytical Chemistry
Nicolas S Piuzzi, Assem A Sultan, Julian Gatta, Mitchell Ng, William A Cantrell, Anton Khlopas, Jared M Newman, Nipun Sodhi, Steven F Harwin, Michael A Mont
Total number of citations has been considered a proxy for a published study's importance within a given field. However, there are multiple pitfalls to correlating the total number of citations alone with the quality of a study. In this review, the authors aimed to identify the top 100 most-cited studies of hip and knee arthroplasty and then assess study design and quality of reporting. More than half of these studies were level IV evidence, unblinded, not randomized, and not controlled. This underscores the need for higher-quality study design to support practice...
February 14, 2019: Orthopedics
Peter J O'Shaughnessy, Jean Philippe Antignac, Bruno Le Bizec, Marie-Line Morvan, Konstantin Svechnikov, Olle Söder, Iuliia Savchuk, Ana Monteiro, Ugo Soffientini, Zoe C Johnston, Michelle Bellingham, Denise Hough, Natasha Walker, Panagiotis Filis, Paul A Fowler
Masculinization of the external genitalia in humans is dependent on formation of 5α-dihydrotestosterone (DHT) through both the canonical androgenic pathway and an alternative (backdoor) pathway. The fetal testes are essential for canonical androgen production, but little is known about the synthesis of backdoor androgens, despite their known critical role in masculinization. In this study, we have measured plasma and tissue levels of endogenous steroids in second trimester human fetuses using multidimensional and high-resolution mass spectrometry...
February 2019: PLoS Biology
Kyung Joon Oh, Roberto Romero, Jee Yoon Park, Jihyun Kang, Joon-Seok Hong, Bo Hyun Yoon
Objective To determine whether the risk of intra-amniotic infection/inflammation and spontaneous preterm delivery (SPTD) varies as a function of the concentration of cervical fetal fibronectin (fFN) in patients with preterm labor and intact membranes. Methods This prospective study included 180 patients with preterm labor and intact membranes who had a sample collected for quantitative fFN measurement and underwent amniocentesis. Amniotic fluid was cultured for aerobic and anaerobic bacteria and genital mycoplasmas...
February 15, 2019: Journal of Perinatal Medicine
Julie Ng, Marc P Pelletier
New England Journal of Medicine, Volume 380, Issue 7, February 2019.
February 14, 2019: New England Journal of Medicine
Ingunn A Samdal, Kjersti E Løvberg, Anja B Kristoffersen, Lyn R Briggs, Jane Kilcoyne, Craig J Forsyth, Christopher O Miles
Azaspiracids (AZAs) are a group of biotoxins that appear periodically in shellfish and can cause food poisoning in humans. Current methods for quantifying the regulated AZAs are restricted to LC-MS but are not well suited to detecting novel and unregulated AZAs. An ELISA method for total AZAs in shellfish was reported recently, but unfortunately, it used relatively large amounts of the AZA-1-containing plate-coating conjugate, consuming significant amounts of pure AZA-1 per assay. Therefore, a new plate-coater, OVA-cdiAZA1 was produced, resulting in an ELISA with a working range of 0...
February 14, 2019: Journal of Agricultural and Food Chemistry
Shaowei Wang, Wenbo Wu, Purnima Manghnani, Shidang Xu, Yuanbo Wang, Chi Ching Goh, Lai Guan Ng, Bin Liu
Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep tissue and high spatiotemporal precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen (1O2) generation efficiency and large two-photon absorption (2PA) cross section are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that polymerization of small molecule PSs with aggregation-induced emission (AIE) could yield conjugated polymer PSs with good brightness, high 1O2 generation efficiency and large 2PA cross section...
February 14, 2019: ACS Nano
Juliane Schulz, Carina Knappe, Christian Graetz, Louisa Mewes, Kathrin Türk, Anna K Black, Wolfgang Lieb, Arne S Schäfer, Karim M Fawzy El-Sayed, Christof E Dörfer, Stefan Schreiber, Matthias Laudes, Dominik M Schulte
AIM: Recombinant secreted frizzled-related protein 5 (sFRP5) improved periodontal status in mice. Thus, this study aimed to investigate this finding in human periodontitis using an epidemiological approach. MATERIALS AND METHODS: sFRP5 and wnt5a concentrations were determined in human serum from the Food Chain Plus cohort using ELISAs. 128 patients with periodontitis and tooth loss and 245 patients with periodontitis without tooth loss were compared to 373 sex-, smoker-, age- and BMI-matched individuals in a nested case-control design...
February 14, 2019: Journal of Clinical Periodontology
Yi-Hsuan Lee, Chia-Wen Lu, Chi-Ting Huang, Hao-Hsiang Chang, Kuen-Cheh Yang, Chia-Sheng Kuo, Yu-Kang Chang, Chih-Cheng Hsu, Kuo-Chin Huang
The aim of this study was to evaluate the impact of home health care (HHC) for disabled patients.We conducted a nationwide population-based retrospective cohort study. A total of 5838 disabled patients with HHC were identified to match by propensity score with 15,829 disabled patients without HHC receiving tube or catheter care (tracheostomy tube, nasogastric tube, urinary catheter, cystostomy tube, nephrostomy tube) or stage 3 or 4 pressure sore care from the Taiwanese National Health Insurance Research Database between 2005 and 2009...
February 2019: Medicine (Baltimore)
Shun-Ku Lin, Pei-Chia Lo, Wang-Chuan Chen, Jung-Nien Lai
Reducing the need for advanced nursing care and medical expenses is an essential concern of dementia care. We investigated the impact of traditional Chinese medicine (TCM) on advanced nursing care and medical costs.We used Longitudinal Health Insurance Database to implement a cohort study of patients with dementia between 1997 and 2012 in Taiwan. Data from the onset of dementia to 1st advanced nursing care for the endotracheal tube, urinal indwelling catheterization, and nasogastric tube were assessed using Cox regression proportional hazards model, and independent t test was used to determine the difference of hospitalization costs and days...
February 2019: Medicine (Baltimore)
Rachel A Hoopsick, D Lynn Homish, R Lorraine Collins, Thomas H Nochajski, Jennifer P Read, Gregory G Homish
A general assumption that deployment is the primary catalyst for psychological and social difficulties may contribute to underrecognition and undertreatment of problems among never-deployed service members (i.e., having no history of ever being deployed). We aimed to determine if ever-deployed (i.e., having a history of at least one deployment) and never-deployed United States Army Reserve and National Guard (USAR/NG) soldiers differed in mental health, substance use, and resiliency factors, and to determine the relative influence of deployment status and each of these factors on poor psychosocial outcomes...
February 14, 2019: Psychological Services
Thomas W H Ng, Kai Chi Yam
Drawing on self-enhancement theory, we propose that, intraindividually, employees tend to give themselves credit when they engage in creativity. Perceived creative credit, in turn, activates multiple psychological motives that ultimately affect deviance. On the one hand, perceived creative credit is associated with greater creativity-driven norm-breaking motives and greater entitlement motives, which in turn should increase deviance. On the other hand, perceived creative credit is associated with greater image preservation motives, which in turn should decrease deviance...
February 14, 2019: Journal of Applied Psychology
Selma Korkmaz, Gülben Sayılan Özgün
Background/aim: Adropin is a peptide-structure hormone that plays a role in preventing the development of insulin resistance, which has been linked to obesity and metabolic regulation. The purpose of this study is to assess serum adropin levels and their relationship with metabolic parameters in psoriasis vulgaris patients both with and without metabolic syndrome (MetS). Materials and methods: Fifty-three patients and 26 healthy controls were included in this study...
February 11, 2019: Turkish Journal of Medical Sciences
Lin Qiao, Xiaobo Zheng, Jing Zheng, She-Jun Chen, Changqin Zhong, Jinghua Chen, Zhong-Yi Yang, Bi-Xian Xian Mai
Legacy organic contaminants, such as polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), and several currently used organic contaminants, such as novel brominated retardants (NBFRs), organophosphate flame retardants (OPFRs), and Dechlorane Plus (DPs), were measured in the segmented hair and hand wipes of e-waste dismantling workers and in the dust from their working place in an e-waste recycling site in South China to assess the accumulation and sources of organic contaminants in the hair shaft...
February 14, 2019: Environmental Science & Technology
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