keyword
https://read.qxmd.com/read/38547325/inter-and-intraobserver-variability-on-endoscopic-scoring-systems-in-crohn-s-disease-and-ulcerative-colitis-a-systematic-review-and-meta-analysis
#1
JOURNAL ARTICLE
Jana G Hashash, Faye Yu Ci Ng, Francis A Farraye, Yeli Wang, Daniel R Colucci, Shrujal Baxi, Sadaf Muneer, Mitchell Reddan, Pratik Shingru, Gil Y Melmed
BACKGROUND: Endoscopy scoring is a key component in the diagnosis of ulcerative colitis (UC) and Crohn's disease (CD). Variability in endoscopic scoring can impact patient trial eligibility and treatment effect measurement. In this study, we examine inter- and intraobserver variability of inflammatory bowel disease endoscopic scoring systems in a systematic review and meta-analysis. METHODS: We included observational studies that evaluated the inter- and intraobserver variability using UC (endoscopic Mayo Score [eMS], Ulcerative Colitis Endoscopic Index of Severity [UCEIS]) or CD (Crohn's Disease Endoscopic Index of Severity [CDEIS], Simple Endoscopic Score for Crohn's Disease [SES-CD]) systems among adults (≥18 years of age) and were published in English...
March 28, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38547243/topological-defects-in-self-assembled-patterns-of-mesenchymal-stromal-cells-in-vitro-are-predictive-attributes-of-condensation-and-chondrogenesis
#2
JOURNAL ARTICLE
Ekta Makhija, Yang Zheng, Jiahao Wang, Han Ren Leong, Rashidah Binte Othman, Ee Xien Ng, Eng Hin Lee, Lisa Tucker Kellogg, Yie Hou Lee, Hanry Yu, Zhiyong Poon, Krystyn J Van Vliet
Mesenchymal stromal cells (MSCs) are promising therapeutic agents for cartilage regeneration, including the potential of cells to promote chondrogenesis in vivo. However, process development and regulatory approval of MSCs as cell therapy products benefit from facile in vitro approaches that can predict potency for a given production run. Current standard in vitro approaches include a 21 day 3D differentiation assay followed by quantification of cartilage matrix proteins. We propose a novel biophysical marker that is cell population-based and can be measured from in vitro monolayer culture of MSCs...
2024: PloS One
https://read.qxmd.com/read/38547215/national-clinical-and-financial-outcomes-associated-with-acute-kidney-injury-following-esophagectomy-for-cancer
#3
JOURNAL ARTICLE
Ayesha P Ng, Nikhil Chervu, Corynn Branche, Syed Shahyan Bakhtiyar, Mehrab Marzban, Paul A Toste, Peyman Benharash
BACKGROUND: Esophagectomy is a complex oncologic operation associated with high rates of postoperative complications. While respiratory and septic complications have been well-defined, the implications of acute kidney injury (AKI) remain unclear. Using a nationally representative database, we aimed to characterize the association of AKI with mortality, resource use, and 30-day readmission. METHODS: All adults undergoing elective esophagectomy with a diagnosis of esophageal or gastric cancer were identified in the 2010-2019 Nationwide Readmissions Database...
2024: PloS One
https://read.qxmd.com/read/38547110/what-influences-stroke-survivors-with-physical-disabilities-to-be-physically-active-a-qualitative-study-informed-by-the-theoretical-domains-framework
#4
JOURNAL ARTICLE
L K Kwah, K Doshi, D A De Silva, W M Ng, S Thilarajah
BACKGROUND: Although the benefits of regular physical activity (PA) after stroke are well established, many stroke survivors do not achieve recommended PA levels. To date, studies exploring determinants to PA have not used a behaviour change theory and focused on stroke survivors with physical disabilities. As a precursor to an intervention development study, we aimed to use the Theoretical Domains Framework (TDF) to identify factors influencing PA in stroke survivors with physical disabilities in Singapore...
2024: PloS One
https://read.qxmd.com/read/38546981/the-role-and-mechanism-of-nicotinamide-riboside-in-oxidative-damage-and-a-fibrosis-model-of-trabecular-meshwork-cells
#5
JOURNAL ARTICLE
Yuping Zeng, Yijun Lin, Juhua Yang, Xiaohui Wang, Yihua Zhu, Biting Zhou
PURPOSE: To investigate the potential effects and mechanism of nicotinamide riboside (NR) on the oxidative stress and fibrosis model of human trabecular meshwork (HTM) cell line cells. METHODS: HTM cells were pretreated with NR, followed by the induction of oxidative injury and fibrosis by hydrogen peroxide (H2O2) and TGF-β2, respectively. Cell viability was tested using Hoechst staining and MTT assays, cell proliferation was assessed by EdU assay, and cell apoptosis was detected by flow cytometry and western blotting...
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38546760/exposure-to-benzotriazoles-and-benzothiazoles-in-czech-male-population-and-its-associations-with-biomarkers-of-liver-function-serum-lipids-and-oxidative-stress
#6
JOURNAL ARTICLE
Nina Pálešová, Lucie Bláhová, Tomáš Janoš, Katarína Řiháčková, Aleš Pindur, Ludmila Šebejová, Pavel Čupr
INTRODUCTION: Benzotriazoles and benzothiazoles (BTs) are high-production volume chemicals as well as widely distributed emerging pollutants with potential health risk. However, information about human exposure to BTs and associated health outcomes is limited. OBJECTIVE: We aimed to characterise exposure to BTs among Czech men, including possible occupational exposure among firefighters, its predictors, and its associations with liver function, serum lipids and oxidative stress...
March 28, 2024: International Archives of Occupational and Environmental Health
https://read.qxmd.com/read/38546730/development-and-external-validation-of-machine-learning-models-for-diabetic-microvascular-complications-cross-sectional-study-with-metabolites
#7
JOURNAL ARTICLE
Feng He, Clarissa Ng Yin Ling, Simon Nusinovici, Ching-Yu Cheng, Tien Yin Wong, Jialiang Li, Charumathi Sabanayagam
BACKGROUND: Diabetic kidney disease (DKD) and diabetic retinopathy (DR) are major diabetic microvascular complications, contributing significantly to morbidity, disability, and mortality worldwide. The kidney and the eye, having similar microvascular structures and physiological and pathogenic features, may experience similar metabolic changes in diabetes. OBJECTIVE: This study aimed to use machine learning (ML) methods integrated with metabolic data to identify biomarkers associated with DKD and DR in a multiethnic Asian population with diabetes, as well as to improve the performance of DKD and DR detection models beyond traditional risk factors...
March 28, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38546621/what-works-better-1-year-outcomes-of-an-effectiveness-trial-comparing-online-telehealth-and-group-based-formats-of-a-military-parenting-program
#8
JOURNAL ARTICLE
Abigail H Gewirtz, David S DeGarmo, Susanne Lee
OBJECTIVE: The present study, conducted with a population of military families, examined the comparative effectiveness of three program formats of Adaptive Parenting Tools (ADAPT), a parenting program for families of school-aged children in which a National Guard or Reserve (NG/R) parent had returned from deployment to the post-9/11 conflicts. Despite well-documented need, parenting programs for NG/R families are scarce and often inaccessible. We predicted that both facilitator-delivered conditions (i...
March 28, 2024: Journal of Consulting and Clinical Psychology
https://read.qxmd.com/read/38546437/discovering-novel-organophosphorus-compounds-in-wastewater-treatment-plant-effluents-through-suspect-screening-and-nontarget-analysis
#9
JOURNAL ARTICLE
Jingrun Hu, Yitao Lyu, Mingzhen Li, Lei Wang, Yi Jiang, Weiling Sun
Limited knowledge on the structure of emerging organophosphorus compounds (OPCs) hampers our comprehensive understanding of their environmental occurrence and potential risks. Through suspect and nontarget screening, combining data-dependent acquisition, data-independent acquisition, and parallel reaction monitoring modes, we identified 60 OPCs (17 traditional and 43 emerging compounds) in effluents of 14 wastewater treatment plants (WWTPs) in Beijing and Qinghai, China. These OPCs comprise 26 organophosphate triesters, 17 organophosphate diesters, 6 organophosphonates, 7 organothiophosphate esters, and 4 other OPCs...
March 28, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38546383/value-of-serum-iron-and-urine-neutrophil-gelatinase-associated-lipocalin-in-predicting-the-mortality-of-critically-ill-patients-with-sepsis
#10
JOURNAL ARTICLE
Rui Zhao, Jiang-Hua Liu, Ze-Liang Qiu
INTRODUCTION: We aimed to investigate the association of iron metabolism-related parameters with 60-day mortality in critically ill patients with sepsis. METHODS: Serum or urine concentrations of iron metabolism-related parameters on intensive care unit admission were measured in a prospective cohort of 133 eligible patients with sepsis according to the Sepsis-3 criteria, and these values were compared between survivors and nonsurvivors, categorized according to their 60-day survival status...
March 1, 2024: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/38546251/fast-track-versus-conventional-perioperative-care-protocols-in-paediatric-intestinal-stoma-closure-%C3%A2-a-randomised-study
#11
JOURNAL ARTICLE
Tanzil Farhad, Md Khurshid Alam Sarwar, Mohammad Zonaid Chowdhury, Adnan Walid, Ayesha Sadia, Tanvir Kabir Chowdhury
BACKGROUND: It is still unclear to what extent fast-track (FT) surgery is applicable in paediatric surgery. The aim of the study was to compare the outcome between FT and conventional perioperative care protocols in paediatric intestinal stoma closure to assess the safety for future application. MATERIALS AND METHODS: This study was a prospective randomised study. Twenty-six paediatric patients who underwent intestinal stoma closure from December 2019 to March 2021 were divided into two groups: group A, conventional methods and Group B FT protocol...
April 1, 2024: African Journal of Paediatric Surgery: AJPS
https://read.qxmd.com/read/38546096/a-self-powered-electrochemical-aptasensor-for-the-detection-of-17%C3%AE-estradiol-based-on-carbon-nanocages-gold-nanoparticles-and-dna-bioconjugate-mediated-biofuel-cells
#12
JOURNAL ARTICLE
Yongju Wu, Dan Luo, Jinfei Yi, Rong Li, Dan Yang, Pengfei Pang, Hongbin Wang, Wenrong Yang, Yanli Zhang
17β-Estradiol (E2) is an important endogenous estrogen, which disturbs the endocrine system and poses a threat to human health because of its accumulation in the human body. Herein, a biofuel cell (BFC)-based self-powered electrochemical aptasensor was developed for E2 detection. Porous carbon nanocage/gold nanoparticle composite modified indium tin oxide (CNC/AuNP/ITO) and glucose oxidase modified CNC/AuNP/ITO were used as the biocathode and bioanode of BFCs, respectively. [Fe(CN)6 ]3- was selected as an electroactive probe, which was entrapped in the pores of positively charged magnetic Fe3 O4 nanoparticles (PMNPs) and then capped with a negatively charged E2 aptamer to form a DNA bioconjugate...
March 28, 2024: Analyst
https://read.qxmd.com/read/38546079/evaluation-of-the-cutoff-point-and-diagnostic-value-of-the-neutrophil-to-lymphocyte-ratio-in-predicting-ovarian-cancer-compared-to-pathological-findings
#13
JOURNAL ARTICLE
Maryam Sadat Hosseini, Fatemeh Amiri, Maysam Rezapour, Tahereh Ashraf Ganjoie, Farah Farzaneh, Maliheh Arab, Maryam Talayeh, Rezvaneh Beheshti Rooy, Fatemeh Hadi
PURPOSE: This research aims to establish a neutrophil-to-lymphocyte ratio (NLR) threshold and evaluate its diagnostic accuracy compared to pathological criteria for diagnosing Epithelial Ovarian Cancer (EOC). METHODS: We conducted a cross-sectional study at Imam Hossein Hospital involving 204 women aged 18 and older with confirmed ovarian mass based on pathology. We recorded clinical, pathological, and preoperative blood count data, including neutrophil-to-lymphocyte ratio (NLR)...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38546056/investigation-of-plasma-cell-free-dna-and-mirna-in-cholangiocarcinoma-and-opisthorchiasis-viverrini-patients
#14
JOURNAL ARTICLE
Sattrachai Prasopdee, Montinee Pholhelm, Siraphatsorn Yusuk, Sithichoke Tangphatsornruang, Kritiya Butthongkomvong, Anthicha Kunjantarachot, Teva Phanaksri, Jutharat Kulsantiwong, Smarn Tesana, Veerachai Thitapakorn
OBJECTIVES: This study aimed to assess the diagnostic potential of cell-free DNA (cfDNA) and cell-free miRNA (cf-miRNA) for distinguishing between Healthy, asymptomatic opisthorchiasis viverrini and cholangiocarcinoma in a preliminary manner. METHODS: In this study, 36 participants were enrolled into three health status groups: a healthy control group (HC), Opisthorchis viverrini-infected group (OV), and a cholangiocarcinoma group (CCA), each comprising 12 participants...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38546019/the-crp-troponin-test-ctt-stratifies-mortality-risk-in-patients-with-non-st-elevation-myocardial-infarction-nstemi
#15
JOURNAL ARTICLE
Rafael Y Brzezinski, Shmuel Banai, Malka Katz Shalhav, Moshe Stark, Ilana Goldiner, Ori Rogowski, Itzhak Shapira, David Zeltser, Noa Sasson, Shlomo Berliner, Yacov Shacham
INTRODUCTION: The C-reactive protein (CRP)-troponin-test (CTT) comprises simultaneous serial measurements of CRP and cardiac troponin and might reflect the systemic inflammatory response in patients with acute coronary syndrome. We sought to test its ability to stratify the short- and long-term mortality risk in patients with non-ST elevation myocardial infarction (NSTEMI). METHODS: We examined 1,675 patients diagnosed with NSTEMI on discharge who had at least two successive measurements of combined CRP and cardiac troponin within 48 h of admission...
April 2024: Clinical Cardiology
https://read.qxmd.com/read/38545920/concentrations-of-pfas-in-vegetables-from-sydney-and-newcastle-australia
#16
JOURNAL ARTICLE
Siyuan Liu, Luchun Duan, Feng Shi, Gabriel M Filippelli, Ravi Naidu
BACKGROUND: This study investigated per - and polyfluoro alkyl substance (PFAS) in 53 fruit and vegetable samples collected from a local wholesale and retail market in Sydney and a local supermarket in Newcastle. As there are limited information about PFAS levels in vegetables on the markets, this study aimed to fill this gap and assess potential risks for human through consumption of these vegetables. METHODS: QuEChERS extraction- a solid phase extraction method, a portmanteau word formed from 'quick, easy, cheap, effective, rugged, and safe' followed by enhanced matrix removal (EMR)-lipid cleaning along and LC-MS/MS analysis were used to detect 30 PFASs in vegetables...
March 28, 2024: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38545760/comparison-of-the-multiples-of-the-median-of-serum-anti-m%C3%A3-llerian-hormone-and-pregnancy-outcomes-in-patients-with-gestational-trophoblastic-disease-a-case-control-study
#17
JOURNAL ARTICLE
Theodora Hei Tung Lai, Lesley Suk Kwan Lau, Siew Fei Ngu, Man Yee Mandy Chu, Karen Kar Loen Chan, Ernest Hung Yu Ng, Hextan Yuen Sheung Ngan, Raymond Hang Wun Li, Ka Yu Tse
INTRODUCTION: Chemotherapy is crucial in treating gestational trophoblastic neoplasia (GTN), but its impact on gonadotoxicity is unclear. MATERIALS AND METHODS: This case-control study included 57 GTN patients and 19 age-matched patients with molar pregnancies (MP) in 2012-2018. Multiples of the median (MoM) of the serum AMH levels were compared between the two groups, and between patients using single-agent and combination chemotherapy, at baseline, 6, 12, and 24 months after treatment...
April 2024: Cancer Medicine
https://read.qxmd.com/read/38545613/tympanal-ears-mediate-male-male-competition-courtship-and-mating-success-in-bicyclus-anynana-butterflies
#18
JOURNAL ARTICLE
Galen J L Tiong, Lin Naing, Edwin Ng, Emilie Dion, Antónia Monteiro
The presence of intra-specific acoustic communication in diurnal butterflies is not well established. Here, we examined the function of the tympanal ear (Vogel's organ, VO) in the seasonally polyphenic butterfly Bicyclus anynana in the context of sexual signalling. We investigated how the VO and the flanking enlarged veins, which are suggested sound resonance chambers, scale with wing size across sexes and seasonal forms, and how disruptions to the VO alter courtship behaviour and mating outcomes. We found that males have VOs similar in size to females despite having smaller wings, and dry season (DS) male cubital and anal veins do not scale with the wing size...
March 2024: Royal Society Open Science
https://read.qxmd.com/read/38545602/long-term-effects-of-mobile-exoneuromusculoskeleton-enms-assisted-self-help-telerehabilitation-after-stroke
#19
JOURNAL ARTICLE
Wanyi Qing, Ching-Yi Nam, Harvey Man-Hok Shum, Marko Ka-Leung Chan, King-Pong Yu, Serena Sin-Wah Ng, Bibo Yang, Xiaoling Hu
Investigation on long-term effects of robot-assisted poststroke rehabilitation is challenging because of the difficulties in administration and follow-up of individuals throughout the process. A mobile hybrid neuromuscular electrical stimulation (NMES)-robot, i.e., exoneuromusculoskeleton (ENSM) was adopted for a single-group trial to investigate the long-term effects of the robot-assisted self-help telerehabilitation on upper limb motor function after stroke. Twenty-two patients with chronic stroke were recruited to attend a 20-session telerehabilitation program assisted by the wrist/hand module of the ENMS (WH-ENMS)...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38545510/the-effectiveness-and-safety-of-lifestyle-medicine-and-integrative-therapies-in-inflammatory-arthritis-an-umbrella-review-using-a-hierarchical-evidence-gathering-approach
#20
REVIEW
Joshua Lin, Jing Liu, Allana O'Fee, Chhiti Pandey, Sarah Benna-Doyle, Alison Maunder, Vibhuti Rao, Simon Alesi, Beverly Ng, Carolyn Ee
OBJECTIVE: An umbrella review was conducted to provide a comprehensive evaluation of the evidence on lifestyle medicine and integrative therapies for inflammatory arthritis. METHODS: Five electronic databases were searched for umbrella reviews, meta-analyses, and systematic reviews of randomised controlled trials on acupuncture, diet, exercise, herbal medicine, nutrient supplements, and mind-body therapies for rheumatoid arthritis, spondyloarthritis, and gout published from January 2012 to December 2022...
2024: Frontiers in Medicine
keyword
keyword
158707
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.